BRE1 E3 ubiquitin ligase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Coiled-coil domain-containing protein 40 homolog

Species:

Leishmania donovani

UniProt:

A0A3S7X6D9_LEIDO

TriTrypDb:

LdBPK_330630.1 , LdCL_330011800 , LDHU3_33.0910

Length:

875

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X6D9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6D9

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	12
GO:0001578	microtubule bundle formation	4	12
GO:0006996	organelle organization	4	12
GO:0007010	cytoskeleton organization	5	12
GO:0007017	microtubule-based process	2	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0035082	axoneme assembly	5	12
GO:0071840	cellular component organization or biogenesis	2	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016874	ligase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	215	219	PF00656	0.550
CLV_C14_Caspase3-7	294	298	PF00656	0.414
CLV_NRD_NRD_1	157	159	PF00675	0.466
CLV_NRD_NRD_1	246	248	PF00675	0.427
CLV_NRD_NRD_1	251	253	PF00675	0.427
CLV_NRD_NRD_1	31	33	PF00675	0.543
CLV_NRD_NRD_1	334	336	PF00675	0.619
CLV_NRD_NRD_1	37	39	PF00675	0.493
CLV_NRD_NRD_1	391	393	PF00675	0.589
CLV_NRD_NRD_1	456	458	PF00675	0.465
CLV_NRD_NRD_1	462	464	PF00675	0.476
CLV_NRD_NRD_1	611	613	PF00675	0.277
CLV_NRD_NRD_1	615	617	PF00675	0.270
CLV_NRD_NRD_1	652	654	PF00675	0.414
CLV_NRD_NRD_1	754	756	PF00675	0.599
CLV_NRD_NRD_1	847	849	PF00675	0.457
CLV_PCSK_KEX2_1	157	159	PF00082	0.466
CLV_PCSK_KEX2_1	186	188	PF00082	0.479
CLV_PCSK_KEX2_1	210	212	PF00082	0.569
CLV_PCSK_KEX2_1	246	248	PF00082	0.427
CLV_PCSK_KEX2_1	31	33	PF00082	0.577
CLV_PCSK_KEX2_1	455	457	PF00082	0.473
CLV_PCSK_KEX2_1	582	584	PF00082	0.309
CLV_PCSK_KEX2_1	611	613	PF00082	0.273
CLV_PCSK_KEX2_1	617	619	PF00082	0.273
CLV_PCSK_KEX2_1	749	751	PF00082	0.482
CLV_PCSK_KEX2_1	754	756	PF00082	0.491
CLV_PCSK_KEX2_1	809	811	PF00082	0.508
CLV_PCSK_KEX2_1	847	849	PF00082	0.439
CLV_PCSK_PC1ET2_1	186	188	PF00082	0.479
CLV_PCSK_PC1ET2_1	210	212	PF00082	0.569
CLV_PCSK_PC1ET2_1	582	584	PF00082	0.311
CLV_PCSK_PC1ET2_1	617	619	PF00082	0.278
CLV_PCSK_PC1ET2_1	749	751	PF00082	0.481
CLV_PCSK_PC1ET2_1	809	811	PF00082	0.533
CLV_PCSK_PC7_1	206	212	PF00082	0.570
CLV_PCSK_PC7_1	750	756	PF00082	0.518
CLV_PCSK_SKI1_1	358	362	PF00082	0.599
CLV_PCSK_SKI1_1	385	389	PF00082	0.595
CLV_PCSK_SKI1_1	392	396	PF00082	0.510
CLV_PCSK_SKI1_1	679	683	PF00082	0.618
CLV_PCSK_SKI1_1	741	745	PF00082	0.541
CLV_PCSK_SKI1_1	758	762	PF00082	0.424
DEG_APCC_DBOX_1	237	245	PF00400	0.537
DEG_APCC_DBOX_1	37	45	PF00400	0.513
DEG_APCC_KENBOX_2	736	740	PF00400	0.598
DEG_Nend_UBRbox_1	1	4	PF02207	0.618
DOC_MAPK_gen_1	174	182	PF00069	0.535
DOC_MAPK_gen_1	60	69	PF00069	0.461
DOC_MAPK_gen_1	616	623	PF00069	0.407
DOC_MAPK_gen_1	676	683	PF00069	0.484
DOC_MAPK_gen_1	713	721	PF00069	0.576
DOC_MAPK_gen_1	847	853	PF00069	0.426
DOC_MAPK_MEF2A_6	176	184	PF00069	0.536
DOC_MAPK_MEF2A_6	573	581	PF00069	0.290
DOC_PP1_RVXF_1	644	651	PF00149	0.414
DOC_PP1_RVXF_1	677	684	PF00149	0.624
DOC_USP7_MATH_1	110	114	PF00917	0.567
DOC_USP7_MATH_1	291	295	PF00917	0.564
DOC_USP7_MATH_1	4	8	PF00917	0.681
DOC_USP7_MATH_1	505	509	PF00917	0.497
DOC_USP7_MATH_1	594	598	PF00917	0.328
DOC_USP7_MATH_1	9	13	PF00917	0.650
DOC_USP7_UBL2_3	341	345	PF12436	0.633
DOC_USP7_UBL2_3	354	358	PF12436	0.494
DOC_USP7_UBL2_3	381	385	PF12436	0.592
LIG_14-3-3_CanoR_1	238	242	PF00244	0.523
LIG_14-3-3_CanoR_1	252	258	PF00244	0.454
LIG_14-3-3_CanoR_1	520	528	PF00244	0.419
LIG_14-3-3_CanoR_1	583	588	PF00244	0.467
LIG_14-3-3_CanoR_1	631	641	PF00244	0.458
LIG_APCC_ABBA_1	740	745	PF00400	0.513
LIG_APCC_ABBAyCdc20_2	646	652	PF00400	0.418
LIG_BRCT_BRCA1_1	857	861	PF00533	0.571
LIG_Clathr_ClatBox_1	139	143	PF01394	0.554
LIG_Clathr_ClatBox_1	265	269	PF01394	0.540
LIG_DLG_GKlike_1	176	184	PF00625	0.486
LIG_FHA_1	134	140	PF00498	0.451
LIG_FHA_1	521	527	PF00498	0.305
LIG_FHA_2	161	167	PF00498	0.467
LIG_FHA_2	213	219	PF00498	0.505
LIG_FHA_2	404	410	PF00498	0.583
LIG_FHA_2	430	436	PF00498	0.412
LIG_FHA_2	49	55	PF00498	0.567
LIG_FHA_2	680	686	PF00498	0.612
LIG_FHA_2	775	781	PF00498	0.491
LIG_LIR_Gen_1	318	329	PF02991	0.461
LIG_LIR_Gen_1	517	526	PF02991	0.292
LIG_LIR_Nem_3	318	324	PF02991	0.452
LIG_LIR_Nem_3	517	521	PF02991	0.412
LIG_LIR_Nem_3	858	864	PF02991	0.467
LIG_MYND_1	862	866	PF01753	0.597
LIG_PCNA_yPIPBox_3	280	293	PF02747	0.559
LIG_PDZ_Class_1	870	875	PF00595	0.506
LIG_Rb_LxCxE_1	666	685	PF01857	0.604
LIG_REV1ctd_RIR_1	601	611	PF16727	0.216
LIG_SH2_GRB2like	128	131	PF00017	0.479
LIG_SH2_STAP1	475	479	PF00017	0.557
LIG_SH2_STAT3	70	73	PF00017	0.445
LIG_SH2_STAT5	125	128	PF00017	0.554
LIG_SH3_3	22	28	PF00018	0.557
LIG_SUMO_SIM_anti_2	264	269	PF11976	0.542
