Protein phosphatase 2A regulatory subunit, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein phosphatase 2A regulatory subunit, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X6D7_LEIDO

TriTrypDb:

LdBPK_330720.1 , LdCL_330012700 , LDHU3_33.1010

Length:

867

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0000159	protein phosphatase type 2A complex	5	8
GO:0008287	protein serine/threonine phosphatase complex	4	8
GO:0032991	protein-containing complex	1	8
GO:1902494	catalytic complex	2	8
GO:1903293	phosphatase complex	3	8
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3S7X6D7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6D7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0019208	phosphatase regulator activity	3	8
GO:0019888	protein phosphatase regulator activity	4	8
GO:0030234	enzyme regulator activity	2	8
GO:0098772	molecular function regulator activity	1	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	220	222	PF00675	0.740
CLV_NRD_NRD_1	278	280	PF00675	0.720
CLV_NRD_NRD_1	415	417	PF00675	0.615
CLV_NRD_NRD_1	56	58	PF00675	0.480
CLV_NRD_NRD_1	715	717	PF00675	0.765
CLV_NRD_NRD_1	734	736	PF00675	0.561
CLV_NRD_NRD_1	809	811	PF00675	0.630
CLV_PCSK_KEX2_1	219	221	PF00082	0.742
CLV_PCSK_KEX2_1	277	279	PF00082	0.718
CLV_PCSK_KEX2_1	415	417	PF00082	0.615
CLV_PCSK_KEX2_1	435	437	PF00082	0.567
CLV_PCSK_KEX2_1	56	58	PF00082	0.480
CLV_PCSK_KEX2_1	715	717	PF00082	0.765
CLV_PCSK_KEX2_1	734	736	PF00082	0.544
CLV_PCSK_KEX2_1	809	811	PF00082	0.630
CLV_PCSK_PC1ET2_1	219	221	PF00082	0.742
CLV_PCSK_PC1ET2_1	277	279	PF00082	0.718
CLV_PCSK_PC1ET2_1	435	437	PF00082	0.730
CLV_PCSK_SKI1_1	24	28	PF00082	0.258
CLV_PCSK_SKI1_1	416	420	PF00082	0.650
CLV_PCSK_SKI1_1	735	739	PF00082	0.583
DEG_APCC_DBOX_1	414	422	PF00400	0.441
DEG_APCC_DBOX_1	742	750	PF00400	0.364
DEG_Nend_Nbox_1	1	3	PF02207	0.361
DEG_SPOP_SBC_1	268	272	PF00917	0.509
DOC_CKS1_1	711	716	PF01111	0.520
DOC_CYCLIN_RxL_1	413	420	PF00134	0.437
DOC_CYCLIN_yClb5_NLxxxL_5	89	98	PF00134	0.497
DOC_MAPK_gen_1	31	40	PF00069	0.604
DOC_MAPK_gen_1	415	421	PF00069	0.453
DOC_MAPK_gen_1	510	520	PF00069	0.324
DOC_MAPK_MEF2A_6	31	40	PF00069	0.603
DOC_MAPK_MEF2A_6	689	696	PF00069	0.288
DOC_PP2B_LxvP_1	159	162	PF13499	0.511
DOC_PP2B_LxvP_1	27	30	PF13499	0.497
DOC_PP2B_LxvP_1	307	310	PF13499	0.476
DOC_PP2B_LxvP_1	38	41	PF13499	0.605
DOC_PP2B_LxvP_1	68	71	PF13499	0.233
DOC_PP2B_PxIxI_1	16	22	PF00149	0.221
DOC_PP4_FxxP_1	326	329	PF00568	0.425
DOC_PP4_FxxP_1	448	451	PF00568	0.452
DOC_PP4_FxxP_1	656	659	PF00568	0.378
DOC_SPAK_OSR1_1	31	35	PF12202	0.602
DOC_USP7_MATH_1	189	193	PF00917	0.502
DOC_USP7_MATH_1	239	243	PF00917	0.528
DOC_USP7_MATH_1	281	285	PF00917	0.522
DOC_USP7_MATH_1	298	302	PF00917	0.520
DOC_USP7_MATH_1	310	314	PF00917	0.455
DOC_USP7_MATH_1	332	336	PF00917	0.455
DOC_USP7_MATH_1	351	355	PF00917	0.404
DOC_USP7_MATH_1	364	368	PF00917	0.498
DOC_USP7_MATH_1	385	389	PF00917	0.378
DOC_USP7_MATH_1	41	45	PF00917	0.636
DOC_USP7_MATH_1	443	447	PF00917	0.529
DOC_USP7_MATH_1	594	598	PF00917	0.336
DOC_USP7_MATH_1	728	732	PF00917	0.417
DOC_USP7_MATH_1	81	85	PF00917	0.520
DOC_USP7_MATH_1	839	843	PF00917	0.370
DOC_USP7_UBL2_3	532	536	PF12436	0.443
DOC_WW_Pin1_4	116	121	PF00397	0.498
DOC_WW_Pin1_4	157	162	PF00397	0.517
DOC_WW_Pin1_4	197	202	PF00397	0.536
DOC_WW_Pin1_4	260	265	PF00397	0.527
DOC_WW_Pin1_4	269	274	PF00397	0.535
DOC_WW_Pin1_4	279	284	PF00397	0.514
DOC_WW_Pin1_4	446	451	PF00397	0.530
DOC_WW_Pin1_4	483	488	PF00397	0.329
DOC_WW_Pin1_4	602	607	PF00397	0.432
DOC_WW_Pin1_4	677	682	PF00397	0.337
DOC_WW_Pin1_4	710	715	PF00397	0.533
DOC_WW_Pin1_4	724	729	PF00397	0.496
LIG_14-3-3_CanoR_1	101	106	PF00244	0.523
LIG_14-3-3_CanoR_1	121	131	PF00244	0.500
LIG_14-3-3_CanoR_1	144	150	PF00244	0.585
LIG_14-3-3_CanoR_1	267	273	PF00244	0.516
LIG_14-3-3_CanoR_1	31	37	PF00244	0.599
LIG_14-3-3_CanoR_1	340	350	PF00244	0.522
LIG_14-3-3_CanoR_1	415	419	PF00244	0.434
LIG_14-3-3_CanoR_1	436	440	PF00244	0.517
LIG_14-3-3_CanoR_1	452	460	PF00244	0.505
LIG_14-3-3_CanoR_1	546	551	PF00244	0.365
LIG_14-3-3_CanoR_1	643	647	PF00244	0.447
LIG_14-3-3_CanoR_1	8	17	PF00244	0.210
LIG_14-3-3_CanoR_1	809	814	PF00244	0.435
LIG_14-3-3_CanoR_1	822	829	PF00244	0.484
LIG_14-3-3_CanoR_1	832	836	PF00244	0.350
LIG_14-3-3_CanoR_1	838	844	PF00244	0.345
LIG_Actin_WH2_2	633	649	PF00022	0.398
LIG_APCC_ABBAyCdc20_2	557	563	PF00400	0.280
LIG_BRCT_BRCA1_1	444	448	PF00533	0.498
LIG_BRCT_BRCA1_1	574	578	PF00533	0.340
LIG_DLG_GKlike_1	199	206	PF00625	0.456
LIG_EH_1	524	528	PF12763	0.455
LIG_eIF4E_1	750	756	PF01652	0.379
LIG_FHA_1	1	7	PF00498	0.367
LIG_FHA_1	154	160	PF00498	0.591
LIG_FHA_1	312	318	PF00498	0.415
LIG_FHA_1	397	403	PF00498	0.373
LIG_FHA_1	452	458	PF00498	0.471
LIG_FHA_1	499	505	PF00498	0.358
LIG_FHA_1	533	539	PF00498	0.445
LIG_FHA_1	545	551	PF00498	0.407
LIG_FHA_1	583	589	PF00498	0.304
LIG_FHA_1	598	604	PF00498	0.356
LIG_FHA_1	669	675	PF00498	0.368
LIG_FHA_1	778	784	PF00498	0.312
LIG_FHA_1	794	800	PF00498	0.364
LIG_FHA_2	225	231	PF00498	0.536
LIG_FHA_2	415	421	PF00498	0.458
LIG_FHA_2	578	584	PF00498	0.320
LIG_FHA_2	594	600	PF00498	0.287
LIG_FHA_2	784	790	PF00498	0.433
LIG_LIR_Apic_2	445	451	PF02991	0.455
LIG_LIR_Gen_1	391	397	PF02991	0.355
LIG_LIR_Gen_1	624	631	PF02991	0.340
LIG_LIR_Gen_1	664	674	PF02991	0.384
LIG_LIR_Gen_1	690	699	PF02991	0.315
LIG_LIR_Gen_1	796	805	PF02991	0.431
LIG_LIR_LC3C_4	18	22	PF02991	0.233
LIG_LIR_Nem_3	391	395	PF02991	0.356
LIG_LIR_Nem_3	462	467	PF02991	0.476
LIG_LIR_Nem_3	624	629	PF02991	0.347
LIG_LIR_Nem_3	664	670	PF02991	0.402
LIG_LIR_Nem_3	690	694	PF02991	0.311
LIG_LIR_Nem_3	796	800	PF02991	0.442
LIG_LIR_Nem_3	861	865	PF02991	0.397
LIG_LYPXL_SIV_4	472	480	PF13949	0.382
LIG_Pex14_1	589	593	PF04695	0.387
LIG_Pex14_2	326	330	PF04695	0.412
LIG_Pex14_2	759	763	PF04695	0.296
LIG_PTB_Apo_2	773	780	PF02174	0.362
LIG_PTB_Phospho_1	773	779	PF10480	0.364
LIG_Rb_LxCxE_1	583	602	PF01857	0.325
LIG_SH2_CRK	862	866	PF00017	0.373
LIG_SH2_PTP2	473	476	PF00017	0.371
LIG_SH2_SRC	473	476	PF00017	0.371
LIG_SH2_SRC	607	610	PF00017	0.447
LIG_SH2_STAP1	464	468	PF00017	0.364
LIG_SH2_STAP1	574	578	PF00017	0.412
LIG_SH2_STAP1	779	783	PF00017	0.359
LIG_SH2_STAT3	467	470	PF00017	0.377
LIG_SH2_STAT3	574	577	PF00017	0.411
LIG_SH2_STAT5	324	327	PF00017	0.388
LIG_SH2_STAT5	382	385	PF00017	0.378
LIG_SH2_STAT5	39	42	PF00017	0.615
LIG_SH2_STAT5	467	470	PF00017	0.372
LIG_SH2_STAT5	473	476	PF00017	0.308
LIG_SH2_STAT5	503	506	PF00017	0.349
LIG_SH2_STAT5	685	688	PF00017	0.342
LIG_SH2_STAT5	779	782	PF00017	0.299
LIG_SH3_1	619	625	PF00018	0.338
LIG_SH3_1	708	714	PF00018	0.533
LIG_SH3_2	711	716	PF14604	0.541
LIG_SH3_3	457	463	PF00018	0.425
LIG_SH3_3	619	625	PF00018	0.338
LIG_SH3_3	708	714	PF00018	0.492
LIG_Sin3_3	65	72	PF02671	0.221
LIG_SUMO_SIM_anti_2	168	174	PF11976	0.551
LIG_SUMO_SIM_anti_2	18	24	PF11976	0.233
LIG_SUMO_SIM_anti_2	313	319	PF11976	0.439
LIG_SUMO_SIM_anti_2	417	423	PF11976	0.454
LIG_SUMO_SIM_par_1	313	319	PF11976	0.403
LIG_TRAF2_1	104	107	PF00917	0.521
LIG_TRAF2_1	428	431	PF00917	0.398
LIG_TRAF2_1	660	663	PF00917	0.435
LIG_TYR_ITIM	860	865	PF00017	0.332
LIG_WRC_WIRS_1	2	7	PF05994	0.389
LIG_WRC_WIRS_1	794	799	PF05994	0.382
LIG_WW_3	449	453	PF00397	0.423
LIG_WW_3	658	662	PF00397	0.429
MOD_CDC14_SPxK_1	449	452	PF00782	0.491
MOD_CDK_SPK_2	116	121	PF00069	0.498
MOD_CDK_SPK_2	710	715	PF00069	0.538
MOD_CDK_SPxK_1	446	452	PF00069	0.494
MOD_CDK_SPxK_1	710	716	PF00069	0.539
MOD_CDK_SPxxK_3	260	267	PF00069	0.525
MOD_CDK_SPxxK_3	677	684	PF00069	0.320
MOD_CK1_1	148	154	PF00069	0.601
MOD_CK1_1	215	221	PF00069	0.634
MOD_CK1_1	259	265	PF00069	0.602
MOD_CK1_1	284	290	PF00069	0.625
MOD_CK1_1	308	314	PF00069	0.443
MOD_CK1_1	316	322	PF00069	0.379
MOD_CK1_1	335	341	PF00069	0.393
MOD_CK1_1	343	349	PF00069	0.515
MOD_CK1_1	384	390	PF00069	0.367
MOD_CK1_1	438	444	PF00069	0.540
MOD_CK1_1	446	452	PF00069	0.501
MOD_CK1_1	498	504	PF00069	0.386
MOD_CK1_1	544	550	PF00069	0.421
MOD_CK1_1	597	603	PF00069	0.348
MOD_CK1_1	633	639	PF00069	0.358
MOD_CK1_1	668	674	PF00069	0.363
MOD_CK1_1	787	793	PF00069	0.387
MOD_CK1_1	831	837	PF00069	0.457
MOD_CK1_1	84	90	PF00069	0.426
MOD_CK2_1	101	107	PF00069	0.520
MOD_CK2_1	162	168	PF00069	0.516
MOD_CK2_1	177	183	PF00069	0.533
MOD_CK2_1	516	522	PF00069	0.434
MOD_CK2_1	593	599	PF00069	0.384
MOD_CK2_1	602	608	PF00069	0.432
MOD_DYRK1A_RPxSP_1	157	161	PF00069	0.473
MOD_GlcNHglycan	11	14	PF01048	0.221
MOD_GlcNHglycan	147	150	PF01048	0.724
MOD_GlcNHglycan	195	198	PF01048	0.728
MOD_GlcNHglycan	206	209	PF01048	0.714
MOD_GlcNHglycan	283	286	PF01048	0.793
MOD_GlcNHglycan	292	295	PF01048	0.692
MOD_GlcNHglycan	307	310	PF01048	0.616
MOD_GlcNHglycan	334	337	PF01048	0.646
MOD_GlcNHglycan	353	356	PF01048	0.787
MOD_GlcNHglycan	366	369	PF01048	0.781
MOD_GlcNHglycan	383	386	PF01048	0.460
MOD_GlcNHglycan	424	427	PF01048	0.687
MOD_GlcNHglycan	441	444	PF01048	0.648
MOD_GlcNHglycan	497	500	PF01048	0.630
MOD_GlcNHglycan	632	635	PF01048	0.557
MOD_GlcNHglycan	681	684	PF01048	0.604
MOD_GlcNHglycan	703	706	PF01048	0.707
MOD_GlcNHglycan	786	789	PF01048	0.642
MOD_GlcNHglycan	813	816	PF01048	0.595
MOD_GlcNHglycan	843	846	PF01048	0.593
MOD_GSK3_1	11	18	PF00069	0.221
MOD_GSK3_1	139	146	PF00069	0.584
MOD_GSK3_1	153	160	PF00069	0.538
MOD_GSK3_1	163	170	PF00069	0.540
MOD_GSK3_1	189	196	PF00069	0.494
MOD_GSK3_1	255	262	PF00069	0.589
MOD_GSK3_1	332	339	PF00069	0.465
MOD_GSK3_1	346	353	PF00069	0.543
MOD_GSK3_1	377	384	PF00069	0.357
MOD_GSK3_1	435	442	PF00069	0.529
MOD_GSK3_1	479	486	PF00069	0.393
MOD_GSK3_1	48	55	PF00069	0.646
MOD_GSK3_1	495	502	PF00069	0.350
MOD_GSK3_1	516	523	PF00069	0.391
MOD_GSK3_1	541	548	PF00069	0.441
MOD_GSK3_1	593	600	PF00069	0.340
MOD_GSK3_1	629	636	PF00069	0.324
MOD_GSK3_1	724	731	PF00069	0.412
MOD_GSK3_1	745	752	PF00069	0.380
MOD_GSK3_1	783	790	PF00069	0.410
MOD_GSK3_1	799	806	PF00069	0.392
MOD_GSK3_1	96	103	PF00069	0.504
MOD_N-GLC_1	290	295	PF02516	0.687
MOD_N-GLC_1	668	673	PF02516	0.576
MOD_N-GLC_1	774	779	PF02516	0.566
MOD_NEK2_1	1	6	PF00069	0.390
MOD_NEK2_1	11	16	PF00069	0.202
MOD_NEK2_1	122	127	PF00069	0.454
MOD_NEK2_1	145	150	PF00069	0.584
MOD_NEK2_1	153	158	PF00069	0.515
MOD_NEK2_1	32	37	PF00069	0.644
MOD_NEK2_1	334	339	PF00069	0.458
MOD_NEK2_1	350	355	PF00069	0.485
MOD_NEK2_1	439	444	PF00069	0.554
MOD_NEK2_1	541	546	PF00069	0.450
MOD_NEK2_1	629	634	PF00069	0.308
MOD_NEK2_1	701	706	PF00069	0.460
MOD_NEK2_1	75	80	PF00069	0.481
MOD_NEK2_1	763	768	PF00069	0.364
MOD_NEK2_1	774	779	PF00069	0.283
MOD_NEK2_1	808	813	PF00069	0.396
MOD_NEK2_1	841	846	PF00069	0.398
MOD_NEK2_1	858	863	PF00069	0.279
MOD_NEK2_1	94	99	PF00069	0.472
MOD_NEK2_2	443	448	PF00069	0.479
MOD_NEK2_2	611	616	PF00069	0.368
MOD_PIKK_1	122	128	PF00454	0.535
MOD_PIKK_1	308	314	PF00454	0.465
MOD_PIKK_1	343	349	PF00454	0.507
MOD_PIKK_1	377	383	PF00454	0.426
MOD_PIKK_1	385	391	PF00454	0.392
MOD_PIKK_1	597	603	PF00454	0.307
MOD_PK_1	101	107	PF00069	0.510
MOD_PK_1	516	522	PF00069	0.386
MOD_PKA_1	435	441	PF00069	0.529
MOD_PKA_1	809	815	PF00069	0.434
MOD_PKA_2	100	106	PF00069	0.530
MOD_PKA_2	143	149	PF00069	0.587
MOD_PKA_2	204	210	PF00069	0.581
MOD_PKA_2	32	38	PF00069	0.598
MOD_PKA_2	339	345	PF00069	0.554
MOD_PKA_2	414	420	PF00069	0.415
MOD_PKA_2	435	441	PF00069	0.492
MOD_PKA_2	451	457	PF00069	0.505
MOD_PKA_2	520	526	PF00069	0.424
MOD_PKA_2	545	551	PF00069	0.369
MOD_PKA_2	58	64	PF00069	0.627
MOD_PKA_2	611	617	PF00069	0.408
MOD_PKA_2	642	648	PF00069	0.443
MOD_PKA_2	808	814	PF00069	0.420
MOD_PKA_2	821	827	PF00069	0.381
MOD_PKA_2	831	837	PF00069	0.338
MOD_Plk_1	167	173	PF00069	0.536
MOD_Plk_1	582	588	PF00069	0.301
MOD_Plk_1	594	600	PF00069	0.340
MOD_Plk_1	728	734	PF00069	0.495
MOD_Plk_1	774	780	PF00069	0.364
MOD_Plk_4	1	7	PF00069	0.391
MOD_Plk_4	15	21	PF00069	0.205
MOD_Plk_4	443	449	PF00069	0.491
MOD_Plk_4	499	505	PF00069	0.319
MOD_Plk_4	58	64	PF00069	0.650
MOD_Plk_4	582	588	PF00069	0.339
MOD_Plk_4	728	734	PF00069	0.511
MOD_Plk_4	745	751	PF00069	0.295
MOD_Plk_4	774	780	PF00069	0.328
MOD_Plk_4	831	837	PF00069	0.377
MOD_Plk_4	84	90	PF00069	0.413
MOD_ProDKin_1	116	122	PF00069	0.498
MOD_ProDKin_1	157	163	PF00069	0.518
MOD_ProDKin_1	197	203	PF00069	0.537
MOD_ProDKin_1	260	266	PF00069	0.528
MOD_ProDKin_1	269	275	PF00069	0.533
MOD_ProDKin_1	279	285	PF00069	0.513
MOD_ProDKin_1	446	452	PF00069	0.530
MOD_ProDKin_1	483	489	PF00069	0.325
MOD_ProDKin_1	602	608	PF00069	0.433
MOD_ProDKin_1	677	683	PF00069	0.337
MOD_ProDKin_1	710	716	PF00069	0.534
MOD_ProDKin_1	724	730	PF00069	0.485
MOD_SUMO_for_1	800	803	PF00179	0.412
MOD_SUMO_rev_2	48	55	PF00179	0.657
TRG_ENDOCYTIC_2	473	476	PF00928	0.334
TRG_ENDOCYTIC_2	515	518	PF00928	0.335
TRG_ENDOCYTIC_2	862	865	PF00928	0.364
TRG_ER_diArg_1	405	408	PF00400	0.369
TRG_ER_diArg_1	414	416	PF00400	0.398
TRG_ER_diArg_1	56	59	PF00400	0.687
TRG_ER_diArg_1	714	716	PF00400	0.562
TRG_ER_diArg_1	733	735	PF00400	0.362
TRG_ER_diArg_1	808	810	PF00400	0.438
TRG_ER_FFAT_2	380	388	PF00635	0.376
TRG_Pf-PMV_PEXEL_1	416	420	PF00026	0.640

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBP1	Leptomonas seymouri	64%	100%
A4HLA7	Leishmania braziliensis	78%	100%
A4I8T3	Leishmania infantum	100%	100%
E9B3P9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q4D8	Leishmania major	92%	100%
V5BFC1	Trypanosoma cruzi	39%	100%