Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X6E0_LEIDO

TriTrypDb:

LdBPK_330440.1 , LdCL_330009900 , LDHU3_33.0690

Length:

1046

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X6E0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6E0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	683	687	PF00656	0.640
CLV_C14_Caspase3-7	868	872	PF00656	0.601
CLV_MEL_PAP_1	26	32	PF00089	0.636
CLV_NRD_NRD_1	158	160	PF00675	0.712
CLV_NRD_NRD_1	173	175	PF00675	0.387
CLV_NRD_NRD_1	323	325	PF00675	0.647
CLV_NRD_NRD_1	357	359	PF00675	0.681
CLV_NRD_NRD_1	553	555	PF00675	0.700
CLV_NRD_NRD_1	617	619	PF00675	0.638
CLV_NRD_NRD_1	622	624	PF00675	0.672
CLV_NRD_NRD_1	730	732	PF00675	0.706
CLV_NRD_NRD_1	734	736	PF00675	0.657
CLV_PCSK_FUR_1	156	160	PF00082	0.652
CLV_PCSK_FUR_1	620	624	PF00082	0.614
CLV_PCSK_KEX2_1	158	160	PF00082	0.707
CLV_PCSK_KEX2_1	173	175	PF00082	0.383
CLV_PCSK_KEX2_1	322	324	PF00082	0.640
CLV_PCSK_KEX2_1	356	358	PF00082	0.679
CLV_PCSK_KEX2_1	553	555	PF00082	0.700
CLV_PCSK_KEX2_1	617	619	PF00082	0.698
CLV_PCSK_KEX2_1	622	624	PF00082	0.730
CLV_PCSK_KEX2_1	730	732	PF00082	0.702
CLV_PCSK_KEX2_1	734	736	PF00082	0.652
CLV_PCSK_KEX2_1	898	900	PF00082	0.575
CLV_PCSK_PC1ET2_1	898	900	PF00082	0.575
CLV_PCSK_PC7_1	618	624	PF00082	0.610
CLV_PCSK_PC7_1	730	736	PF00082	0.776
CLV_PCSK_SKI1_1	180	184	PF00082	0.552
CLV_PCSK_SKI1_1	310	314	PF00082	0.656
CLV_PCSK_SKI1_1	477	481	PF00082	0.627
CLV_PCSK_SKI1_1	487	491	PF00082	0.612
CLV_PCSK_SKI1_1	911	915	PF00082	0.637
CLV_PCSK_SKI1_1	936	940	PF00082	0.537
CLV_Separin_Metazoa	319	323	PF03568	0.691
DEG_APCC_DBOX_1	179	187	PF00400	0.568
DEG_SCF_FBW7_1	606	613	PF00400	0.625
DEG_SCF_FBW7_1	841	848	PF00400	0.574
DEG_SPOP_SBC_1	42	46	PF00917	0.571
DOC_ANK_TNKS_1	445	452	PF00023	0.684
DOC_CDC14_PxL_1	183	191	PF14671	0.711
DOC_CKS1_1	211	216	PF01111	0.731
DOC_CKS1_1	607	612	PF01111	0.627
DOC_CYCLIN_RxL_1	174	188	PF00134	0.571
DOC_CYCLIN_RxL_1	931	941	PF00134	0.562
DOC_CYCLIN_yCln2_LP_2	300	306	PF00134	0.617
DOC_MAPK_gen_1	173	183	PF00069	0.619
DOC_MAPK_gen_1	322	330	PF00069	0.728
DOC_MAPK_gen_1	889	896	PF00069	0.733
DOC_MAPK_HePTP_8	171	183	PF00069	0.597
DOC_MAPK_MEF2A_6	174	183	PF00069	0.633
DOC_MAPK_MEF2A_6	322	330	PF00069	0.728
DOC_MAPK_MEF2A_6	50	58	PF00069	0.574
DOC_MAPK_MEF2A_6	876	883	PF00069	0.604
DOC_MAPK_MEF2A_6	889	896	PF00069	0.707
DOC_PP2B_LxvP_1	184	187	PF13499	0.597
DOC_PP2B_LxvP_1	292	295	PF13499	0.633
DOC_PP2B_LxvP_1	300	303	PF13499	0.566
DOC_PP2B_LxvP_1	564	567	PF13499	0.592
DOC_PP2B_LxvP_1	663	666	PF13499	0.656
DOC_PP2B_LxvP_1	816	819	PF13499	0.747
DOC_PP4_FxxP_1	578	581	PF00568	0.615
DOC_USP7_MATH_1	121	125	PF00917	0.535
DOC_USP7_MATH_1	18	22	PF00917	0.600
DOC_USP7_MATH_1	192	196	PF00917	0.679
DOC_USP7_MATH_1	2	6	PF00917	0.697
DOC_USP7_MATH_1	217	221	PF00917	0.688
DOC_USP7_MATH_1	261	265	PF00917	0.653
DOC_USP7_MATH_1	375	379	PF00917	0.720
DOC_USP7_MATH_1	42	46	PF00917	0.624
DOC_USP7_MATH_1	421	425	PF00917	0.642
DOC_USP7_MATH_1	524	528	PF00917	0.680
DOC_USP7_MATH_1	698	702	PF00917	0.686
DOC_USP7_MATH_1	745	749	PF00917	0.643
DOC_USP7_MATH_1	77	81	PF00917	0.615
DOC_USP7_MATH_1	825	829	PF00917	0.674
DOC_USP7_MATH_1	870	874	PF00917	0.676
DOC_USP7_UBL2_3	876	880	PF12436	0.685
DOC_WW_Pin1_4	1007	1012	PF00397	0.640
DOC_WW_Pin1_4	210	215	PF00397	0.812
DOC_WW_Pin1_4	419	424	PF00397	0.790
DOC_WW_Pin1_4	606	611	PF00397	0.689
DOC_WW_Pin1_4	703	708	PF00397	0.764
DOC_WW_Pin1_4	717	722	PF00397	0.642
DOC_WW_Pin1_4	826	831	PF00397	0.723
DOC_WW_Pin1_4	833	838	PF00397	0.667
DOC_WW_Pin1_4	841	846	PF00397	0.504
DOC_WW_Pin1_4	905	910	PF00397	0.792
LIG_14-3-3_CanoR_1	29	36	PF00244	0.586
LIG_14-3-3_CanoR_1	503	507	PF00244	0.627
LIG_14-3-3_CanoR_1	509	518	PF00244	0.540
LIG_14-3-3_CanoR_1	754	760	PF00244	0.703
LIG_14-3-3_CanoR_1	853	859	PF00244	0.490
LIG_14-3-3_CanoR_1	911	920	PF00244	0.504
LIG_BIR_II_1	1	5	PF00653	0.716
LIG_BIR_III_2	208	212	PF00653	0.690
LIG_BIR_III_3	1	5	PF00653	0.633
LIG_BRCT_BRCA1_1	1011	1015	PF00533	0.675
LIG_BRCT_BRCA1_1	263	267	PF00533	0.653
LIG_BRCT_BRCA1_1	513	517	PF00533	0.604
LIG_BRCT_BRCA1_1	855	859	PF00533	0.519
LIG_CaM_NSCaTE_8	506	513	PF13499	0.621
LIG_CaM_NSCaTE_8	808	815	PF13499	0.658
LIG_CtBP_PxDLS_1	88	92	PF00389	0.534
LIG_deltaCOP1_diTrp_1	950	955	PF00928	0.617
LIG_DLG_GKlike_1	185	193	PF00625	0.645
LIG_EVH1_1	65	69	PF00568	0.797
LIG_FHA_1	112	118	PF00498	0.594
LIG_FHA_1	126	132	PF00498	0.390
LIG_FHA_1	134	140	PF00498	0.543
LIG_FHA_1	211	217	PF00498	0.814
LIG_FHA_1	229	235	PF00498	0.579
LIG_FHA_1	253	259	PF00498	0.633
LIG_FHA_1	296	302	PF00498	0.675
LIG_FHA_1	303	309	PF00498	0.623
LIG_FHA_1	38	44	PF00498	0.754
LIG_FHA_1	547	553	PF00498	0.577
LIG_FHA_1	561	567	PF00498	0.599
LIG_FHA_1	652	658	PF00498	0.732
LIG_FHA_1	665	671	PF00498	0.639
LIG_FHA_1	727	733	PF00498	0.795
LIG_FHA_1	784	790	PF00498	0.664
LIG_FHA_1	815	821	PF00498	0.585
LIG_FHA_1	842	848	PF00498	0.678
LIG_FHA_1	891	897	PF00498	0.742
LIG_FHA_1	908	914	PF00498	0.668
LIG_FHA_1	996	1002	PF00498	0.780
LIG_FHA_2	466	472	PF00498	0.678
LIG_FHA_2	607	613	PF00498	0.631
LIG_GBD_Chelix_1	1020	1028	PF00786	0.555
LIG_Integrin_isoDGR_2	651	653	PF01839	0.745
LIG_LIR_Apic_2	386	390	PF02991	0.665
LIG_LIR_Gen_1	1012	1021	PF02991	0.709
LIG_LIR_Gen_1	11	20	PF02991	0.485
LIG_LIR_Gen_1	188	197	PF02991	0.630
LIG_LIR_Gen_1	806	816	PF02991	0.473
LIG_LIR_Gen_1	958	965	PF02991	0.661
LIG_LIR_Gen_1	986	995	PF02991	0.749
LIG_LIR_Nem_3	1012	1018	PF02991	0.730
LIG_LIR_Nem_3	11	15	PF02991	0.476
LIG_LIR_Nem_3	188	193	PF02991	0.584
LIG_LIR_Nem_3	311	316	PF02991	0.500
LIG_LIR_Nem_3	63	68	PF02991	0.708
LIG_LIR_Nem_3	806	811	PF02991	0.521
LIG_LIR_Nem_3	941	947	PF02991	0.681
LIG_LIR_Nem_3	958	962	PF02991	0.594
LIG_LIR_Nem_3	986	990	PF02991	0.667
LIG_MLH1_MIPbox_1	855	859	PF16413	0.519
LIG_NRBOX	547	553	PF00104	0.678
LIG_Pex14_1	130	134	PF04695	0.494
LIG_Pex14_1	955	959	PF04695	0.698
LIG_Pex14_1	987	991	PF04695	0.762
LIG_PTAP_UEV_1	218	223	PF05743	0.646
LIG_REV1ctd_RIR_1	930	940	PF16727	0.557
LIG_RPA_C_Fungi	618	630	PF08784	0.691
LIG_RPA_C_Fungi	799	811	PF08784	0.492
LIG_SH2_CRK	190	194	PF00017	0.566
LIG_SH2_CRK	959	963	PF00017	0.667
LIG_SH2_NCK_1	190	194	PF00017	0.743
LIG_SH2_NCK_1	991	995	PF00017	0.739
LIG_SH2_SRC	991	994	PF00017	0.744
LIG_SH2_STAP1	991	995	PF00017	0.574
LIG_SH2_STAT3	583	586	PF00017	0.647
LIG_SH2_STAT3	7	10	PF00017	0.479
LIG_SH2_STAT5	134	137	PF00017	0.630
LIG_SH2_STAT5	190	193	PF00017	0.660
LIG_SH2_STAT5	382	385	PF00017	0.744
LIG_SH2_STAT5	7	10	PF00017	0.487
LIG_SH2_STAT5	743	746	PF00017	0.758
LIG_SH2_STAT5	858	861	PF00017	0.522
LIG_SH2_STAT5	959	962	PF00017	0.795
LIG_SH3_3	208	214	PF00018	0.731
LIG_SH3_3	216	222	PF00018	0.635
LIG_SH3_3	435	441	PF00018	0.808
LIG_SH3_3	46	52	PF00018	0.681
LIG_SH3_3	585	591	PF00018	0.668
LIG_SH3_3	604	610	PF00018	0.625
LIG_SH3_3	627	633	PF00018	0.708
LIG_SH3_3	63	69	PF00018	0.582
LIG_SH3_3	772	778	PF00018	0.643
LIG_SH3_3	959	965	PF00018	0.666
LIG_SUMO_SIM_anti_2	298	303	PF11976	0.685
LIG_SUMO_SIM_anti_2	327	332	PF11976	0.714
LIG_SUMO_SIM_anti_2	337	343	PF11976	0.549
LIG_SUMO_SIM_anti_2	521	527	PF11976	0.593
LIG_SUMO_SIM_anti_2	532	538	PF11976	0.499
LIG_SUMO_SIM_par_1	535	541	PF11976	0.557
LIG_SUMO_SIM_par_1	562	569	PF11976	0.549
LIG_SUMO_SIM_par_1	90	96	PF11976	0.534
LIG_TRAF2_1	378	381	PF00917	0.758
LIG_TRAF2_1	470	473	PF00917	0.744
LIG_TRAF2_2	495	500	PF00917	0.686
LIG_UBA3_1	874	880	PF00899	0.576
LIG_WW_1	635	638	PF00397	0.708
LIG_WW_2	66	69	PF00397	0.797
LIG_WW_3	319	323	PF00397	0.670
MOD_CDC14_SPxK_1	908	911	PF00782	0.688
MOD_CDK_SPxK_1	905	911	PF00069	0.704
MOD_CDK_SPxxK_3	610	617	PF00069	0.709
MOD_CK1_1	1004	1010	PF00069	0.711
MOD_CK1_1	1013	1019	PF00069	0.590
MOD_CK1_1	188	194	PF00069	0.652
MOD_CK1_1	311	317	PF00069	0.665
MOD_CK1_1	404	410	PF00069	0.787
MOD_CK1_1	429	435	PF00069	0.730
MOD_CK1_1	546	552	PF00069	0.575
MOD_CK1_1	692	698	PF00069	0.710
MOD_CK1_1	706	712	PF00069	0.487
MOD_CK1_1	907	913	PF00069	0.687
MOD_CK2_1	1037	1043	PF00069	0.750
MOD_CK2_1	226	232	PF00069	0.730
MOD_CK2_1	375	381	PF00069	0.712
MOD_CK2_1	410	416	PF00069	0.742
MOD_CK2_1	444	450	PF00069	0.699
MOD_CK2_1	465	471	PF00069	0.676
MOD_CK2_1	57	63	PF00069	0.686
MOD_CK2_1	606	612	PF00069	0.626
MOD_CK2_1	677	683	PF00069	0.621
MOD_CK2_1	800	806	PF00069	0.518
MOD_CMANNOS	952	955	PF00535	0.635
MOD_GlcNHglycan	1012	1015	PF01048	0.615
MOD_GlcNHglycan	105	108	PF01048	0.656
MOD_GlcNHglycan	120	124	PF01048	0.364
MOD_GlcNHglycan	194	197	PF01048	0.706
MOD_GlcNHglycan	219	222	PF01048	0.742
MOD_GlcNHglycan	223	226	PF01048	0.781
MOD_GlcNHglycan	288	291	PF01048	0.747
MOD_GlcNHglycan	30	33	PF01048	0.628
MOD_GlcNHglycan	310	313	PF01048	0.689
MOD_GlcNHglycan	336	339	PF01048	0.582
MOD_GlcNHglycan	393	396	PF01048	0.650
MOD_GlcNHglycan	419	422	PF01048	0.646
MOD_GlcNHglycan	423	426	PF01048	0.639
MOD_GlcNHglycan	431	434	PF01048	0.629
MOD_GlcNHglycan	446	449	PF01048	0.719
MOD_GlcNHglycan	45	48	PF01048	0.576
MOD_GlcNHglycan	511	514	PF01048	0.578
MOD_GlcNHglycan	526	529	PF01048	0.552
MOD_GlcNHglycan	600	603	PF01048	0.708
MOD_GlcNHglycan	70	73	PF01048	0.674
MOD_GlcNHglycan	700	703	PF01048	0.698
MOD_GlcNHglycan	747	750	PF01048	0.715
MOD_GSK3_1	1001	1008	PF00069	0.731
MOD_GSK3_1	1009	1016	PF00069	0.580
MOD_GSK3_1	1028	1035	PF00069	0.684
MOD_GSK3_1	121	128	PF00069	0.523
MOD_GSK3_1	129	136	PF00069	0.592
MOD_GSK3_1	188	195	PF00069	0.730
MOD_GSK3_1	196	203	PF00069	0.688
MOD_GSK3_1	217	224	PF00069	0.795
MOD_GSK3_1	228	235	PF00069	0.687
MOD_GSK3_1	246	253	PF00069	0.772
MOD_GSK3_1	304	311	PF00069	0.668
MOD_GSK3_1	37	44	PF00069	0.648
MOD_GSK3_1	397	404	PF00069	0.683
MOD_GSK3_1	415	422	PF00069	0.788
MOD_GSK3_1	606	613	PF00069	0.738
MOD_GSK3_1	698	705	PF00069	0.707
MOD_GSK3_1	745	752	PF00069	0.716
MOD_GSK3_1	821	828	PF00069	0.635
MOD_GSK3_1	833	840	PF00069	0.669
MOD_GSK3_1	841	848	PF00069	0.566
MOD_GSK3_1	849	856	PF00069	0.457
MOD_GSK3_1	870	877	PF00069	0.579
MOD_GSK3_1	879	886	PF00069	0.583
MOD_GSK3_1	897	904	PF00069	0.547
MOD_GSK3_1	907	914	PF00069	0.760
MOD_N-GLC_1	821	826	PF02516	0.705
MOD_N-GLC_1	841	846	PF02516	0.430
MOD_N-GLC_2	401	403	PF02516	0.612
MOD_NEK2_1	1028	1033	PF00069	0.565
MOD_NEK2_1	1037	1042	PF00069	0.642
MOD_NEK2_1	111	116	PF00069	0.668
MOD_NEK2_1	252	257	PF00069	0.713
MOD_NEK2_1	268	273	PF00069	0.428
MOD_NEK2_1	304	309	PF00069	0.659
MOD_NEK2_1	334	339	PF00069	0.500
MOD_NEK2_1	518	523	PF00069	0.634
MOD_NEK2_1	760	765	PF00069	0.616
MOD_NEK2_1	789	794	PF00069	0.577
MOD_NEK2_1	8	13	PF00069	0.548
MOD_NEK2_1	800	805	PF00069	0.528
MOD_NEK2_1	854	859	PF00069	0.518
MOD_NEK2_1	874	879	PF00069	0.343
MOD_NEK2_2	129	134	PF00069	0.510
MOD_NEK2_2	749	754	PF00069	0.596
MOD_NEK2_2	926	931	PF00069	0.539
MOD_PIKK_1	349	355	PF00454	0.665
MOD_PIKK_1	518	524	PF00454	0.681
MOD_PIKK_1	760	766	PF00454	0.730
MOD_PKA_2	250	256	PF00069	0.685
MOD_PKA_2	28	34	PF00069	0.639
MOD_PKA_2	502	508	PF00069	0.652
MOD_PKA_2	783	789	PF00069	0.665
MOD_PKA_2	890	896	PF00069	0.623
MOD_Plk_1	1028	1034	PF00069	0.686
MOD_Plk_1	18	24	PF00069	0.573
MOD_Plk_1	326	332	PF00069	0.612
MOD_Plk_1	375	381	PF00069	0.761
MOD_Plk_1	870	876	PF00069	0.578
MOD_Plk_1	926	932	PF00069	0.547
MOD_Plk_2-3	226	232	PF00069	0.730
MOD_Plk_2-3	677	683	PF00069	0.779
MOD_Plk_4	185	191	PF00069	0.720
MOD_Plk_4	295	301	PF00069	0.644
MOD_Plk_4	3	9	PF00069	0.499
MOD_Plk_4	326	332	PF00069	0.713
MOD_Plk_4	401	407	PF00069	0.703
MOD_Plk_4	410	416	PF00069	0.666
MOD_Plk_4	502	508	PF00069	0.630
MOD_Plk_4	543	549	PF00069	0.574
MOD_Plk_4	566	572	PF00069	0.633
MOD_Plk_4	755	761	PF00069	0.620
MOD_Plk_4	854	860	PF00069	0.498
MOD_Plk_4	870	876	PF00069	0.578
MOD_Plk_4	934	940	PF00069	0.652
MOD_ProDKin_1	1007	1013	PF00069	0.640
MOD_ProDKin_1	210	216	PF00069	0.814
MOD_ProDKin_1	419	425	PF00069	0.791
MOD_ProDKin_1	606	612	PF00069	0.692
MOD_ProDKin_1	703	709	PF00069	0.766
MOD_ProDKin_1	717	723	PF00069	0.641
MOD_ProDKin_1	826	832	PF00069	0.723
MOD_ProDKin_1	833	839	PF00069	0.660
MOD_ProDKin_1	841	847	PF00069	0.494
MOD_ProDKin_1	905	911	PF00069	0.786
TRG_DiLeu_BaLyEn_6	547	552	PF01217	0.671
TRG_DiLeu_BaLyEn_6	728	733	PF01217	0.792
TRG_DiLeu_BaLyEn_6	807	812	PF01217	0.486
TRG_DiLeu_BaLyEn_6	850	855	PF01217	0.485
TRG_DiLeu_BaLyEn_6	942	947	PF01217	0.682
TRG_ENDOCYTIC_2	190	193	PF00928	0.566
TRG_ENDOCYTIC_2	959	962	PF00928	0.671
TRG_ENDOCYTIC_2	991	994	PF00928	0.643
TRG_ER_diArg_1	156	159	PF00400	0.747
TRG_ER_diArg_1	173	176	PF00400	0.367
TRG_ER_diArg_1	321	324	PF00400	0.583
TRG_ER_diArg_1	356	358	PF00400	0.721
TRG_ER_diArg_1	552	554	PF00400	0.702
TRG_ER_diArg_1	617	620	PF00400	0.699
TRG_ER_diArg_1	622	624	PF00400	0.720
TRG_ER_diArg_1	730	732	PF00400	0.697
TRG_ER_diArg_1	733	735	PF00400	0.655
TRG_ER_diArg_1	888	891	PF00400	0.709
TRG_NES_CRM1_1	529	541	PF08389	0.622
TRG_NES_CRM1_1	90	104	PF08389	0.553
TRG_Pf-PMV_PEXEL_1	173	178	PF00026	0.553
TRG_Pf-PMV_PEXEL_1	653	658	PF00026	0.626
TRG_Pf-PMV_PEXEL_1	669	673	PF00026	0.642
TRG_Pf-PMV_PEXEL_1	945	950	PF00026	0.637

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEX3	Leptomonas seymouri	40%	95%
A4HL78	Leishmania braziliensis	73%	100%
A4I8Q7	Leishmania infantum	100%	100%
E9B3M1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q4G6	Leishmania major	89%	100%