LeishMANIAdb
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SET domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
SET domain containing protein, putative
Gene product:
SET domain containing protein, putative
Species:
Leishmania donovani
UniProt:
A0A3S7X6B7_LEIDO
TriTrypDb:
LdBPK_330520.1 * , LdCL_330010700 , LDHU3_33.0770
Length:
1004

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A0A3S7X6B7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6B7

Function

Biological processes
Term Name Level Count
GO:0006479 protein methylation 4 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0008213 protein alkylation 5 1
GO:0009987 cellular process 1 1
GO:0016570 histone modification 5 1
GO:0016571 histone methylation 5 1
GO:0018022 peptidyl-lysine methylation 5 1
GO:0018193 peptidyl-amino acid modification 5 1
GO:0018205 peptidyl-lysine modification 6 1
GO:0019538 protein metabolic process 3 1
GO:0032259 methylation 2 1
GO:0034968 histone lysine methylation 6 1
GO:0036211 protein modification process 4 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043412 macromolecule modification 4 1
GO:0043414 macromolecule methylation 3 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 1
GO:0008168 methyltransferase activity 4 1
GO:0008170 N-methyltransferase activity 5 1
GO:0008276 protein methyltransferase activity 3 1
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 5 1
GO:0016278 lysine N-methyltransferase activity 6 1
GO:0016279 protein-lysine N-methyltransferase activity 4 1
GO:0016740 transferase activity 2 1
GO:0016741 transferase activity, transferring one-carbon groups 3 1
GO:0018024 obsolete histone lysine N-methyltransferase activity 5 1
GO:0042054 histone methyltransferase activity 4 1
GO:0140096 catalytic activity, acting on a protein 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 147 149 PF00675 0.512
CLV_NRD_NRD_1 433 435 PF00675 0.551
CLV_NRD_NRD_1 458 460 PF00675 0.552
CLV_NRD_NRD_1 546 548 PF00675 0.545
CLV_NRD_NRD_1 764 766 PF00675 0.498
CLV_NRD_NRD_1 8 10 PF00675 0.502
CLV_NRD_NRD_1 938 940 PF00675 0.318
CLV_PCSK_KEX2_1 147 149 PF00082 0.512
CLV_PCSK_KEX2_1 433 435 PF00082 0.551
CLV_PCSK_KEX2_1 546 548 PF00082 0.609
CLV_PCSK_KEX2_1 602 604 PF00082 0.520
CLV_PCSK_KEX2_1 749 751 PF00082 0.494
CLV_PCSK_KEX2_1 763 765 PF00082 0.468
CLV_PCSK_KEX2_1 8 10 PF00082 0.502
CLV_PCSK_KEX2_1 938 940 PF00082 0.318
CLV_PCSK_PC1ET2_1 602 604 PF00082 0.516
CLV_PCSK_PC1ET2_1 749 751 PF00082 0.489
CLV_PCSK_PC7_1 429 435 PF00082 0.517
CLV_PCSK_SKI1_1 174 178 PF00082 0.490
CLV_PCSK_SKI1_1 194 198 PF00082 0.494
CLV_PCSK_SKI1_1 235 239 PF00082 0.553
CLV_PCSK_SKI1_1 277 281 PF00082 0.405
CLV_PCSK_SKI1_1 334 338 PF00082 0.427
CLV_PCSK_SKI1_1 502 506 PF00082 0.485
CLV_PCSK_SKI1_1 624 628 PF00082 0.423
CLV_PCSK_SKI1_1 703 707 PF00082 0.387
CLV_PCSK_SKI1_1 710 714 PF00082 0.402
CLV_PCSK_SKI1_1 793 797 PF00082 0.595
CLV_PCSK_SKI1_1 8 12 PF00082 0.503
CLV_PCSK_SKI1_1 827 831 PF00082 0.371
DEG_APCC_DBOX_1 173 181 PF00400 0.481
DEG_APCC_DBOX_1 193 201 PF00400 0.420
DEG_APCC_DBOX_1 333 341 PF00400 0.428
DEG_Nend_UBRbox_3 1 3 PF02207 0.539
DEG_SCF_FBW7_2 129 135 PF00400 0.539
DEG_SPOP_SBC_1 345 349 PF00917 0.470
DEG_SPOP_SBC_1 57 61 PF00917 0.531
DOC_CDC14_PxL_1 205 213 PF14671 0.470
DOC_CDC14_PxL_1 560 568 PF14671 0.506
DOC_CKS1_1 129 134 PF01111 0.538
DOC_CKS1_1 51 56 PF01111 0.512
DOC_CYCLIN_RxL_1 700 708 PF00134 0.375
DOC_CYCLIN_RxL_1 824 832 PF00134 0.366
DOC_MAPK_gen_1 235 243 PF00069 0.455
DOC_MAPK_gen_1 332 340 PF00069 0.655
DOC_MAPK_MEF2A_6 194 202 PF00069 0.480
DOC_MAPK_MEF2A_6 332 340 PF00069 0.655
DOC_MAPK_MEF2A_6 785 794 PF00069 0.379
DOC_PP2B_LxvP_1 165 168 PF13499 0.428
DOC_USP7_MATH_1 103 107 PF00917 0.436
DOC_USP7_MATH_1 17 21 PF00917 0.509
DOC_USP7_MATH_1 207 211 PF00917 0.516
DOC_USP7_MATH_1 245 249 PF00917 0.491
DOC_USP7_MATH_1 264 268 PF00917 0.332
DOC_USP7_MATH_1 30 34 PF00917 0.455
DOC_USP7_MATH_1 345 349 PF00917 0.493
DOC_USP7_MATH_1 365 369 PF00917 0.477
DOC_USP7_MATH_1 46 50 PF00917 0.447
DOC_USP7_MATH_1 506 510 PF00917 0.524
DOC_USP7_MATH_1 612 616 PF00917 0.447
DOC_USP7_MATH_1 737 741 PF00917 0.504
DOC_USP7_MATH_1 745 749 PF00917 0.478
DOC_USP7_MATH_1 968 972 PF00917 0.328
DOC_WW_Pin1_4 128 133 PF00397 0.565
DOC_WW_Pin1_4 15 20 PF00397 0.506
DOC_WW_Pin1_4 341 346 PF00397 0.435
DOC_WW_Pin1_4 422 427 PF00397 0.555
DOC_WW_Pin1_4 50 55 PF00397 0.517
DOC_WW_Pin1_4 530 535 PF00397 0.566
DOC_WW_Pin1_4 645 650 PF00397 0.448
LIG_14-3-3_CanoR_1 148 156 PF00244 0.490
LIG_14-3-3_CanoR_1 160 165 PF00244 0.426
LIG_14-3-3_CanoR_1 174 183 PF00244 0.455
LIG_14-3-3_CanoR_1 277 285 PF00244 0.472
LIG_14-3-3_CanoR_1 314 324 PF00244 0.669
LIG_14-3-3_CanoR_1 332 337 PF00244 0.654
LIG_14-3-3_CanoR_1 42 51 PF00244 0.457
LIG_14-3-3_CanoR_1 433 443 PF00244 0.536
LIG_14-3-3_CanoR_1 546 552 PF00244 0.513
LIG_14-3-3_CanoR_1 750 754 PF00244 0.433
LIG_14-3-3_CanoR_1 763 772 PF00244 0.430
LIG_14-3-3_CanoR_1 776 783 PF00244 0.392
LIG_14-3-3_CanoR_1 8 13 PF00244 0.512
LIG_14-3-3_CanoR_1 975 979 PF00244 0.353
LIG_Actin_WH2_2 474 492 PF00022 0.452
