WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X6A1_LEIDO

TriTrypDb:

LdBPK_323970.1 , LdCL_320045700 , LDHU3_32.5100

Length:

359

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	11
GO:0034708	methyltransferase complex	4	11
GO:0035097	histone methyltransferase complex	3	11
GO:0048188	Set1C/COMPASS complex	4	11
GO:0140513	nuclear protein-containing complex	2	11
GO:1902494	catalytic complex	2	11
GO:1990234	transferase complex	3	11

Expansion

Sequence features

A0A3S7X6A1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6A1

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	4
GO:0008152	metabolic process	1	4
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0016570	histone modification	5	1
GO:0016571	histone methylation	5	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018023	peptidyl-lysine trimethylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032259	methylation	2	1
GO:0034968	histone lysine methylation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	4
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	4
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0051568	histone H3-K4 methylation	7	1
GO:0071704	organic substance metabolic process	2	4
GO:0080182	histone H3-K4 trimethylation	7	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003682	chromatin binding	2	1
GO:0005488	binding	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	180	182	PF00675	0.388
CLV_NRD_NRD_1	247	249	PF00675	0.375
CLV_PCSK_KEX2_1	180	182	PF00082	0.494
CLV_PCSK_KEX2_1	247	249	PF00082	0.396
CLV_PCSK_SKI1_1	131	135	PF00082	0.316
CLV_PCSK_SKI1_1	174	178	PF00082	0.370
CLV_PCSK_SKI1_1	181	185	PF00082	0.377
CLV_PCSK_SKI1_1	194	198	PF00082	0.358
CLV_PCSK_SKI1_1	217	221	PF00082	0.448
CLV_PCSK_SKI1_1	282	286	PF00082	0.343
CLV_PCSK_SKI1_1	332	336	PF00082	0.403
DEG_APCC_DBOX_1	184	192	PF00400	0.342
DEG_Nend_Nbox_1	1	3	PF02207	0.506
DEG_SCF_FBW7_1	104	111	PF00400	0.430
DEG_SCF_FBW7_1	143	150	PF00400	0.447
DEG_SPOP_SBC_1	196	200	PF00917	0.460
DOC_CYCLIN_RxL_1	204	214	PF00134	0.419
DOC_MAPK_MEF2A_6	310	318	PF00069	0.409
DOC_PP1_RVXF_1	172	179	PF00149	0.517
DOC_PP1_RVXF_1	205	212	PF00149	0.409
DOC_PP1_RVXF_1	330	337	PF00149	0.386
DOC_PP4_FxxP_1	184	187	PF00568	0.421
DOC_USP7_MATH_1	147	151	PF00917	0.492
DOC_USP7_MATH_1	213	217	PF00917	0.358
DOC_USP7_MATH_1	291	295	PF00917	0.561
DOC_USP7_MATH_1	330	334	PF00917	0.420
DOC_USP7_MATH_1	338	342	PF00917	0.478
DOC_WW_Pin1_4	104	109	PF00397	0.434
DOC_WW_Pin1_4	143	148	PF00397	0.449
DOC_WW_Pin1_4	266	271	PF00397	0.454
LIG_14-3-3_CanoR_1	180	184	PF00244	0.402
LIG_14-3-3_CanoR_1	217	227	PF00244	0.394
LIG_14-3-3_CanoR_1	332	337	PF00244	0.391
LIG_14-3-3_CanoR_1	57	67	PF00244	0.356
LIG_BIR_III_4	255	259	PF00653	0.370
LIG_BIR_III_4	49	53	PF00653	0.492
LIG_BRCT_BRCA1_1	84	88	PF00533	0.518
LIG_FHA_1	117	123	PF00498	0.425
LIG_FHA_1	41	47	PF00498	0.374
LIG_FHA_2	347	353	PF00498	0.511
LIG_FHA_2	39	45	PF00498	0.485
LIG_LIR_Apic_2	182	187	PF02991	0.369
LIG_LIR_Gen_1	107	118	PF02991	0.375
LIG_LIR_Gen_1	345	353	PF02991	0.523
LIG_LIR_Nem_3	107	113	PF02991	0.370
LIG_LIR_Nem_3	17	21	PF02991	0.488
LIG_LIR_Nem_3	333	339	PF02991	0.398
LIG_LIR_Nem_3	345	350	PF02991	0.460
LIG_MLH1_MIPbox_1	84	88	PF16413	0.449
LIG_PTB_Apo_2	52	59	PF02174	0.399
LIG_PTB_Phospho_1	52	58	PF10480	0.401
LIG_SH2_CRK	110	114	PF00017	0.336
LIG_SH2_CRK	3	7	PF00017	0.603
LIG_SH2_CRK	347	351	PF00017	0.541
LIG_SH2_GRB2like	93	96	PF00017	0.568
LIG_SH2_STAP1	110	114	PF00017	0.422
LIG_SH2_STAT3	305	308	PF00017	0.425
LIG_SH2_STAT5	241	244	PF00017	0.400
LIG_SH2_STAT5	3	6	PF00017	0.595
LIG_SH2_STAT5	58	61	PF00017	0.466
LIG_SH2_STAT5	93	96	PF00017	0.511
LIG_SUMO_SIM_par_1	186	192	PF11976	0.384
LIG_TYR_ITIM	228	233	PF00017	0.353
LIG_UBA3_1	303	310	PF00899	0.550
MOD_CDK_SPxK_1	143	149	PF00069	0.497
MOD_CK1_1	25	31	PF00069	0.416
MOD_CK1_1	276	282	PF00069	0.514
MOD_CK1_1	294	300	PF00069	0.563
MOD_CK1_1	309	315	PF00069	0.441
MOD_CK2_1	220	226	PF00069	0.351
MOD_CK2_1	339	345	PF00069	0.486
MOD_CK2_1	346	352	PF00069	0.480
MOD_GlcNHglycan	139	142	PF01048	0.400
MOD_GlcNHglycan	210	214	PF01048	0.424
MOD_GlcNHglycan	223	226	PF01048	0.404
MOD_GlcNHglycan	24	27	PF01048	0.446
MOD_GlcNHglycan	252	255	PF01048	0.490
MOD_GlcNHglycan	293	296	PF01048	0.605
MOD_GSK3_1	104	111	PF00069	0.429
MOD_GSK3_1	143	150	PF00069	0.363
MOD_GSK3_1	195	202	PF00069	0.509
MOD_GSK3_1	209	216	PF00069	0.266
MOD_GSK3_1	272	279	PF00069	0.504
MOD_GSK3_1	291	298	PF00069	0.340
MOD_GSK3_1	326	333	PF00069	0.423
MOD_GSK3_1	348	355	PF00069	0.477
MOD_GSK3_1	56	63	PF00069	0.477
MOD_N-GLC_1	14	19	PF02516	0.419
MOD_N-GLC_1	38	43	PF02516	0.514
MOD_NEK2_1	1	6	PF00069	0.550
MOD_NEK2_1	197	202	PF00069	0.465
MOD_NEK2_1	218	223	PF00069	0.324
MOD_NEK2_1	272	277	PF00069	0.445
MOD_NEK2_1	326	331	PF00069	0.341
MOD_NEK2_1	339	344	PF00069	0.387
MOD_PIKK_1	158	164	PF00454	0.414
MOD_PIKK_1	82	88	PF00454	0.448
MOD_PKA_2	179	185	PF00069	0.459
MOD_PKA_2	56	62	PF00069	0.350
MOD_PKA_2	9	15	PF00069	0.399
MOD_Plk_1	14	20	PF00069	0.329
MOD_Plk_1	147	153	PF00069	0.381
MOD_Plk_1	213	219	PF00069	0.503
MOD_Plk_1	82	88	PF00069	0.448
MOD_Plk_4	339	345	PF00069	0.466
MOD_Plk_4	60	66	PF00069	0.414
MOD_ProDKin_1	104	110	PF00069	0.422
MOD_ProDKin_1	143	149	PF00069	0.458
MOD_ProDKin_1	266	272	PF00069	0.447
TRG_DiLeu_BaLyEn_6	134	139	PF01217	0.373
TRG_DiLeu_BaLyEn_6	214	219	PF01217	0.415
TRG_DiLeu_BaLyEn_6	299	304	PF01217	0.528
TRG_DiLeu_BaLyEn_6	30	35	PF01217	0.331
TRG_ENDOCYTIC_2	110	113	PF00928	0.338
TRG_ENDOCYTIC_2	230	233	PF00928	0.362
TRG_ENDOCYTIC_2	3	6	PF00928	0.601
TRG_ENDOCYTIC_2	347	350	PF00928	0.520
TRG_Pf-PMV_PEXEL_1	302	306	PF00026	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC17	Leptomonas seymouri	71%	93%
A0A0S4IL54	Bodo saltans	30%	82%
A0A1X0NRZ4	Trypanosomatidae	53%	100%
A0A422P323	Trypanosoma rangeli	53%	99%
A4HL19	Leishmania braziliensis	90%	100%
A4I8K0	Leishmania infantum	100%	100%
D0AAL9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B3G0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q4P0	Leishmania major	96%	100%
V5BR02	Trypanosoma cruzi	53%	89%