Iwr1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Selenoprotein 1, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X690_LEIDO

TriTrypDb:

LdBPK_330160.1 , LdCL_330006500 , LDHU3_33.0180

Length:

279

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X690

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X690

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.551
CLV_C14_Caspase3-7	168	172	PF00656	0.494
CLV_C14_Caspase3-7	223	227	PF00656	0.684
CLV_C14_Caspase3-7	68	72	PF00656	0.504
CLV_NRD_NRD_1	139	141	PF00675	0.634
CLV_NRD_NRD_1	203	205	PF00675	0.274
CLV_NRD_NRD_1	21	23	PF00675	0.502
CLV_NRD_NRD_1	248	250	PF00675	0.590
CLV_PCSK_KEX2_1	121	123	PF00082	0.583
CLV_PCSK_KEX2_1	139	141	PF00082	0.493
CLV_PCSK_KEX2_1	21	23	PF00082	0.502
CLV_PCSK_KEX2_1	247	249	PF00082	0.599
CLV_PCSK_PC1ET2_1	121	123	PF00082	0.582
CLV_PCSK_PC7_1	117	123	PF00082	0.618
CLV_PCSK_SKI1_1	17	21	PF00082	0.498
DOC_PP4_FxxP_1	135	138	PF00568	0.639
DOC_PP4_FxxP_1	51	54	PF00568	0.577
DOC_USP7_MATH_1	158	162	PF00917	0.632
DOC_USP7_MATH_1	240	244	PF00917	0.714
DOC_USP7_MATH_1	253	257	PF00917	0.551
DOC_USP7_MATH_1	28	32	PF00917	0.574
DOC_USP7_MATH_1	40	44	PF00917	0.535
DOC_WW_Pin1_4	156	161	PF00397	0.664
DOC_WW_Pin1_4	50	55	PF00397	0.576
LIG_14-3-3_CanoR_1	117	121	PF00244	0.581
LIG_14-3-3_CanoR_1	140	146	PF00244	0.743
LIG_14-3-3_CanoR_1	255	259	PF00244	0.548
LIG_14-3-3_CanoR_1	57	65	PF00244	0.506
LIG_BIR_III_4	169	173	PF00653	0.586
LIG_BIR_III_4	224	228	PF00653	0.576
LIG_Clathr_ClatBox_1	184	188	PF01394	0.541
LIG_Clathr_ClatBox_1	85	89	PF01394	0.642
LIG_FHA_1	14	20	PF00498	0.500
LIG_FHA_1	140	146	PF00498	0.659
LIG_FHA_1	192	198	PF00498	0.627
LIG_FHA_2	106	112	PF00498	0.447
LIG_FHA_2	166	172	PF00498	0.607
LIG_FHA_2	91	97	PF00498	0.573
LIG_LIR_Apic_2	195	201	PF02991	0.563
LIG_LIR_Apic_2	48	54	PF02991	0.591
LIG_LIR_Gen_1	180	189	PF02991	0.626
LIG_LIR_Nem_3	100	105	PF02991	0.555
LIG_LIR_Nem_3	161	166	PF02991	0.644
LIG_LIR_Nem_3	180	184	PF02991	0.585
LIG_LIR_Nem_3	256	261	PF02991	0.516
LIG_Rb_LxCxE_1	180	202	PF01857	0.578
LIG_SH2_CRK	258	262	PF00017	0.473
LIG_SH2_STAP1	181	185	PF00017	0.549
LIG_SH2_STAT5	134	137	PF00017	0.567
LIG_SH2_STAT5	198	201	PF00017	0.569
LIG_SUMO_SIM_par_1	81	87	PF11976	0.506
LIG_TRAF2_1	92	95	PF00917	0.550
LIG_TRFH_1	134	138	PF08558	0.638
MOD_CDC14_SPxK_1	159	162	PF00782	0.673
MOD_CDK_SPxK_1	156	162	PF00069	0.666
MOD_CDK_SPxxK_3	50	57	PF00069	0.571
MOD_CK1_1	13	19	PF00069	0.576
MOD_CK1_1	229	235	PF00069	0.707
MOD_CK1_1	241	247	PF00069	0.555
MOD_CK1_1	254	260	PF00069	0.538
MOD_CK1_1	267	273	PF00069	0.459
MOD_CK1_1	90	96	PF00069	0.624
MOD_CK2_1	208	214	PF00069	0.474
MOD_CK2_1	50	56	PF00069	0.563
MOD_CK2_1	94	100	PF00069	0.491
MOD_Cter_Amidation	245	248	PF01082	0.563
MOD_GlcNHglycan	149	152	PF01048	0.615
MOD_GlcNHglycan	156	159	PF01048	0.560
MOD_GlcNHglycan	214	219	PF01048	0.396
MOD_GlcNHglycan	228	231	PF01048	0.561
MOD_GlcNHglycan	237	243	PF01048	0.597
MOD_GlcNHglycan	272	275	PF01048	0.521
MOD_GlcNHglycan	60	63	PF01048	0.587
MOD_GSK3_1	154	161	PF00069	0.630
MOD_GSK3_1	238	245	PF00069	0.692
MOD_GSK3_1	270	277	PF00069	0.539
MOD_GSK3_1	41	48	PF00069	0.548
MOD_GSK3_1	90	97	PF00069	0.492
MOD_NEK2_1	8	13	PF00069	0.555
MOD_NEK2_2	10	15	PF00069	0.553
MOD_PKA_1	139	145	PF00069	0.574
MOD_PKA_2	116	122	PF00069	0.614
MOD_PKA_2	139	145	PF00069	0.574
MOD_PKA_2	254	260	PF00069	0.548
MOD_PKA_2	45	51	PF00069	0.650
MOD_PKA_2	56	62	PF00069	0.479
MOD_PKB_1	249	257	PF00069	0.508
MOD_Plk_1	267	273	PF00069	0.528
MOD_Plk_1	94	100	PF00069	0.492
MOD_Plk_2-3	84	90	PF00069	0.520
MOD_Plk_2-3	94	100	PF00069	0.539
MOD_Plk_4	94	100	PF00069	0.492
MOD_ProDKin_1	156	162	PF00069	0.666
MOD_ProDKin_1	50	56	PF00069	0.573
TRG_DiLeu_BaEn_1	180	185	PF01217	0.586
TRG_DiLeu_BaEn_4	126	132	PF01217	0.637
TRG_DiLeu_BaLyEn_6	173	178	PF01217	0.572
TRG_ENDOCYTIC_2	181	184	PF00928	0.550
TRG_ENDOCYTIC_2	258	261	PF00928	0.520
TRG_ER_diArg_1	122	125	PF00400	0.571
TRG_ER_diArg_1	138	140	PF00400	0.695
TRG_ER_diArg_1	20	22	PF00400	0.506
TRG_ER_diArg_1	247	249	PF00400	0.566
TRG_NES_CRM1_1	96	111	PF08389	0.520
TRG_NLS_MonoExtC_3	120	126	PF00514	0.591
TRG_Pf-PMV_PEXEL_1	176	180	PF00026	0.610
TRG_Pf-PMV_PEXEL_1	24	29	PF00026	0.535

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5U4	Leptomonas seymouri	44%	82%
A4HL52	Leishmania braziliensis	69%	100%
A4I8N1	Leishmania infantum	100%	100%
E9B3J3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q4K8	Leishmania major	88%	100%