Centrosomal protein of 19 kDa

Quick info Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CEP19-like protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X6D1_LEIDO

TriTrypDb:

LdBPK_330130.1 , LdCL_330006200 , LDHU3_33.0150

Length:

366

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0005814	centriole	5	12
GO:0005929	cilium	4	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	11
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	11
GO:0000922	spindle pole	2	1
GO:0005813	centrosome	3	1
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1

Phosphorylation

Promastigote: 365

Expansion

Sequence features

A0A3S7X6D1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6D1

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0006903	vesicle targeting	2	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007017	microtubule-based process	2	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0034453	microtubule anchoring	4	1
GO:0034454	microtubule anchoring at centrosome	6	1
GO:0048199	vesicle targeting, to, from or within Golgi	3	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0072393	microtubule anchoring at microtubule organizing center	5	1
GO:0097712	vesicle targeting, trans-Golgi to periciliary membrane compartment	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	312	316	PF00656	0.448
CLV_C14_Caspase3-7	82	86	PF00656	0.443
CLV_NRD_NRD_1	18	20	PF00675	0.429
CLV_NRD_NRD_1	202	204	PF00675	0.291
CLV_NRD_NRD_1	22	24	PF00675	0.435
CLV_NRD_NRD_1	221	223	PF00675	0.266
CLV_NRD_NRD_1	25	27	PF00675	0.414
CLV_NRD_NRD_1	67	69	PF00675	0.485
CLV_PCSK_KEX2_1	129	131	PF00082	0.462
CLV_PCSK_KEX2_1	202	204	PF00082	0.268
CLV_PCSK_KEX2_1	22	24	PF00082	0.420
CLV_PCSK_KEX2_1	221	223	PF00082	0.194
CLV_PCSK_KEX2_1	348	350	PF00082	0.250
CLV_PCSK_KEX2_1	67	69	PF00082	0.423
CLV_PCSK_KEX2_1	80	82	PF00082	0.517
CLV_PCSK_PC1ET2_1	129	131	PF00082	0.462
CLV_PCSK_PC1ET2_1	348	350	PF00082	0.250
CLV_PCSK_PC1ET2_1	80	82	PF00082	0.403
CLV_PCSK_SKI1_1	222	226	PF00082	0.351
CLV_PCSK_SKI1_1	335	339	PF00082	0.345
DOC_MAPK_gen_1	26	34	PF00069	0.492
DOC_MAPK_gen_1	291	299	PF00069	0.541
DOC_MAPK_RevD_3	115	130	PF00069	0.454
DOC_MAPK_RevD_3	334	349	PF00069	0.497
DOC_USP7_MATH_1	251	255	PF00917	0.523
DOC_USP7_MATH_1	287	291	PF00917	0.486
DOC_USP7_MATH_1	355	359	PF00917	0.538
DOC_WW_Pin1_4	247	252	PF00397	0.566
DOC_WW_Pin1_4	278	283	PF00397	0.566
DOC_WW_Pin1_4	55	60	PF00397	0.446
LIG_14-3-3_CanoR_1	108	115	PF00244	0.397
LIG_14-3-3_CanoR_1	168	174	PF00244	0.464
LIG_14-3-3_CanoR_1	222	231	PF00244	0.473
LIG_14-3-3_CanoR_1	67	72	PF00244	0.503
LIG_BIR_II_1	1	5	PF00653	0.546
LIG_deltaCOP1_diTrp_1	9	18	PF00928	0.479
LIG_FHA_1	168	174	PF00498	0.376
LIG_FHA_1	185	191	PF00498	0.541
LIG_FHA_1	214	220	PF00498	0.450
LIG_FHA_1	259	265	PF00498	0.557
LIG_FHA_2	318	324	PF00498	0.453
LIG_FHA_2	34	40	PF00498	0.519
LIG_LIR_Apic_2	191	195	PF02991	0.541
LIG_LIR_Gen_1	233	241	PF02991	0.552
LIG_LIR_Gen_1	58	69	PF02991	0.473
LIG_LIR_Gen_1	9	18	PF02991	0.371
LIG_LIR_Nem_3	187	192	PF02991	0.544
LIG_LIR_Nem_3	233	239	PF02991	0.482
LIG_LIR_Nem_3	323	327	PF02991	0.541
LIG_LIR_Nem_3	9	14	PF02991	0.368
LIG_MYND_1	115	119	PF01753	0.452
LIG_PCNA_PIPBox_1	87	96	PF02747	0.403
LIG_PCNA_yPIPBox_3	80	94	PF02747	0.402
LIG_PTB_Apo_2	326	333	PF02174	0.541
LIG_SH2_NCK_1	192	196	PF00017	0.541
LIG_SH2_SRC	103	106	PF00017	0.350
LIG_SH2_STAP1	103	107	PF00017	0.347
LIG_SH2_STAP1	346	350	PF00017	0.477
LIG_SH2_STAT5	189	192	PF00017	0.474
LIG_SH2_STAT5	344	347	PF00017	0.482
LIG_SH3_3	156	162	PF00018	0.411
LIG_SH3_3	209	215	PF00018	0.471
LIG_SH3_3	279	285	PF00018	0.461
LIG_SH3_3	333	339	PF00018	0.464
LIG_SH3_3	349	355	PF00018	0.529
LIG_SH3_3	41	47	PF00018	0.613
LIG_TRAF2_1	28	31	PF00917	0.395
LIG_TRAF2_1	320	323	PF00917	0.464
LIG_UBA3_1	71	80	PF00899	0.408
MOD_CK1_1	250	256	PF00069	0.476
MOD_CK1_1	260	266	PF00069	0.434
MOD_CK1_1	353	359	PF00069	0.560
MOD_CK2_1	140	146	PF00069	0.442
MOD_CK2_1	317	323	PF00069	0.449
MOD_CK2_1	33	39	PF00069	0.509
MOD_CK2_1	67	73	PF00069	0.496
MOD_GlcNHglycan	109	112	PF01048	0.431
MOD_GlcNHglycan	253	256	PF01048	0.381
MOD_GlcNHglycan	358	361	PF01048	0.392
MOD_GSK3_1	176	183	PF00069	0.473
MOD_GSK3_1	247	254	PF00069	0.475
MOD_GSK3_1	260	267	PF00069	0.421
MOD_GSK3_1	272	279	PF00069	0.477
MOD_GSK3_1	283	290	PF00069	0.435
MOD_GSK3_1	63	70	PF00069	0.481
MOD_N-GLC_1	98	103	PF02516	0.481
MOD_NEK2_1	107	112	PF00069	0.253
MOD_NEK2_1	89	94	PF00069	0.436
MOD_PIKK_1	353	359	PF00454	0.461
MOD_PKA_1	67	73	PF00069	0.308
MOD_PKA_2	107	113	PF00069	0.387
MOD_PKA_2	167	173	PF00069	0.407
MOD_PKA_2	174	180	PF00069	0.488
MOD_PKA_2	287	293	PF00069	0.525
MOD_PKA_2	67	73	PF00069	0.511
MOD_Plk_1	30	36	PF00069	0.412
MOD_Plk_1	317	323	PF00069	0.439
MOD_Plk_2-3	317	323	PF00069	0.446
MOD_Plk_4	184	190	PF00069	0.541
MOD_Plk_4	235	241	PF00069	0.497
MOD_Plk_4	67	73	PF00069	0.540
MOD_Plk_4	89	95	PF00069	0.437
MOD_ProDKin_1	247	253	PF00069	0.566
MOD_ProDKin_1	278	284	PF00069	0.566
MOD_ProDKin_1	55	61	PF00069	0.442
MOD_SUMO_rev_2	317	327	PF00179	0.450
TRG_DiLeu_BaEn_1	9	14	PF01217	0.368
TRG_ENDOCYTIC_2	61	64	PF00928	0.404
TRG_ER_diArg_1	201	203	PF00400	0.451
TRG_ER_diArg_1	21	23	PF00400	0.484
TRG_ER_diArg_1	221	223	PF00400	0.421
TRG_NES_CRM1_1	150	164	PF08389	0.276
TRG_NLS_MonoExtC_3	18	23	PF00514	0.406
TRG_Pf-PMV_PEXEL_1	81	85	PF00026	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6Z2	Leptomonas seymouri	58%	95%
A0A0S4JKX9	Bodo saltans	35%	100%
A0A1X0P0L9	Trypanosomatidae	39%	94%
A0A3R7KC81	Trypanosoma rangeli	39%	96%
A4HL49	Leishmania braziliensis	78%	100%
A4I8M8	Leishmania infantum	100%	100%
D0A4K6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	96%
E9B3J0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q4L1	Leishmania major	94%	100%
V5BKD3	Trypanosoma cruzi	40%	96%