Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X647_LEIDO

TriTrypDb:

LdBPK_323480.1 , LdCL_320040700 , LDHU3_32.4410

Length:

834

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X647

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X647

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	464	468	PF00656	0.550
CLV_NRD_NRD_1	314	316	PF00675	0.602
CLV_NRD_NRD_1	441	443	PF00675	0.573
CLV_NRD_NRD_1	496	498	PF00675	0.675
CLV_NRD_NRD_1	515	517	PF00675	0.574
CLV_NRD_NRD_1	601	603	PF00675	0.614
CLV_NRD_NRD_1	677	679	PF00675	0.637
CLV_PCSK_KEX2_1	314	316	PF00082	0.602
CLV_PCSK_KEX2_1	441	443	PF00082	0.573
CLV_PCSK_KEX2_1	487	489	PF00082	0.607
CLV_PCSK_KEX2_1	496	498	PF00082	0.579
CLV_PCSK_KEX2_1	601	603	PF00082	0.614
CLV_PCSK_KEX2_1	676	678	PF00082	0.643
CLV_PCSK_KEX2_1	790	792	PF00082	0.598
CLV_PCSK_KEX2_1	828	830	PF00082	0.667
CLV_PCSK_PC1ET2_1	487	489	PF00082	0.594
CLV_PCSK_PC1ET2_1	790	792	PF00082	0.637
CLV_PCSK_PC1ET2_1	828	830	PF00082	0.667
CLV_PCSK_PC7_1	672	678	PF00082	0.618
CLV_PCSK_SKI1_1	162	166	PF00082	0.607
CLV_PCSK_SKI1_1	221	225	PF00082	0.671
CLV_PCSK_SKI1_1	315	319	PF00082	0.516
CLV_PCSK_SKI1_1	382	386	PF00082	0.630
CLV_PCSK_SKI1_1	425	429	PF00082	0.594
CLV_PCSK_SKI1_1	634	638	PF00082	0.630
CLV_PCSK_SKI1_1	677	681	PF00082	0.643
CLV_PCSK_SKI1_1	822	826	PF00082	0.605
DEG_APCC_DBOX_1	685	693	PF00400	0.537
DEG_COP1_1	378	390	PF00400	0.637
DEG_SPOP_SBC_1	635	639	PF00917	0.673
DEG_SPOP_SBC_1	807	811	PF00917	0.641
DOC_CKS1_1	211	216	PF01111	0.615
DOC_CKS1_1	397	402	PF01111	0.585
DOC_CKS1_1	58	63	PF01111	0.641
DOC_CYCLIN_RxL_1	715	724	PF00134	0.511
DOC_CYCLIN_yClb1_LxF_4	410	415	PF00134	0.602
DOC_CYCLIN_yCln2_LP_2	394	400	PF00134	0.602
DOC_MAPK_DCC_7	775	783	PF00069	0.603
DOC_MAPK_gen_1	558	567	PF00069	0.564
DOC_MAPK_MEF2A_6	356	365	PF00069	0.557
DOC_MAPK_MEF2A_6	558	567	PF00069	0.564
DOC_MAPK_MEF2A_6	775	783	PF00069	0.603
DOC_PP1_RVXF_1	410	416	PF00149	0.601
DOC_PP2B_LxvP_1	169	172	PF13499	0.565
DOC_PP2B_LxvP_1	394	397	PF13499	0.621
DOC_PP2B_LxvP_1	557	560	PF13499	0.607
DOC_PP2B_PxIxI_1	358	364	PF00149	0.558
DOC_PP4_FxxP_1	18	21	PF00568	0.598
DOC_PP4_FxxP_1	662	665	PF00568	0.557
DOC_USP7_MATH_1	102	106	PF00917	0.470
DOC_USP7_MATH_1	130	134	PF00917	0.529
DOC_USP7_MATH_1	172	176	PF00917	0.674
DOC_USP7_MATH_1	253	257	PF00917	0.572
DOC_USP7_MATH_1	327	331	PF00917	0.527
DOC_USP7_MATH_1	377	381	PF00917	0.654
DOC_USP7_MATH_1	398	402	PF00917	0.644
DOC_USP7_MATH_1	481	485	PF00917	0.592
DOC_USP7_MATH_1	511	515	PF00917	0.534
DOC_USP7_MATH_1	52	56	PF00917	0.664
DOC_USP7_MATH_1	566	570	PF00917	0.626
DOC_USP7_MATH_1	617	621	PF00917	0.598
DOC_USP7_MATH_1	635	639	PF00917	0.546
DOC_USP7_MATH_1	644	648	PF00917	0.728
DOC_USP7_MATH_1	695	699	PF00917	0.627
DOC_USP7_MATH_1	705	709	PF00917	0.530
DOC_USP7_MATH_1	716	720	PF00917	0.566
DOC_USP7_MATH_1	80	84	PF00917	0.550
DOC_USP7_MATH_1	802	806	PF00917	0.800
DOC_USP7_MATH_1	807	811	PF00917	0.667
DOC_USP7_MATH_2	272	278	PF00917	0.620
DOC_USP7_UBL2_3	786	790	PF12436	0.635
DOC_USP7_UBL2_3	822	826	PF12436	0.574
DOC_WW_Pin1_4	210	215	PF00397	0.618
DOC_WW_Pin1_4	216	221	PF00397	0.554
DOC_WW_Pin1_4	229	234	PF00397	0.546
DOC_WW_Pin1_4	396	401	PF00397	0.600
DOC_WW_Pin1_4	436	441	PF00397	0.563
DOC_WW_Pin1_4	473	478	PF00397	0.576
DOC_WW_Pin1_4	507	512	PF00397	0.619
DOC_WW_Pin1_4	54	59	PF00397	0.673
DOC_WW_Pin1_4	542	547	PF00397	0.584
DOC_WW_Pin1_4	583	588	PF00397	0.738
DOC_WW_Pin1_4	590	595	PF00397	0.587
DOC_WW_Pin1_4	606	611	PF00397	0.604
DOC_WW_Pin1_4	638	643	PF00397	0.599
DOC_WW_Pin1_4	684	689	PF00397	0.774
DOC_WW_Pin1_4	700	705	PF00397	0.527
DOC_WW_Pin1_4	71	76	PF00397	0.504
DOC_WW_Pin1_4	749	754	PF00397	0.660
DOC_WW_Pin1_4	791	796	PF00397	0.616
LIG_14-3-3_CanoR_1	144	153	PF00244	0.503
LIG_14-3-3_CanoR_1	202	208	PF00244	0.572
LIG_14-3-3_CanoR_1	221	226	PF00244	0.649
LIG_14-3-3_CanoR_1	227	233	PF00244	0.601
LIG_14-3-3_CanoR_1	314	318	PF00244	0.592
LIG_14-3-3_CanoR_1	412	418	PF00244	0.599
LIG_14-3-3_CanoR_1	634	644	PF00244	0.635
LIG_14-3-3_CanoR_1	771	779	PF00244	0.578
LIG_14-3-3_CterR_2	829	834	PF00244	0.573
LIG_BIR_III_2	550	554	PF00653	0.604
LIG_BRCT_BRCA1_1	62	66	PF00533	0.685
LIG_BRCT_BRCA1_1	658	662	PF00533	0.718
LIG_CaM_NSCaTE_8	495	502	PF13499	0.637
LIG_FHA_1	123	129	PF00498	0.530
LIG_FHA_1	15	21	PF00498	0.595
LIG_FHA_1	358	364	PF00498	0.599
LIG_FHA_1	408	414	PF00498	0.648
LIG_FHA_1	429	435	PF00498	0.634
LIG_FHA_1	474	480	PF00498	0.618
LIG_FHA_1	668	674	PF00498	0.560
LIG_FHA_1	77	83	PF00498	0.572
LIG_FHA_2	143	149	PF00498	0.540
LIG_FHA_2	442	448	PF00498	0.622
LIG_FHA_2	462	468	PF00498	0.482
LIG_FHA_2	48	54	PF00498	0.689
LIG_FHA_2	8	14	PF00498	0.557
LIG_LIR_Apic_2	17	21	PF02991	0.598
LIG_LIR_Apic_2	659	665	PF02991	0.564
LIG_LIR_Gen_1	13	23	PF02991	0.622
LIG_LIR_Gen_1	174	184	PF02991	0.499
LIG_LIR_Nem_3	13	19	PF02991	0.622
LIG_LIR_Nem_3	174	179	PF02991	0.521
LIG_LIR_Nem_3	83	88	PF02991	0.516
LIG_LYPXL_SIV_4	607	615	PF13949	0.565
LIG_PDZ_Class_2	829	834	PF00595	0.556
LIG_REV1ctd_RIR_1	138	148	PF16727	0.560
LIG_SH2_CRK	16	20	PF00017	0.642
LIG_SH2_NCK_1	608	612	PF00017	0.566
LIG_SH2_SRC	766	769	PF00017	0.538
LIG_SH2_STAP1	16	20	PF00017	0.642
LIG_SH2_STAP1	766	770	PF00017	0.538
LIG_SH2_STAT5	16	19	PF00017	0.642
LIG_SH2_STAT5	22	25	PF00017	0.576
LIG_SH3_1	604	610	PF00018	0.604
LIG_SH3_3	244	250	PF00018	0.565
LIG_SH3_3	275	281	PF00018	0.634
LIG_SH3_3	292	298	PF00018	0.481
LIG_SH3_3	307	313	PF00018	0.648
LIG_SH3_3	349	355	PF00018	0.630
LIG_SH3_3	394	400	PF00018	0.569
LIG_SH3_3	418	424	PF00018	0.562
LIG_SH3_3	437	443	PF00018	0.599
LIG_SH3_3	500	506	PF00018	0.644
LIG_SH3_3	533	539	PF00018	0.746
LIG_SH3_3	55	61	PF00018	0.601
LIG_SH3_3	556	562	PF00018	0.597
LIG_SH3_3	579	585	PF00018	0.592
LIG_SH3_3	604	610	PF00018	0.604
LIG_SH3_3	72	78	PF00018	0.568
LIG_SH3_4	786	793	PF00018	0.635
LIG_SH3_CIN85_PxpxPR_1	436	441	PF14604	0.583
LIG_SUMO_SIM_anti_2	360	367	PF11976	0.612
LIG_SUMO_SIM_par_1	297	304	PF11976	0.651
LIG_SUMO_SIM_par_1	563	571	PF11976	0.607
LIG_WRC_WIRS_1	657	662	PF05994	0.576
LIG_WW_3	526	530	PF00397	0.580
LIG_WW_3	558	562	PF00397	0.585
MOD_CDK_SPK_2	216	221	PF00069	0.611
MOD_CDK_SPK_2	436	441	PF00069	0.561
MOD_CDK_SPK_2	542	547	PF00069	0.582
MOD_CDK_SPK_2	638	643	PF00069	0.597
MOD_CDK_SPK_2	791	796	PF00069	0.616
MOD_CDK_SPxK_1	436	442	PF00069	0.563
MOD_CDK_SPxxK_3	229	236	PF00069	0.619
MOD_CDK_SPxxK_3	791	798	PF00069	0.621
MOD_CK1_1	219	225	PF00069	0.777
MOD_CK1_1	33	39	PF00069	0.669
MOD_CK1_1	375	381	PF00069	0.606
MOD_CK1_1	386	392	PF00069	0.814
MOD_CK1_1	401	407	PF00069	0.549
MOD_CK1_1	416	422	PF00069	0.549
MOD_CK1_1	426	432	PF00069	0.577
MOD_CK1_1	510	516	PF00069	0.565
MOD_CK1_1	57	63	PF00069	0.668
MOD_CK1_1	626	632	PF00069	0.612
MOD_CK1_1	638	644	PF00069	0.765
MOD_CK1_1	817	823	PF00069	0.608
MOD_CK2_1	142	148	PF00069	0.534
MOD_CK2_1	177	183	PF00069	0.540
MOD_CK2_1	192	198	PF00069	0.618
MOD_CK2_1	377	383	PF00069	0.635
MOD_CK2_1	441	447	PF00069	0.590
MOD_CK2_1	47	53	PF00069	0.672
MOD_CK2_1	56	62	PF00069	0.579
MOD_CK2_1	687	693	PF00069	0.583
MOD_CK2_1	7	13	PF00069	0.721
MOD_CK2_1	742	748	PF00069	0.553
MOD_CK2_1	762	768	PF00069	0.547
MOD_Cter_Amidation	485	488	PF01082	0.597
MOD_Cter_Amidation	788	791	PF01082	0.615
MOD_DYRK1A_RPxSP_1	229	233	PF00069	0.616
MOD_GlcNHglycan	128	131	PF01048	0.543
MOD_GlcNHglycan	154	157	PF01048	0.594
MOD_GlcNHglycan	244	247	PF01048	0.587
MOD_GlcNHglycan	25	28	PF01048	0.570
MOD_GlcNHglycan	310	313	PF01048	0.588
MOD_GlcNHglycan	329	332	PF01048	0.478
MOD_GlcNHglycan	379	382	PF01048	0.642
MOD_GlcNHglycan	401	404	PF01048	0.630
MOD_GlcNHglycan	428	431	PF01048	0.637
MOD_GlcNHglycan	50	53	PF01048	0.636
MOD_GlcNHglycan	574	577	PF01048	0.626
MOD_GlcNHglycan	638	641	PF01048	0.677
MOD_GlcNHglycan	646	649	PF01048	0.723
MOD_GlcNHglycan	651	654	PF01048	0.611
MOD_GlcNHglycan	693	696	PF01048	0.639
MOD_GlcNHglycan	707	710	PF01048	0.573
MOD_GlcNHglycan	772	775	PF01048	0.598
MOD_GlcNHglycan	804	807	PF01048	0.631
MOD_GlcNHglycan	817	820	PF01048	0.675
MOD_GSK3_1	122	129	PF00069	0.550
MOD_GSK3_1	219	226	PF00069	0.606
MOD_GSK3_1	35	42	PF00069	0.605
MOD_GSK3_1	372	379	PF00069	0.621
MOD_GSK3_1	382	389	PF00069	0.717
MOD_GSK3_1	399	406	PF00069	0.570
MOD_GSK3_1	44	51	PF00069	0.573
MOD_GSK3_1	461	468	PF00069	0.642
MOD_GSK3_1	507	514	PF00069	0.563
MOD_GSK3_1	52	59	PF00069	0.543
MOD_GSK3_1	568	575	PF00069	0.633
MOD_GSK3_1	617	624	PF00069	0.602
MOD_GSK3_1	62	69	PF00069	0.615
MOD_GSK3_1	634	641	PF00069	0.714
MOD_GSK3_1	644	651	PF00069	0.728
MOD_GSK3_1	687	694	PF00069	0.602
MOD_GSK3_1	695	702	PF00069	0.605
MOD_GSK3_1	732	739	PF00069	0.647
MOD_GSK3_1	74	81	PF00069	0.541
MOD_GSK3_1	802	809	PF00069	0.660
MOD_GSK3_1	813	820	PF00069	0.542
MOD_GSK3_1	84	91	PF00069	0.502
MOD_LATS_1	812	818	PF00433	0.629
MOD_N-GLC_1	407	412	PF02516	0.629
MOD_N-GLC_1	649	654	PF02516	0.615
MOD_N-GLC_1	814	819	PF02516	0.626
MOD_NEK2_1	223	228	PF00069	0.607
MOD_NEK2_1	30	35	PF00069	0.565
MOD_NEK2_1	372	377	PF00069	0.557
MOD_NEK2_1	413	418	PF00069	0.631
MOD_NEK2_1	428	433	PF00069	0.538
MOD_NEK2_1	465	470	PF00069	0.606
MOD_NEK2_1	597	602	PF00069	0.609
MOD_NEK2_1	623	628	PF00069	0.695
MOD_NEK2_1	636	641	PF00069	0.619
MOD_NEK2_1	658	663	PF00069	0.517
MOD_NEK2_1	66	71	PF00069	0.624
MOD_NEK2_1	770	775	PF00069	0.566
MOD_NEK2_2	313	318	PF00069	0.535
MOD_NEK2_2	511	516	PF00069	0.536
MOD_OFUCOSY	616	621	PF10250	0.534
MOD_PIKK_1	33	39	PF00454	0.553
MOD_PIKK_1	595	601	PF00454	0.679
MOD_PIKK_1	623	629	PF00454	0.633
MOD_PK_1	289	295	PF00069	0.613
MOD_PK_1	84	90	PF00069	0.535
MOD_PKA_1	441	447	PF00069	0.560
MOD_PKA_1	828	834	PF00069	0.629
MOD_PKA_2	157	163	PF00069	0.547
MOD_PKA_2	228	234	PF00069	0.619
MOD_PKA_2	313	319	PF00069	0.583
MOD_PKA_2	441	447	PF00069	0.565
MOD_PKA_2	770	776	PF00069	0.568
MOD_PKA_2	828	834	PF00069	0.599
MOD_Plk_1	274	280	PF00069	0.632
MOD_Plk_1	382	388	PF00069	0.629
MOD_Plk_1	66	72	PF00069	0.547
MOD_Plk_2-3	62	68	PF00069	0.598
MOD_Plk_4	14	20	PF00069	0.637
MOD_Plk_4	149	155	PF00069	0.627
MOD_Plk_4	253	259	PF00069	0.512
MOD_Plk_4	423	429	PF00069	0.586
MOD_ProDKin_1	210	216	PF00069	0.617
MOD_ProDKin_1	229	235	PF00069	0.640
MOD_ProDKin_1	396	402	PF00069	0.602
MOD_ProDKin_1	436	442	PF00069	0.564
MOD_ProDKin_1	473	479	PF00069	0.575
MOD_ProDKin_1	507	513	PF00069	0.617
MOD_ProDKin_1	54	60	PF00069	0.673
MOD_ProDKin_1	542	548	PF00069	0.585
MOD_ProDKin_1	583	589	PF00069	0.740
MOD_ProDKin_1	590	596	PF00069	0.589
MOD_ProDKin_1	606	612	PF00069	0.601
MOD_ProDKin_1	638	644	PF00069	0.598
MOD_ProDKin_1	684	690	PF00069	0.774
MOD_ProDKin_1	700	706	PF00069	0.528
MOD_ProDKin_1	71	77	PF00069	0.500
MOD_ProDKin_1	749	755	PF00069	0.664
MOD_ProDKin_1	791	797	PF00069	0.618
MOD_SUMO_rev_2	104	113	PF00179	0.492
TRG_DiLeu_BaEn_1	675	680	PF01217	0.604
TRG_DiLeu_BaLyEn_6	662	667	PF01217	0.555
TRG_DiLeu_LyEn_5	675	680	PF01217	0.528
TRG_ENDOCYTIC_2	16	19	PF00928	0.642
TRG_ER_diArg_1	313	315	PF00400	0.595
TRG_ER_diArg_1	440	442	PF00400	0.608
TRG_ER_diArg_1	495	497	PF00400	0.636
TRG_ER_diArg_1	601	604	PF00400	0.617
TRG_ER_diArg_1	676	678	PF00400	0.599
TRG_Pf-PMV_PEXEL_1	678	683	PF00026	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC13	Leptomonas seymouri	39%	99%
A4HKX3	Leishmania braziliensis	48%	100%
A4I8F3	Leishmania infantum	100%	100%
E9B3B1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q4U4	Leishmania major	87%	100%