RGG-containing protein 2, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RGG-containing protein 2, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X6A5_LEIDO

TriTrypDb:

LdBPK_330280.1 , LdCL_330007700 , LDHU3_33.0330

Length:

339

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0032473	cytoplasmic side of mitochondrial outer membrane	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098552	side of membrane	2	1
GO:0098562	cytoplasmic side of membrane	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X6A5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6A5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	5
GO:0003723	RNA binding	4	5
GO:0005488	binding	1	5
GO:0097159	organic cyclic compound binding	2	5
GO:1901363	heterocyclic compound binding	2	5
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	124	128	PF00656	0.845
CLV_C14_Caspase3-7	304	308	PF00656	0.702
CLV_C14_Caspase3-7	44	48	PF00656	0.561
CLV_C14_Caspase3-7	56	60	PF00656	0.558
CLV_C14_Caspase3-7	92	96	PF00656	0.564
CLV_NRD_NRD_1	163	165	PF00675	0.841
CLV_NRD_NRD_1	197	199	PF00675	0.796
CLV_NRD_NRD_1	299	301	PF00675	0.619
CLV_NRD_NRD_1	3	5	PF00675	0.783
CLV_NRD_NRD_1	312	314	PF00675	0.509
CLV_NRD_NRD_1	321	323	PF00675	0.657
CLV_PCSK_KEX2_1	163	165	PF00082	0.841
CLV_PCSK_KEX2_1	197	199	PF00082	0.796
CLV_PCSK_KEX2_1	299	301	PF00082	0.743
CLV_PCSK_KEX2_1	3	5	PF00082	0.783
CLV_PCSK_KEX2_1	321	323	PF00082	0.729
CLV_PCSK_PC7_1	159	165	PF00082	0.843
CLV_PCSK_SKI1_1	269	273	PF00082	0.430
DEG_Nend_Nbox_1	1	3	PF02207	0.784
DOC_MAPK_gen_1	197	204	PF00069	0.784
DOC_MAPK_gen_1	287	296	PF00069	0.703
DOC_PP4_FxxP_1	192	195	PF00568	0.799
DOC_PP4_FxxP_1	261	264	PF00568	0.630
DOC_USP7_MATH_1	122	126	PF00917	0.846
DOC_USP7_MATH_1	317	321	PF00917	0.627
DOC_USP7_MATH_1	33	37	PF00917	0.776
DOC_USP7_MATH_1	332	336	PF00917	0.535
DOC_USP7_MATH_1	45	49	PF00917	0.546
DOC_USP7_MATH_1	57	61	PF00917	0.565
DOC_USP7_MATH_1	69	73	PF00917	0.549
DOC_USP7_MATH_1	81	85	PF00917	0.599
DOC_USP7_MATH_1	93	97	PF00917	0.600
LIG_14-3-3_CanoR_1	12	18	PF00244	0.646
LIG_14-3-3_CanoR_1	3	7	PF00244	0.779
LIG_deltaCOP1_diTrp_1	181	192	PF00928	0.799
LIG_FHA_1	281	287	PF00498	0.630
LIG_FHA_1	291	297	PF00498	0.561
LIG_FHA_2	203	209	PF00498	0.752
LIG_FHA_2	233	239	PF00498	0.533
LIG_LIR_Apic_2	191	195	PF02991	0.797
LIG_LIR_Apic_2	260	264	PF02991	0.630
LIG_LIR_Gen_1	230	240	PF02991	0.568
LIG_LIR_Gen_1	245	252	PF02991	0.457
LIG_LIR_Nem_3	230	236	PF02991	0.568
LIG_LIR_Nem_3	245	251	PF02991	0.457
LIG_LIR_Nem_3	5	9	PF02991	0.773
LIG_Pex14_2	248	252	PF04695	0.630
LIG_SH2_STAT5	285	288	PF00017	0.500
LIG_SUMO_SIM_par_1	200	205	PF11976	0.776
LIG_SUMO_SIM_par_1	291	298	PF11976	0.722
LIG_TRAF2_1	180	183	PF00917	0.609
MOD_CK1_1	225	231	PF00069	0.568
MOD_CK2_1	202	208	PF00069	0.762
MOD_CK2_1	274	280	PF00069	0.630
MOD_CK2_1	317	323	PF00069	0.609
MOD_GlcNHglycan	103	106	PF01048	0.523
MOD_GlcNHglycan	117	120	PF01048	0.529
MOD_GlcNHglycan	137	140	PF01048	0.536
MOD_GlcNHglycan	168	171	PF01048	0.830
MOD_GlcNHglycan	224	227	PF01048	0.430
MOD_GlcNHglycan	252	255	PF01048	0.430
MOD_GlcNHglycan	31	34	PF01048	0.615
MOD_GlcNHglycan	334	337	PF01048	0.787
MOD_GlcNHglycan	37	40	PF01048	0.635
MOD_GlcNHglycan	43	46	PF01048	0.517
MOD_GlcNHglycan	49	52	PF01048	0.463
MOD_GlcNHglycan	55	58	PF01048	0.455
MOD_GlcNHglycan	61	64	PF01048	0.470
MOD_GlcNHglycan	67	70	PF01048	0.452
MOD_GlcNHglycan	73	76	PF01048	0.447
MOD_GlcNHglycan	79	82	PF01048	0.588
MOD_GlcNHglycan	85	88	PF01048	0.564
MOD_GlcNHglycan	91	94	PF01048	0.520
MOD_GlcNHglycan	97	100	PF01048	0.546
MOD_GSK3_1	111	118	PF00069	0.789
MOD_GSK3_1	225	232	PF00069	0.625
MOD_GSK3_1	29	36	PF00069	0.737
MOD_GSK3_1	41	48	PF00069	0.512
MOD_GSK3_1	53	60	PF00069	0.561
MOD_GSK3_1	65	72	PF00069	0.527
MOD_GSK3_1	77	84	PF00069	0.517
MOD_GSK3_1	89	96	PF00069	0.637
MOD_N-GLC_1	332	337	PF02516	0.781
MOD_N-GLC_1	34	39	PF02516	0.588
MOD_N-GLC_1	70	75	PF02516	0.474
MOD_N-GLC_1	82	87	PF02516	0.501
MOD_NEK2_1	2	7	PF00069	0.781
MOD_NEK2_1	202	207	PF00069	0.763
MOD_NEK2_1	295	300	PF00069	0.620
MOD_PKA_2	11	17	PF00069	0.642
MOD_PKA_2	2	8	PF00069	0.778
MOD_PKB_1	164	172	PF00069	0.833
MOD_Plk_1	228	234	PF00069	0.630
MOD_Plk_1	244	250	PF00069	0.445
MOD_Plk_1	290	296	PF00069	0.721
MOD_Plk_4	280	286	PF00069	0.630
MOD_Plk_4	290	296	PF00069	0.559
TRG_DiLeu_BaEn_1	291	296	PF01217	0.719
TRG_DiLeu_BaLyEn_6	5	10	PF01217	0.773
TRG_ER_diArg_1	162	164	PF00400	0.849
TRG_ER_diArg_1	196	198	PF00400	0.803
TRG_ER_diArg_1	2	4	PF00400	0.788
TRG_ER_diArg_1	310	313	PF00400	0.717
TRG_Pf-PMV_PEXEL_1	269	273	PF00026	0.430
TRG_Pf-PMV_PEXEL_1	300	304	PF00026	0.724

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4I8P4	Leishmania infantum	96%	96%
E9B3K5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	96%
Q4Q4J4	Leishmania major	92%	100%