LeishMANIAdb
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Roadblock/LC7 domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Roadblock/LC7 domain containing protein, putative
Gene product:
Roadblock/LC7 domain containing protein, putative
Species:
Leishmania donovani
UniProt:
A0A3S7X636_LEIDO
TriTrypDb:
LdBPK_323720.1 , LdCL_320043200 , LDHU3_32.4720
Length:
252

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 3
NetGPI no yes: 0, no: 3
Cellular components
TermNameLevelCount
GO:0005737 cytoplasm 2 1
GO:0005868 cytoplasmic dynein complex 4 1
GO:0005875 microtubule associated complex 2 1
GO:0030286 dynein complex 3 1
GO:0032991 protein-containing complex 1 1
GO:0110165 cellular anatomical entity 1 1
GO:1902494 catalytic complex 2 1
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Expansion

Sequence features

A0A3S7X636
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X636

Function

Biological processes
TermNameLevelCount
GO:0007017 microtubule-based process 2 1
GO:0007018 microtubule-based movement 3 1
GO:0009987 cellular process 1 1
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Molecular functions
TermNameLevelCount
GO:0005488 binding 1 1
GO:0005515 protein binding 2 1
GO:0045505 dynein intermediate chain binding 3 1
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_PCSK_SKI1_1 142 146 PF00082 0.302
CLV_PCSK_SKI1_1 207 211 PF00082 0.784
CLV_PCSK_SKI1_1 228 232 PF00082 0.401
DEG_APCC_DBOX_1 227 235 PF00400 0.377
DEG_SCF_FBW7_1 185 192 PF00400 0.462
DEG_SPOP_SBC_1 33 37 PF00917 0.513
DOC_CKS1_1 186 191 PF01111 0.461
DOC_CYCLIN_RxL_1 225 233 PF00134 0.382
DOC_MAPK_MEF2A_6 142 149 PF00069 0.302
DOC_PP2B_LxvP_1 113 116 PF13499 0.518
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Homologs

ProteinTaxonomySequence identityCoverage
A4I8H6 Leishmania infantum 99% 100%
Q4Q4R6 Leishmania major 87% 100%
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Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS