Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X6B5_LEIDO

TriTrypDb:

LdBPK_330040.1 , LdCL_330005300 , LDHU3_33.0050

Length:

520

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X6B5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6B5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	68	72	PF00656	0.427
CLV_NRD_NRD_1	2	4	PF00675	0.481
CLV_NRD_NRD_1	339	341	PF00675	0.551
CLV_NRD_NRD_1	412	414	PF00675	0.723
CLV_NRD_NRD_1	88	90	PF00675	0.468
CLV_PCSK_KEX2_1	2	4	PF00082	0.481
CLV_PCSK_KEX2_1	338	340	PF00082	0.566
CLV_PCSK_KEX2_1	412	414	PF00082	0.578
CLV_PCSK_KEX2_1	88	90	PF00082	0.468
CLV_PCSK_SKI1_1	18	22	PF00082	0.344
CLV_PCSK_SKI1_1	217	221	PF00082	0.525
CLV_PCSK_SKI1_1	307	311	PF00082	0.595
CLV_PCSK_SKI1_1	451	455	PF00082	0.431
CLV_PCSK_SKI1_1	89	93	PF00082	0.506
DEG_APCC_DBOX_1	17	25	PF00400	0.393
DEG_APCC_DBOX_1	216	224	PF00400	0.385
DEG_Nend_UBRbox_1	1	4	PF02207	0.597
DEG_SPOP_SBC_1	359	363	PF00917	0.504
DOC_CYCLIN_RxL_1	112	121	PF00134	0.295
DOC_CYCLIN_RxL_1	213	224	PF00134	0.424
DOC_PP1_RVXF_1	114	121	PF00149	0.282
DOC_PP4_FxxP_1	452	455	PF00568	0.424
DOC_USP7_MATH_1	159	163	PF00917	0.507
DOC_USP7_MATH_1	253	257	PF00917	0.609
DOC_USP7_MATH_1	319	323	PF00917	0.473
DOC_USP7_MATH_1	359	363	PF00917	0.504
DOC_USP7_MATH_1	486	490	PF00917	0.332
DOC_WW_Pin1_4	138	143	PF00397	0.638
DOC_WW_Pin1_4	147	152	PF00397	0.571
DOC_WW_Pin1_4	297	302	PF00397	0.450
DOC_WW_Pin1_4	315	320	PF00397	0.497
DOC_WW_Pin1_4	36	41	PF00397	0.417
DOC_WW_Pin1_4	390	395	PF00397	0.674
DOC_WW_Pin1_4	43	48	PF00397	0.378
DOC_WW_Pin1_4	49	54	PF00397	0.316
LIG_14-3-3_CanoR_1	11	21	PF00244	0.362
LIG_14-3-3_CanoR_1	338	345	PF00244	0.542
LIG_14-3-3_CanoR_1	88	94	PF00244	0.575
LIG_Actin_WH2_2	457	475	PF00022	0.357
LIG_BIR_III_4	121	125	PF00653	0.323
LIG_BIR_III_4	289	293	PF00653	0.450
LIG_BRCT_BRCA1_1	51	55	PF00533	0.362
LIG_FHA_1	148	154	PF00498	0.471
LIG_FHA_1	194	200	PF00498	0.353
LIG_FHA_1	339	345	PF00498	0.645
LIG_FHA_1	444	450	PF00498	0.420
LIG_FHA_2	124	130	PF00498	0.631
LIG_FHA_2	438	444	PF00498	0.507
LIG_FHA_2	483	489	PF00498	0.471
LIG_FHA_2	55	61	PF00498	0.492
LIG_FHA_2	66	72	PF00498	0.285
LIG_HCF-1_HBM_1	200	203	PF13415	0.407
LIG_LIR_Apic_2	450	455	PF02991	0.420
LIG_LIR_Gen_1	117	125	PF02991	0.319
LIG_LIR_Gen_1	393	400	PF02991	0.508
LIG_LIR_Nem_3	14	20	PF02991	0.291
LIG_LIR_Nem_3	393	399	PF02991	0.614
LIG_Pex14_2	51	55	PF04695	0.294
LIG_SH2_NCK_1	262	266	PF00017	0.501
LIG_SH2_SRC	31	34	PF00017	0.332
LIG_SH2_STAP1	262	266	PF00017	0.501
LIG_SH2_STAT5	245	248	PF00017	0.434
LIG_SH2_STAT5	262	265	PF00017	0.533
LIG_SH2_STAT5	448	451	PF00017	0.507
LIG_SH2_STAT5	483	486	PF00017	0.356
LIG_SH2_STAT5	77	80	PF00017	0.320
LIG_SH2_STAT5	85	88	PF00017	0.362
LIG_SH3_2	33	38	PF14604	0.323
LIG_SH3_3	30	36	PF00018	0.444
LIG_SH3_3	417	423	PF00018	0.468
LIG_SH3_3	44	50	PF00018	0.481
LIG_SUMO_SIM_anti_2	291	297	PF11976	0.448
LIG_TRAF2_1	126	129	PF00917	0.442
LIG_TRAF2_1	371	374	PF00917	0.561
MOD_CDK_SPxxK_3	147	154	PF00069	0.459
MOD_CK1_1	135	141	PF00069	0.602
MOD_CK1_1	256	262	PF00069	0.564
MOD_CK1_1	323	329	PF00069	0.551
MOD_CK1_1	392	398	PF00069	0.608
MOD_CK2_1	123	129	PF00069	0.519
MOD_CK2_1	368	374	PF00069	0.540
MOD_CK2_1	400	406	PF00069	0.510
MOD_CK2_1	437	443	PF00069	0.455
MOD_CK2_1	482	488	PF00069	0.415
MOD_GlcNHglycan	136	140	PF01048	0.682
MOD_GlcNHglycan	257	261	PF01048	0.589
MOD_GlcNHglycan	325	328	PF01048	0.551
MOD_GlcNHglycan	370	373	PF01048	0.511
MOD_GlcNHglycan	465	468	PF01048	0.349
MOD_GlcNHglycan	488	491	PF01048	0.336
MOD_GlcNHglycan	78	81	PF01048	0.381
MOD_GSK3_1	131	138	PF00069	0.596
MOD_GSK3_1	239	246	PF00069	0.431
MOD_GSK3_1	256	263	PF00069	0.495
MOD_GSK3_1	297	304	PF00069	0.553
MOD_GSK3_1	315	322	PF00069	0.454
MOD_GSK3_1	359	366	PF00069	0.691
MOD_GSK3_1	39	46	PF00069	0.421
MOD_GSK3_1	477	484	PF00069	0.375
MOD_GSK3_1	486	493	PF00069	0.355
MOD_GSK3_1	49	56	PF00069	0.287
MOD_GSK3_1	7	14	PF00069	0.355
MOD_GSK3_1	92	99	PF00069	0.396
MOD_N-GLC_1	12	17	PF02516	0.254
MOD_NEK2_1	460	465	PF00069	0.360
MOD_NEK2_1	54	59	PF00069	0.512
MOD_NEK2_1	7	12	PF00069	0.491
MOD_PIKK_1	152	158	PF00454	0.453
MOD_PIKK_1	338	344	PF00454	0.603
MOD_PIKK_1	400	406	PF00454	0.502
MOD_PIKK_1	54	60	PF00454	0.370
MOD_PKA_1	338	344	PF00069	0.453
MOD_PKA_2	338	344	PF00069	0.558
MOD_PKA_2	411	417	PF00069	0.574
MOD_PKA_2	481	487	PF00069	0.357
MOD_PKA_2	7	13	PF00069	0.496
MOD_Plk_1	12	18	PF00069	0.259
MOD_Plk_1	307	313	PF00069	0.525
MOD_Plk_1	460	466	PF00069	0.358
MOD_ProDKin_1	138	144	PF00069	0.637
MOD_ProDKin_1	147	153	PF00069	0.571
MOD_ProDKin_1	297	303	PF00069	0.454
MOD_ProDKin_1	315	321	PF00069	0.499
MOD_ProDKin_1	36	42	PF00069	0.416
MOD_ProDKin_1	390	396	PF00069	0.678
MOD_ProDKin_1	43	49	PF00069	0.374
MOD_SUMO_rev_2	466	475	PF00179	0.357
TRG_DiLeu_BaLyEn_6	148	153	PF01217	0.463
TRG_DiLeu_BaLyEn_6	214	219	PF01217	0.371
TRG_ENDOCYTIC_2	17	20	PF00928	0.385
TRG_ENDOCYTIC_2	426	429	PF00928	0.634
TRG_ER_diArg_1	1	3	PF00400	0.491
TRG_ER_diArg_1	248	251	PF00400	0.395
TRG_ER_diArg_1	337	340	PF00400	0.504
TRG_ER_diArg_1	411	413	PF00400	0.630

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKK4	Leptomonas seymouri	58%	99%
A0A0S4JPU3	Bodo saltans	34%	95%
A0A422NYF9	Trypanosoma rangeli	44%	100%
A4HL40	Leishmania braziliensis	79%	100%
A4I8M0	Leishmania infantum	100%	100%
C9ZPU4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	98%
E9B3I1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q4L9	Leishmania major	92%	100%
V5AUZ3	Trypanosoma cruzi	47%	100%