Mitochondrial RNA binding protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial RNA binding protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X637_LEIDO

TriTrypDb:

LdBPK_323380.1 , LdCL_320039700 , LDHU3_32.4250

Length:

673

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X637

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X637

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	222	224	PF00675	0.549
CLV_NRD_NRD_1	269	271	PF00675	0.584
CLV_NRD_NRD_1	292	294	PF00675	0.644
CLV_NRD_NRD_1	396	398	PF00675	0.485
CLV_PCSK_KEX2_1	12	14	PF00082	0.653
CLV_PCSK_KEX2_1	222	224	PF00082	0.549
CLV_PCSK_KEX2_1	269	271	PF00082	0.584
CLV_PCSK_KEX2_1	291	293	PF00082	0.657
CLV_PCSK_KEX2_1	395	397	PF00082	0.583
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.653
CLV_PCSK_PC7_1	265	271	PF00082	0.567
CLV_PCSK_PC7_1	288	294	PF00082	0.605
CLV_PCSK_SKI1_1	12	16	PF00082	0.546
CLV_PCSK_SKI1_1	169	173	PF00082	0.501
CLV_PCSK_SKI1_1	222	226	PF00082	0.395
CLV_PCSK_SKI1_1	237	241	PF00082	0.436
CLV_PCSK_SKI1_1	265	269	PF00082	0.661
CLV_PCSK_SKI1_1	299	303	PF00082	0.577
CLV_PCSK_SKI1_1	318	322	PF00082	0.311
CLV_PCSK_SKI1_1	328	332	PF00082	0.407
CLV_PCSK_SKI1_1	336	340	PF00082	0.373
CLV_PCSK_SKI1_1	428	432	PF00082	0.599
CLV_PCSK_SKI1_1	499	503	PF00082	0.512
CLV_PCSK_SKI1_1	51	55	PF00082	0.414
CLV_PCSK_SKI1_1	522	526	PF00082	0.664
CLV_PCSK_SKI1_1	536	540	PF00082	0.362
CLV_PCSK_SKI1_1	571	575	PF00082	0.617
CLV_PCSK_SKI1_1	615	619	PF00082	0.525
CLV_Separin_Metazoa	333	337	PF03568	0.399
CLV_Separin_Metazoa	612	616	PF03568	0.410
DEG_APCC_DBOX_1	327	335	PF00400	0.416
DEG_APCC_DBOX_1	38	46	PF00400	0.601
DEG_APCC_DBOX_1	498	506	PF00400	0.505
DEG_APCC_DBOX_1	614	622	PF00400	0.535
DOC_ANK_TNKS_1	268	275	PF00023	0.586
DOC_CDC14_PxL_1	411	419	PF14671	0.592
DOC_CKS1_1	282	287	PF01111	0.681
DOC_CKS1_1	658	663	PF01111	0.626
DOC_CYCLIN_RxL_1	325	333	PF00134	0.542
DOC_CYCLIN_RxL_1	401	410	PF00134	0.457
DOC_CYCLIN_RxL_1	499	507	PF00134	0.502
DOC_CYCLIN_RxL_1	643	653	PF00134	0.404
DOC_CYCLIN_RxL_1	68	78	PF00134	0.541
DOC_CYCLIN_yClb5_NLxxxL_5	71	79	PF00134	0.536
DOC_MAPK_MEF2A_6	169	176	PF00069	0.502
DOC_MAPK_MEF2A_6	412	419	PF00069	0.607
DOC_MAPK_MEF2A_6	495	504	PF00069	0.510
DOC_MAPK_MEF2A_6	552	561	PF00069	0.489
DOC_MAPK_NFAT4_5	169	177	PF00069	0.440
DOC_MAPK_NFAT4_5	552	560	PF00069	0.460
DOC_PP1_RVXF_1	316	323	PF00149	0.539
DOC_PP1_RVXF_1	402	409	PF00149	0.441
DOC_PP4_FxxP_1	341	344	PF00568	0.510
DOC_USP7_MATH_1	258	262	PF00917	0.597
DOC_USP7_MATH_1	364	368	PF00917	0.649
DOC_USP7_MATH_1	594	598	PF00917	0.452
DOC_WW_Pin1_4	105	110	PF00397	0.536
DOC_WW_Pin1_4	2	7	PF00397	0.725
DOC_WW_Pin1_4	226	231	PF00397	0.536
DOC_WW_Pin1_4	281	286	PF00397	0.751
DOC_WW_Pin1_4	432	437	PF00397	0.618
DOC_WW_Pin1_4	476	481	PF00397	0.473
DOC_WW_Pin1_4	545	550	PF00397	0.379
DOC_WW_Pin1_4	657	662	PF00397	0.593
LIG_14-3-3_CanoR_1	120	124	PF00244	0.429
LIG_14-3-3_CanoR_1	141	151	PF00244	0.472
LIG_14-3-3_CanoR_1	395	400	PF00244	0.587
LIG_14-3-3_CanoR_1	503	512	PF00244	0.387
LIG_Actin_WH2_2	69	84	PF00022	0.423
LIG_APCC_ABBA_1	310	315	PF00400	0.515
LIG_BIR_III_4	271	275	PF00653	0.703
LIG_BRCT_BRCA1_1	220	224	PF00533	0.469
LIG_eIF4E_1	175	181	PF01652	0.524
LIG_FHA_1	109	115	PF00498	0.388
LIG_FHA_1	120	126	PF00498	0.443
LIG_FHA_1	143	149	PF00498	0.429
LIG_FHA_1	180	186	PF00498	0.551
LIG_FHA_1	192	198	PF00498	0.391
LIG_FHA_1	227	233	PF00498	0.488
LIG_FHA_1	238	244	PF00498	0.396
LIG_FHA_1	26	32	PF00498	0.585
LIG_FHA_1	3	9	PF00498	0.625
LIG_FHA_1	425	431	PF00498	0.615
LIG_FHA_1	461	467	PF00498	0.472
LIG_FHA_1	489	495	PF00498	0.431
LIG_FHA_1	580	586	PF00498	0.454
LIG_FHA_1	587	593	PF00498	0.352
LIG_FHA_1	76	82	PF00498	0.422
LIG_FHA_1	89	95	PF00498	0.402
LIG_FHA_2	162	168	PF00498	0.525
LIG_FHA_2	247	253	PF00498	0.499
LIG_FHA_2	282	288	PF00498	0.696
LIG_FHA_2	33	39	PF00498	0.600
LIG_FHA_2	602	608	PF00498	0.543
LIG_FHA_2	664	670	PF00498	0.693
LIG_LIR_Gen_1	111	118	PF02991	0.405
LIG_LIR_Gen_1	129	137	PF02991	0.376
LIG_LIR_Gen_1	551	562	PF02991	0.529
LIG_LIR_Nem_3	111	115	PF02991	0.563
LIG_LIR_Nem_3	126	131	PF02991	0.245
LIG_LIR_Nem_3	295	301	PF02991	0.590
LIG_LIR_Nem_3	3	7	PF02991	0.576
LIG_LIR_Nem_3	304	310	PF02991	0.412
LIG_LIR_Nem_3	409	414	PF02991	0.593
LIG_LIR_Nem_3	551	557	PF02991	0.448
LIG_LIR_Nem_3	63	67	PF02991	0.536
LIG_NRBOX	501	507	PF00104	0.495
LIG_PCNA_TLS_4	169	176	PF02747	0.497
LIG_Pex14_2	130	134	PF04695	0.427
LIG_Pex14_2	64	68	PF04695	0.441
LIG_PTAP_UEV_1	602	607	PF05743	0.516
LIG_PTB_Apo_2	211	218	PF02174	0.432
LIG_SH2_SRC	250	253	PF00017	0.508
LIG_SH2_STAP1	387	391	PF00017	0.562
LIG_SH2_STAT5	102	105	PF00017	0.345
LIG_SH2_STAT5	175	178	PF00017	0.567
LIG_SH2_STAT5	250	253	PF00017	0.486
LIG_SH2_STAT5	4	7	PF00017	0.674
LIG_SH2_STAT5	554	557	PF00017	0.393
LIG_SH2_STAT5	587	590	PF00017	0.344
LIG_SH2_STAT5	92	95	PF00017	0.438
LIG_SH3_3	274	280	PF00018	0.815
LIG_SH3_3	600	606	PF00018	0.527
LIG_SUMO_SIM_anti_2	147	153	PF11976	0.524
LIG_SUMO_SIM_par_1	589	597	PF11976	0.514
LIG_TRAF2_1	136	139	PF00917	0.450
LIG_TRAF2_1	490	493	PF00917	0.437
LIG_TRAF2_1	529	532	PF00917	0.613
LIG_TRAF2_2	276	281	PF00917	0.629
LIG_UBA3_1	170	177	PF00899	0.366
LIG_UBA3_1	75	82	PF00899	0.417
MOD_CDK_SPK_2	226	231	PF00069	0.536
MOD_CDK_SPxxK_3	281	288	PF00069	0.738
MOD_CDK_SPxxK_3	545	552	PF00069	0.502
MOD_CK1_1	108	114	PF00069	0.562
MOD_CK1_1	207	213	PF00069	0.483
MOD_CK1_1	365	371	PF00069	0.716
MOD_CK1_1	548	554	PF00069	0.502
MOD_CK2_1	161	167	PF00069	0.421
MOD_CK2_1	246	252	PF00069	0.481
MOD_CK2_1	281	287	PF00069	0.748
MOD_CK2_1	32	38	PF00069	0.522
MOD_CK2_1	487	493	PF00069	0.437
MOD_CK2_1	663	669	PF00069	0.720
MOD_CMANNOS	322	325	PF00535	0.552
MOD_GlcNHglycan	103	106	PF01048	0.519
MOD_GlcNHglycan	199	203	PF01048	0.544
MOD_GlcNHglycan	206	209	PF01048	0.451
MOD_GlcNHglycan	364	367	PF01048	0.559
MOD_GlcNHglycan	371	374	PF01048	0.532
MOD_GlcNHglycan	420	423	PF01048	0.462
MOD_GSK3_1	101	108	PF00069	0.546
MOD_GSK3_1	179	186	PF00069	0.532
MOD_GSK3_1	365	372	PF00069	0.574
MOD_GSK3_1	510	517	PF00069	0.436
MOD_GSK3_1	8	15	PF00069	0.659
MOD_LATS_1	10	16	PF00433	0.603
MOD_NEK2_1	103	108	PF00069	0.415
MOD_NEK2_1	316	321	PF00069	0.416
MOD_NEK2_1	32	37	PF00069	0.640
MOD_NEK2_1	406	411	PF00069	0.580
MOD_NEK2_1	511	516	PF00069	0.497
MOD_NEK2_1	561	566	PF00069	0.551
MOD_NEK2_1	579	584	PF00069	0.351
MOD_NEK2_1	586	591	PF00069	0.392
MOD_NEK2_1	593	598	PF00069	0.354
MOD_NEK2_1	75	80	PF00069	0.530
MOD_NEK2_1	90	95	PF00069	0.296
MOD_PIKK_1	103	109	PF00454	0.441
MOD_PIKK_1	32	38	PF00454	0.602
MOD_PIKK_1	441	447	PF00454	0.542
MOD_PIKK_1	594	600	PF00454	0.413
MOD_PIKK_1	663	669	PF00454	0.705
MOD_PKA_1	12	18	PF00069	0.660
MOD_PKA_1	395	401	PF00069	0.585
MOD_PKA_2	119	125	PF00069	0.412
MOD_PKA_2	12	18	PF00069	0.660
MOD_PKA_2	395	401	PF00069	0.585
MOD_PKA_2	514	520	PF00069	0.537
MOD_PKB_1	49	57	PF00069	0.405
MOD_Plk_1	286	292	PF00069	0.726
MOD_Plk_1	40	46	PF00069	0.541
MOD_Plk_1	51	57	PF00069	0.398
MOD_Plk_4	119	125	PF00069	0.420
MOD_Plk_4	147	153	PF00069	0.555
MOD_Plk_4	246	252	PF00069	0.466
MOD_Plk_4	587	593	PF00069	0.489
MOD_ProDKin_1	105	111	PF00069	0.531
MOD_ProDKin_1	2	8	PF00069	0.719
MOD_ProDKin_1	226	232	PF00069	0.531
MOD_ProDKin_1	281	287	PF00069	0.747
MOD_ProDKin_1	432	438	PF00069	0.614
MOD_ProDKin_1	476	482	PF00069	0.467
MOD_ProDKin_1	545	551	PF00069	0.378
MOD_ProDKin_1	657	663	PF00069	0.606
MOD_SUMO_rev_2	490	497	PF00179	0.493
TRG_DiLeu_BaEn_1	167	172	PF01217	0.428
TRG_DiLeu_BaEn_1	297	302	PF01217	0.395
TRG_DiLeu_BaEn_1	492	497	PF01217	0.457
TRG_DiLeu_BaLyEn_6	166	171	PF01217	0.384
TRG_DiLeu_BaLyEn_6	326	331	PF01217	0.540
TRG_DiLeu_BaLyEn_6	341	346	PF01217	0.362
TRG_DiLeu_BaLyEn_6	415	420	PF01217	0.432
TRG_ENDOCYTIC_2	131	134	PF00928	0.390
TRG_ENDOCYTIC_2	307	310	PF00928	0.416
TRG_ENDOCYTIC_2	411	414	PF00928	0.602
TRG_ENDOCYTIC_2	554	557	PF00928	0.511
TRG_ER_diArg_1	18	21	PF00400	0.716
TRG_ER_diArg_1	222	224	PF00400	0.549
TRG_ER_diArg_1	268	270	PF00400	0.577
TRG_ER_diArg_1	290	293	PF00400	0.705
TRG_ER_diArg_1	394	397	PF00400	0.486
TRG_NES_CRM1_1	300	315	PF08389	0.357
TRG_Pf-PMV_PEXEL_1	169	173	PF00026	0.378
TRG_Pf-PMV_PEXEL_1	183	187	PF00026	0.403
TRG_Pf-PMV_PEXEL_1	234	238	PF00026	0.445
TRG_Pf-PMV_PEXEL_1	299	304	PF00026	0.406
TRG_Pf-PMV_PEXEL_1	328	333	PF00026	0.424
TRG_Pf-PMV_PEXEL_1	389	393	PF00026	0.575
TRG_Pf-PMV_PEXEL_1	441	445	PF00026	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTY7	Leptomonas seymouri	36%	100%
A4HKW3	Leishmania braziliensis	76%	100%
A4I8E3	Leishmania infantum	100%	100%
E9B3A1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q4V4	Leishmania major	92%	100%