LeishMANIAdb
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Palmitoyltransferase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Palmitoyltransferase
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7X6D2_LEIDO
TriTrypDb:
LdBPK_330240.1 , LdCL_330007300 , LDHU3_33.0280
Length:
572

Annotations

LeishMANIAdb annotations

Related to other Eukaryotic ZDHHC-type palmitoyltransferases (e.g animal ZDHHC20).

Annotations by Jardim et al.

Protein pamitoylation, Palmitoyltransferase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9
GO:0005737 cytoplasm 2 1
GO:0005783 endoplasmic reticulum 5 1
GO:0005794 Golgi apparatus 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Expansion

Sequence features

A0A3S7X6D2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6D2

Function

Biological processes
Term Name Level Count
GO:0006497 protein lipidation 5 1
GO:0006605 protein targeting 5 1
GO:0006612 protein targeting to membrane 5 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0006810 transport 3 1
GO:0006886 intracellular protein transport 4 1
GO:0006897 endocytosis 5 1
GO:0008104 protein localization 4 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 1
GO:0015031 protein transport 4 1
GO:0016192 vesicle-mediated transport 4 1
GO:0018193 peptidyl-amino acid modification 5 1
GO:0018198 peptidyl-cysteine modification 6 1
GO:0018230 peptidyl-L-cysteine S-palmitoylation 7 1
GO:0018231 peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine 7 1
GO:0018345 protein palmitoylation 6 1
GO:0019538 protein metabolic process 3 1
GO:0033036 macromolecule localization 2 1
GO:0036211 protein modification process 4 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043412 macromolecule modification 4 1
GO:0043543 protein acylation 5 1
GO:0044238 primary metabolic process 2 1
GO:0045184 establishment of protein localization 3 1
GO:0046907 intracellular transport 3 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0051641 cellular localization 2 1
GO:0051649 establishment of localization in cell 3 1
GO:0051668 localization within membrane 3 1
GO:0070727 cellular macromolecule localization 3 1
GO:0071702 organic substance transport 4 1
GO:0071704 organic substance metabolic process 2 1
GO:0071705 nitrogen compound transport 4 1
GO:0072657 protein localization to membrane 4 1
GO:0090150 establishment of protein localization to membrane 4 1
GO:1901564 organonitrogen compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 9
GO:0016409 palmitoyltransferase activity 5 9
GO:0016417 S-acyltransferase activity 5 9
GO:0016740 transferase activity 2 9
GO:0016746 acyltransferase activity 3 9
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4 9
GO:0019706 protein-cysteine S-palmitoyltransferase activity 4 9
GO:0019707 protein-cysteine S-acyltransferase activity 3 9
GO:0140096 catalytic activity, acting on a protein 2 9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 449 453 PF00656 0.728
CLV_NRD_NRD_1 320 322 PF00675 0.546
CLV_NRD_NRD_1 384 386 PF00675 0.463
CLV_NRD_NRD_1 423 425 PF00675 0.490
CLV_NRD_NRD_1 458 460 PF00675 0.553
CLV_PCSK_KEX2_1 362 364 PF00082 0.337
CLV_PCSK_KEX2_1 384 386 PF00082 0.463
CLV_PCSK_KEX2_1 423 425 PF00082 0.490
CLV_PCSK_KEX2_1 458 460 PF00082 0.539
CLV_PCSK_PC1ET2_1 362 364 PF00082 0.382
CLV_PCSK_PC7_1 419 425 PF00082 0.442
CLV_PCSK_SKI1_1 363 367 PF00082 0.335
CLV_PCSK_SKI1_1 384 388 PF00082 0.510
CLV_PCSK_SKI1_1 433 437 PF00082 0.436
CLV_PCSK_SKI1_1 478 482 PF00082 0.435
DEG_MDM2_SWIB_1 475 483 PF02201 0.609
DEG_SCF_FBW7_1 303 310 PF00400 0.337
DOC_MAPK_gen_1 128 137 PF00069 0.669
DOC_MAPK_gen_1 423 431 PF00069 0.649
DOC_MAPK_MEF2A_6 265 272 PF00069 0.501
DOC_MAPK_MEF2A_6 561 568 PF00069 0.744
DOC_PP4_FxxP_1 140 143 PF00568 0.686
DOC_PP4_FxxP_1 205 208 PF00568 0.728
DOC_PP4_FxxP_1 45 48 PF00568 0.424
DOC_USP7_MATH_1 129 133 PF00917 0.665
DOC_USP7_MATH_1 311 315 PF00917 0.359
DOC_USP7_MATH_1 505 509 PF00917 0.720
DOC_USP7_MATH_1 559 563 PF00917 0.711
DOC_USP7_MATH_1 63 67 PF00917 0.549
DOC_WW_Pin1_4 146 151 PF00397 0.761
DOC_WW_Pin1_4 303 308 PF00397 0.346
DOC_WW_Pin1_4 314 319 PF00397 0.355
DOC_WW_Pin1_4 400 405 PF00397 0.781
DOC_WW_Pin1_4 75 80 PF00397 0.460
LIG_14-3-3_CanoR_1 128 137 PF00244 0.628
LIG_14-3-3_CanoR_1 168 173 PF00244 0.732
LIG_14-3-3_CanoR_1 363 368 PF00244 0.505
LIG_14-3-3_CanoR_1 369 379 PF00244 0.461
LIG_14-3-3_CanoR_1 414 419 PF00244 0.688
LIG_14-3-3_CanoR_1 503 511 PF00244 0.728
LIG_14-3-3_CanoR_1 514 520 PF00244 0.564
LIG_14-3-3_CanoR_1 7 15 PF00244 0.625
LIG_APCC_ABBA_1 436 441 PF00400 0.649
LIG_BIR_III_2 407 411 PF00653 0.660
LIG_BRCT_BRCA1_1 349 353 PF00533 0.474
LIG_Clathr_ClatBox_1 102 106 PF01394 0.474
LIG_CtBP_PxDLS_1 79 83 PF00389 0.459
LIG_EH1_1 109 117 PF00400 0.544
LIG_eIF4E_1 264 270 PF01652 0.484
LIG_FHA_1 109 115 PF00498 0.546
LIG_FHA_1 14 20 PF00498 0.354
LIG_FHA_1 272 278 PF00498 0.351
LIG_FHA_1 288 294 PF00498 0.289
LIG_FHA_1 355 361 PF00498 0.425
LIG_FHA_1 41 47 PF00498 0.433
LIG_FHA_2 137 143 PF00498 0.679
LIG_FHA_2 371 377 PF00498 0.484
LIG_FHA_2 389 395 PF00498 0.672
LIG_Integrin_RGD_1 405 407 PF01839 0.465
LIG_LIR_Apic_2 138 143 PF02991 0.683
LIG_LIR_Apic_2 202 208 PF02991 0.731
LIG_LIR_Apic_2 229 233 PF02991 0.555
LIG_LIR_Apic_2 31 35 PF02991 0.394
LIG_LIR_Apic_2 43 48 PF02991 0.400
LIG_LIR_Gen_1 212 221 PF02991 0.686
LIG_LIR_Gen_1 28 38 PF02991 0.371
LIG_LIR_Gen_1 494 500 PF02991 0.767
LIG_LIR_Gen_1 6 17 PF02991 0.650
LIG_LIR_Gen_1 72 82 PF02991 0.485
LIG_LIR_Gen_1 98 109 PF02991 0.369
LIG_LIR_Nem_3 138 144 PF02991 0.686
LIG_LIR_Nem_3 212 216 PF02991 0.681
LIG_LIR_Nem_3 28 33 PF02991 0.347
LIG_LIR_Nem_3 494 498 PF02991 0.767
LIG_LIR_Nem_3 6 12 PF02991 0.657
LIG_LIR_Nem_3 72 77 PF02991 0.503
LIG_LIR_Nem_3 98 104 PF02991 0.363
LIG_NRBOX 267 273 PF00104 0.425
LIG_PALB2_WD40_1 475 483 PF16756 0.609
LIG_Pex14_2 45 49 PF04695 0.418
LIG_Pex14_2 475 479 PF04695 0.629
LIG_REV1ctd_RIR_1 478 484 PF16727 0.628
LIG_SH2_CRK 213 217 PF00017 0.684
LIG_SH2_CRK 230 234 PF00017 0.555
LIG_SH2_CRK 30 34 PF00017 0.398
LIG_SH2_GRB2like 220 223 PF00017 0.492
LIG_SH2_GRB2like 380 383 PF00017 0.664
LIG_SH2_NCK_1 213 217 PF00017 0.684
LIG_SH2_SRC 248 251 PF00017 0.484
LIG_SH2_STAP1 110 114 PF00017 0.545
LIG_SH2_STAP1 273 277 PF00017 0.362
LIG_SH2_STAP1 30 34 PF00017 0.437
LIG_SH2_STAP1 461 465 PF00017 0.716
LIG_SH2_STAT3 489 492 PF00017 0.610
LIG_SH2_STAT5 110 113 PF00017 0.432
LIG_SH2_STAT5 213 216 PF00017 0.680
LIG_SH2_STAT5 220 223 PF00017 0.555
LIG_SH2_STAT5 267 270 PF00017 0.337
LIG_SH2_STAT5 273 276 PF00017 0.337
LIG_SH2_STAT5 292 295 PF00017 0.284
LIG_SH2_STAT5 30 33 PF00017 0.365
LIG_SH2_STAT5 359 362 PF00017 0.378
LIG_SH2_STAT5 461 464 PF00017 0.700
LIG_SH3_3 111 117 PF00018 0.556
LIG_SH3_3 190 196 PF00018 0.753
LIG_SH3_3 333 339 PF00018 0.301
LIG_SUMO_SIM_anti_2 10 16 PF11976 0.526
LIG_SUMO_SIM_par_1 10 16 PF11976 0.526
LIG_SUMO_SIM_par_1 268 274 PF11976 0.414
LIG_SUMO_SIM_par_1 280 286 PF11976 0.355
LIG_SUMO_SIM_par_1 292 299 PF11976 0.338
LIG_TRFH_1 301 305 PF08558 0.257
LIG_TRFH_1 481 485 PF08558 0.615
LIG_TYR_ITIM 271 276 PF00017 0.337
LIG_UBA3_1 300 308 PF00899 0.257
LIG_WRC_WIRS_1 137 142 PF05994 0.675
LIG_WRC_WIRS_1 169 174 PF05994 0.728
LIG_WW_3 231 235 PF00397 0.555
LIG_WW_3 318 322 PF00397 0.377
MOD_CDK_SPK_2 303 308 PF00069 0.346
MOD_CDK_SPK_2 400 405 PF00069 0.718
MOD_CDK_SPxxK_3 314 321 PF00069 0.355
MOD_CK1_1 156 162 PF00069 0.768
MOD_CK1_1 212 218 PF00069 0.688
MOD_CK1_1 25 31 PF00069 0.485
MOD_CK1_1 314 320 PF00069 0.332
MOD_CK1_1 388 394 PF00069 0.736
MOD_CK1_1 501 507 PF00069 0.701
MOD_CK1_1 512 518 PF00069 0.559
MOD_CK1_1 541 547 PF00069 0.708
MOD_CK1_1 72 78 PF00069 0.489
MOD_CK1_1 81 87 PF00069 0.396
MOD_CK2_1 136 142 PF00069 0.671
MOD_CK2_1 392 398 PF00069 0.761
MOD_CK2_1 50 56 PF00069 0.471
MOD_DYRK1A_RPxSP_1 146 150 PF00069 0.761
MOD_GlcNHglycan 131 134 PF01048 0.390
MOD_GlcNHglycan 155 158 PF01048 0.531
MOD_GlcNHglycan 184 187 PF01048 0.563
MOD_GlcNHglycan 24 27 PF01048 0.389
MOD_GlcNHglycan 313 316 PF01048 0.532
MOD_GlcNHglycan 503 506 PF01048 0.515
MOD_GlcNHglycan 511 514 PF01048 0.445
MOD_GlcNHglycan 52 55 PF01048 0.650
MOD_GlcNHglycan 561 564 PF01048 0.542
MOD_GlcNHglycan 67 70 PF01048 0.689
MOD_GSK3_1 127 134 PF00069 0.628
MOD_GSK3_1 142 149 PF00069 0.643
MOD_GSK3_1 18 25 PF00069 0.437
MOD_GSK3_1 271 278 PF00069 0.337
MOD_GSK3_1 283 290 PF00069 0.337
MOD_GSK3_1 303 310 PF00069 0.150
MOD_GSK3_1 385 392 PF00069 0.707
MOD_GSK3_1 396 403 PF00069 0.775
MOD_GSK3_1 499 506 PF00069 0.695
MOD_GSK3_1 61 68 PF00069 0.539
MOD_LATS_1 166 172 PF00433 0.717
MOD_N-GLC_1 370 375 PF02516 0.284
MOD_N-GLC_1 50 55 PF02516 0.692
MOD_N-GLC_1 61 66 PF02516 0.632
MOD_N-GLC_2 222 224 PF02516 0.355
MOD_N-GLC_2 242 244 PF02516 0.150
MOD_NEK2_1 135 140 PF00069 0.623
MOD_NEK2_1 18 23 PF00069 0.390
MOD_NEK2_1 226 231 PF00069 0.555
MOD_NEK2_1 271 276 PF00069 0.374
MOD_NEK2_1 354 359 PF00069 0.362
MOD_NEK2_1 80 85 PF00069 0.419
MOD_NEK2_1 95 100 PF00069 0.308
MOD_NEK2_2 136 141 PF00069 0.663
MOD_NEK2_2 505 510 PF00069 0.757
MOD_PKA_2 127 133 PF00069 0.670
MOD_PKA_2 535 541 PF00069 0.754
MOD_PKA_2 72 78 PF00069 0.529
MOD_Plk_1 370 376 PF00069 0.484
MOD_Plk_1 5 11 PF00069 0.671
MOD_Plk_4 136 142 PF00069 0.671
MOD_Plk_4 19 25 PF00069 0.410
MOD_Plk_4 271 277 PF00069 0.362
MOD_Plk_4 28 34 PF00069 0.391
MOD_Plk_4 280 286 PF00069 0.362
MOD_Plk_4 287 293 PF00069 0.362
MOD_Plk_4 347 353 PF00069 0.356
MOD_Plk_4 355 361 PF00069 0.300
MOD_Plk_4 538 544 PF00069 0.709
MOD_Plk_4 96 102 PF00069 0.343
MOD_ProDKin_1 146 152 PF00069 0.763
MOD_ProDKin_1 303 309 PF00069 0.346
MOD_ProDKin_1 314 320 PF00069 0.355
MOD_ProDKin_1 400 406 PF00069 0.777
MOD_ProDKin_1 75 81 PF00069 0.454
TRG_DiLeu_BaEn_1 549 554 PF01217 0.703
TRG_DiLeu_BaEn_4 549 555 PF01217 0.703
TRG_DiLeu_BaLyEn_6 479 484 PF01217 0.576
TRG_ENDOCYTIC_2 141 144 PF00928 0.696
TRG_ENDOCYTIC_2 213 216 PF00928 0.680
TRG_ENDOCYTIC_2 220 223 PF00928 0.555
TRG_ENDOCYTIC_2 267 270 PF00928 0.337
TRG_ENDOCYTIC_2 273 276 PF00928 0.337
TRG_ENDOCYTIC_2 30 33 PF00928 0.372
TRG_ENDOCYTIC_2 519 522 PF00928 0.703
TRG_ER_diArg_1 125 128 PF00400 0.696
TRG_ER_diArg_1 384 386 PF00400 0.672
TRG_ER_diArg_1 413 416 PF00400 0.705
TRG_ER_diArg_1 422 424 PF00400 0.592
TRG_ER_diArg_1 457 459 PF00400 0.756
TRG_ER_diArg_1 470 473 PF00400 0.737
TRG_Pf-PMV_PEXEL_1 424 428 PF00026 0.462
TRG_Pf-PMV_PEXEL_1 433 437 PF00026 0.410

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5U1 Leptomonas seymouri 61% 98%
A0A0S4KLP7 Bodo saltans 31% 100%
A0A3R7KZF6 Trypanosoma rangeli 33% 100%
A4I8P0 Leishmania infantum 100% 100%
D0A4L6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 100%
E9B3K1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4Q4K0 Leishmania major 94% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS