Zinc-finger of the MIZ type in Nse subunit/MIZ/SP-RING zinc finger containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MIZ/SP-RING zinc finger, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X626_LEIDO

TriTrypDb:

LdBPK_323270.1 , LdCL_320038700 , LDHU3_32.4130

Length:

456

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X626

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X626

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016925	protein sumoylation	7	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0008270	zinc ion binding	6	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0046914	transition metal ion binding	5	12
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1
GO:0019787	ubiquitin-like protein transferase activity	3	1
GO:0019789	SUMO transferase activity	4	1
GO:0061659	ubiquitin-like protein ligase activity	4	1
GO:0061665	SUMO ligase activity	5	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	143	147	PF00656	0.588
CLV_C14_Caspase3-7	158	162	PF00656	0.660
CLV_C14_Caspase3-7	174	178	PF00656	0.515
CLV_C14_Caspase3-7	404	408	PF00656	0.580
CLV_NRD_NRD_1	13	15	PF00675	0.797
CLV_NRD_NRD_1	135	137	PF00675	0.616
CLV_NRD_NRD_1	192	194	PF00675	0.791
CLV_NRD_NRD_1	316	318	PF00675	0.425
CLV_NRD_NRD_1	424	426	PF00675	0.614
CLV_NRD_NRD_1	91	93	PF00675	0.555
CLV_PCSK_FUR_1	133	137	PF00082	0.658
CLV_PCSK_FUR_1	422	426	PF00082	0.681
CLV_PCSK_KEX2_1	13	15	PF00082	0.797
CLV_PCSK_KEX2_1	135	137	PF00082	0.570
CLV_PCSK_KEX2_1	192	194	PF00082	0.791
CLV_PCSK_KEX2_1	316	318	PF00082	0.424
CLV_PCSK_KEX2_1	422	424	PF00082	0.583
CLV_PCSK_KEX2_1	91	93	PF00082	0.495
CLV_PCSK_PC7_1	419	425	PF00082	0.579
CLV_PCSK_SKI1_1	353	357	PF00082	0.523
CLV_PCSK_SKI1_1	91	95	PF00082	0.542
DEG_COP1_1	407	417	PF00400	0.493
DEG_SPOP_SBC_1	172	176	PF00917	0.633
DEG_SPOP_SBC_1	378	382	PF00917	0.510
DEG_SPOP_SBC_1	93	97	PF00917	0.565
DOC_CKS1_1	18	23	PF01111	0.741
DOC_CYCLIN_RxL_1	348	360	PF00134	0.580
DOC_MAPK_gen_1	135	144	PF00069	0.610
DOC_PP4_FxxP_1	418	421	PF00568	0.496
DOC_SPAK_OSR1_1	387	391	PF12202	0.482
DOC_USP7_MATH_1	12	16	PF00917	0.813
DOC_USP7_MATH_1	125	129	PF00917	0.456
DOC_USP7_MATH_1	188	192	PF00917	0.735
DOC_USP7_MATH_1	271	275	PF00917	0.575
DOC_USP7_MATH_1	320	324	PF00917	0.510
DOC_USP7_MATH_1	426	430	PF00917	0.704
DOC_USP7_MATH_1	450	454	PF00917	0.735
DOC_USP7_MATH_1	52	56	PF00917	0.486
DOC_WW_Pin1_4	17	22	PF00397	0.720
DOC_WW_Pin1_4	195	200	PF00397	0.764
DOC_WW_Pin1_4	216	221	PF00397	0.794
DOC_WW_Pin1_4	241	246	PF00397	0.679
DOC_WW_Pin1_4	5	10	PF00397	0.794
LIG_14-3-3_CanoR_1	13	21	PF00244	0.809
LIG_14-3-3_CanoR_1	91	100	PF00244	0.458
LIG_BIR_III_4	307	311	PF00653	0.539
LIG_BRCT_BRCA1_1	34	38	PF00533	0.577
LIG_deltaCOP1_diTrp_1	311	318	PF00928	0.409
LIG_deltaCOP1_diTrp_1	377	383	PF00928	0.560
LIG_FHA_1	113	119	PF00498	0.504
LIG_FHA_1	331	337	PF00498	0.413
LIG_FHA_2	129	135	PF00498	0.670
LIG_FHA_2	146	152	PF00498	0.505
LIG_FHA_2	172	178	PF00498	0.717
LIG_FHA_2	247	253	PF00498	0.586
LIG_Integrin_RGDW_4	309	312	PF00362	0.534
LIG_LIR_Apic_2	416	421	PF02991	0.566
LIG_LIR_Gen_1	311	320	PF02991	0.418
LIG_LIR_Gen_1	35	44	PF02991	0.395
LIG_LIR_Gen_1	354	364	PF02991	0.623
LIG_LIR_Gen_1	67	73	PF02991	0.474
LIG_LIR_Nem_3	150	155	PF02991	0.672
LIG_LIR_Nem_3	311	315	PF02991	0.385
LIG_LIR_Nem_3	35	41	PF02991	0.472
LIG_LIR_Nem_3	360	364	PF02991	0.619
LIG_Pex14_1	379	383	PF04695	0.494
LIG_Pex14_2	314	318	PF04695	0.458
LIG_Pex14_2	388	392	PF04695	0.500
LIG_SH2_CRK	352	356	PF00017	0.610
LIG_SH2_CRK	361	365	PF00017	0.586
LIG_SH2_CRK	372	376	PF00017	0.354
LIG_SH2_CRK	44	48	PF00017	0.522
LIG_SH2_GRB2like	152	155	PF00017	0.663
LIG_SH2_NCK_1	361	365	PF00017	0.615
LIG_SH2_STAP1	152	156	PF00017	0.680
LIG_SH2_STAP1	361	365	PF00017	0.638
LIG_SH2_STAT5	155	158	PF00017	0.692
LIG_SH2_STAT5	345	348	PF00017	0.430
LIG_SH3_3	196	202	PF00018	0.791
LIG_SH3_3	242	248	PF00018	0.764
LIG_SH3_3	79	85	PF00018	0.484
LIG_SUMO_SIM_par_1	115	121	PF11976	0.477
LIG_TRAF2_1	249	252	PF00917	0.565
MOD_CK1_1	128	134	PF00069	0.473
MOD_CK1_1	17	23	PF00069	0.742
MOD_CK1_1	176	182	PF00069	0.637
MOD_CK1_1	246	252	PF00069	0.629
MOD_CK1_1	322	328	PF00069	0.427
MOD_CK1_1	408	414	PF00069	0.585
MOD_CK1_1	429	435	PF00069	0.663
MOD_CK2_1	128	134	PF00069	0.584
MOD_CK2_1	246	252	PF00069	0.703
MOD_CK2_1	351	357	PF00069	0.526
MOD_CK2_1	360	366	PF00069	0.567
MOD_DYRK1A_RPxSP_1	216	220	PF00069	0.706
MOD_GlcNHglycan	127	130	PF01048	0.407
MOD_GlcNHglycan	182	185	PF01048	0.679
MOD_GlcNHglycan	205	208	PF01048	0.788
MOD_GlcNHglycan	209	212	PF01048	0.724
MOD_GlcNHglycan	428	431	PF01048	0.724
MOD_GlcNHglycan	440	443	PF01048	0.473
MOD_GSK3_1	125	132	PF00069	0.438
MOD_GSK3_1	172	179	PF00069	0.693
MOD_GSK3_1	203	210	PF00069	0.781
MOD_GSK3_1	243	250	PF00069	0.673
MOD_GSK3_1	318	325	PF00069	0.519
MOD_GSK3_1	32	39	PF00069	0.492
MOD_GSK3_1	426	433	PF00069	0.713
MOD_N-GLC_2	56	58	PF02516	0.311
MOD_N-GLC_2	74	76	PF02516	0.161
MOD_NEK2_1	281	286	PF00069	0.565
MOD_NEK2_1	318	323	PF00069	0.540
MOD_NEK2_1	351	356	PF00069	0.554
MOD_PIKK_1	14	20	PF00454	0.793
MOD_PIKK_1	145	151	PF00454	0.508
MOD_PIKK_1	247	253	PF00454	0.727
MOD_PIKK_1	271	277	PF00454	0.474
MOD_PIKK_1	432	438	PF00454	0.694
MOD_PIKK_1	450	456	PF00454	0.749
MOD_PKA_1	91	97	PF00069	0.486
MOD_PKA_2	12	18	PF00069	0.810
MOD_PKA_2	91	97	PF00069	0.486
MOD_Plk_1	36	42	PF00069	0.362
MOD_Plk_2-3	360	366	PF00069	0.647
MOD_Plk_4	330	336	PF00069	0.411
MOD_Plk_4	408	414	PF00069	0.562
MOD_Plk_4	65	71	PF00069	0.475
MOD_ProDKin_1	17	23	PF00069	0.719
MOD_ProDKin_1	195	201	PF00069	0.763
MOD_ProDKin_1	216	222	PF00069	0.793
MOD_ProDKin_1	241	247	PF00069	0.681
MOD_ProDKin_1	5	11	PF00069	0.795
MOD_SUMO_for_1	225	228	PF00179	0.623
MOD_SUMO_for_1	291	294	PF00179	0.586
TRG_DiLeu_BaEn_1	27	32	PF01217	0.749
TRG_ENDOCYTIC_2	352	355	PF00928	0.591
TRG_ENDOCYTIC_2	361	364	PF00928	0.578
TRG_ENDOCYTIC_2	44	47	PF00928	0.478
TRG_ER_diArg_1	192	195	PF00400	0.794
TRG_ER_diArg_1	315	317	PF00400	0.458
TRG_ER_diArg_1	421	424	PF00400	0.581
TRG_ER_diArg_1	91	93	PF00400	0.560
TRG_Pf-PMV_PEXEL_1	353	357	PF00026	0.609

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P907	Leptomonas seymouri	65%	73%
A0A0S4IQ84	Bodo saltans	31%	77%
A0A1X0NSE9	Trypanosomatidae	40%	99%
A0A3R7NRN3	Trypanosoma rangeli	40%	100%
A4HKV3	Leishmania braziliensis	84%	100%
A4I8D2	Leishmania infantum	99%	100%
D0AAU1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9B391	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q4W4	Leishmania major	94%	100%
V5B5L3	Trypanosoma cruzi	42%	100%