LIG_APCC_ABBA_1 130 135 PF00400 0.566
LIG_APCC_ABBA_1 260 265 PF00400 0.397
LIG_APCC_ABBA_1 355 360 PF00400 0.407
LIG_BIR_III_2 461 465 PF00653 0.528
LIG_BIR_III_4 217 221 PF00653 0.535
LIG_Clathr_ClatBox_1 818 822 PF01394 0.329
LIG_EH1_1 330 338 PF00400 0.394
LIG_EVH1_1 165 169 PF00568 0.447
LIG_FHA_1 151 157 PF00498 0.505
LIG_FHA_1 176 182 PF00498 0.488
LIG_FHA_1 333 339 PF00498 0.451
LIG_FHA_1 409 415 PF00498 0.760
LIG_FHA_1 439 445 PF00498 0.535
LIG_FHA_1 58 64 PF00498 0.535
LIG_FHA_1 682 688 PF00498 0.434
LIG_FHA_1 737 743 PF00498 0.593
LIG_FHA_1 764 770 PF00498 0.447
LIG_FHA_1 830 836 PF00498 0.349
LIG_FHA_2 231 237 PF00498 0.456
LIG_FHA_2 377 383 PF00498 0.591
LIG_FHA_2 866 872 PF00498 0.344
LIG_FHA_2 984 990 PF00498 0.349
LIG_GBD_Chelix_1 849 857 PF00786 0.328
LIG_Integrin_RGD_1 603 605 PF01839 0.515
LIG_LIR_Gen_1 832 841 PF02991 0.335
LIG_LIR_Gen_1 947 957 PF02991 0.387
LIG_LIR_Nem_3 143 149 PF02991 0.525
LIG_LIR_Nem_3 231 237 PF02991 0.465
LIG_LIR_Nem_3 832 837 PF02991 0.343
LIG_LIR_Nem_3 947 952 PF02991 0.354
LIG_LYPXL_SIV_4 845 853 PF13949 0.365
LIG_NRBOX 336 342 PF00104 0.431
LIG_NRBOX 36 42 PF00104 0.428
LIG_NRBOX 477 483 PF00104 0.460
LIG_PCNA_yPIPBox_3 784 796 PF02747 0.388
LIG_PDZ_Class_3 999 1004 PF00595 0.441
LIG_Pex14_1 146 150 PF04695 0.498
LIG_PTAP_UEV_1 117 122 PF05743 0.503
LIG_Rb_LxCxE_1 989 1004 PF01857 0.402
LIG_SH2_CRK 846 850 PF00017 0.350
LIG_SH2_NCK_1 263 267 PF00017 0.387
LIG_SH2_NCK_1 846 850 PF00017 0.350
LIG_SH2_PTP2 949 952 PF00017 0.370
LIG_SH2_SRC 263 266 PF00017 0.390
LIG_SH2_SRC 354 357 PF00017 0.671
LIG_SH2_SRC 559 562 PF00017 0.469
LIG_SH2_SRC 680 683 PF00017 0.434
LIG_SH2_STAP1 846 850 PF00017 0.350
LIG_SH2_STAP1 976 980 PF00017 0.340
LIG_SH2_STAT5 150 153 PF00017 0.479
LIG_SH2_STAT5 354 357 PF00017 0.679
LIG_SH2_STAT5 559 562 PF00017 0.597
LIG_SH2_STAT5 680 683 PF00017 0.666
LIG_SH2_STAT5 889 892 PF00017 0.307
LIG_SH2_STAT5 949 952 PF00017 0.370
LIG_SH3_1 115 121 PF00018 0.491
LIG_SH3_1 52 58 PF00018 0.511
LIG_SH3_3 115 121 PF00018 0.479
LIG_SH3_3 123 129 PF00018 0.549
LIG_SH3_3 13 19 PF00018 0.505
LIG_SH3_3 163 169 PF00018 0.448
LIG_SH3_3 206 212 PF00018 0.470
LIG_SH3_3 26 32 PF00018 0.481
LIG_SH3_3 51 57 PF00018 0.525
LIG_SH3_3 558 564 PF00018 0.529
LIG_SH3_3 929 935 PF00018 0.322
LIG_SH3_3 99 105 PF00018 0.389
LIG_SUMO_SIM_anti_2 109 115 PF11976 0.442
LIG_SUMO_SIM_anti_2 272 278 PF11976 0.397
LIG_SUMO_SIM_par_1 152 158 PF11976 0.502
LIG_SUMO_SIM_par_1 178 184 PF11976 0.493
LIG_SUMO_SIM_par_1 373 379 PF11976 0.364
