Transmembrane protein 18

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Transmembrane protein 18, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X686_LEIDO

TriTrypDb:

LdBPK_323880.1 , LdCL_320044800 , LDHU3_32.5010

Length:

205

Annotations

LeishMANIAdb annotations

Part of the eukaryotic TMEM18 family, consisting of conserved 3TM nuclear membrane proteins.. Localization: Perinuclear (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0031090	organelle membrane	3	1
GO:0031965	nuclear membrane	4	1

Expansion

Sequence features

A0A3S7X686

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X686

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	178	180	PF00675	0.331
CLV_NRD_NRD_1	185	187	PF00675	0.455
CLV_PCSK_KEX2_1	172	174	PF00082	0.290
CLV_PCSK_KEX2_1	177	179	PF00082	0.155
CLV_PCSK_KEX2_1	185	187	PF00082	0.468
CLV_PCSK_PC1ET2_1	172	174	PF00082	0.290
CLV_PCSK_PC7_1	173	179	PF00082	0.331
CLV_PCSK_PC7_1	181	187	PF00082	0.452
DOC_MAPK_MEF2A_6	163	171	PF00069	0.561
DOC_PP4_FxxP_1	126	129	PF00568	0.361
DOC_USP7_MATH_1	113	117	PF00917	0.391
DOC_USP7_MATH_1	198	202	PF00917	0.688
DOC_USP7_MATH_1	38	42	PF00917	0.497
LIG_14-3-3_CanoR_1	163	168	PF00244	0.591
LIG_Actin_WH2_2	144	161	PF00022	0.483
LIG_Actin_WH2_2	41	56	PF00022	0.447
LIG_BIR_II_1	1	5	PF00653	0.435
LIG_BRCT_BRCA1_1	65	69	PF00533	0.308
LIG_CaM_NSCaTE_8	81	88	PF13499	0.444
LIG_EH1_1	161	169	PF00400	0.585
LIG_eIF4E_1	145	151	PF01652	0.453
LIG_eIF4E_1	162	168	PF01652	0.414
LIG_LIR_Apic_2	123	129	PF02991	0.361
LIG_LIR_Nem_3	55	60	PF02991	0.375
LIG_LIR_Nem_3	66	72	PF02991	0.295
LIG_LIR_Nem_3	86	92	PF02991	0.155
LIG_Pex14_1	65	69	PF04695	0.290
LIG_REV1ctd_RIR_1	67	75	PF16727	0.361
LIG_RPA_C_Fungi	27	39	PF08784	0.393
LIG_SH2_CRK	162	166	PF00017	0.494
LIG_SH2_CRK	60	64	PF00017	0.416
LIG_SH2_NCK_1	60	64	PF00017	0.485
LIG_SH2_STAT5	133	136	PF00017	0.379
LIG_SH2_STAT5	145	148	PF00017	0.498
LIG_SH2_STAT5	155	158	PF00017	0.320
LIG_SH2_STAT5	60	63	PF00017	0.418
LIG_SH2_STAT5	72	75	PF00017	0.320
LIG_Sin3_3	76	83	PF02671	0.272
LIG_SUMO_SIM_anti_2	93	101	PF11976	0.323
LIG_SUMO_SIM_par_1	105	110	PF11976	0.485
LIG_TRAF2_1	6	9	PF00917	0.517
LIG_TYR_ITIM	153	158	PF00017	0.408
LIG_UBA3_1	167	172	PF00899	0.382
MOD_CK1_1	41	47	PF00069	0.561
MOD_CK2_1	3	9	PF00069	0.523
MOD_CK2_1	44	50	PF00069	0.517
MOD_GlcNHglycan	109	112	PF01048	0.498
MOD_GSK3_1	132	139	PF00069	0.474
MOD_N-GLC_1	63	68	PF02516	0.401
MOD_NEK2_1	107	112	PF00069	0.416
MOD_NEK2_1	26	31	PF00069	0.505
MOD_NEK2_1	3	8	PF00069	0.547
MOD_PKA_1	185	191	PF00069	0.613
MOD_PKA_2	185	191	PF00069	0.613
MOD_Plk_4	136	142	PF00069	0.485
MOD_Plk_4	163	169	PF00069	0.485
MOD_SUMO_rev_2	195	204	PF00179	0.737
TRG_DiLeu_BaLyEn_6	145	150	PF01217	0.460
TRG_ENDOCYTIC_2	155	158	PF00928	0.485
TRG_ENDOCYTIC_2	162	165	PF00928	0.370
TRG_ENDOCYTIC_2	60	63	PF00928	0.387
TRG_ENDOCYTIC_2	72	75	PF00928	0.309
TRG_ER_diArg_1	176	179	PF00400	0.403
TRG_ER_diLys_1	202	205	PF00400	0.651

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIZ0	Leptomonas seymouri	48%	100%
A0A1X0NRY6	Trypanosomatidae	42%	100%
A0A3R7KYB3	Trypanosoma rangeli	38%	100%
A4HL10	Leishmania braziliensis	79%	100%
A4I8J1	Leishmania infantum	100%	100%
D0AAM7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9B3F1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q4P9	Leishmania major	94%	100%