LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, unknown function
Species:
Leishmania donovani
UniProt:
A0A3S7X6B9_LEIDO
TriTrypDb:
LdBPK_330220.1 * , LdCL_330007100
Length:
914

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 9
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6

Expansion

Sequence features

A0A3S7X6B9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6B9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 122 126 PF00656 0.721
CLV_C14_Caspase3-7 652 656 PF00656 0.569
CLV_C14_Caspase3-7 80 84 PF00656 0.642
CLV_C14_Caspase3-7 894 898 PF00656 0.593
CLV_C14_Caspase3-7 907 911 PF00656 0.669
CLV_NRD_NRD_1 266 268 PF00675 0.531
CLV_NRD_NRD_1 689 691 PF00675 0.371
CLV_NRD_NRD_1 752 754 PF00675 0.353
CLV_NRD_NRD_1 759 761 PF00675 0.356
CLV_PCSK_KEX2_1 266 268 PF00082 0.531
CLV_PCSK_KEX2_1 752 754 PF00082 0.353
CLV_PCSK_KEX2_1 759 761 PF00082 0.356
CLV_PCSK_KEX2_1 76 78 PF00082 0.474
CLV_PCSK_PC1ET2_1 76 78 PF00082 0.494
CLV_PCSK_SKI1_1 287 291 PF00082 0.277
CLV_PCSK_SKI1_1 341 345 PF00082 0.497
CLV_PCSK_SKI1_1 427 431 PF00082 0.416
CLV_PCSK_SKI1_1 463 467 PF00082 0.548
CLV_PCSK_SKI1_1 558 562 PF00082 0.483
CLV_PCSK_SKI1_1 591 595 PF00082 0.325
DEG_Nend_Nbox_1 1 3 PF02207 0.557
DOC_CDC14_PxL_1 584 592 PF14671 0.603
DOC_CKS1_1 259 264 PF01111 0.712
DOC_CKS1_1 345 350 PF01111 0.607
DOC_CKS1_1 389 394 PF01111 0.451
DOC_CKS1_1 464 469 PF01111 0.750
DOC_CYCLIN_RxL_1 553 564 PF00134 0.679
DOC_CYCLIN_yClb5_NLxxxL_5 421 430 PF00134 0.509
DOC_CYCLIN_yCln2_LP_2 155 161 PF00134 0.736
DOC_MAPK_gen_1 284 294 PF00069 0.508
DOC_MAPK_gen_1 628 636 PF00069 0.617
DOC_MAPK_gen_1 810 819 PF00069 0.731
DOC_MAPK_gen_1 824 833 PF00069 0.528
DOC_MAPK_MEF2A_6 630 638 PF00069 0.599
DOC_MAPK_MEF2A_6 813 821 PF00069 0.677
DOC_MAPK_RevD_3 326 342 PF00069 0.383
DOC_PP1_RVXF_1 34 41 PF00149 0.355
DOC_PP1_RVXF_1 732 739 PF00149 0.586
DOC_PP2B_LxvP_1 155 158 PF13499 0.707
DOC_PP2B_LxvP_1 16 19 PF13499 0.266
DOC_PP2B_LxvP_1 190 193 PF13499 0.683
DOC_PP2B_LxvP_1 290 293 PF13499 0.349
DOC_PP2B_LxvP_1 328 331 PF13499 0.359
DOC_PP2B_LxvP_1 541 544 PF13499 0.690
DOC_PP4_FxxP_1 738 741 PF00568 0.578
DOC_PP4_MxPP_1 512 515 PF00568 0.720
DOC_USP7_MATH_1 133 137 PF00917 0.709
DOC_USP7_MATH_1 169 173 PF00917 0.773
DOC_USP7_MATH_1 280 284 PF00917 0.639
DOC_USP7_MATH_1 293 297 PF00917 0.392
DOC_USP7_MATH_1 478 482 PF00917 0.787
DOC_USP7_MATH_1 537 541 PF00917 0.681
DOC_USP7_MATH_1 548 552 PF00917 0.660
DOC_USP7_MATH_1 610 614 PF00917 0.626
DOC_USP7_MATH_1 676 680 PF00917 0.572
DOC_USP7_MATH_1 68 72 PF00917 0.552
DOC_USP7_MATH_1 695 699 PF00917 0.586
DOC_USP7_MATH_1 716 720 PF00917 0.523
DOC_USP7_MATH_1 886 890 PF00917 0.611
DOC_USP7_MATH_2 522 528 PF00917 0.726
DOC_USP7_UBL2_3 241 245 PF12436 0.735
DOC_USP7_UBL2_3 806 810 PF12436 0.712
DOC_WW_Pin1_4 105 110 PF00397 0.693
DOC_WW_Pin1_4 137 142 PF00397 0.697
DOC_WW_Pin1_4 159 164 PF00397 0.736
DOC_WW_Pin1_4 188 193 PF00397 0.704
DOC_WW_Pin1_4 240 245 PF00397 0.714
DOC_WW_Pin1_4 258 263 PF00397 0.598
DOC_WW_Pin1_4 322 327 PF00397 0.449
DOC_WW_Pin1_4 344 349 PF00397 0.563
DOC_WW_Pin1_4 388 393 PF00397 0.465
DOC_WW_Pin1_4 397 402 PF00397 0.359
DOC_WW_Pin1_4 463 468 PF00397 0.755
DOC_WW_Pin1_4 476 481 PF00397 0.651
DOC_WW_Pin1_4 561 566 PF00397 0.733
LIG_14-3-3_CanoR_1 149 153 PF00244 0.806
LIG_14-3-3_CanoR_1 254 260 PF00244 0.726
LIG_14-3-3_CanoR_1 266 271 PF00244 0.745
LIG_14-3-3_CanoR_1 351 355 PF00244 0.623
LIG_14-3-3_CanoR_1 357 362 PF00244 0.601
LIG_14-3-3_CanoR_1 405 410 PF00244 0.281
LIG_14-3-3_CanoR_1 507 515 PF00244 0.679
LIG_14-3-3_CanoR_1 783 793 PF00244 0.557
LIG_Actin_WH2_2 272 289 PF00022 0.666
LIG_BIR_III_2 203 207 PF00653 0.729
LIG_BIR_III_4 647 651 PF00653 0.638
LIG_BRCT_BRCA1_1 611 615 PF00533 0.633
LIG_BRCT_BRCA1_1 634 638 PF00533 0.654
LIG_Clathr_ClatBox_1 683 687 PF01394 0.534
LIG_DLG_GKlike_1 760 768 PF00625 0.577
LIG_EH_1 772 776 PF12763 0.680
LIG_EH1_1 22 30 PF00400 0.269
LIG_eIF4E_1 316 322 PF01652 0.291
LIG_eIF4E_1 409 415 PF01652 0.449
LIG_EVH1_2 19 23 PF00568 0.349
LIG_EVH1_2 702 706 PF00568 0.714
LIG_FHA_1 138 144 PF00498 0.735
LIG_FHA_1 185 191 PF00498 0.704
LIG_FHA_1 222 228 PF00498 0.716
LIG_FHA_1 298 304 PF00498 0.365
LIG_FHA_1 307 313 PF00498 0.402
LIG_FHA_1 316 322 PF00498 0.233
LIG_FHA_1 431 437 PF00498 0.627
LIG_FHA_1 464 470 PF00498 0.775
LIG_FHA_1 631 637 PF00498 0.599
LIG_FHA_2 227 233 PF00498 0.676
LIG_FHA_2 241 247 PF00498 0.669
LIG_FHA_2 518 524 PF00498 0.715
LIG_FHA_2 660 666 PF00498 0.634
LIG_FHA_2 840 846 PF00498 0.621
LIG_GBD_Chelix_1 901 909 PF00786 0.427
LIG_HCF-1_HBM_1 197 200 PF13415 0.675
LIG_HP1_1 293 297 PF01393 0.383
LIG_LIR_Apic_2 386 392 PF02991 0.484
LIG_LIR_Apic_2 408 412 PF02991 0.303
LIG_LIR_Gen_1 296 306 PF02991 0.334
LIG_LIR_Gen_1 41 50 PF02991 0.242
LIG_LIR_Gen_1 635 645 PF02991 0.559
LIG_LIR_Gen_1 772 780 PF02991 0.525