LIG_SUMO_SIM_par_1 641 646 PF11976 0.448
LIG_SUMO_SIM_par_1 663 669 PF11976 0.417
LIG_SUMO_SIM_par_1 817 822 PF11976 0.332
LIG_SxIP_EBH_1 238 247 PF03271 0.454
LIG_TRAF2_1 141 144 PF00917 0.527
LIG_TRAF2_1 672 675 PF00917 0.632
LIG_TRAF2_1 868 871 PF00917 0.345
LIG_TRFH_1 353 357 PF08558 0.421
LIG_WRC_WIRS_1 969 974 PF05994 0.357
LIG_WW_2 29 32 PF00397 0.486
LIG_WW_3 580 584 PF00397 0.541
MOD_CDK_SPxxK_3 422 429 PF00069 0.555
MOD_CK1_1 175 181 PF00069 0.470
MOD_CK1_1 322 328 PF00069 0.489
MOD_CK1_1 344 350 PF00069 0.499
MOD_CK1_1 408 414 PF00069 0.537
MOD_CK1_1 438 444 PF00069 0.523
MOD_CK1_1 519 525 PF00069 0.550
MOD_CK1_1 59 65 PF00069 0.539
MOD_CK1_1 748 754 PF00069 0.425
MOD_CK1_1 81 87 PF00069 0.399
MOD_CK1_1 855 861 PF00069 0.410
MOD_CK2_1 376 382 PF00069 0.580
MOD_CK2_1 669 675 PF00069 0.525
MOD_CK2_1 687 693 PF00069 0.388
MOD_CK2_1 864 870 PF00069 0.331
MOD_CK2_1 983 989 PF00069 0.344
MOD_CK2_1 992 998 PF00069 0.347
MOD_GlcNHglycan 118 121 PF01048 0.520
MOD_GlcNHglycan 174 177 PF01048 0.477
MOD_GlcNHglycan 19 22 PF01048 0.509
MOD_GlcNHglycan 256 259 PF01048 0.368
MOD_GlcNHglycan 33 36 PF01048 0.438
MOD_GlcNHglycan 411 414 PF01048 0.553
MOD_GlcNHglycan 437 440 PF01048 0.545
MOD_GlcNHglycan 44 47 PF01048 0.427
MOD_GlcNHglycan 471 475 PF01048 0.477
MOD_GlcNHglycan 48 51 PF01048 0.470
MOD_GlcNHglycan 490 493 PF01048 0.424
MOD_GlcNHglycan 508 511 PF01048 0.488
MOD_GlcNHglycan 616 619 PF01048 0.261
MOD_GlcNHglycan 654 657 PF01048 0.286
MOD_GlcNHglycan 671 674 PF01048 0.488
MOD_GlcNHglycan 777 780 PF01048 0.435
MOD_GlcNHglycan 857 860 PF01048 0.451
MOD_GSK3_1 124 131 PF00069 0.540
MOD_GSK3_1 245 252 PF00069 0.469
MOD_GSK3_1 271 278 PF00069 0.559
MOD_GSK3_1 31 38 PF00069 0.452
MOD_GSK3_1 315 322 PF00069 0.659
MOD_GSK3_1 341 348 PF00069 0.468
MOD_GSK3_1 359 366 PF00069 0.374
MOD_GSK3_1 391 398 PF00069 0.421
MOD_GSK3_1 405 412 PF00069 0.511
MOD_GSK3_1 42 49 PF00069 0.438
MOD_GSK3_1 434 441 PF00069 0.529
MOD_GSK3_1 530 537 PF00069 0.574
MOD_GSK3_1 681 688 PF00069 0.430
MOD_GSK3_1 745 752 PF00069 0.496
MOD_GSK3_1 770 777 PF00069 0.458
MOD_GSK3_1 825 832 PF00069 0.454
MOD_N-GLC_1 537 542 PF02516 0.556
MOD_NEK2_1 149 154 PF00069 0.506
MOD_NEK2_1 172 177 PF00069 0.656
MOD_NEK2_1 230 235 PF00069 0.443
MOD_NEK2_1 243 248 PF00069 0.447
MOD_NEK2_1 275 280 PF00069 0.408
MOD_NEK2_1 346 351 PF00069 0.490
MOD_NEK2_1 36 41 PF00069 0.416
MOD_NEK2_1 488 493 PF00069 0.445
MOD_NEK2_1 516 521 PF00069 0.539
MOD_NEK2_1 687 692 PF00069 0.425
MOD_NEK2_1 694 699 PF00069 0.398
MOD_NEK2_1 705 710 PF00069 0.346
MOD_NEK2_1 844 849 PF00069 0.601
MOD_NEK2_1 853 858 PF00069 0.464
MOD_NEK2_1 864 869 PF00069 0.253
MOD_NEK2_1 890 895 PF00069 0.359
MOD_NEK2_2 245 250 PF00069 0.435
MOD_OFUCOSY 760 767 PF10250 0.446
MOD_PIKK_1 687 693 PF00454 0.424
MOD_PIKK_1 705 711 PF00454 0.350
MOD_PKA_1 749 755 PF00069 0.453
MOD_PKA_1 763 769 PF00069 0.442
MOD_PKA_1 8 14 PF00069 0.500
MOD_PKA_2 159 165 PF00069 0.440
MOD_PKA_2 313 319 PF00069 0.624
MOD_PKA_2 749 755 PF00069 0.453
MOD_PKA_2 763 769 PF00069 0.442
MOD_PKA_2 775 781 PF00069 0.405
MOD_PKA_2 8 14 PF00069 0.516
MOD_PKA_2 974 980 PF00069 0.353
MOD_Plk_1 142 148 PF00069 0.531
MOD_Plk_1 222 228 PF00069 0.504
MOD_Plk_1 264 270 PF00069 0.406
MOD_Plk_1 325 331 PF00069 0.440
MOD_Plk_1 359 365 PF00069 0.425
MOD_Plk_1 619 625 PF00069 0.251
MOD_Plk_1 674 680 PF00069 0.525
MOD_Plk_1 81 87 PF00069 0.390
MOD_Plk_2-3 186 192 PF00069 0.480
MOD_Plk_4 160 166 PF00069 0.441
MOD_Plk_4 36 42 PF00069 0.426
MOD_Plk_4 477 483 PF00069 0.460
MOD_Plk_4 59 65 PF00069 0.528
MOD_Plk_4 660 666 PF00069 0.268
MOD_Plk_4 676 682 PF00069 0.290
MOD_Plk_4 737 743 PF00069 0.496
MOD_Plk_4 749 755 PF00069 0.448
MOD_Plk_4 81 87 PF00069 0.401
MOD_Plk_4 968 974 PF00069 0.350
MOD_ProDKin_1 128 134 PF00069 0.567
MOD_ProDKin_1 15 21 PF00069 0.508
MOD_ProDKin_1 341 347 PF00069 0.441
MOD_ProDKin_1 422 428 PF00069 0.555
MOD_ProDKin_1 50 56 PF00069 0.519
MOD_ProDKin_1 530 536 PF00069 0.565
MOD_ProDKin_1 645 651 PF00069 0.268
MOD_SUMO_for_1 795 798 PF00179 0.487
MOD_SUMO_rev_2 231 239 PF00179 0.517
TRG_DiLeu_BaEn_1 721 726 PF01217 0.396
TRG_DiLeu_BaEn_1 871 876 PF01217 0.387
TRG_DiLeu_BaEn_1 922 927 PF01217 0.383
TRG_DiLeu_BaEn_1 965 970 PF01217 0.360
TRG_DiLeu_BaEn_1 989 994 PF01217 0.360
TRG_DiLeu_BaLyEn_6 39 44 PF01217 0.429
TRG_DiLeu_BaLyEn_6 878 883 PF01217 0.381
TRG_ENDOCYTIC_2 846 849 PF00928 0.355
TRG_ENDOCYTIC_2 889 892 PF00928 0.307
TRG_ENDOCYTIC_2 949 952 PF00928 0.370
TRG_ER_diArg_1 146 148 PF00400 0.518
TRG_ER_diArg_1 432 434 PF00400 0.549
TRG_ER_diArg_1 545 547 PF00400 0.547
TRG_ER_diArg_1 763 765 PF00400 0.494
TRG_ER_diArg_1 835 838 PF00400 0.318
TRG_ER_diArg_1 937 939 PF00400 0.313
TRG_Pf-PMV_PEXEL_1 692 696 PF00026 0.380
TRG_Pf-PMV_PEXEL_1 785 789 PF00026 0.374
TRG_Pf-PMV_PEXEL_1 816 820 PF00026 0.342

Homologs

Protein Taxonomy Sequence identity Coverage
A4HL86 Leishmania braziliensis 69% 100%
A4I8R4 Leishmania infantum 99% 100%
E9B3M9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%
Q4Q4F8 Leishmania major 90% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS