Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X6C3_LEIDO

TriTrypDb:

LdBPK_330090.1 , LdCL_330005800 , LDHU3_33.0100

Length:

616

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X6C3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6C3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	360	364	PF00656	0.621
CLV_C14_Caspase3-7	564	568	PF00656	0.635
CLV_NRD_NRD_1	227	229	PF00675	0.472
CLV_NRD_NRD_1	335	337	PF00675	0.542
CLV_NRD_NRD_1	338	340	PF00675	0.377
CLV_NRD_NRD_1	385	387	PF00675	0.536
CLV_NRD_NRD_1	5	7	PF00675	0.634
CLV_PCSK_FUR_1	336	340	PF00082	0.450
CLV_PCSK_KEX2_1	227	229	PF00082	0.491
CLV_PCSK_KEX2_1	335	337	PF00082	0.585
CLV_PCSK_KEX2_1	338	340	PF00082	0.377
CLV_PCSK_KEX2_1	385	387	PF00082	0.536
CLV_PCSK_PC7_1	381	387	PF00082	0.530
CLV_PCSK_SKI1_1	101	105	PF00082	0.490
CLV_PCSK_SKI1_1	283	287	PF00082	0.415
CLV_PCSK_SKI1_1	381	385	PF00082	0.482
CLV_PCSK_SKI1_1	389	393	PF00082	0.490
CLV_PCSK_SKI1_1	482	486	PF00082	0.474
CLV_PCSK_SKI1_1	538	542	PF00082	0.659
DEG_APCC_DBOX_1	456	464	PF00400	0.432
DEG_SPOP_SBC_1	544	548	PF00917	0.672
DEG_SPOP_SBC_1	552	556	PF00917	0.613
DOC_ANK_TNKS_1	187	194	PF00023	0.619
DOC_CDC14_PxL_1	109	117	PF14671	0.472
DOC_CYCLIN_yCln2_LP_2	569	575	PF00134	0.639
DOC_MAPK_gen_1	227	235	PF00069	0.479
DOC_MAPK_MEF2A_6	10	17	PF00069	0.674
DOC_MAPK_MEF2A_6	300	309	PF00069	0.530
DOC_MAPK_MEF2A_6	570	577	PF00069	0.513
DOC_MAPK_MEF2A_6	589	598	PF00069	0.290
DOC_MAPK_NFAT4_5	304	312	PF00069	0.345
DOC_PP2B_LxvP_1	284	287	PF13499	0.358
DOC_PP2B_LxvP_1	569	572	PF13499	0.667
DOC_PP4_FxxP_1	182	185	PF00568	0.465
DOC_PP4_FxxP_1	76	79	PF00568	0.487
DOC_USP7_MATH_1	131	135	PF00917	0.424
DOC_USP7_MATH_1	174	178	PF00917	0.571
DOC_USP7_MATH_1	217	221	PF00917	0.432
DOC_USP7_MATH_1	323	327	PF00917	0.529
DOC_USP7_MATH_1	349	353	PF00917	0.664
DOC_USP7_MATH_1	355	359	PF00917	0.601
DOC_USP7_MATH_2	16	22	PF00917	0.631
DOC_WW_Pin1_4	175	180	PF00397	0.386
DOC_WW_Pin1_4	368	373	PF00397	0.564
DOC_WW_Pin1_4	39	44	PF00397	0.453
DOC_WW_Pin1_4	511	516	PF00397	0.703
DOC_WW_Pin1_4	611	616	PF00397	0.518
DOC_WW_Pin1_4	92	97	PF00397	0.397
LIG_14-3-3_CanoR_1	101	107	PF00244	0.390
LIG_14-3-3_CanoR_1	119	125	PF00244	0.543
LIG_14-3-3_CanoR_1	227	233	PF00244	0.346
LIG_14-3-3_CanoR_1	252	257	PF00244	0.426
LIG_14-3-3_CanoR_1	300	307	PF00244	0.537
LIG_14-3-3_CanoR_1	338	346	PF00244	0.391
LIG_14-3-3_CanoR_1	482	487	PF00244	0.515
LIG_14-3-3_CanoR_1	488	498	PF00244	0.502
LIG_Actin_WH2_2	307	323	PF00022	0.406
LIG_Actin_WH2_2	466	484	PF00022	0.486
LIG_APCC_ABBAyCdc20_2	165	171	PF00400	0.433
LIG_deltaCOP1_diTrp_1	251	256	PF00928	0.428
LIG_deltaCOP1_diTrp_1	606	611	PF00928	0.538
