Roadblock/LC7 domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Roadblock/LC7 domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X636_LEIDO

TriTrypDb:

LdBPK_323720.1 , LdCL_320043200 , LDHU3_32.4720

Length:

252

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005868	cytoplasmic dynein complex	4	1
GO:0005875	microtubule associated complex	2	1
GO:0030286	dynein complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A0A3S7X636

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X636

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0009987	cellular process	1	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0045505	dynein intermediate chain binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	142	146	PF00082	0.302
CLV_PCSK_SKI1_1	207	211	PF00082	0.784
CLV_PCSK_SKI1_1	228	232	PF00082	0.401
DEG_APCC_DBOX_1	227	235	PF00400	0.377
DEG_SCF_FBW7_1	185	192	PF00400	0.462
DEG_SPOP_SBC_1	33	37	PF00917	0.513
DOC_CKS1_1	186	191	PF01111	0.461
DOC_CYCLIN_RxL_1	225	233	PF00134	0.382
DOC_MAPK_MEF2A_6	142	149	PF00069	0.302
DOC_PP2B_LxvP_1	113	116	PF13499	0.518
DOC_PP2B_LxvP_1	5	8	PF13499	0.675
DOC_USP7_MATH_1	189	193	PF00917	0.526
DOC_USP7_MATH_1	196	200	PF00917	0.554
DOC_USP7_MATH_1	22	26	PF00917	0.690
DOC_WW_Pin1_4	12	17	PF00397	0.571
DOC_WW_Pin1_4	152	157	PF00397	0.282
DOC_WW_Pin1_4	185	190	PF00397	0.445
DOC_WW_Pin1_4	197	202	PF00397	0.574
DOC_WW_Pin1_4	209	214	PF00397	0.784
LIG_14-3-3_CanoR_1	137	141	PF00244	0.302
LIG_14-3-3_CanoR_1	194	203	PF00244	0.612
LIG_14-3-3_CanoR_1	226	231	PF00244	0.414
LIG_14-3-3_CanoR_1	237	244	PF00244	0.480
LIG_14-3-3_CanoR_1	93	100	PF00244	0.670
LIG_BRCT_BRCA1_1	110	114	PF00533	0.523
LIG_BRCT_BRCA1_1	238	242	PF00533	0.395
LIG_BRCT_BRCA1_1	34	38	PF00533	0.507
LIG_BRCT_BRCA1_1	52	56	PF00533	0.527
LIG_FHA_1	105	111	PF00498	0.594
LIG_FHA_1	139	145	PF00498	0.348
LIG_FHA_1	77	83	PF00498	0.495
LIG_LIR_Gen_1	111	118	PF02991	0.518
LIG_LIR_Gen_1	159	169	PF02991	0.508
LIG_LIR_Gen_1	171	180	PF02991	0.323
LIG_LIR_Nem_3	111	115	PF02991	0.709
LIG_LIR_Nem_3	159	164	PF02991	0.302
LIG_LIR_Nem_3	35	41	PF02991	0.713
LIG_SH2_STAP1	172	176	PF00017	0.302
LIG_SH2_STAT5	140	143	PF00017	0.302
LIG_SH2_STAT5	88	91	PF00017	0.582
LIG_SH3_3	210	216	PF00018	0.688
LIG_SH3_3	244	250	PF00018	0.349
LIG_SUMO_SIM_anti_2	219	226	PF11976	0.427
LIG_TRAF2_1	216	219	PF00917	0.535
MOD_CDC14_SPxK_1	15	18	PF00782	0.518
MOD_CDK_SPxK_1	12	18	PF00069	0.520
MOD_CDK_SPxK_1	152	158	PF00069	0.282
MOD_CDK_SPxK_1	185	191	PF00069	0.455
MOD_CK1_1	152	158	PF00069	0.488
MOD_CK1_1	197	203	PF00069	0.578
MOD_CK1_1	6	12	PF00069	0.515
MOD_CK1_1	75	81	PF00069	0.606
MOD_CK1_1	91	97	PF00069	0.600
MOD_CK2_1	217	223	PF00069	0.482
MOD_GlcNHglycan	100	103	PF01048	0.569
MOD_GlcNHglycan	126	129	PF01048	0.546
MOD_GlcNHglycan	24	27	PF01048	0.500
MOD_GlcNHglycan	5	8	PF01048	0.654
MOD_GlcNHglycan	90	93	PF01048	0.629
MOD_GSK3_1	104	111	PF00069	0.512
MOD_GSK3_1	148	155	PF00069	0.320
MOD_GSK3_1	164	171	PF00069	0.488
MOD_GSK3_1	185	192	PF00069	0.462
MOD_GSK3_1	22	29	PF00069	0.472
MOD_GSK3_1	3	10	PF00069	0.610
MOD_GSK3_1	39	46	PF00069	0.635
MOD_GSK3_1	47	54	PF00069	0.703
MOD_GSK3_1	72	79	PF00069	0.483
MOD_N-GLC_1	75	80	PF02516	0.490
MOD_NEK2_1	164	169	PF00069	0.431
MOD_NEK2_1	3	8	PF00069	0.521
MOD_NEK2_1	82	87	PF00069	0.460
MOD_NEK2_2	51	56	PF00069	0.507
MOD_OFUCOSY	59	66	PF10250	0.495
MOD_PIKK_1	43	49	PF00454	0.510
MOD_PIKK_1	93	99	PF00454	0.526
MOD_PKA_2	136	142	PF00069	0.302
MOD_PKA_2	157	163	PF00069	0.415
MOD_PKA_2	236	242	PF00069	0.452
MOD_PKA_2	98	104	PF00069	0.604
MOD_Plk_1	164	170	PF00069	0.302
MOD_Plk_1	218	224	PF00069	0.461
MOD_Plk_1	43	49	PF00069	0.547
MOD_Plk_1	75	81	PF00069	0.493
MOD_Plk_4	108	114	PF00069	0.573
MOD_Plk_4	51	57	PF00069	0.544
MOD_Plk_4	82	88	PF00069	0.437
MOD_ProDKin_1	12	18	PF00069	0.572
MOD_ProDKin_1	152	158	PF00069	0.282
MOD_ProDKin_1	185	191	PF00069	0.455
MOD_ProDKin_1	197	203	PF00069	0.578
MOD_ProDKin_1	209	215	PF00069	0.779
TRG_ENDOCYTIC_2	172	175	PF00928	0.302
TRG_ER_diArg_1	225	228	PF00400	0.369
TRG_ER_diArg_1	27	30	PF00400	0.532
TRG_Pf-PMV_PEXEL_1	166	170	PF00026	0.302
TRG_Pf-PMV_PEXEL_1	228	233	PF00026	0.389

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4I8H6	Leishmania infantum	99%	100%
Q4Q4R6	Leishmania major	87%	100%