LIG_LIR_Gen_1 844 851 PF02991 0.601
LIG_LIR_Gen_1 859 868 PF02991 0.568
LIG_LIR_LC3C_4 178 181 PF02991 0.766
LIG_LIR_LC3C_4 846 851 PF02991 0.594
LIG_LIR_Nem_3 296 301 PF02991 0.334
LIG_LIR_Nem_3 363 369 PF02991 0.386
LIG_LIR_Nem_3 387 393 PF02991 0.351
LIG_LIR_Nem_3 408 413 PF02991 0.299
LIG_LIR_Nem_3 41 45 PF02991 0.242
LIG_LIR_Nem_3 594 600 PF02991 0.512
LIG_LIR_Nem_3 635 641 PF02991 0.547
LIG_LIR_Nem_3 772 778 PF02991 0.523
LIG_LIR_Nem_3 844 850 PF02991 0.611
LIG_LIR_Nem_3 859 864 PF02991 0.571
LIG_PALB2_WD40_1 361 369 PF16756 0.383
LIG_PCNA_PIPBox_1 291 300 PF02747 0.383
LIG_PCNA_yPIPBox_3 710 718 PF02747 0.575
LIG_SH2_CRK 298 302 PF00017 0.334
LIG_SH2_CRK 345 349 PF00017 0.611
LIG_SH2_PTP2 24 27 PF00017 0.296
LIG_SH2_SRC 664 667 PF00017 0.625
LIG_SH2_STAP1 200 204 PF00017 0.726
LIG_SH2_STAP1 664 668 PF00017 0.626
LIG_SH2_STAT3 222 225 PF00017 0.753
LIG_SH2_STAT5 200 203 PF00017 0.725
LIG_SH2_STAT5 24 27 PF00017 0.338
LIG_SH2_STAT5 372 375 PF00017 0.301
LIG_SH2_STAT5 409 412 PF00017 0.334
LIG_SH2_STAT5 597 600 PF00017 0.518
LIG_SH2_STAT5 659 662 PF00017 0.564
LIG_SH3_2 282 287 PF14604 0.623
LIG_SH3_3 151 157 PF00018 0.682
LIG_SH3_3 177 183 PF00018 0.763
LIG_SH3_3 210 216 PF00018 0.811
LIG_SH3_3 276 282 PF00018 0.709
LIG_SH3_3 461 467 PF00018 0.775
LIG_SH3_3 512 518 PF00018 0.783
LIG_SH3_3 697 703 PF00018 0.621
LIG_SH3_3 715 721 PF00018 0.528
LIG_SH3_3 768 774 PF00018 0.643
LIG_SUMO_SIM_par_1 304 309 PF11976 0.342
LIG_SUMO_SIM_par_1 357 363 PF11976 0.520
LIG_SUMO_SIM_par_1 413 418 PF11976 0.383
LIG_SUMO_SIM_par_1 682 687 PF11976 0.531
LIG_TRAF2_1 142 145 PF00917 0.690
LIG_TRAF2_1 709 712 PF00917 0.612
LIG_TRAF2_1 842 845 PF00917 0.605
LIG_TYR_ITIM 22 27 PF00017 0.349
LIG_TYR_ITIM 598 603 PF00017 0.386
LIG_UBA3_1 337 342 PF00899 0.484
LIG_UBA3_1 683 691 PF00899 0.385
LIG_WW_3 173 177 PF00397 0.674
MOD_CDK_SPK_2 240 245 PF00069 0.647
MOD_CDK_SPK_2 397 402 PF00069 0.485
MOD_CDK_SPxxK_3 344 351 PF00069 0.405
MOD_CK1_1 108 114 PF00069 0.602
MOD_CK1_1 136 142 PF00069 0.779
MOD_CK1_1 147 153 PF00069 0.592
MOD_CK1_1 191 197 PF00069 0.792
MOD_CK1_1 221 227 PF00069 0.613
MOD_CK1_1 258 264 PF00069 0.658
MOD_CK1_1 269 275 PF00069 0.572
MOD_CK1_1 360 366 PF00069 0.409
MOD_CK1_1 43 49 PF00069 0.378
MOD_CK1_1 488 494 PF00069 0.724
MOD_CK1_1 527 533 PF00069 0.695
MOD_CK1_1 564 570 PF00069 0.763
MOD_CK1_1 60 66 PF00069 0.349
MOD_CK1_1 784 790 PF00069 0.589
