Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X6D3_LEIDO

TriTrypDb:

LdBPK_330550.1 , LdCL_330011000 , LDHU3_33.0810

Length:

202

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X6D3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6D3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	16	20	PF00656	0.573
CLV_NRD_NRD_1	137	139	PF00675	0.637
CLV_PCSK_KEX2_1	137	139	PF00082	0.637
CLV_PCSK_SKI1_1	2	6	PF00082	0.595
CLV_PCSK_SKI1_1	65	69	PF00082	0.547
CLV_PCSK_SKI1_1	77	81	PF00082	0.502
CLV_Separin_Metazoa	52	56	PF03568	0.510
DEG_Nend_UBRbox_1	1	4	PF02207	0.704
DOC_ANK_TNKS_1	173	180	PF00023	0.441
DOC_PP2B_LxvP_1	46	49	PF13499	0.534
DOC_PP4_FxxP_1	106	109	PF00568	0.663
DOC_PP4_FxxP_1	149	152	PF00568	0.555
DOC_USP7_MATH_1	113	117	PF00917	0.664
LIG_14-3-3_CanoR_1	128	132	PF00244	0.446
LIG_14-3-3_CanoR_1	188	192	PF00244	0.595
LIG_14-3-3_CanoR_1	24	32	PF00244	0.550
LIG_14-3-3_CanoR_1	39	47	PF00244	0.300
LIG_14-3-3_CanoR_1	65	70	PF00244	0.460
LIG_14-3-3_CanoR_1	77	85	PF00244	0.453
LIG_Actin_WH2_2	25	41	PF00022	0.581
LIG_BRCT_BRCA1_1	141	145	PF00533	0.725
LIG_EH1_1	128	136	PF00400	0.675
LIG_EH1_1	69	77	PF00400	0.505
LIG_eIF4E_1	129	135	PF01652	0.669
LIG_FHA_1	103	109	PF00498	0.676
LIG_FHA_1	146	152	PF00498	0.583
LIG_FHA_1	153	159	PF00498	0.534
LIG_FHA_2	109	115	PF00498	0.647
LIG_FHA_2	24	30	PF00498	0.593
LIG_GBD_Chelix_1	157	165	PF00786	0.567
LIG_LIR_Apic_2	105	109	PF02991	0.662
LIG_LIR_Apic_2	146	152	PF02991	0.587
LIG_LIR_Gen_1	168	178	PF02991	0.412
LIG_LIR_Nem_3	168	173	PF02991	0.422
LIG_PCNA_yPIPBox_3	77	89	PF02747	0.580
LIG_Pex14_2	145	149	PF04695	0.365
LIG_SH2_NCK_1	129	133	PF00017	0.687
LIG_SH2_SRC	45	48	PF00017	0.484
LIG_SH2_STAT5	129	132	PF00017	0.702
LIG_SH2_STAT5	45	48	PF00017	0.424
LIG_SH2_STAT5	88	91	PF00017	0.530
LIG_SH3_3	172	178	PF00018	0.376
LIG_SH3_3	41	47	PF00018	0.496
LIG_SUMO_SIM_anti_2	50	55	PF11976	0.501
MOD_GlcNHglycan	114	118	PF01048	0.713
MOD_GlcNHglycan	140	144	PF01048	0.698
MOD_GlcNHglycan	33	37	PF01048	0.574
MOD_GSK3_1	104	111	PF00069	0.592
MOD_GSK3_1	139	146	PF00069	0.672
MOD_GSK3_1	152	159	PF00069	0.367
MOD_GSK3_1	177	184	PF00069	0.543
MOD_GSK3_1	23	30	PF00069	0.565
MOD_GSK3_1	34	41	PF00069	0.354
MOD_GSK3_1	57	64	PF00069	0.511
MOD_NEK2_1	13	18	PF00069	0.476
MOD_NEK2_1	145	150	PF00069	0.608
MOD_NEK2_1	32	37	PF00069	0.519
MOD_NEK2_1	38	43	PF00069	0.425
MOD_PIKK_1	156	162	PF00454	0.561
MOD_PKA_2	127	133	PF00069	0.443
MOD_PKA_2	187	193	PF00069	0.601
MOD_PKA_2	23	29	PF00069	0.563
MOD_PKA_2	38	44	PF00069	0.291
MOD_PKA_2	8	14	PF00069	0.532
MOD_Plk_1	28	34	PF00069	0.636
MOD_Plk_4	130	136	PF00069	0.615
MOD_Plk_4	145	151	PF00069	0.498
MOD_Plk_4	177	183	PF00069	0.459
MOD_Plk_4	187	193	PF00069	0.523
MOD_Plk_4	8	14	PF00069	0.569
TRG_ER_diArg_1	136	138	PF00400	0.613
TRG_NES_CRM1_1	156	168	PF08389	0.443

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILI4	Leptomonas seymouri	49%	89%
A0A1X0P1T8	Trypanosomatidae	28%	78%
A0A3S5IQJ3	Trypanosoma rangeli	27%	85%
A4HL90	Leishmania braziliensis	86%	100%
D0A4Q6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	89%
E9AHN2	Leishmania infantum	98%	100%
E9B3N2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q4F5	Leishmania major	95%	100%
V5AM33	Trypanosoma cruzi	28%	82%