SHQ1 protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SHQ1 protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X679_LEIDO

TriTrypDb:

LdBPK_323960.1 , LdCL_320045600 , LDHU3_32.5090

Length:

577

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X679

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X679

Function

Biological processes
Term	Name	Level	Count
GO:0000491	small nucleolar ribonucleoprotein complex assembly	7	12
GO:0000493	box H/ACA snoRNP assembly	8	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0022618	ribonucleoprotein complex assembly	6	12
GO:0043933	protein-containing complex organization	4	12
GO:0065003	protein-containing complex assembly	5	12
GO:0071826	ribonucleoprotein complex subunit organization	5	12
GO:0071840	cellular component organization or biogenesis	2	12

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0051082	unfolded protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	133	137	PF00656	0.654
CLV_C14_Caspase3-7	181	185	PF00656	0.427
CLV_C14_Caspase3-7	216	220	PF00656	0.383
CLV_C14_Caspase3-7	87	91	PF00656	0.403
CLV_NRD_NRD_1	195	197	PF00675	0.409
CLV_NRD_NRD_1	439	441	PF00675	0.231
CLV_PCSK_KEX2_1	194	196	PF00082	0.394
CLV_PCSK_KEX2_1	439	441	PF00082	0.231
CLV_PCSK_PC7_1	191	197	PF00082	0.429
CLV_PCSK_SKI1_1	18	22	PF00082	0.441
CLV_PCSK_SKI1_1	286	290	PF00082	0.553
CLV_PCSK_SKI1_1	374	378	PF00082	0.242
CLV_PCSK_SKI1_1	439	443	PF00082	0.231
CLV_PCSK_SKI1_1	463	467	PF00082	0.248
CLV_PCSK_SKI1_1	473	477	PF00082	0.216
CLV_PCSK_SKI1_1	479	483	PF00082	0.201
CLV_PCSK_SKI1_1	488	492	PF00082	0.231
CLV_PCSK_SKI1_1	515	519	PF00082	0.290
CLV_PCSK_SKI1_1	551	555	PF00082	0.434
DEG_APCC_DBOX_1	101	109	PF00400	0.504
DEG_APCC_DBOX_1	17	25	PF00400	0.473
DEG_APCC_DBOX_1	368	376	PF00400	0.478
DEG_Nend_Nbox_1	1	3	PF02207	0.383
DEG_SCF_FBW7_2	1	7	PF00400	0.489
DOC_CDC14_PxL_1	258	266	PF14671	0.434
DOC_CKS1_1	1	6	PF01111	0.376
DOC_CYCLIN_RxL_1	369	380	PF00134	0.493
DOC_CYCLIN_yCln2_LP_2	89	95	PF00134	0.393
DOC_MAPK_DCC_7	369	377	PF00069	0.498
DOC_MAPK_DCC_7	551	560	PF00069	0.371
DOC_MAPK_gen_1	100	108	PF00069	0.470
DOC_MAPK_gen_1	191	199	PF00069	0.463
DOC_MAPK_gen_1	369	377	PF00069	0.474
DOC_MAPK_gen_1	512	520	PF00069	0.440
DOC_MAPK_MEF2A_6	352	359	PF00069	0.521
DOC_MAPK_MEF2A_6	369	377	PF00069	0.390
DOC_MAPK_MEF2A_6	473	482	PF00069	0.535
DOC_MAPK_MEF2A_6	512	520	PF00069	0.440
DOC_MAPK_MEF2A_6	526	534	PF00069	0.427
DOC_PP1_RVXF_1	372	378	PF00149	0.454
DOC_PP1_RVXF_1	47	53	PF00149	0.326
DOC_PP2B_LxvP_1	348	351	PF13499	0.358
DOC_PP2B_LxvP_1	376	379	PF13499	0.416
DOC_PP2B_LxvP_1	563	566	PF13499	0.353
DOC_PP4_FxxP_1	298	301	PF00568	0.481
DOC_USP7_MATH_1	112	116	PF00917	0.696
DOC_USP7_MATH_1	139	143	PF00917	0.685
DOC_USP7_MATH_1	144	148	PF00917	0.698
DOC_USP7_MATH_1	154	158	PF00917	0.289
DOC_USP7_MATH_1	316	320	PF00917	0.712
DOC_USP7_MATH_1	326	330	PF00917	0.562
DOC_USP7_MATH_1	542	546	PF00917	0.517
DOC_WW_Pin1_4	377	382	PF00397	0.496
DOC_WW_Pin1_4	41	46	PF00397	0.475
DOC_WW_Pin1_4	415	420	PF00397	0.431
LIG_14-3-3_CanoR_1	102	106	PF00244	0.486
LIG_14-3-3_CanoR_1	18	27	PF00244	0.428
LIG_14-3-3_CanoR_1	286	291	PF00244	0.549
LIG_14-3-3_CanoR_1	538	547	PF00244	0.557
LIG_14-3-3_CanoR_1	63	67	PF00244	0.400
LIG_BIR_III_2	284	288	PF00653	0.573
LIG_BIR_III_4	117	121	PF00653	0.493
LIG_BRCT_BRCA1_1	156	160	PF00533	0.386
LIG_BRCT_BRCA1_1	164	168	PF00533	0.316
LIG_BRCT_BRCA1_1	254	258	PF00533	0.426
LIG_BRCT_BRCA1_1	328	332	PF00533	0.742
LIG_BRCT_BRCA1_1	355	359	PF00533	0.364
LIG_BRCT_BRCA1_2	164	170	PF00533	0.501
LIG_Clathr_ClatBox_1	212	216	PF01394	0.401
LIG_EH1_1	13	21	PF00400	0.336
LIG_EH1_1	205	213	PF00400	0.423
LIG_EH1_1	469	477	PF00400	0.439
LIG_eIF4E_1	447	453	PF01652	0.522
LIG_eIF4E_1	470	476	PF01652	0.442
LIG_FHA_1	126	132	PF00498	0.575
LIG_FHA_1	26	32	PF00498	0.341
LIG_FHA_1	275	281	PF00498	0.574
LIG_FHA_1	362	368	PF00498	0.591
LIG_FHA_1	386	392	PF00498	0.435
LIG_FHA_1	460	466	PF00498	0.533
LIG_FHA_1	491	497	PF00498	0.456
LIG_FHA_1	529	535	PF00498	0.501
LIG_FHA_1	63	69	PF00498	0.391
LIG_FHA_1	72	78	PF00498	0.333
LIG_FHA_2	187	193	PF00498	0.424
LIG_FHA_2	202	208	PF00498	0.347
LIG_FHA_2	315	321	PF00498	0.734
LIG_FHA_2	358	364	PF00498	0.448
LIG_FHA_2	427	433	PF00498	0.535
LIG_FHA_2	85	91	PF00498	0.393
LIG_LIR_Apic_2	297	301	PF02991	0.505
LIG_LIR_Apic_2	40	45	PF02991	0.423
LIG_LIR_Apic_2	422	426	PF02991	0.491
LIG_LIR_Apic_2	492	498	PF02991	0.444
LIG_LIR_Gen_1	11	21	PF02991	0.342
LIG_LIR_Gen_1	165	176	PF02991	0.377
LIG_LIR_Gen_1	255	266	PF02991	0.439
LIG_LIR_Gen_1	394	401	PF02991	0.433
LIG_LIR_Gen_1	44	52	PF02991	0.436
LIG_LIR_Gen_1	84	94	PF02991	0.379
LIG_LIR_Nem_3	11	17	PF02991	0.340
LIG_LIR_Nem_3	165	171	PF02991	0.370
LIG_LIR_Nem_3	255	261	PF02991	0.397
LIG_LIR_Nem_3	36	42	PF02991	0.411
LIG_LIR_Nem_3	394	400	PF02991	0.465
LIG_LIR_Nem_3	44	50	PF02991	0.424
LIG_LIR_Nem_3	84	89	PF02991	0.362
LIG_PCNA_yPIPBox_3	463	476	PF02747	0.462
LIG_Pex14_2	160	164	PF04695	0.347
LIG_PTB_Apo_2	26	33	PF02174	0.375
LIG_PTB_Apo_2	88	95	PF02174	0.394
LIG_PTB_Phospho_1	88	94	PF10480	0.402
LIG_SH2_CRK	42	46	PF00017	0.432
LIG_SH2_SRC	228	231	PF00017	0.478
LIG_SH2_SRC	423	426	PF00017	0.535
LIG_SH2_SRC	495	498	PF00017	0.552
LIG_SH2_SRC	94	97	PF00017	0.353
LIG_SH2_STAP1	397	401	PF00017	0.442
LIG_SH2_STAP1	431	435	PF00017	0.431
LIG_SH2_STAP1	470	474	PF00017	0.535
LIG_SH2_STAP1	66	70	PF00017	0.431
LIG_SH2_STAT5	130	133	PF00017	0.574
LIG_SH2_STAT5	228	231	PF00017	0.354
LIG_SH2_STAT5	42	45	PF00017	0.358
LIG_SH2_STAT5	423	426	PF00017	0.535
LIG_SH2_STAT5	47	50	PF00017	0.294
LIG_SH2_STAT5	470	473	PF00017	0.442
LIG_SH2_STAT5	495	498	PF00017	0.574
LIG_SH2_STAT5	76	79	PF00017	0.331
LIG_SH2_STAT5	94	97	PF00017	0.278
LIG_SH3_3	338	344	PF00018	0.661
LIG_SH3_3	367	373	PF00018	0.587
LIG_SH3_3	375	381	PF00018	0.466
LIG_SH3_3	72	78	PF00018	0.315
LIG_SUMO_SIM_anti_2	253	258	PF11976	0.432
LIG_SUMO_SIM_par_1	178	184	PF11976	0.406
LIG_SUMO_SIM_par_1	286	292	PF11976	0.548
LIG_SUMO_SIM_par_1	530	537	PF11976	0.512
LIG_TRAF2_1	190	193	PF00917	0.537
LIG_TRAF2_1	247	250	PF00917	0.680
LIG_TRAF2_1	271	274	PF00917	0.644
LIG_TRAF2_1	360	363	PF00917	0.427
LIG_TRAF2_1	568	571	PF00917	0.479
MOD_CK1_1	405	411	PF00069	0.501
MOD_CK1_1	533	539	PF00069	0.599
MOD_CK2_1	186	192	PF00069	0.406
MOD_CK2_1	215	221	PF00069	0.440
MOD_CK2_1	244	250	PF00069	0.670
MOD_CK2_1	314	320	PF00069	0.678
MOD_CK2_1	357	363	PF00069	0.442
MOD_CK2_1	377	383	PF00069	0.535
MOD_CK2_1	480	486	PF00069	0.535
MOD_CK2_1	522	528	PF00069	0.501
MOD_CK2_1	565	571	PF00069	0.541
MOD_GlcNHglycan	141	144	PF01048	0.585
MOD_GlcNHglycan	164	167	PF01048	0.400
MOD_GlcNHglycan	21	24	PF01048	0.362
MOD_GlcNHglycan	246	249	PF01048	0.648
MOD_GlcNHglycan	291	294	PF01048	0.651
MOD_GlcNHglycan	403	407	PF01048	0.335
MOD_GlcNHglycan	540	543	PF01048	0.586
MOD_GSK3_1	107	114	PF00069	0.641
MOD_GSK3_1	135	142	PF00069	0.635
MOD_GSK3_1	353	360	PF00069	0.494
MOD_GSK3_1	37	44	PF00069	0.421
MOD_GSK3_1	415	422	PF00069	0.440
MOD_GSK3_1	524	531	PF00069	0.472
MOD_GSK3_1	534	541	PF00069	0.581
MOD_N-GLC_1	112	117	PF02516	0.534
MOD_N-GLC_1	412	417	PF02516	0.278
MOD_N-GLC_1	468	473	PF02516	0.262
MOD_NEK2_1	19	24	PF00069	0.441
MOD_NEK2_1	257	262	PF00069	0.493
MOD_NEK2_1	490	495	PF00069	0.500
MOD_NEK2_1	530	535	PF00069	0.528
MOD_NEK2_2	426	431	PF00069	0.478
MOD_PIKK_1	34	40	PF00454	0.395
MOD_PIKK_1	412	418	PF00454	0.564
MOD_PIKK_1	6	12	PF00454	0.402
MOD_PKA_1	551	557	PF00069	0.379
MOD_PKA_2	101	107	PF00069	0.490
MOD_PKA_2	62	68	PF00069	0.405
MOD_Plk_1	135	141	PF00069	0.547
MOD_Plk_1	274	280	PF00069	0.652
MOD_Plk_1	412	418	PF00069	0.478
MOD_Plk_1	468	474	PF00069	0.462
MOD_Plk_2-3	178	184	PF00069	0.536
MOD_Plk_2-3	62	68	PF00069	0.483
MOD_Plk_4	101	107	PF00069	0.490
MOD_Plk_4	252	258	PF00069	0.440
MOD_Plk_4	275	281	PF00069	0.665
MOD_Plk_4	286	292	PF00069	0.629
MOD_Plk_4	407	413	PF00069	0.457
MOD_Plk_4	419	425	PF00069	0.483
MOD_Plk_4	426	432	PF00069	0.538
MOD_Plk_4	490	496	PF00069	0.442
MOD_Plk_4	542	548	PF00069	0.492
MOD_Plk_4	551	557	PF00069	0.385
MOD_Plk_4	71	77	PF00069	0.324
MOD_ProDKin_1	377	383	PF00069	0.496
MOD_ProDKin_1	41	47	PF00069	0.476
MOD_ProDKin_1	415	421	PF00069	0.431
MOD_SUMO_rev_2	292	301	PF00179	0.544
MOD_SUMO_rev_2	483	490	PF00179	0.498
MOD_SUMO_rev_2	545	553	PF00179	0.502
TRG_DiLeu_BaEn_1	275	280	PF01217	0.663
TRG_DiLeu_BaEn_1	363	368	PF01217	0.474
TRG_DiLeu_BaEn_1	486	491	PF01217	0.535
TRG_DiLeu_BaEn_4	192	198	PF01217	0.424
TRG_DiLeu_BaEn_4	249	255	PF01217	0.513
TRG_DiLeu_BaEn_4	275	281	PF01217	0.584
TRG_DiLeu_BaLyEn_6	298	303	PF01217	0.510
TRG_DiLeu_BaLyEn_6	371	376	PF01217	0.434
TRG_DiLeu_BaLyEn_6	460	465	PF01217	0.442
TRG_DiLeu_BaLyEn_6	495	500	PF01217	0.431
TRG_DiLeu_BaLyEn_6	509	514	PF01217	0.431
TRG_ENDOCYTIC_2	397	400	PF00928	0.431
TRG_ENDOCYTIC_2	47	50	PF00928	0.309
TRG_ER_diArg_1	194	196	PF00400	0.516
TRG_ER_diArg_1	344	347	PF00400	0.512
TRG_ER_diArg_1	476	479	PF00400	0.442
TRG_ER_diArg_1	48	51	PF00400	0.398
TRG_Pf-PMV_PEXEL_1	300	304	PF00026	0.458

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0Y0	Leptomonas seymouri	66%	99%
A0A0S4IU29	Bodo saltans	37%	100%
A0A1X0NS82	Trypanosomatidae	47%	100%
A0A422P315	Trypanosoma rangeli	48%	100%
A4HL18	Leishmania braziliensis	81%	100%
A4I8J9	Leishmania infantum	99%	100%
D0AAM0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9B3F9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q4P1	Leishmania major	93%	100%
V5BR05	Trypanosoma cruzi	48%	100%