LIG_SUMO_SIM_anti_2	299	304	PF11976	0.413
LIG_SUMO_SIM_par_1	264	269	PF11976	0.542
LIG_SUMO_SIM_par_1	299	304	PF11976	0.489
LIG_TRAF2_1	103	106	PF00917	0.597
LIG_TRAF2_1	331	334	PF00917	0.609
LIG_TRAF2_1	387	390	PF00917	0.529
LIG_UBA3_1	180	186	PF00899	0.437
LIG_UBA3_1	556	564	PF00899	0.309
LIG_UBA3_1	698	704	PF00899	0.537
LIG_UBA3_1	742	749	PF00899	0.475
MOD_CK1_1	14	20	PF00069	0.592
MOD_CK1_1	327	333	PF00069	0.574
MOD_CK1_1	375	381	PF00069	0.581
MOD_CK2_1	106	112	PF00069	0.602
MOD_CK2_1	165	171	PF00069	0.461
MOD_CK2_1	201	207	PF00069	0.474
MOD_CK2_1	218	224	PF00069	0.436
MOD_CK2_1	279	285	PF00069	0.585
MOD_CK2_1	327	333	PF00069	0.446
MOD_CK2_1	347	353	PF00069	0.418
MOD_CK2_1	403	409	PF00069	0.576
MOD_CK2_1	48	54	PF00069	0.568
MOD_CK2_1	506	512	PF00069	0.504
MOD_CK2_1	679	685	PF00069	0.608
MOD_CK2_1	760	766	PF00069	0.497
MOD_CK2_1	774	780	PF00069	0.391
MOD_Cter_Amidation	845	848	PF01082	0.565
MOD_GlcNHglycan	108	111	PF01048	0.583
MOD_GlcNHglycan	112	115	PF01048	0.578
MOD_GlcNHglycan	194	197	PF01048	0.518
MOD_GlcNHglycan	443	446	PF01048	0.528
MOD_GlcNHglycan	54	58	PF01048	0.578
MOD_GlcNHglycan	596	599	PF01048	0.328
MOD_GlcNHglycan	855	860	PF01048	0.540
MOD_GSK3_1	106	113	PF00069	0.495
MOD_GSK3_1	176	183	PF00069	0.573
MOD_GSK3_1	287	294	PF00069	0.483
MOD_GSK3_1	324	331	PF00069	0.523
MOD_GSK3_1	372	379	PF00069	0.604
MOD_GSK3_1	425	432	PF00069	0.461
MOD_GSK3_1	75	82	PF00069	0.554
MOD_N-GLC_1	192	197	PF02516	0.540
MOD_N-GLC_1	4	9	PF02516	0.665
MOD_N-GLC_1	425	430	PF02516	0.450
MOD_N-GLC_1	558	563	PF02516	0.392
MOD_N-GLC_1	571	576	PF02516	0.309
MOD_NEK2_1	135	140	PF00069	0.431
MOD_NEK2_1	180	185	PF00069	0.535
MOD_NEK2_1	324	329	PF00069	0.582
MOD_NEK2_1	429	434	PF00069	0.454
MOD_NEK2_1	493	498	PF00069	0.463
MOD_NEK2_1	630	635	PF00069	0.460
MOD_PIKK_1	201	207	PF00454	0.459
MOD_PIKK_1	279	285	PF00454	0.574
MOD_PIKK_1	403	409	PF00454	0.512
MOD_PIKK_1	42	48	PF00454	0.526
MOD_PIKK_1	586	592	PF00454	0.290
MOD_PIKK_1	686	692	PF00454	0.624
MOD_PIKK_1	720	726	PF00454	0.573
MOD_PIKK_1	774	780	PF00454	0.532
MOD_PKA_2	212	218	PF00069	0.538
MOD_PKA_2	237	243	PF00069	0.520
MOD_PKA_2	251	257	PF00069	0.455
MOD_PKA_2	279	285	PF00069	0.481
MOD_PKA_2	375	381	PF00069	0.519
MOD_PKA_2	61	67	PF00069	0.579
MOD_PKA_2	630	636	PF00069	0.463
MOD_PKA_2	658	664	PF00069	0.568
MOD_PKA_2	686	692	PF00069	0.524
MOD_PKB_1	414	422	PF00069	0.475
MOD_Plk_1	192	198	PF00069	0.483
MOD_Plk_1	324	330	PF00069	0.581
MOD_Plk_1	376	382	PF00069	0.656
MOD_Plk_1	4	10	PF00069	0.727
MOD_Plk_1	425	431	PF00069	0.449
MOD_Plk_1	493	499	PF00069	0.459
MOD_Plk_1	679	685	PF00069	0.611
MOD_Plk_2-3	218	224	PF00069	0.510
MOD_Plk_4	135	141	PF00069	0.451
MOD_Plk_4	176	182	PF00069	0.486
MOD_Plk_4	237	243	PF00069	0.415
MOD_Plk_4	544	550	PF00069	0.273
MOD_Plk_4	583	589	PF00069	0.419
MOD_SUMO_for_1	140	143	PF00179	0.463
MOD_SUMO_for_1	149	152	PF00179	0.400
MOD_SUMO_for_1	312	315	PF00179	0.535
MOD_SUMO_for_1	380	383	PF00179	0.571
MOD_SUMO_for_1	677	680	PF00179	0.620
MOD_SUMO_for_1	798	801	PF00179	0.579
MOD_SUMO_rev_2	204	212	PF00179	0.525
MOD_SUMO_rev_2	224	233	PF00179	0.335
MOD_SUMO_rev_2	330	338	PF00179	0.487
MOD_SUMO_rev_2	377	387	PF00179	0.584
MOD_SUMO_rev_2	396	406	PF00179	0.315
MOD_SUMO_rev_2	574	584	PF00179	0.331
MOD_SUMO_rev_2	619	627	PF00179	0.413
MOD_SUMO_rev_2	647	655	PF00179	0.390
MOD_SUMO_rev_2	689	698	PF00179	0.613
MOD_SUMO_rev_2	801	811	PF00179	0.499
TRG_DiLeu_BaEn_1	229	234	PF01217	0.430
TRG_DiLeu_BaEn_1	367	372	PF01217	0.663
TRG_DiLeu_BaEn_1	694	699	PF01217	0.516
TRG_DiLeu_BaEn_3	700	706	PF01217	0.590
TRG_DiLeu_BaLyEn_6	552	557	PF01217	0.290
TRG_ENDOCYTIC_2	321	324	PF00928	0.469
TRG_ENDOCYTIC_2	475	478	PF00928	0.532
TRG_ENDOCYTIC_2	827	830	PF00928	0.597
TRG_ER_diArg_1	101	104	PF00400	0.587
TRG_ER_diArg_1	31	33	PF00400	0.621
TRG_ER_diArg_1	414	417	PF00400	0.466
TRG_ER_diArg_1	454	457	PF00400	0.501
TRG_ER_diArg_1	610	612	PF00400	0.290
TRG_Pf-PMV_PEXEL_1	31	35	PF00026	0.548
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.476
TRG_Pf-PMV_PEXEL_1	392	396	PF00026	0.582
TRG_Pf-PMV_PEXEL_1	611	615	PF00026	0.273
TRG_Pf-PMV_PEXEL_1	696	700	PF00026	0.494

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I582	Leptomonas seymouri	82%	100%
A0A0S4JM03	Bodo saltans	50%	99%
A0A1X0P1D5	Trypanosomatidae	59%	100%
A0A3R7RFG2	Trypanosoma rangeli	59%	100%
A4HL98	Leishmania braziliensis	91%	100%
A4I8S4	Leishmania infantum	100%	100%
D0A4R8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9B3P0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4G0X9	Homo sapiens	25%	77%
Q4Q4E7	Leishmania major	98%	100%
Q56A40	Danio rerio	24%	93%
Q8BI79	Mus musculus	25%	73%
V5BJZ2	Trypanosoma cruzi	58%	100%