LIG_eIF4E_1	229	235	PF01652	0.360
LIG_EVH1_1	207	211	PF00568	0.418
LIG_FHA_1	119	125	PF00498	0.403
LIG_FHA_1	185	191	PF00498	0.509
LIG_FHA_1	229	235	PF00498	0.360
LIG_FHA_1	279	285	PF00498	0.365
LIG_FHA_1	300	306	PF00498	0.554
LIG_FHA_1	511	517	PF00498	0.700
LIG_FHA_1	527	533	PF00498	0.594
LIG_FHA_1	554	560	PF00498	0.701
LIG_FHA_1	595	601	PF00498	0.463
LIG_FHA_2	260	266	PF00498	0.490
LIG_FHA_2	540	546	PF00498	0.730
LIG_LIR_Apic_2	180	185	PF02991	0.616
LIG_LIR_Apic_2	74	79	PF02991	0.499
LIG_LIR_Gen_1	432	441	PF02991	0.402
LIG_LIR_Gen_1	445	456	PF02991	0.397
LIG_LIR_Gen_1	489	499	PF02991	0.495
LIG_LIR_Nem_3	251	256	PF02991	0.423
LIG_LIR_Nem_3	432	437	PF02991	0.390
LIG_LIR_Nem_3	445	451	PF02991	0.385
LIG_LIR_Nem_3	489	494	PF02991	0.435
LIG_LIR_Nem_3	52	57	PF02991	0.387
LIG_LIR_Nem_3	92	97	PF02991	0.520
LIG_MAD2	123	131	PF02301	0.543
LIG_NRBOX	465	471	PF00104	0.403
LIG_PCNA_yPIPBox_3	292	304	PF02747	0.467
LIG_PCNA_yPIPBox_3	55	69	PF02747	0.441
LIG_Pex14_1	434	438	PF04695	0.364
LIG_Pex14_2	444	448	PF04695	0.505
LIG_PTB_Apo_2	88	95	PF02174	0.411
LIG_SH2_CRK	229	233	PF00017	0.362
LIG_SH2_NCK_1	438	442	PF00017	0.442
LIG_SH2_STAP1	170	174	PF00017	0.359
LIG_SH2_STAP1	229	233	PF00017	0.477
LIG_SH2_STAP1	301	305	PF00017	0.542
LIG_SH2_STAP1	592	596	PF00017	0.462
LIG_SH2_STAT5	301	304	PF00017	0.553
LIG_SH2_STAT5	438	441	PF00017	0.396
LIG_SH3_1	10	16	PF00018	0.643
LIG_SH3_3	10	16	PF00018	0.693
LIG_SH3_3	110	116	PF00018	0.465
LIG_SH3_3	180	186	PF00018	0.614
LIG_SH3_3	205	211	PF00018	0.416
LIG_SUMO_SIM_anti_2	230	237	PF11976	0.366
LIG_SUMO_SIM_anti_2	528	534	PF11976	0.567
LIG_SUMO_SIM_anti_2	597	602	PF11976	0.470
LIG_SUMO_SIM_par_1	230	237	PF11976	0.481
LIG_SUMO_SIM_par_1	465	471	PF11976	0.416
LIG_SUMO_SIM_par_1	513	520	PF11976	0.695
LIG_SUMO_SIM_par_1	528	534	PF11976	0.404
LIG_SUMO_SIM_par_1	595	602	PF11976	0.403
LIG_UBA3_1	50	55	PF00899	0.517
LIG_Vh1_VBS_1	583	601	PF01044	0.447
LIG_WRC_WIRS_1	81	86	PF05994	0.362
MOD_CK1_1	107	113	PF00069	0.603
MOD_CK1_1	177	183	PF00069	0.440
MOD_CK1_1	21	27	PF00069	0.622
MOD_CK1_1	436	442	PF00069	0.513
MOD_CK1_1	489	495	PF00069	0.490
MOD_CK1_1	553	559	PF00069	0.635
MOD_CK1_1	610	616	PF00069	0.483
MOD_CK1_1	72	78	PF00069	0.527
MOD_CK2_1	252	258	PF00069	0.459
MOD_CK2_1	259	265	PF00069	0.375
MOD_CK2_1	411	417	PF00069	0.600
MOD_CK2_1	545	551	PF00069	0.661
MOD_CK2_1	610	616	PF00069	0.548
MOD_CK2_1	80	86	PF00069	0.520
MOD_CMANNOS	343	346	PF00535	0.485
MOD_GlcNHglycan	106	109	PF01048	0.412
MOD_GlcNHglycan	127	130	PF01048	0.464
MOD_GlcNHglycan	215	218	PF01048	0.420
MOD_GlcNHglycan	219	222	PF01048	0.433
MOD_GlcNHglycan	267	270	PF01048	0.394
MOD_GlcNHglycan	316	319	PF01048	0.384
MOD_GlcNHglycan	352	355	PF01048	0.667
MOD_GlcNHglycan	408	411	PF01048	0.444
MOD_GlcNHglycan	413	416	PF01048	0.404
MOD_GlcNHglycan	47	50	PF01048	0.540
MOD_GlcNHglycan	533	536	PF01048	0.577
MOD_GlcNHglycan	57	60	PF01048	0.304
MOD_GlcNHglycan	601	604	PF01048	0.536
MOD_GlcNHglycan	71	74	PF01048	0.470
MOD_GSK3_1	18	25	PF00069	0.622
MOD_GSK3_1	213	220	PF00069	0.435
MOD_GSK3_1	319	326	PF00069	0.525
MOD_GSK3_1	330	337	PF00069	0.594
MOD_GSK3_1	35	42	PF00069	0.553
MOD_GSK3_1	350	357	PF00069	0.572
MOD_GSK3_1	368	375	PF00069	0.422
MOD_GSK3_1	418	425	PF00069	0.497
MOD_GSK3_1	429	436	PF00069	0.387
MOD_GSK3_1	45	52	PF00069	0.583
MOD_GSK3_1	482	489	PF00069	0.551
MOD_GSK3_1	539	546	PF00069	0.737
MOD_GSK3_1	607	614	PF00069	0.643
MOD_GSK3_1	68	75	PF00069	0.485
MOD_N-GLC_1	90	95	PF02516	0.508
MOD_NEK2_1	102	107	PF00069	0.418
MOD_NEK2_1	125	130	PF00069	0.576
MOD_NEK2_1	215	220	PF00069	0.487
MOD_NEK2_1	234	239	PF00069	0.338
MOD_NEK2_1	451	456	PF00069	0.578
MOD_NEK2_1	486	491	PF00069	0.468
MOD_NEK2_1	516	521	PF00069	0.684
MOD_NEK2_1	68	73	PF00069	0.530
MOD_NEK2_2	433	438	PF00069	0.351
MOD_NEK2_2	49	54	PF00069	0.450
MOD_PIKK_1	288	294	PF00454	0.521
MOD_PIKK_1	489	495	PF00454	0.480
MOD_PKA_1	227	233	PF00069	0.427
MOD_PKA_1	338	344	PF00069	0.396
MOD_PKA_2	11	17	PF00069	0.637
MOD_PKA_2	118	124	PF00069	0.402
MOD_PKA_2	227	233	PF00069	0.381
MOD_PKA_2	299	305	PF00069	0.425
MOD_PKA_2	334	340	PF00069	0.599
MOD_PKA_2	350	356	PF00069	0.654
MOD_PKA_2	487	493	PF00069	0.517
MOD_PKB_1	336	344	PF00069	0.406
MOD_Plk_1	400	406	PF00069	0.496
MOD_Plk_1	592	598	PF00069	0.460
MOD_Plk_1	90	96	PF00069	0.534
MOD_Plk_4	228	234	PF00069	0.380
MOD_Plk_4	294	300	PF00069	0.420
MOD_Plk_4	418	424	PF00069	0.493
MOD_Plk_4	429	435	PF00069	0.358
MOD_Plk_4	482	488	PF00069	0.492
MOD_Plk_4	49	55	PF00069	0.459
MOD_Plk_4	494	500	PF00069	0.426
MOD_Plk_4	80	86	PF00069	0.586
MOD_ProDKin_1	175	181	PF00069	0.390
MOD_ProDKin_1	368	374	PF00069	0.560
MOD_ProDKin_1	39	45	PF00069	0.448
MOD_ProDKin_1	511	517	PF00069	0.700
MOD_ProDKin_1	92	98	PF00069	0.391
TRG_DiLeu_BaLyEn_6	110	115	PF01217	0.449
TRG_DiLeu_BaLyEn_6	280	285	PF01217	0.321
TRG_ENDOCYTIC_2	197	200	PF00928	0.353
TRG_ENDOCYTIC_2	229	232	PF00928	0.362
TRG_ER_diArg_1	226	228	PF00400	0.451
TRG_ER_diArg_1	335	338	PF00400	0.441
TRG_ER_diArg_1	384	386	PF00400	0.534
TRG_ER_diArg_1	9	12	PF00400	0.710
TRG_Pf-PMV_PEXEL_1	386	390	PF00026	0.509
TRG_Pf-PMV_PEXEL_1	402	406	PF00026	0.369

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P687	Leptomonas seymouri	43%	67%
A4HL45	Leishmania braziliensis	72%	100%
A4I8M4	Leishmania infantum	99%	100%
E9B3I6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q4L4	Leishmania major	90%	100%