Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X692_LEIDO

TriTrypDb:

LdBPK_324110.1 , LdCL_320047100 , LDHU3_32.5280

Length:

185

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X692

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X692

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	138	142	PF00656	0.532
CLV_NRD_NRD_1	134	136	PF00675	0.425
CLV_NRD_NRD_1	164	166	PF00675	0.509
CLV_NRD_NRD_1	175	177	PF00675	0.484
CLV_NRD_NRD_1	38	40	PF00675	0.475
CLV_NRD_NRD_1	46	48	PF00675	0.501
CLV_PCSK_KEX2_1	134	136	PF00082	0.452
CLV_PCSK_KEX2_1	175	177	PF00082	0.547
CLV_PCSK_PC1ET2_1	175	177	PF00082	0.547
CLV_PCSK_PC7_1	171	177	PF00082	0.607
CLV_PCSK_SKI1_1	176	180	PF00082	0.588
CLV_PCSK_SKI1_1	39	43	PF00082	0.453
DEG_APCC_DBOX_1	92	100	PF00400	0.505
DEG_Nend_Nbox_1	1	3	PF02207	0.658
DOC_MAPK_gen_1	39	46	PF00069	0.445
DOC_MAPK_MEF2A_6	39	46	PF00069	0.426
DOC_MAPK_MEF2A_6	8	15	PF00069	0.662
DOC_MAPK_NFAT4_5	39	47	PF00069	0.433
DOC_MAPK_RevD_3	27	40	PF00069	0.508
DOC_USP7_MATH_1	18	22	PF00917	0.609
DOC_USP7_UBL2_3	149	153	PF12436	0.442
DOC_USP7_UBL2_3	173	177	PF12436	0.540
DOC_WW_Pin1_4	14	19	PF00397	0.584
LIG_FHA_1	51	57	PF00498	0.591
LIG_FHA_2	157	163	PF00498	0.548
LIG_FHA_2	179	185	PF00498	0.551
LIG_FHA_2	61	67	PF00498	0.460
LIG_LIR_Nem_3	108	112	PF02991	0.508
LIG_LIR_Nem_3	35	41	PF02991	0.433
LIG_Pex14_2	132	136	PF04695	0.543
LIG_PTAP_UEV_1	19	24	PF05743	0.636
LIG_SH2_CRK	38	42	PF00017	0.421
LIG_SH2_GRB2like	100	103	PF00017	0.638
LIG_SH2_STAP1	65	69	PF00017	0.554
LIG_SH2_STAT5	45	48	PF00017	0.459
LIG_SH3_3	17	23	PF00018	0.566
LIG_TRAF2_1	128	131	PF00917	0.513
LIG_TRAF2_1	74	77	PF00917	0.613
LIG_TRAF2_2	23	28	PF00917	0.605
LIG_TRFH_1	27	31	PF08558	0.647
LIG_TYR_ITIM	36	41	PF00017	0.428
LIG_UBA3_1	41	48	PF00899	0.440
LIG_UBA3_1	80	84	PF00899	0.569
MOD_CK2_1	125	131	PF00069	0.532
MOD_CK2_1	60	66	PF00069	0.467
MOD_CK2_1	71	77	PF00069	0.542
MOD_GlcNHglycan	127	130	PF01048	0.626
MOD_GlcNHglycan	20	23	PF01048	0.561
MOD_GSK3_1	14	21	PF00069	0.671
MOD_GSK3_1	48	55	PF00069	0.497
MOD_LATS_1	137	143	PF00433	0.585
MOD_N-GLC_1	105	110	PF02516	0.530
MOD_N-GLC_1	71	76	PF02516	0.494
MOD_PK_1	3	9	PF00069	0.450
MOD_PKA_2	156	162	PF00069	0.519
MOD_Plk_1	105	111	PF00069	0.541
MOD_Plk_4	105	111	PF00069	0.516
MOD_Plk_4	32	38	PF00069	0.474
MOD_Plk_4	52	58	PF00069	0.463
MOD_ProDKin_1	14	20	PF00069	0.584
MOD_SUMO_for_1	11	14	PF00179	0.591
MOD_SUMO_rev_2	141	151	PF00179	0.468
TRG_DiLeu_BaEn_1	76	81	PF01217	0.557
TRG_DiLeu_BaEn_4	76	82	PF01217	0.612
TRG_ENDOCYTIC_2	38	41	PF00928	0.426
TRG_ER_diArg_1	133	135	PF00400	0.427
TRG_NLS_Bipartite_1	165	180	PF00514	0.626
TRG_NLS_MonoExtC_3	174	179	PF00514	0.564
TRG_NLS_MonoExtN_4	173	180	PF00514	0.526

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Q7	Leptomonas seymouri	88%	100%
A0A0S4INC1	Bodo saltans	56%	86%
A0A1X0NTH6	Trypanosomatidae	67%	99%
A0A422NHV0	Trypanosoma rangeli	62%	100%
A4HL33	Leishmania braziliensis	94%	100%
A4I8L4	Leishmania infantum	99%	100%
D0AAK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	99%
E9B3H4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q4M6	Leishmania major	96%	100%