LeishMANIAdb
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Thiol-dependent_reductase_1/GeneDB:LmjF.33.0240

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Thiol-dependent_reductase_1/GeneDB:LmjF.33.0240
Gene product:
thiol-dependent reductase 1
Species:
Leishmania donovani
UniProt:
A0A3S7X699_LEIDO
TriTrypDb:
LdBPK_330260.1 , LdCL_330007500 , LDHU3_33.0310
Length:
450

Annotations

Annotations by Jardim et al.

Redox homeostasis, Thiol-dependent reductase 1 TDR1 PE=1 SV=1 - [A4I8P2_LEIIN]

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 4
Forrest at al. (procyclic) yes yes: 4
Silverman et al. no yes: 0
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A0A3S7X699
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X699

PDB structure(s): 4ags_A , 4ags_B , 4ags_C

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 8
GO:0015035 protein-disulfide reductase activity 3 6
GO:0015036 disulfide oxidoreductase activity 4 6
GO:0015038 glutathione disulfide oxidoreductase activity 5 3
GO:0016209 antioxidant activity 1 3
GO:0016491 oxidoreductase activity 2 6
GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 3 6
GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor 4 6
GO:0016672 oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor 4 3
GO:0016740 transferase activity 2 4
GO:0019153 protein-disulfide reductase (glutathione) activity 4 6
GO:0045174 glutathione dehydrogenase (ascorbate) activity 2 3
GO:0140096 catalytic activity, acting on a protein 2 6
GO:0000166 nucleotide binding 3 1
GO:0005488 binding 1 2
GO:0036094 small molecule binding 2 1
GO:0043167 ion binding 2 1
GO:0043168 anion binding 3 1
GO:0050661 NADP binding 4 1
GO:0070402 NADPH binding 4 1
GO:0097159 organic cyclic compound binding 2 1
GO:1901265 nucleoside phosphate binding 3 1
GO:1901363 heterocyclic compound binding 2 1
GO:0005515 protein binding 2 1
GO:0042802 identical protein binding 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 125 127 PF00675 0.351
CLV_NRD_NRD_1 252 254 PF00675 0.483
CLV_NRD_NRD_1 440 442 PF00675 0.500
CLV_NRD_NRD_1 445 447 PF00675 0.567
CLV_PCSK_FUR_1 443 447 PF00082 0.588
CLV_PCSK_KEX2_1 125 127 PF00082 0.373
CLV_PCSK_KEX2_1 377 379 PF00082 0.483
CLV_PCSK_KEX2_1 442 444 PF00082 0.596
CLV_PCSK_KEX2_1 445 447 PF00082 0.616
CLV_PCSK_KEX2_1 65 67 PF00082 0.444
CLV_PCSK_PC1ET2_1 125 127 PF00082 0.381
CLV_PCSK_PC1ET2_1 377 379 PF00082 0.483
CLV_PCSK_PC1ET2_1 442 444 PF00082 0.480
CLV_PCSK_PC1ET2_1 65 67 PF00082 0.427
CLV_PCSK_PC7_1 441 447 PF00082 0.574
CLV_PCSK_SKI1_1 170 174 PF00082 0.381
CLV_PCSK_SKI1_1 4 8 PF00082 0.423
CLV_PCSK_SKI1_1 427 431 PF00082 0.379
CLV_PCSK_SKI1_1 66 70 PF00082 0.444
DEG_SCF_FBW7_2 283 289 PF00400 0.483
DOC_CKS1_1 283 288 PF01111 0.381
DOC_CKS1_1 421 426 PF01111 0.386
DOC_CYCLIN_RxL_1 1 11 PF00134 0.456
DOC_MAPK_DCC_7 52 60 PF00069 0.381
DOC_MAPK_gen_1 253 259 PF00069 0.394
DOC_MAPK_MEF2A_6 52 60 PF00069 0.381
DOC_WW_Pin1_4 202 207 PF00397 0.532
DOC_WW_Pin1_4 282 287 PF00397 0.381
DOC_WW_Pin1_4 420 425 PF00397 0.386
LIG_14-3-3_CanoR_1 198 202 PF00244 0.450
LIG_14-3-3_CanoR_1 247 255 PF00244 0.323
LIG_14-3-3_CterR_2 445 450 PF00244 0.491
LIG_Actin_WH2_2 156 172 PF00022 0.444
LIG_APCC_ABBA_1 239 244 PF00400 0.450
LIG_BIR_II_1 1 5 PF00653 0.531
LIG_BRCT_BRCA1_1 235 239 PF00533 0.405
LIG_EH1_1 331 339 PF00400 0.483
LIG_eIF4E_1 332 338 PF01652 0.483
LIG_FHA_1 55 61 PF00498 0.411
LIG_FHA_2 154 160 PF00498 0.483
LIG_FHA_2 430 436 PF00498 0.576
LIG_GBD_Chelix_1 34 42 PF00786 0.444
LIG_Integrin_RGD_1 314 316 PF01839 0.556
LIG_LIR_Gen_1 30 38 PF02991 0.471
LIG_LIR_Gen_1 401 412 PF02991 0.387
LIG_LIR_Nem_3 213 218 PF02991 0.529
LIG_LIR_Nem_3 236 242 PF02991 0.405
LIG_LIR_Nem_3 269 274 PF02991 0.398
LIG_LIR_Nem_3 30 34 PF02991 0.426
LIG_LIR_Nem_3 401 407 PF02991 0.370
LIG_LIR_Nem_3 428 433 PF02991 0.377
LIG_MYND_3 55 59 PF01753 0.483
LIG_PCNA_TLS_4 96 103 PF02747 0.483
LIG_Pex14_2 396 400 PF04695 0.466
LIG_PTB_Apo_2 326 333 PF02174 0.483
LIG_PTB_Phospho_1 326 332 PF10480 0.483
LIG_REV1ctd_RIR_1 371 382 PF16727 0.483
LIG_SH2_CRK 235 239 PF00017 0.366
LIG_SH2_CRK 271 275 PF00017 0.405
LIG_SH2_CRK 31 35 PF00017 0.454
LIG_SH2_CRK 46 50 PF00017 0.264
LIG_SH2_GRB2like 235 238 PF00017 0.411
LIG_SH2_GRB2like 273 276 PF00017 0.405
LIG_SH2_NCK_1 31 35 PF00017 0.480
LIG_SH2_PTP2 273 276 PF00017 0.405
LIG_SH2_SRC 135 138 PF00017 0.359
LIG_SH2_SRC 273 276 PF00017 0.405
LIG_SH2_STAP1 235 239 PF00017 0.483
LIG_SH2_STAP1 31 35 PF00017 0.486
LIG_SH2_STAP1 404 408 PF00017 0.411
LIG_SH2_STAT5 135 138 PF00017 0.365
LIG_SH2_STAT5 150 153 PF00017 0.420
LIG_SH2_STAT5 273 276 PF00017 0.480
LIG_SH2_STAT5 300 303 PF00017 0.358
LIG_SH2_STAT5 332 335 PF00017 0.416
LIG_SH2_STAT5 77 80 PF00017 0.338
LIG_SH2_STAT5 9 12 PF00017 0.415
LIG_SH3_3 257 263 PF00018 0.462
LIG_SUMO_SIM_anti_2 159 164 PF11976 0.328
LIG_SUMO_SIM_anti_2 383 388 PF11976 0.358
LIG_TRAF2_1 432 435 PF00917 0.562
LIG_TYR_ITIM 233 238 PF00017 0.366
LIG_TYR_ITIM 29 34 PF00017 0.418
LIG_UBA3_1 386 394 PF00899 0.390
MOD_CDK_SPxxK_3 420 427 PF00069 0.386
MOD_CK2_1 197 203 PF00069 0.371
MOD_CK2_1 429 435 PF00069 0.542
MOD_Cter_Amidation 375 378 PF01082 0.405
MOD_GlcNHglycan 10 13 PF01048 0.366
MOD_GlcNHglycan 121 124 PF01048 0.472
MOD_GlcNHglycan 221 224 PF01048 0.579
MOD_GlcNHglycan 286 289 PF01048 0.483
MOD_GlcNHglycan 308 311 PF01048 0.479
MOD_GlcNHglycan 399 403 PF01048 0.417
MOD_GlcNHglycan 79 83 PF01048 0.538
MOD_GlcNHglycan 91 94 PF01048 0.477
MOD_GSK3_1 197 204 PF00069 0.346
MOD_GSK3_1 425 432 PF00069 0.412
MOD_N-GLC_1 142 147 PF02516 0.483
MOD_NEK2_1 68 73 PF00069 0.344
MOD_NEK2_1 78 83 PF00069 0.479
MOD_NEK2_1 8 13 PF00069 0.396
MOD_NEK2_1 88 93 PF00069 0.392
MOD_PIKK_1 291 297 PF00454 0.408
MOD_PKA_2 197 203 PF00069 0.338
MOD_PKA_2 276 282 PF00069 0.325
MOD_PKA_2 51 57 PF00069 0.338
MOD_PKB_1 245 253 PF00069 0.269
MOD_Plk_1 153 159 PF00069 0.418
MOD_Plk_4 336 342 PF00069 0.490
MOD_Plk_4 425 431 PF00069 0.317
MOD_Plk_4 68 74 PF00069 0.496
MOD_ProDKin_1 202 208 PF00069 0.532
MOD_ProDKin_1 282 288 PF00069 0.381
MOD_ProDKin_1 420 426 PF00069 0.386
MOD_SUMO_for_1 348 351 PF00179 0.411
MOD_SUMO_rev_2 346 350 PF00179 0.432
TRG_DiLeu_BaEn_2 321 327 PF01217 0.483
TRG_DiLeu_BaLyEn_6 408 413 PF01217 0.483
TRG_ENDOCYTIC_2 179 182 PF00928 0.338
TRG_ENDOCYTIC_2 215 218 PF00928 0.554
TRG_ENDOCYTIC_2 235 238 PF00928 0.153
TRG_ENDOCYTIC_2 271 274 PF00928 0.411
TRG_ENDOCYTIC_2 31 34 PF00928 0.393
TRG_ENDOCYTIC_2 404 407 PF00928 0.344
TRG_ENDOCYTIC_2 46 49 PF00928 0.268
TRG_ER_diArg_1 245 248 PF00400 0.381
TRG_ER_diArg_1 440 443 PF00400 0.530
TRG_NLS_MonoExtC_3 440 445 PF00514 0.419
TRG_NLS_MonoExtN_4 441 446 PF00514 0.432
TRG_Pf-PMV_PEXEL_1 216 221 PF00026 0.564
TRG_Pf-PMV_PEXEL_1 431 435 PF00026 0.511

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0S4IX62 Bodo saltans 40% 94%
A0A0S4KHM5 Bodo saltans 40% 93%
A0A1X0P247 Trypanosomatidae 46% 100%
A0A422NGA2 Trypanosoma rangeli 51% 100%
A4HJ18 Leishmania braziliensis 80% 100%
A4I8P2 Leishmania infantum 100% 100%
E9B3K3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q70GE8 Leishmania major 96% 100%
V5DBY4 Trypanosoma cruzi 48% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS