Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X650_LEIDO

TriTrypDb:

LdBPK_323540.1 , LdCL_320041300 , LDHU3_32.4470

Length:

1111

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X650

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X650

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1103	1107	PF00656	0.606
CLV_C14_Caspase3-7	317	321	PF00656	0.668
CLV_C14_Caspase3-7	357	361	PF00656	0.466
CLV_C14_Caspase3-7	447	451	PF00656	0.588
CLV_C14_Caspase3-7	544	548	PF00656	0.512
CLV_NRD_NRD_1	1086	1088	PF00675	0.676
CLV_NRD_NRD_1	1098	1100	PF00675	0.554
CLV_NRD_NRD_1	13	15	PF00675	0.549
CLV_NRD_NRD_1	374	376	PF00675	0.523
CLV_NRD_NRD_1	528	530	PF00675	0.583
CLV_NRD_NRD_1	685	687	PF00675	0.582
CLV_NRD_NRD_1	900	902	PF00675	0.755
CLV_NRD_NRD_1	989	991	PF00675	0.595
CLV_PCSK_KEX2_1	1086	1088	PF00082	0.722
CLV_PCSK_KEX2_1	13	15	PF00082	0.443
CLV_PCSK_KEX2_1	374	376	PF00082	0.525
CLV_PCSK_KEX2_1	528	530	PF00082	0.549
CLV_PCSK_KEX2_1	609	611	PF00082	0.542
CLV_PCSK_KEX2_1	685	687	PF00082	0.582
CLV_PCSK_KEX2_1	900	902	PF00082	0.755
CLV_PCSK_KEX2_1	989	991	PF00082	0.618
CLV_PCSK_PC1ET2_1	609	611	PF00082	0.542
CLV_PCSK_SKI1_1	1048	1052	PF00082	0.600
CLV_PCSK_SKI1_1	1102	1106	PF00082	0.707
CLV_PCSK_SKI1_1	151	155	PF00082	0.593
CLV_PCSK_SKI1_1	254	258	PF00082	0.525
CLV_PCSK_SKI1_1	337	341	PF00082	0.702
CLV_PCSK_SKI1_1	375	379	PF00082	0.513
CLV_PCSK_SKI1_1	504	508	PF00082	0.538
CLV_PCSK_SKI1_1	613	617	PF00082	0.486
CLV_PCSK_SKI1_1	956	960	PF00082	0.612
DEG_APCC_DBOX_1	1058	1066	PF00400	0.673
DEG_APCC_DBOX_1	503	511	PF00400	0.489
DEG_Nend_Nbox_1	1	3	PF02207	0.479
DEG_SCF_FBW7_1	572	579	PF00400	0.551
DEG_SPOP_SBC_1	312	316	PF00917	0.548
DEG_SPOP_SBC_1	708	712	PF00917	0.647
DOC_CKS1_1	573	578	PF01111	0.564
DOC_CYCLIN_RxL_1	28	36	PF00134	0.549
DOC_CYCLIN_RxL_1	385	396	PF00134	0.535
DOC_CYCLIN_RxL_1	819	833	PF00134	0.637
DOC_CYCLIN_yCln2_LP_2	869	872	PF00134	0.732
DOC_CYCLIN_yCln2_LP_2	947	953	PF00134	0.556
DOC_MAPK_DCC_7	992	1001	PF00069	0.446
DOC_MAPK_gen_1	1102	1110	PF00069	0.672
DOC_MAPK_gen_1	29	37	PF00069	0.514
DOC_MAPK_gen_1	821	829	PF00069	0.551
DOC_MAPK_MEF2A_6	1059	1067	PF00069	0.606
DOC_MAPK_MEF2A_6	277	286	PF00069	0.410
DOC_MAPK_MEF2A_6	29	37	PF00069	0.509
DOC_PP1_RVXF_1	669	676	PF00149	0.532
DOC_PP2B_LxvP_1	116	119	PF13499	0.572
DOC_PP2B_LxvP_1	510	513	PF13499	0.575
DOC_PP2B_LxvP_1	869	872	PF13499	0.694
DOC_PP2B_LxvP_1	947	950	PF13499	0.546
DOC_PP2B_PxIxI_1	565	571	PF00149	0.540
DOC_USP7_MATH_1	1024	1028	PF00917	0.659
DOC_USP7_MATH_1	1089	1093	PF00917	0.736
DOC_USP7_MATH_1	119	123	PF00917	0.584
DOC_USP7_MATH_1	153	157	PF00917	0.527
DOC_USP7_MATH_1	174	178	PF00917	0.693
DOC_USP7_MATH_1	282	286	PF00917	0.444
DOC_USP7_MATH_1	312	316	PF00917	0.611
DOC_USP7_MATH_1	355	359	PF00917	0.614
DOC_USP7_MATH_1	51	55	PF00917	0.655
DOC_USP7_MATH_1	511	515	PF00917	0.639
DOC_USP7_MATH_1	65	69	PF00917	0.704
DOC_USP7_MATH_1	687	691	PF00917	0.663
DOC_USP7_MATH_1	708	712	PF00917	0.765
DOC_USP7_MATH_1	893	897	PF00917	0.770
DOC_WW_Pin1_4	1072	1077	PF00397	0.624
DOC_WW_Pin1_4	262	267	PF00397	0.588
DOC_WW_Pin1_4	290	295	PF00397	0.609
DOC_WW_Pin1_4	410	415	PF00397	0.768
DOC_WW_Pin1_4	428	433	PF00397	0.502
DOC_WW_Pin1_4	572	577	PF00397	0.552
DOC_WW_Pin1_4	77	82	PF00397	0.669
LIG_14-3-3_CanoR_1	1038	1044	PF00244	0.602
LIG_14-3-3_CanoR_1	1099	1105	PF00244	0.707
LIG_14-3-3_CanoR_1	254	260	PF00244	0.503
LIG_14-3-3_CanoR_1	302	311	PF00244	0.567
LIG_14-3-3_CanoR_1	337	342	PF00244	0.749
LIG_14-3-3_CanoR_1	34	38	PF00244	0.568
LIG_14-3-3_CanoR_1	374	382	PF00244	0.557
LIG_14-3-3_CanoR_1	577	583	PF00244	0.543
LIG_14-3-3_CanoR_1	613	622	PF00244	0.465
LIG_14-3-3_CanoR_1	746	752	PF00244	0.461
LIG_14-3-3_CanoR_1	792	798	PF00244	0.498
LIG_14-3-3_CanoR_1	823	828	PF00244	0.578
LIG_14-3-3_CanoR_1	842	849	PF00244	0.457
LIG_Actin_WH2_2	21	36	PF00022	0.461
LIG_Actin_WH2_2	382	400	PF00022	0.571
LIG_Actin_WH2_2	620	636	PF00022	0.530
LIG_Actin_WH2_2	726	744	PF00022	0.390
LIG_Actin_WH2_2	764	780	PF00022	0.461
LIG_BIR_III_4	360	364	PF00653	0.574
LIG_BRCT_BRCA1_1	444	448	PF00533	0.292
LIG_Clathr_ClatBox_1	194	198	PF01394	0.541
LIG_EH1_1	496	504	PF00400	0.467
LIG_FHA_1	1001	1007	PF00498	0.661
LIG_FHA_1	333	339	PF00498	0.740
LIG_FHA_1	479	485	PF00498	0.508
LIG_FHA_1	567	573	PF00498	0.564
LIG_FHA_1	582	588	PF00498	0.494
LIG_FHA_1	736	742	PF00498	0.389
LIG_FHA_1	746	752	PF00498	0.390
LIG_FHA_1	784	790	PF00498	0.519
LIG_FHA_1	824	830	PF00498	0.484
LIG_FHA_1	832	838	PF00498	0.558
LIG_FHA_1	968	974	PF00498	0.643
LIG_FHA_1	977	983	PF00498	0.544
LIG_FHA_2	429	435	PF00498	0.669
LIG_FHA_2	577	583	PF00498	0.606
LIG_FHA_2	612	618	PF00498	0.493
LIG_FHA_2	724	730	PF00498	0.382
LIG_FHA_2	794	800	PF00498	0.526
LIG_FHA_2	957	963	PF00498	0.629
LIG_FHA_2	970	976	PF00498	0.661
LIG_GBD_Chelix_1	192	200	PF00786	0.473
LIG_HP1_1	282	286	PF01393	0.432
LIG_LIR_Apic_2	1027	1033	PF02991	0.654
LIG_LIR_Apic_2	156	160	PF02991	0.645
LIG_LIR_Apic_2	261	266	PF02991	0.595
LIG_LIR_Gen_1	736	745	PF02991	0.534
LIG_LIR_Gen_1	773	780	PF02991	0.488
LIG_LIR_Gen_1	807	815	PF02991	0.523
LIG_LIR_Gen_1	914	925	PF02991	0.554
LIG_LIR_Nem_3	243	248	PF02991	0.477
LIG_LIR_Nem_3	518	523	PF02991	0.435
LIG_LIR_Nem_3	736	740	PF02991	0.496
LIG_LIR_Nem_3	76	82	PF02991	0.732
LIG_LIR_Nem_3	773	777	PF02991	0.460
LIG_LIR_Nem_3	807	812	PF02991	0.505
LIG_LIR_Nem_3	914	920	PF02991	0.550
LIG_LIR_Nem_3	95	101	PF02991	0.302
LIG_LYPXL_yS_3	394	397	PF13949	0.587
LIG_NRBOX	385	391	PF00104	0.516
LIG_NRBOX	582	588	PF00104	0.512
LIG_NRBOX	729	735	PF00104	0.420
LIG_NRBOX	88	94	PF00104	0.406
LIG_PCNA_yPIPBox_3	577	587	PF02747	0.429
LIG_Pex14_1	1030	1034	PF04695	0.703
LIG_Pex14_2	735	739	PF04695	0.483
LIG_Pex14_2	913	917	PF04695	0.530
LIG_PTAP_UEV_1	894	899	PF05743	0.637
LIG_SH2_CRK	1034	1038	PF00017	0.674
LIG_SH2_CRK	157	161	PF00017	0.660
LIG_SH2_CRK	520	524	PF00017	0.479
LIG_SH2_CRK	772	776	PF00017	0.383
LIG_SH2_SRC	221	224	PF00017	0.558
LIG_SH2_STAP1	505	509	PF00017	0.510
LIG_SH2_STAT3	661	664	PF00017	0.447
LIG_SH2_STAT5	1034	1037	PF00017	0.675
LIG_SH2_STAT5	157	160	PF00017	0.658
LIG_SH2_STAT5	221	224	PF00017	0.532
LIG_SH2_STAT5	263	266	PF00017	0.494
LIG_SH2_STAT5	645	648	PF00017	0.464
LIG_SH2_STAT5	661	664	PF00017	0.300
LIG_SH2_STAT5	82	85	PF00017	0.586
LIG_SH2_STAT5	98	101	PF00017	0.314
LIG_SH3_2	1033	1038	PF14604	0.669
LIG_SH3_2	471	476	PF14604	0.558
LIG_SH3_2	895	900	PF14604	0.635
LIG_SH3_3	1030	1036	PF00018	0.676
LIG_SH3_3	422	428	PF00018	0.673
LIG_SH3_3	468	474	PF00018	0.792
LIG_SH3_3	510	516	PF00018	0.601
LIG_SH3_3	865	871	PF00018	0.764
LIG_SH3_3	887	893	PF00018	0.722
LIG_SH3_3	904	910	PF00018	0.653
LIG_SH3_3	992	998	PF00018	0.666
LIG_SH3_CIN85_PxpxPR_1	424	429	PF14604	0.547
LIG_SUMO_SIM_anti_2	1061	1068	PF11976	0.504
LIG_SUMO_SIM_anti_2	285	291	PF11976	0.577
LIG_SUMO_SIM_anti_2	826	834	PF11976	0.585
LIG_SUMO_SIM_par_1	192	198	PF11976	0.557
LIG_SUMO_SIM_par_1	948	955	PF11976	0.673
LIG_SUMO_SIM_par_1	997	1003	PF11976	0.564
LIG_TRAF2_1	40	43	PF00917	0.559
LIG_TRAF2_1	593	596	PF00917	0.551
LIG_TRAF2_1	616	619	PF00917	0.547
LIG_TYR_ITIM	392	397	PF00017	0.574
LIG_TYR_ITIM	96	101	PF00017	0.422
LIG_TYR_ITSM	516	523	PF00017	0.494
LIG_UBA3_1	586	594	PF00899	0.432
LIG_UBA3_1	751	756	PF00899	0.510
LIG_WRC_WIRS_1	222	227	PF05994	0.464
LIG_WRC_WIRS_1	443	448	PF05994	0.292
LIG_WRC_WIRS_1	734	739	PF05994	0.411
LIG_WRC_WIRS_1	771	776	PF05994	0.455
LIG_WW_3	1035	1039	PF00397	0.651
MOD_CDK_SPK_2	572	577	PF00069	0.552
MOD_CK1_1	1012	1018	PF00069	0.668
MOD_CK1_1	117	123	PF00069	0.544
MOD_CK1_1	177	183	PF00069	0.736
MOD_CK1_1	258	264	PF00069	0.512
MOD_CK1_1	314	320	PF00069	0.667
MOD_CK1_1	330	336	PF00069	0.573
MOD_CK1_1	63	69	PF00069	0.710
MOD_CK1_1	690	696	PF00069	0.676
MOD_CK1_1	707	713	PF00069	0.769
MOD_CK1_1	80	86	PF00069	0.602
MOD_CK1_1	807	813	PF00069	0.462
MOD_CK1_1	850	856	PF00069	0.464
MOD_CK1_1	967	973	PF00069	0.680
MOD_CK2_1	37	43	PF00069	0.593
MOD_CK2_1	428	434	PF00069	0.661
MOD_CK2_1	51	57	PF00069	0.484
MOD_CK2_1	531	537	PF00069	0.664
MOD_CK2_1	576	582	PF00069	0.616
MOD_CK2_1	611	617	PF00069	0.486
MOD_CK2_1	793	799	PF00069	0.528
MOD_CK2_1	960	966	PF00069	0.637
MOD_CK2_1	969	975	PF00069	0.683
MOD_Cter_Amidation	1084	1087	PF01082	0.759
MOD_GlcNHglycan	1014	1017	PF01048	0.749
MOD_GlcNHglycan	1026	1029	PF01048	0.596
MOD_GlcNHglycan	103	106	PF01048	0.377
MOD_GlcNHglycan	1052	1055	PF01048	0.718
MOD_GlcNHglycan	1087	1090	PF01048	0.711
MOD_GlcNHglycan	1091	1094	PF01048	0.648
MOD_GlcNHglycan	116	119	PF01048	0.500
MOD_GlcNHglycan	172	175	PF01048	0.706
MOD_GlcNHglycan	304	307	PF01048	0.564
MOD_GlcNHglycan	316	319	PF01048	0.658
MOD_GlcNHglycan	327	330	PF01048	0.675
MOD_GlcNHglycan	357	360	PF01048	0.608
MOD_GlcNHglycan	398	401	PF01048	0.642
MOD_GlcNHglycan	410	413	PF01048	0.759
MOD_GlcNHglycan	53	56	PF01048	0.655
MOD_GlcNHglycan	629	632	PF01048	0.592
MOD_GlcNHglycan	689	692	PF01048	0.644
MOD_GlcNHglycan	706	709	PF01048	0.784
MOD_GlcNHglycan	760	763	PF01048	0.441
MOD_GlcNHglycan	852	855	PF01048	0.483
MOD_GlcNHglycan	86	89	PF01048	0.484
MOD_GlcNHglycan	895	898	PF01048	0.745
MOD_GlcNHglycan	940	943	PF01048	0.497
MOD_GSK3_1	1085	1092	PF00069	0.688
MOD_GSK3_1	149	156	PF00069	0.567
MOD_GSK3_1	170	177	PF00069	0.721
MOD_GSK3_1	254	261	PF00069	0.475
MOD_GSK3_1	323	330	PF00069	0.683
MOD_GSK3_1	33	40	PF00069	0.461
MOD_GSK3_1	337	344	PF00069	0.647
MOD_GSK3_1	406	413	PF00069	0.732
MOD_GSK3_1	457	464	PF00069	0.642
MOD_GSK3_1	511	518	PF00069	0.543
MOD_GSK3_1	527	534	PF00069	0.484
MOD_GSK3_1	572	579	PF00069	0.605
MOD_GSK3_1	704	711	PF00069	0.719
MOD_GSK3_1	73	80	PF00069	0.717
MOD_GSK3_1	741	748	PF00069	0.493
MOD_GSK3_1	804	811	PF00069	0.390
MOD_GSK3_1	938	945	PF00069	0.497
MOD_GSK3_1	956	963	PF00069	0.442
MOD_N-GLC_1	290	295	PF02516	0.609
MOD_N-GLC_2	846	848	PF02516	0.523
MOD_NEK2_1	101	106	PF00069	0.552
MOD_NEK2_1	1039	1044	PF00069	0.533
MOD_NEK2_1	1050	1055	PF00069	0.523
MOD_NEK2_1	126	131	PF00069	0.443
MOD_NEK2_1	149	154	PF00069	0.546
MOD_NEK2_1	185	190	PF00069	0.556
MOD_NEK2_1	24	29	PF00069	0.511
MOD_NEK2_1	313	318	PF00069	0.638
MOD_NEK2_1	33	38	PF00069	0.497
MOD_NEK2_1	581	586	PF00069	0.519
MOD_NEK2_1	627	632	PF00069	0.445
MOD_NEK2_1	633	638	PF00069	0.443
MOD_NEK2_1	733	738	PF00069	0.439
MOD_NEK2_1	741	746	PF00069	0.465
MOD_NEK2_1	757	762	PF00069	0.327
MOD_NEK2_1	808	813	PF00069	0.559
MOD_NEK2_1	829	834	PF00069	0.606
MOD_NEK2_1	92	97	PF00069	0.566
MOD_NEK2_1	976	981	PF00069	0.686
MOD_PIKK_1	185	191	PF00454	0.629
MOD_PIKK_1	255	261	PF00454	0.521
MOD_PIKK_1	436	442	PF00454	0.546
MOD_PIKK_1	511	517	PF00454	0.530
MOD_PIKK_1	576	582	PF00454	0.555
MOD_PIKK_1	604	610	PF00454	0.456
MOD_PIKK_1	633	639	PF00454	0.543
MOD_PIKK_1	674	680	PF00454	0.507
MOD_PIKK_1	710	716	PF00454	0.701
MOD_PIKK_1	745	751	PF00454	0.529
MOD_PK_1	1100	1106	PF00069	0.614
MOD_PKA_1	1094	1100	PF00069	0.665
MOD_PKA_2	1012	1018	PF00069	0.723
MOD_PKA_2	1085	1091	PF00069	0.683
MOD_PKA_2	33	39	PF00069	0.572
MOD_PKA_2	527	533	PF00069	0.615
MOD_PKA_2	576	582	PF00069	0.553
MOD_PKA_2	633	639	PF00069	0.532
MOD_PKA_2	741	747	PF00069	0.525
MOD_PKA_2	841	847	PF00069	0.457
MOD_Plk_1	300	306	PF00069	0.580
MOD_Plk_1	489	495	PF00069	0.614
MOD_Plk_1	581	587	PF00069	0.523
MOD_Plk_1	954	960	PF00069	0.538
MOD_Plk_4	282	288	PF00069	0.453
MOD_Plk_4	515	521	PF00069	0.550
MOD_Plk_4	770	776	PF00069	0.439
MOD_Plk_4	804	810	PF00069	0.447
MOD_ProDKin_1	1072	1078	PF00069	0.627
MOD_ProDKin_1	262	268	PF00069	0.582
MOD_ProDKin_1	290	296	PF00069	0.615
MOD_ProDKin_1	410	416	PF00069	0.772
MOD_ProDKin_1	428	434	PF00069	0.494
MOD_ProDKin_1	572	578	PF00069	0.555
MOD_ProDKin_1	77	83	PF00069	0.655
MOD_SUMO_for_1	593	596	PF00179	0.551
MOD_SUMO_rev_2	1075	1084	PF00179	0.758
TRG_DiLeu_BaEn_1	109	114	PF01217	0.540
TRG_DiLeu_BaEn_1	582	587	PF01217	0.514
TRG_DiLeu_BaLyEn_6	145	150	PF01217	0.482
TRG_DiLeu_BaLyEn_6	181	186	PF01217	0.689
TRG_DiLeu_BaLyEn_6	385	390	PF01217	0.514
TRG_DiLeu_BaLyEn_6	505	510	PF01217	0.563
TRG_DiLeu_BaLyEn_6	920	925	PF01217	0.554
TRG_ENDOCYTIC_2	245	248	PF00928	0.479
TRG_ENDOCYTIC_2	276	279	PF00928	0.523
TRG_ENDOCYTIC_2	394	397	PF00928	0.596
TRG_ENDOCYTIC_2	520	523	PF00928	0.477
TRG_ENDOCYTIC_2	772	775	PF00928	0.374
TRG_ENDOCYTIC_2	98	101	PF00928	0.429
TRG_ER_diArg_1	12	14	PF00400	0.531
TRG_ER_diArg_1	374	376	PF00400	0.535
TRG_ER_diArg_1	527	529	PF00400	0.571
TRG_ER_diArg_1	684	686	PF00400	0.555
TRG_ER_diArg_1	822	825	PF00400	0.569
TRG_ER_diArg_1	899	901	PF00400	0.552
TRG_ER_diArg_1	988	990	PF00400	0.613
TRG_NES_CRM1_1	26	38	PF08389	0.484
TRG_NES_CRM1_1	660	674	PF08389	0.512
TRG_NLS_Bipartite_1	1086	1103	PF00514	0.732
TRG_Pf-PMV_PEXEL_1	543	547	PF00026	0.584
TRG_Pf-PMV_PEXEL_1	613	617	PF00026	0.567

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB94	Leptomonas seymouri	56%	100%
A0A0S4JFQ5	Bodo saltans	25%	100%
A0A1X0NTJ4	Trypanosomatidae	32%	100%
A4HKX9	Leishmania braziliensis	83%	99%
A4I8F9	Leishmania infantum	99%	100%
D0AAR1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9B3B7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q4T8	Leishmania major	94%	100%
V5B5Q4	Trypanosoma cruzi	31%	100%