Centrosomal protein of 104 kDa

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X6A2_LEIDO

TriTrypDb:

LdBPK_330070.1 , LdCL_330005600 , LDHU3_33.0080

Length:

695

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0097542	ciliary tip	2	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

A0A3S7X6A2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6A2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	123	125	PF00675	0.499
CLV_NRD_NRD_1	185	187	PF00675	0.802
CLV_NRD_NRD_1	274	276	PF00675	0.390
CLV_NRD_NRD_1	600	602	PF00675	0.548
CLV_PCSK_KEX2_1	184	186	PF00082	0.760
CLV_PCSK_KEX2_1	199	201	PF00082	0.683
CLV_PCSK_KEX2_1	274	276	PF00082	0.391
CLV_PCSK_KEX2_1	600	602	PF00082	0.506
CLV_PCSK_PC1ET2_1	199	201	PF00082	0.633
CLV_PCSK_SKI1_1	102	106	PF00082	0.578
CLV_PCSK_SKI1_1	137	141	PF00082	0.424
CLV_PCSK_SKI1_1	301	305	PF00082	0.486
CLV_PCSK_SKI1_1	553	557	PF00082	0.386
CLV_PCSK_SKI1_1	642	646	PF00082	0.447
CLV_PCSK_SKI1_1	74	78	PF00082	0.486
CLV_PCSK_SKI1_1	82	86	PF00082	0.518
DEG_APCC_DBOX_1	298	306	PF00400	0.487
DEG_APCC_DBOX_1	608	616	PF00400	0.493
DOC_CKS1_1	179	184	PF01111	0.812
DOC_CKS1_1	381	386	PF01111	0.560
DOC_CYCLIN_RxL_1	134	141	PF00134	0.478
DOC_CYCLIN_RxL_1	639	647	PF00134	0.430
DOC_CYCLIN_yCln2_LP_2	165	171	PF00134	0.463
DOC_CYCLIN_yCln2_LP_2	351	357	PF00134	0.542
DOC_CYCLIN_yCln2_LP_2	492	498	PF00134	0.429
DOC_MAPK_gen_1	102	111	PF00069	0.507
DOC_MAPK_gen_1	120	129	PF00069	0.479
DOC_MAPK_gen_1	274	282	PF00069	0.410
DOC_MAPK_gen_1	45	55	PF00069	0.536
DOC_MAPK_gen_1	598	605	PF00069	0.578
DOC_MAPK_MEF2A_6	48	57	PF00069	0.511
DOC_MAPK_MEF2A_6	74	83	PF00069	0.431
DOC_PP1_RVXF_1	135	141	PF00149	0.469
DOC_PP1_RVXF_1	262	269	PF00149	0.556
DOC_PP1_RVXF_1	97	104	PF00149	0.555
DOC_PP2B_LxvP_1	643	646	PF13499	0.519
DOC_PP4_FxxP_1	140	143	PF00568	0.490
DOC_USP7_MATH_1	208	212	PF00917	0.610
DOC_USP7_MATH_1	232	236	PF00917	0.768
DOC_USP7_MATH_1	254	258	PF00917	0.676
DOC_USP7_MATH_1	461	465	PF00917	0.437
DOC_USP7_MATH_1	581	585	PF00917	0.503
DOC_USP7_UBL2_3	677	681	PF12436	0.586
DOC_USP7_UBL2_3	74	78	PF12436	0.486
DOC_WW_Pin1_4	178	183	PF00397	0.802
DOC_WW_Pin1_4	202	207	PF00397	0.556
DOC_WW_Pin1_4	235	240	PF00397	0.702
DOC_WW_Pin1_4	32	37	PF00397	0.724
DOC_WW_Pin1_4	350	355	PF00397	0.683
DOC_WW_Pin1_4	380	385	PF00397	0.600
DOC_WW_Pin1_4	387	392	PF00397	0.627
DOC_WW_Pin1_4	399	404	PF00397	0.475
DOC_WW_Pin1_4	46	51	PF00397	0.508
DOC_WW_Pin1_4	491	496	PF00397	0.476
DOC_WW_Pin1_4	542	547	PF00397	0.426
LIG_14-3-3_CanoR_1	124	128	PF00244	0.537
LIG_14-3-3_CanoR_1	184	192	PF00244	0.796
LIG_14-3-3_CanoR_1	200	207	PF00244	0.644
LIG_14-3-3_CanoR_1	243	247	PF00244	0.634
LIG_14-3-3_CanoR_1	274	282	PF00244	0.527
LIG_14-3-3_CanoR_1	337	342	PF00244	0.463
LIG_14-3-3_CanoR_1	375	381	PF00244	0.773
LIG_14-3-3_CanoR_1	557	565	PF00244	0.477
LIG_14-3-3_CanoR_1	614	618	PF00244	0.509
LIG_14-3-3_CanoR_1	67	75	PF00244	0.402
LIG_Actin_WH2_2	259	276	PF00022	0.565
LIG_Actin_WH2_2	463	480	PF00022	0.477
LIG_AP2alpha_1	268	272	PF02296	0.520
LIG_BIR_II_1	1	5	PF00653	0.501
LIG_BRCT_BRCA1_1	107	111	PF00533	0.472
LIG_BRCT_BRCA1_1	256	260	PF00533	0.590
LIG_BRCT_BRCA1_1	471	475	PF00533	0.453
LIG_BRCT_BRCA1_1	630	634	PF00533	0.494
LIG_Clathr_ClatBox_1	209	213	PF01394	0.657
LIG_CtBP_PxDLS_1	384	388	PF00389	0.572
LIG_deltaCOP1_diTrp_1	90	98	PF00928	0.575
LIG_eIF4E_1	134	140	PF01652	0.464
LIG_FHA_1	124	130	PF00498	0.467
LIG_FHA_1	50	56	PF00498	0.505
LIG_FHA_1	570	576	PF00498	0.491
LIG_FHA_1	577	583	PF00498	0.509
LIG_FHA_2	11	17	PF00498	0.534
LIG_FHA_2	338	344	PF00498	0.408
LIG_FHA_2	594	600	PF00498	0.573
LIG_FHA_2	75	81	PF00498	0.417
LIG_GBD_Chelix_1	658	666	PF00786	0.503
LIG_HP1_1	546	550	PF01393	0.473
LIG_Integrin_isoDGR_2	624	626	PF01839	0.404
LIG_LIR_Apic_2	90	95	PF02991	0.595
LIG_LIR_Gen_1	132	143	PF02991	0.466
LIG_LIR_Gen_1	267	273	PF02991	0.534
LIG_LIR_Gen_1	527	533	PF02991	0.330
LIG_LIR_Gen_1	616	622	PF02991	0.389
LIG_LIR_Nem_3	132	138	PF02991	0.461
LIG_LIR_Nem_3	257	263	PF02991	0.552
LIG_LIR_Nem_3	267	271	PF02991	0.489
LIG_LIR_Nem_3	616	621	PF02991	0.386
LIG_LIR_Nem_3	97	101	PF02991	0.442
LIG_NRBOX	616	622	PF00104	0.367
LIG_NRBOX	639	645	PF00104	0.517
LIG_NRP_CendR_1	694	695	PF00754	0.510
LIG_PCNA_PIPBox_1	321	330	PF02747	0.441
LIG_PCNA_yPIPBox_3	333	346	PF02747	0.457
LIG_Pex14_2	140	144	PF04695	0.402
LIG_Pex14_2	268	272	PF04695	0.520
LIG_Pex14_2	453	457	PF04695	0.535
LIG_Pex14_2	471	475	PF04695	0.301
LIG_PTB_Apo_2	447	454	PF02174	0.463
LIG_PTB_Apo_2	517	524	PF02174	0.480
LIG_PTB_Apo_2	97	104	PF02174	0.480
LIG_Rb_pABgroove_1	134	142	PF01858	0.386
LIG_REV1ctd_RIR_1	269	279	PF16727	0.533
LIG_SH2_CRK	7	11	PF00017	0.511
LIG_SH2_STAP1	7	11	PF00017	0.511
LIG_SH2_STAT3	512	515	PF00017	0.464
LIG_SH2_STAT5	134	137	PF00017	0.377
LIG_SH2_STAT5	164	167	PF00017	0.444
LIG_SH2_STAT5	576	579	PF00017	0.489
LIG_SH3_3	14	20	PF00018	0.545
LIG_SH3_3	176	182	PF00018	0.644
LIG_SH3_3	30	36	PF00018	0.680
LIG_SH3_3	375	381	PF00018	0.592
LIG_SH3_3	397	403	PF00018	0.774
LIG_SH3_3	540	546	PF00018	0.402
LIG_SH3_3	645	651	PF00018	0.520
LIG_SUMO_SIM_anti_2	300	307	PF11976	0.541
LIG_SUMO_SIM_par_1	208	213	PF11976	0.612
LIG_SUMO_SIM_par_1	481	487	PF11976	0.466
LIG_SxIP_EBH_1	32	43	PF03271	0.485
LIG_TYR_ITIM	5	10	PF00017	0.500
LIG_UBA3_1	482	488	PF00899	0.364
LIG_WRC_WIRS_1	462	467	PF05994	0.333
LIG_WW_3	181	185	PF00397	0.569
MOD_CDK_SPxK_1	178	184	PF00069	0.793
MOD_CDK_SPxxK_3	178	185	PF00069	0.656
MOD_CK1_1	202	208	PF00069	0.708
MOD_CK1_1	235	241	PF00069	0.662
MOD_CK1_1	350	356	PF00069	0.683
MOD_CK1_1	360	366	PF00069	0.715
MOD_CK1_1	379	385	PF00069	0.643
MOD_CK1_1	586	592	PF00069	0.413
MOD_CK2_1	337	343	PF00069	0.569
MOD_CK2_1	593	599	PF00069	0.571
MOD_CK2_1	74	80	PF00069	0.371
MOD_GlcNHglycan	160	164	PF01048	0.446
MOD_GlcNHglycan	187	190	PF01048	0.769
MOD_GlcNHglycan	202	205	PF01048	0.786
MOD_GlcNHglycan	218	221	PF01048	0.548
MOD_GlcNHglycan	256	259	PF01048	0.668
MOD_GlcNHglycan	359	362	PF01048	0.728
MOD_GlcNHglycan	367	370	PF01048	0.638
MOD_GlcNHglycan	42	45	PF01048	0.496
MOD_GlcNHglycan	588	591	PF01048	0.361
MOD_GlcNHglycan	630	633	PF01048	0.686
MOD_GSK3_1	110	117	PF00069	0.508
MOD_GSK3_1	155	162	PF00069	0.396
MOD_GSK3_1	195	202	PF00069	0.716
MOD_GSK3_1	346	353	PF00069	0.607
MOD_GSK3_1	365	372	PF00069	0.656
MOD_GSK3_1	376	383	PF00069	0.603
MOD_GSK3_1	433	440	PF00069	0.446
MOD_GSK3_1	582	589	PF00069	0.457
MOD_N-GLC_1	376	381	PF02516	0.699
MOD_NEK2_1	159	164	PF00069	0.425
MOD_NEK2_1	304	309	PF00069	0.464
MOD_NEK2_1	346	351	PF00069	0.553
MOD_NEK2_1	471	476	PF00069	0.368
MOD_NEK2_1	514	519	PF00069	0.403
MOD_NEK2_1	533	538	PF00069	0.372
MOD_NEK2_1	658	663	PF00069	0.396
MOD_NEK2_2	613	618	PF00069	0.375
MOD_PK_1	105	111	PF00069	0.535
MOD_PKA_1	185	191	PF00069	0.804
MOD_PKA_1	199	205	PF00069	0.678
MOD_PKA_2	123	129	PF00069	0.509
MOD_PKA_2	185	191	PF00069	0.766
MOD_PKA_2	199	205	PF00069	0.670
MOD_PKA_2	242	248	PF00069	0.636
MOD_PKA_2	273	279	PF00069	0.481
MOD_PKA_2	556	562	PF00069	0.467
MOD_PKA_2	613	619	PF00069	0.380
MOD_PKA_2	687	693	PF00069	0.619
MOD_Plk_1	114	120	PF00069	0.505
MOD_Plk_1	346	352	PF00069	0.463
MOD_Plk_1	376	382	PF00069	0.759
MOD_Plk_4	337	343	PF00069	0.556
MOD_Plk_4	49	55	PF00069	0.488
MOD_Plk_4	524	530	PF00069	0.402
MOD_Plk_4	571	577	PF00069	0.393
MOD_Plk_4	583	589	PF00069	0.487
MOD_Plk_4	613	619	PF00069	0.444
MOD_Plk_4	658	664	PF00069	0.394
MOD_ProDKin_1	178	184	PF00069	0.807
MOD_ProDKin_1	202	208	PF00069	0.556
MOD_ProDKin_1	235	241	PF00069	0.702
MOD_ProDKin_1	32	38	PF00069	0.716
MOD_ProDKin_1	350	356	PF00069	0.693
MOD_ProDKin_1	380	386	PF00069	0.601
MOD_ProDKin_1	387	393	PF00069	0.629
MOD_ProDKin_1	399	405	PF00069	0.473
MOD_ProDKin_1	46	52	PF00069	0.498
MOD_ProDKin_1	491	497	PF00069	0.475
MOD_ProDKin_1	542	548	PF00069	0.426
MOD_SUMO_for_1	129	132	PF00179	0.482
MOD_SUMO_for_1	282	285	PF00179	0.542
MOD_SUMO_rev_2	117	127	PF00179	0.543
MOD_SUMO_rev_2	70	76	PF00179	0.372
TRG_AP2beta_CARGO_1	132	142	PF09066	0.479
TRG_DiLeu_BaEn_4	277	283	PF01217	0.540
TRG_DiLeu_BaLyEn_6	550	555	PF01217	0.367
TRG_ENDOCYTIC_2	7	10	PF00928	0.505
TRG_ER_diArg_1	183	186	PF00400	0.761
TRG_ER_diArg_1	273	275	PF00400	0.427
TRG_NES_CRM1_1	611	623	PF08389	0.471
TRG_Pf-PMV_PEXEL_1	264	269	PF00026	0.452
TRG_Pf-PMV_PEXEL_1	67	72	PF00026	0.409

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5U7	Leptomonas seymouri	61%	98%
A0A0S4ILQ6	Bodo saltans	22%	70%
A0A1X0P6E5	Trypanosomatidae	25%	82%
A0A3R7MW28	Trypanosoma rangeli	27%	81%
A0A3S7WVF9	Leishmania donovani	24%	79%
A4HL43	Leishmania braziliensis	75%	99%
A4HY47	Leishmania infantum	24%	79%
A4I8M3	Leishmania infantum	100%	100%
D0A0E4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	77%
E9ARX6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	79%
E9B3I4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q4L6	Leishmania major	94%	100%
Q4QDJ6	Leishmania major	24%	79%
V5DTJ3	Trypanosoma cruzi	27%	82%