Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X620_LEIDO

TriTrypDb:

LdBPK_323420.1 , LdCL_320040100 , LDHU3_32.4310

Length:

627

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X620

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X620

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	168	170	PF00675	0.676
CLV_NRD_NRD_1	203	205	PF00675	0.580
CLV_NRD_NRD_1	289	291	PF00675	0.391
CLV_NRD_NRD_1	361	363	PF00675	0.535
CLV_NRD_NRD_1	475	477	PF00675	0.616
CLV_NRD_NRD_1	76	78	PF00675	0.661
CLV_NRD_NRD_1	81	83	PF00675	0.629
CLV_PCSK_FUR_1	201	205	PF00082	0.582
CLV_PCSK_KEX2_1	168	170	PF00082	0.676
CLV_PCSK_KEX2_1	203	205	PF00082	0.580
CLV_PCSK_KEX2_1	361	363	PF00082	0.535
CLV_PCSK_KEX2_1	475	477	PF00082	0.616
CLV_PCSK_KEX2_1	76	78	PF00082	0.661
CLV_PCSK_KEX2_1	81	83	PF00082	0.629
CLV_PCSK_PC7_1	77	83	PF00082	0.670
CLV_PCSK_SKI1_1	106	110	PF00082	0.590
CLV_PCSK_SKI1_1	222	226	PF00082	0.545
CLV_PCSK_SKI1_1	380	384	PF00082	0.569
CLV_PCSK_SKI1_1	621	625	PF00082	0.496
DEG_APCC_DBOX_1	232	240	PF00400	0.426
DEG_APCC_DBOX_1	485	493	PF00400	0.689
DEG_Nend_Nbox_1	1	3	PF02207	0.633
DEG_SCF_FBW7_1	432	439	PF00400	0.646
DEG_SPOP_SBC_1	162	166	PF00917	0.640
DOC_CDC14_PxL_1	381	389	PF14671	0.535
DOC_CKS1_1	170	175	PF01111	0.602
DOC_CKS1_1	404	409	PF01111	0.604
DOC_CYCLIN_yCln2_LP_2	383	389	PF00134	0.491
DOC_MAPK_DCC_7	480	489	PF00069	0.609
DOC_MAPK_gen_1	252	259	PF00069	0.443
DOC_MAPK_gen_1	290	297	PF00069	0.405
DOC_MAPK_gen_1	81	88	PF00069	0.625
DOC_MAPK_MEF2A_6	252	259	PF00069	0.450
DOC_MAPK_MEF2A_6	480	489	PF00069	0.609
DOC_PP2B_LxvP_1	179	182	PF13499	0.632
DOC_PP4_FxxP_1	382	385	PF00568	0.538
DOC_USP7_MATH_1	162	166	PF00917	0.637
DOC_USP7_MATH_1	185	189	PF00917	0.590
DOC_USP7_MATH_1	224	228	PF00917	0.499
DOC_USP7_MATH_1	250	254	PF00917	0.543
DOC_USP7_MATH_1	321	325	PF00917	0.453
DOC_USP7_MATH_1	423	427	PF00917	0.709
DOC_USP7_MATH_1	436	440	PF00917	0.597
DOC_USP7_MATH_1	445	449	PF00917	0.580
DOC_USP7_MATH_1	559	563	PF00917	0.719
DOC_USP7_MATH_1	6	10	PF00917	0.619
DOC_USP7_MATH_1	617	621	PF00917	0.447
DOC_USP7_MATH_1	65	69	PF00917	0.594
DOC_USP7_MATH_1	91	95	PF00917	0.758
DOC_WW_Pin1_4	142	147	PF00397	0.632
DOC_WW_Pin1_4	154	159	PF00397	0.625
DOC_WW_Pin1_4	169	174	PF00397	0.525
DOC_WW_Pin1_4	19	24	PF00397	0.643
DOC_WW_Pin1_4	192	197	PF00397	0.615
DOC_WW_Pin1_4	403	408	PF00397	0.701
DOC_WW_Pin1_4	419	424	PF00397	0.521
DOC_WW_Pin1_4	426	431	PF00397	0.602
DOC_WW_Pin1_4	432	437	PF00397	0.591
DOC_WW_Pin1_4	441	446	PF00397	0.562
DOC_WW_Pin1_4	453	458	PF00397	0.642
DOC_WW_Pin1_4	541	546	PF00397	0.594
LIG_14-3-3_CanoR_1	15	25	PF00244	0.691
LIG_14-3-3_CanoR_1	222	229	PF00244	0.554
LIG_14-3-3_CanoR_1	272	276	PF00244	0.487
LIG_14-3-3_CanoR_1	29	39	PF00244	0.552
LIG_14-3-3_CanoR_1	560	568	PF00244	0.682
LIG_14-3-3_CanoR_1	81	88	PF00244	0.625
LIG_Clathr_ClatBox_1	372	376	PF01394	0.530
LIG_Clathr_ClatBox_1	602	606	PF01394	0.546
LIG_DLG_GKlike_1	174	181	PF00625	0.629
LIG_eIF4E_1	234	240	PF01652	0.491
LIG_eIF4E_1	565	571	PF01652	0.500
LIG_FHA_1	147	153	PF00498	0.575
LIG_FHA_1	170	176	PF00498	0.667
LIG_FHA_1	20	26	PF00498	0.666
LIG_FHA_1	32	38	PF00498	0.595
LIG_FHA_1	572	578	PF00498	0.627
LIG_FHA_1	590	596	PF00498	0.440
LIG_FHA_2	109	115	PF00498	0.618
LIG_FHA_2	314	320	PF00498	0.454
LIG_FHA_2	404	410	PF00498	0.649
LIG_FHA_2	433	439	PF00498	0.659
LIG_FHA_2	535	541	PF00498	0.665
LIG_FHA_2	88	94	PF00498	0.729
LIG_LIR_Apic_2	413	417	PF02991	0.656
LIG_LIR_Apic_2	562	568	PF02991	0.504
LIG_LIR_Gen_1	258	265	PF02991	0.486
LIG_LIR_Gen_1	415	425	PF02991	0.586
LIG_LIR_Nem_3	299	305	PF02991	0.403
LIG_LIR_Nem_3	415	421	PF02991	0.587
LIG_LIR_Nem_3	477	482	PF02991	0.479
LIG_LIR_Nem_3	575	581	PF02991	0.570
LIG_NRBOX	308	314	PF00104	0.457
LIG_PAM2_1	419	431	PF00658	0.561
LIG_PTB_Apo_2	138	145	PF02174	0.541
LIG_PTB_Phospho_1	138	144	PF10480	0.545
LIG_SH2_PTP2	294	297	PF00017	0.402
LIG_SH2_PTP2	514	517	PF00017	0.641
LIG_SH2_STAP1	127	131	PF00017	0.515
LIG_SH2_STAP1	333	337	PF00017	0.457
LIG_SH2_STAP1	388	392	PF00017	0.546
LIG_SH2_STAP1	589	593	PF00017	0.571
LIG_SH2_STAT3	215	218	PF00017	0.504
LIG_SH2_STAT5	137	140	PF00017	0.576
LIG_SH2_STAT5	294	297	PF00017	0.402
LIG_SH2_STAT5	414	417	PF00017	0.653
LIG_SH2_STAT5	514	517	PF00017	0.621
LIG_SH2_STAT5	581	584	PF00017	0.577
LIG_SH3_1	514	520	PF00018	0.565
LIG_SH3_3	118	124	PF00018	0.604
LIG_SH3_3	140	146	PF00018	0.570
LIG_SH3_3	167	173	PF00018	0.612
LIG_SH3_3	190	196	PF00018	0.536
LIG_SH3_3	389	395	PF00018	0.549
LIG_SH3_3	401	407	PF00018	0.586
LIG_SH3_3	48	54	PF00018	0.638
LIG_SH3_3	482	488	PF00018	0.570
LIG_SH3_3	507	513	PF00018	0.594
LIG_SH3_3	514	520	PF00018	0.542
LIG_SH3_3	535	541	PF00018	0.579
LIG_SUMO_SIM_par_1	177	184	PF11976	0.631
LIG_SUMO_SIM_par_1	33	41	PF11976	0.560
LIG_TRAF2_1	112	115	PF00917	0.608
LIG_TRAF2_1	304	307	PF00917	0.490
LIG_TRAF2_1	71	74	PF00917	0.669
LIG_WRC_WIRS_1	602	607	PF05994	0.757
LIG_WW_3	483	487	PF00397	0.626
MOD_CDK_SPK_2	169	174	PF00069	0.626
MOD_CDK_SPxxK_3	403	410	PF00069	0.604
MOD_CK1_1	135	141	PF00069	0.574
MOD_CK1_1	145	151	PF00069	0.568
MOD_CK1_1	177	183	PF00069	0.644
MOD_CK1_1	19	25	PF00069	0.686
MOD_CK1_1	227	233	PF00069	0.429
MOD_CK1_1	283	289	PF00069	0.436
MOD_CK1_1	31	37	PF00069	0.566
MOD_CK1_1	339	345	PF00069	0.487
MOD_CK1_1	403	409	PF00069	0.647
MOD_CK1_1	426	432	PF00069	0.601
MOD_CK1_1	444	450	PF00069	0.571
MOD_CK1_1	465	471	PF00069	0.657
MOD_CK1_1	548	554	PF00069	0.613
MOD_CK1_1	558	564	PF00069	0.773
MOD_CK1_1	68	74	PF00069	0.802
MOD_CK1_1	84	90	PF00069	0.524
MOD_CK2_1	108	114	PF00069	0.613
MOD_CK2_1	126	132	PF00069	0.541
MOD_CK2_1	2	8	PF00069	0.619
MOD_CK2_1	313	319	PF00069	0.459
MOD_CK2_1	35	41	PF00069	0.614
MOD_CK2_1	403	409	PF00069	0.647
MOD_CK2_1	432	438	PF00069	0.607
MOD_CK2_1	577	583	PF00069	0.554
MOD_CK2_1	68	74	PF00069	0.807
MOD_CK2_1	87	93	PF00069	0.485
MOD_DYRK1A_RPxSP_1	169	173	PF00069	0.607
MOD_GlcNHglycan	183	186	PF01048	0.619
MOD_GlcNHglycan	226	229	PF01048	0.447
MOD_GlcNHglycan	282	285	PF01048	0.440
MOD_GlcNHglycan	319	322	PF01048	0.516
MOD_GlcNHglycan	4	7	PF01048	0.660
MOD_GlcNHglycan	447	450	PF01048	0.668
MOD_GlcNHglycan	451	454	PF01048	0.738
MOD_GlcNHglycan	464	467	PF01048	0.483
MOD_GlcNHglycan	547	550	PF01048	0.703
MOD_GlcNHglycan	557	560	PF01048	0.600
MOD_GlcNHglycan	70	73	PF01048	0.573
MOD_GlcNHglycan	8	11	PF01048	0.625
MOD_GlcNHglycan	83	86	PF01048	0.513
MOD_GSK3_1	142	149	PF00069	0.619
MOD_GSK3_1	15	22	PF00069	0.602
MOD_GSK3_1	177	184	PF00069	0.631
MOD_GSK3_1	2	9	PF00069	0.612
MOD_GSK3_1	264	271	PF00069	0.546
MOD_GSK3_1	28	35	PF00069	0.568
MOD_GSK3_1	280	287	PF00069	0.376
MOD_GSK3_1	313	320	PF00069	0.471
MOD_GSK3_1	323	330	PF00069	0.445
MOD_GSK3_1	419	426	PF00069	0.632
MOD_GSK3_1	428	435	PF00069	0.581
MOD_GSK3_1	441	448	PF00069	0.557
MOD_GSK3_1	449	456	PF00069	0.720
MOD_GSK3_1	458	465	PF00069	0.593
MOD_GSK3_1	541	548	PF00069	0.644
MOD_GSK3_1	554	561	PF00069	0.672
MOD_GSK3_1	87	94	PF00069	0.593
MOD_N-GLC_1	205	210	PF02516	0.583
MOD_NEK2_1	2	7	PF00069	0.663
MOD_NEK2_1	275	280	PF00069	0.480
MOD_NEK2_1	471	476	PF00069	0.522
MOD_NEK2_1	492	497	PF00069	0.620
MOD_NEK2_1	577	582	PF00069	0.575
MOD_NEK2_2	423	428	PF00069	0.596
MOD_NEK2_2	589	594	PF00069	0.556
MOD_OFUCOSY	450	455	PF10250	0.572
MOD_PIKK_1	132	138	PF00454	0.620
MOD_PIKK_1	374	380	PF00454	0.458
MOD_PIKK_1	458	464	PF00454	0.611
MOD_PIKK_1	531	537	PF00454	0.559
MOD_PKA_1	81	87	PF00069	0.671
MOD_PKA_2	271	277	PF00069	0.499
MOD_PKA_2	28	34	PF00069	0.715
MOD_PKA_2	559	565	PF00069	0.627
MOD_PKA_2	81	87	PF00069	0.671
MOD_Plk_1	132	138	PF00069	0.539
MOD_Plk_1	423	429	PF00069	0.597
MOD_Plk_1	436	442	PF00069	0.597
MOD_Plk_2-3	126	132	PF00069	0.521
MOD_Plk_4	174	180	PF00069	0.671
MOD_Plk_4	255	261	PF00069	0.430
MOD_Plk_4	336	342	PF00069	0.463
MOD_Plk_4	400	406	PF00069	0.685
MOD_Plk_4	423	429	PF00069	0.597
MOD_Plk_4	500	506	PF00069	0.536
MOD_Plk_4	577	583	PF00069	0.611
MOD_Plk_4	65	71	PF00069	0.610
MOD_ProDKin_1	142	148	PF00069	0.629
MOD_ProDKin_1	154	160	PF00069	0.628
MOD_ProDKin_1	169	175	PF00069	0.525
MOD_ProDKin_1	19	25	PF00069	0.647
MOD_ProDKin_1	192	198	PF00069	0.612
MOD_ProDKin_1	403	409	PF00069	0.700
MOD_ProDKin_1	419	425	PF00069	0.523
MOD_ProDKin_1	426	432	PF00069	0.601
MOD_ProDKin_1	441	447	PF00069	0.559
MOD_ProDKin_1	453	459	PF00069	0.644
MOD_ProDKin_1	541	547	PF00069	0.597
TRG_DiLeu_BaEn_1	368	373	PF01217	0.520
TRG_DiLeu_BaLyEn_6	485	490	PF01217	0.583
TRG_ENDOCYTIC_2	294	297	PF00928	0.402
TRG_ER_diArg_1	168	170	PF00400	0.675
TRG_ER_diArg_1	201	204	PF00400	0.614
TRG_ER_diArg_1	27	30	PF00400	0.630
TRG_ER_diArg_1	361	364	PF00400	0.534
TRG_ER_diArg_1	75	77	PF00400	0.663
TRG_ER_diArg_1	80	82	PF00400	0.630
TRG_Pf-PMV_PEXEL_1	237	242	PF00026	0.488
TRG_Pf-PMV_PEXEL_1	303	307	PF00026	0.490

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVM2	Leptomonas seymouri	52%	100%
A4HKW7	Leishmania braziliensis	72%	100%
A4I8E7	Leishmania infantum	97%	100%
E9B3A5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q4V0	Leishmania major	94%	100%