MOD_CK1_1 822 828 PF00069 0.604
MOD_CK1_1 859 865 PF00069 0.387
MOD_CK2_1 111 117 PF00069 0.641
MOD_CK2_1 139 145 PF00069 0.571
MOD_CK2_1 191 197 PF00069 0.660
MOD_CK2_1 497 503 PF00069 0.637
MOD_CK2_1 517 523 PF00069 0.588
MOD_CK2_1 659 665 PF00069 0.536
MOD_CK2_1 764 770 PF00069 0.626
MOD_CK2_1 839 845 PF00069 0.507
MOD_DYRK1A_RPxSP_1 463 467 PF00069 0.694
MOD_GlcNHglycan 171 174 PF01048 0.675
MOD_GlcNHglycan 208 211 PF01048 0.646
MOD_GlcNHglycan 232 236 PF01048 0.805
MOD_GlcNHglycan 268 271 PF01048 0.707
MOD_GlcNHglycan 374 377 PF01048 0.303
MOD_GlcNHglycan 42 45 PF01048 0.386
MOD_GlcNHglycan 480 483 PF01048 0.713
MOD_GlcNHglycan 487 490 PF01048 0.689
MOD_GlcNHglycan 491 494 PF01048 0.641
MOD_GlcNHglycan 499 502 PF01048 0.703
MOD_GlcNHglycan 550 553 PF01048 0.670
MOD_GlcNHglycan 62 65 PF01048 0.305
MOD_GlcNHglycan 652 655 PF01048 0.633
MOD_GlcNHglycan 718 721 PF01048 0.536
MOD_GlcNHglycan 729 732 PF01048 0.531
MOD_GlcNHglycan 799 802 PF01048 0.528
MOD_GlcNHglycan 875 879 PF01048 0.522
MOD_GlcNHglycan 910 913 PF01048 0.424
MOD_GSK3_1 119 126 PF00069 0.613
MOD_GSK3_1 133 140 PF00069 0.696
MOD_GSK3_1 143 150 PF00069 0.671
MOD_GSK3_1 159 166 PF00069 0.619
MOD_GSK3_1 184 191 PF00069 0.640
MOD_GSK3_1 214 221 PF00069 0.625
MOD_GSK3_1 254 261 PF00069 0.586
MOD_GSK3_1 266 273 PF00069 0.636
MOD_GSK3_1 293 300 PF00069 0.446
MOD_GSK3_1 485 492 PF00069 0.766
MOD_GSK3_1 524 531 PF00069 0.714
MOD_GSK3_1 548 555 PF00069 0.735
MOD_GSK3_1 561 568 PF00069 0.683
MOD_GSK3_1 569 576 PF00069 0.683
MOD_GSK3_1 655 662 PF00069 0.533
MOD_GSK3_1 716 723 PF00069 0.398
MOD_GSK3_1 760 767 PF00069 0.511
MOD_GSK3_1 781 788 PF00069 0.587
MOD_GSK3_1 819 826 PF00069 0.603
MOD_GSK3_1 886 893 PF00069 0.563
MOD_LATS_1 355 361 PF00433 0.467
MOD_LATS_1 505 511 PF00433 0.640
MOD_LATS_1 758 764 PF00433 0.489
MOD_N-GLC_1 497 502 PF02516 0.642
MOD_N-GLC_1 568 573 PF02516 0.691
MOD_N-GLC_1 785 790 PF02516 0.395
MOD_N-GLC_1 819 824 PF02516 0.711
MOD_N-GLC_1 897 902 PF02516 0.403
MOD_NEK2_1 124 129 PF00069 0.636
MOD_NEK2_1 134 139 PF00069 0.663
MOD_NEK2_1 184 189 PF00069 0.752
MOD_NEK2_1 297 302 PF00069 0.508
MOD_NEK2_1 306 311 PF00069 0.294
MOD_NEK2_1 350 355 PF00069 0.484
MOD_NEK2_1 40 45 PF00069 0.473
MOD_NEK2_1 554 559 PF00069 0.664
MOD_NEK2_1 583 588 PF00069 0.562
MOD_NEK2_1 615 620 PF00069 0.566
MOD_NEK2_1 624 629 PF00069 0.557
MOD_NEK2_1 67 72 PF00069 0.547
MOD_NEK2_1 727 732 PF00069 0.595
MOD_NEK2_2 293 298 PF00069 0.334
MOD_NEK2_2 537 542 PF00069 0.633
MOD_NEK2_2 610 615 PF00069 0.529
MOD_NEK2_2 729 734 PF00069 0.607
MOD_PIKK_1 108 114 PF00454 0.577
MOD_PIKK_1 221 227 PF00454 0.696
MOD_PIKK_1 575 581 PF00454 0.618
MOD_PIKK_1 787 793 PF00454 0.467
MOD_PIKK_1 93 99 PF00454 0.583
MOD_PK_1 357 363 PF00069 0.346
MOD_PKA_1 214 220 PF00069 0.571
MOD_PKA_1 266 272 PF00069 0.589
MOD_PKA_2 148 154 PF00069 0.766
MOD_PKA_2 184 190 PF00069 0.703
MOD_PKA_2 266 272 PF00069 0.589
MOD_PKA_2 350 356 PF00069 0.414
MOD_PKA_2 68 74 PF00069 0.432
MOD_Plk_1 897 903 PF00069 0.410
MOD_Plk_4 119 125 PF00069 0.596
MOD_Plk_4 191 197 PF00069 0.663
MOD_Plk_4 270 276 PF00069 0.611
MOD_Plk_4 293 299 PF00069 0.334
MOD_Plk_4 308 314 PF00069 0.350
MOD_Plk_4 357 363 PF00069 0.478
MOD_Plk_4 405 411 PF00069 0.327
MOD_Plk_4 528 534 PF00069 0.544
MOD_Plk_4 537 543 PF00069 0.615
MOD_Plk_4 556 562 PF00069 0.506
MOD_Plk_4 57 63 PF00069 0.426
MOD_Plk_4 591 597 PF00069 0.357
MOD_Plk_4 610 616 PF00069 0.568
MOD_Plk_4 655 661 PF00069 0.479
MOD_Plk_4 720 726 PF00069 0.431
MOD_ProDKin_1 105 111 PF00069 0.616
MOD_ProDKin_1 137 143 PF00069 0.625
MOD_ProDKin_1 159 165 PF00069 0.679
MOD_ProDKin_1 188 194 PF00069 0.631
MOD_ProDKin_1 240 246 PF00069 0.644
MOD_ProDKin_1 258 264 PF00069 0.485
MOD_ProDKin_1 322 328 PF00069 0.449
MOD_ProDKin_1 344 350 PF00069 0.432
MOD_ProDKin_1 388 394 PF00069 0.578
MOD_ProDKin_1 397 403 PF00069 0.424
MOD_ProDKin_1 463 469 PF00069 0.704
MOD_ProDKin_1 476 482 PF00069 0.560
MOD_ProDKin_1 561 567 PF00069 0.673
MOD_SUMO_for_1 3 6 PF00179 0.425
MOD_SUMO_rev_2 6 11 PF00179 0.452
TRG_DiLeu_BaEn_1 845 850 PF01217 0.493
TRG_DiLeu_BaEn_1 866 871 PF01217 0.390
TRG_ENDOCYTIC_2 24 27 PF00928 0.339
TRG_ENDOCYTIC_2 298 301 PF00928 0.334
TRG_ENDOCYTIC_2 600 603 PF00928 0.394
TRG_ENDOCYTIC_2 834 837 PF00928 0.369
TRG_ER_diArg_1 265 267 PF00400 0.641
TRG_ER_diArg_1 751 753 PF00400 0.423
TRG_ER_diArg_1 759 761 PF00400 0.433
TRG_NES_CRM1_1 589 602 PF08389 0.505
TRG_Pf-PMV_PEXEL_1 463 468 PF00026 0.781
TRG_Pf-PMV_PEXEL_1 601 605 PF00026 0.444
TRG_Pf-PMV_PEXEL_1 690 694 PF00026 0.349

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HYR4 Leptomonas seymouri 39% 99%
A4HL58 Leishmania braziliensis 57% 100%
A4I8N8 Leishmania infantum 99% 100%
E9B3J9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 80% 100%
Q4Q4K2 Leishmania major 84% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS