LeishMANIAdb
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Mitochondrial pyruvate carrier

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Mitochondrial pyruvate carrier
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7X678_LEIDO
TriTrypDb:
LdBPK_323770.1 , LdCL_320043700 , LDHU3_32.4770
Length:
147

Annotations

LeishMANIAdb annotations

This small protein family has no close known relatives. They might not even be membrane proteins.

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
TermNameLevelCount
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6
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Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A0A3S7X678
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X678

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_PCSK_SKI1_1 142 146 PF00082 0.599
DEG_APCC_DBOX_1 59 67 PF00400 0.619
DOC_PP1_RVXF_1 22 28 PF00149 0.542
DOC_PP4_FxxP_1 96 99 PF00568 0.390
DOC_PP4_MxPP_1 1 4 PF00568 0.557
DOC_USP7_MATH_1 4 8 PF00917 0.556
LIG_14-3-3_CanoR_1 24 28 PF00244 0.648
LIG_14-3-3_CanoR_1 46 52 PF00244 0.548
LIG_BIR_II_1 1 5 PF00653 0.555
LIG_BIR_III_1 1 5 PF00653 0.555
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1IJP5 Leptomonas seymouri 86% 100%
A0A0S4JRP2 Bodo saltans 67% 100%
A0A1X0NRX4 Trypanosomatidae 65% 100%
A0A422P365 Trypanosoma rangeli 66% 100%
A4HL00 Leishmania braziliensis 93% 100%
A4I8I1 Leishmania infantum 100% 100%
D0AAN5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 69% 100%
E9B3E1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
Q4Q4R1 Leishmania major 97% 100%
V5B5U3 Trypanosoma cruzi 67% 100%
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Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS