Lipase_(Class_3)_putative/Pfam:PF01764

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Lipase (class 3), putative

Species:

Leishmania donovani

UniProt:

A0A3S7X618_LEIDO

TriTrypDb:

LdBPK_323560.1 , LdCL_320041500 , LDHU3_32.4500

Length:

809

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X618

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X618

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	7
GO:0008152	metabolic process	1	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:0009056	catabolic process	2	1
GO:0016042	lipid catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016298	lipase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	178	182	PF00656	0.621
CLV_C14_Caspase3-7	670	674	PF00656	0.414
CLV_C14_Caspase3-7	688	692	PF00656	0.483
CLV_C14_Caspase3-7	87	91	PF00656	0.581
CLV_NRD_NRD_1	140	142	PF00675	0.590
CLV_NRD_NRD_1	294	296	PF00675	0.564
CLV_NRD_NRD_1	322	324	PF00675	0.507
CLV_NRD_NRD_1	326	328	PF00675	0.477
CLV_NRD_NRD_1	406	408	PF00675	0.557
CLV_NRD_NRD_1	421	423	PF00675	0.358
CLV_NRD_NRD_1	576	578	PF00675	0.555
CLV_NRD_NRD_1	61	63	PF00675	0.515
CLV_NRD_NRD_1	632	634	PF00675	0.450
CLV_NRD_NRD_1	728	730	PF00675	0.416
CLV_NRD_NRD_1	769	771	PF00675	0.535
CLV_PCSK_KEX2_1	12	14	PF00082	0.579
CLV_PCSK_KEX2_1	139	141	PF00082	0.590
CLV_PCSK_KEX2_1	279	281	PF00082	0.446
CLV_PCSK_KEX2_1	296	298	PF00082	0.571
CLV_PCSK_KEX2_1	322	324	PF00082	0.472
CLV_PCSK_KEX2_1	326	328	PF00082	0.478
CLV_PCSK_KEX2_1	406	408	PF00082	0.557
CLV_PCSK_KEX2_1	421	423	PF00082	0.358
CLV_PCSK_KEX2_1	576	578	PF00082	0.555
CLV_PCSK_KEX2_1	61	63	PF00082	0.515
CLV_PCSK_KEX2_1	632	634	PF00082	0.388
CLV_PCSK_KEX2_1	727	729	PF00082	0.460
CLV_PCSK_KEX2_1	769	771	PF00082	0.535
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.579
CLV_PCSK_PC1ET2_1	279	281	PF00082	0.507
CLV_PCSK_PC1ET2_1	296	298	PF00082	0.442
CLV_PCSK_PC7_1	135	141	PF00082	0.572
CLV_PCSK_PC7_1	322	328	PF00082	0.438
CLV_PCSK_SKI1_1	301	305	PF00082	0.479
CLV_PCSK_SKI1_1	421	425	PF00082	0.429
CLV_PCSK_SKI1_1	459	463	PF00082	0.302
CLV_PCSK_SKI1_1	565	569	PF00082	0.443
CLV_PCSK_SKI1_1	576	580	PF00082	0.534
CLV_PCSK_SKI1_1	618	622	PF00082	0.407
CLV_PCSK_SKI1_1	729	733	PF00082	0.385
CLV_Separin_Metazoa	766	770	PF03568	0.404
DEG_APCC_DBOX_1	664	672	PF00400	0.439
DEG_APCC_DBOX_1	727	735	PF00400	0.411
DEG_Nend_Nbox_1	1	3	PF02207	0.567
DEG_SPOP_SBC_1	105	109	PF00917	0.633
DEG_SPOP_SBC_1	205	209	PF00917	0.654
DEG_SPOP_SBC_1	85	89	PF00917	0.686
DOC_ANK_TNKS_1	487	494	PF00023	0.250
DOC_CDC14_PxL_1	126	134	PF14671	0.536
DOC_CDC14_PxL_1	753	761	PF14671	0.430
DOC_CKS1_1	150	155	PF01111	0.667
DOC_CKS1_1	335	340	PF01111	0.536
DOC_CKS1_1	40	45	PF01111	0.497
DOC_CYCLIN_RxL_1	326	337	PF00134	0.426
DOC_CYCLIN_yCln2_LP_2	335	341	PF00134	0.538
DOC_CYCLIN_yCln2_LP_2	732	738	PF00134	0.396
DOC_MAPK_gen_1	326	335	PF00069	0.413
DOC_MAPK_gen_1	727	736	PF00069	0.410
DOC_MAPK_MEF2A_6	505	514	PF00069	0.341
DOC_MAPK_MEF2A_6	727	736	PF00069	0.385
DOC_PP1_RVXF_1	650	657	PF00149	0.428
DOC_PP1_RVXF_1	770	776	PF00149	0.339
DOC_PP2B_LxvP_1	154	157	PF13499	0.625
DOC_PP2B_LxvP_1	713	716	PF13499	0.351
DOC_PP2B_LxvP_1	732	735	PF13499	0.395
DOC_PP4_FxxP_1	269	272	PF00568	0.534
DOC_USP7_MATH_1	158	162	PF00917	0.630
DOC_USP7_MATH_1	177	181	PF00917	0.534
DOC_USP7_MATH_1	205	209	PF00917	0.676
DOC_USP7_MATH_1	229	233	PF00917	0.599
DOC_USP7_MATH_1	307	311	PF00917	0.423
DOC_USP7_MATH_1	567	571	PF00917	0.417
DOC_USP7_MATH_1	597	601	PF00917	0.657
DOC_USP7_MATH_1	703	707	PF00917	0.607
DOC_USP7_MATH_1	86	90	PF00917	0.593
DOC_USP7_MATH_1	92	96	PF00917	0.593
DOC_WW_Pin1_4	100	105	PF00397	0.622
DOC_WW_Pin1_4	149	154	PF00397	0.669
DOC_WW_Pin1_4	225	230	PF00397	0.676
DOC_WW_Pin1_4	334	339	PF00397	0.598
DOC_WW_Pin1_4	341	346	PF00397	0.570
DOC_WW_Pin1_4	39	44	PF00397	0.536
DOC_WW_Pin1_4	466	471	PF00397	0.329
DOC_WW_Pin1_4	798	803	PF00397	0.565
LIG_14-3-3_CanoR_1	271	281	PF00244	0.501
LIG_14-3-3_CanoR_1	301	308	PF00244	0.396
LIG_14-3-3_CanoR_1	314	318	PF00244	0.576
LIG_14-3-3_CanoR_1	439	443	PF00244	0.366
LIG_14-3-3_CanoR_1	459	465	PF00244	0.183
LIG_14-3-3_CanoR_1	46	55	PF00244	0.528
LIG_14-3-3_CanoR_1	505	514	PF00244	0.341
LIG_14-3-3_CanoR_1	530	539	PF00244	0.363
LIG_14-3-3_CanoR_1	61	65	PF00244	0.541
LIG_Actin_WH2_2	429	445	PF00022	0.395
LIG_ActinCP_TwfCPI_2	269	279	PF01115	0.520
LIG_AP2alpha_2	262	264	PF02296	0.556
LIG_APCC_ABBAyCdc20_2	61	67	PF00400	0.517
LIG_FHA_1	149	155	PF00498	0.633
LIG_FHA_1	219	225	PF00498	0.665
LIG_FHA_1	276	282	PF00498	0.461
LIG_FHA_1	314	320	PF00498	0.452
LIG_FHA_1	455	461	PF00498	0.420
LIG_FHA_1	536	542	PF00498	0.373
LIG_FHA_1	570	576	PF00498	0.532
LIG_FHA_1	615	621	PF00498	0.370
LIG_FHA_2	246	252	PF00498	0.622
LIG_FHA_2	40	46	PF00498	0.530
LIG_FHA_2	467	473	PF00498	0.316
LIG_FHA_2	496	502	PF00498	0.343
LIG_GSK3_LRP6_1	149	154	PF00069	0.669
LIG_LIR_Apic_2	267	272	PF02991	0.524
LIG_LIR_Apic_2	27	31	PF02991	0.476
LIG_LIR_Apic_2	63	68	PF02991	0.541
LIG_LIR_Gen_1	273	282	PF02991	0.472
LIG_LIR_Gen_1	447	456	PF02991	0.450
LIG_LIR_Gen_1	478	489	PF02991	0.306
LIG_LIR_Gen_1	554	563	PF02991	0.332
LIG_LIR_Nem_3	273	277	PF02991	0.483
LIG_LIR_Nem_3	447	452	PF02991	0.440
LIG_LIR_Nem_3	478	484	PF02991	0.306
LIG_LIR_Nem_3	49	55	PF02991	0.530
LIG_LIR_Nem_3	534	539	PF02991	0.363
LIG_LIR_Nem_3	554	559	PF02991	0.183
LIG_LYPXL_yS_3	756	759	PF13949	0.432
LIG_NRBOX	554	560	PF00104	0.363
LIG_NRBOX	763	769	PF00104	0.365
LIG_PCNA_yPIPBox_3	552	565	PF02747	0.334
LIG_SH2_CRK	35	39	PF00017	0.527
LIG_SH2_CRK	382	386	PF00017	0.339
LIG_SH2_CRK	481	485	PF00017	0.352
LIG_SH2_CRK	679	683	PF00017	0.591
LIG_SH2_GRB2like	481	484	PF00017	0.302
LIG_SH2_NCK_1	377	381	PF00017	0.321
LIG_SH2_NCK_1	65	69	PF00017	0.546
LIG_SH2_NCK_1	679	683	PF00017	0.591
LIG_SH2_SRC	481	484	PF00017	0.302
LIG_SH2_SRC	65	68	PF00017	0.544
LIG_SH2_STAP1	302	306	PF00017	0.427
LIG_SH2_STAP1	377	381	PF00017	0.321
LIG_SH2_STAP1	440	444	PF00017	0.374
LIG_SH2_STAP1	481	485	PF00017	0.302
LIG_SH2_STAP1	515	519	PF00017	0.302
LIG_SH2_STAT3	302	305	PF00017	0.436
LIG_SH2_STAT5	106	109	PF00017	0.597
LIG_SH2_STAT5	239	242	PF00017	0.601
LIG_SH2_STAT5	373	376	PF00017	0.380
LIG_SH2_STAT5	390	393	PF00017	0.483
LIG_SH2_STAT5	408	411	PF00017	0.316
LIG_SH2_STAT5	55	58	PF00017	0.536
LIG_SH2_STAT5	560	563	PF00017	0.355
LIG_SH2_STAT5	760	763	PF00017	0.375
LIG_SH2_STAT5	79	82	PF00017	0.562
LIG_SH3_3	147	153	PF00018	0.660
LIG_SH3_3	743	749	PF00018	0.385
LIG_SUMO_SIM_anti_2	743	750	PF11976	0.443
LIG_SUMO_SIM_par_1	472	479	PF11976	0.274
LIG_SUMO_SIM_par_1	743	750	PF11976	0.382
LIG_TRAF2_1	682	685	PF00917	0.603
LIG_WRC_WIRS_1	461	466	PF05994	0.302
LIG_WW_3	13	17	PF00397	0.561
MOD_CDC14_SPxK_1	801	804	PF00782	0.535
MOD_CDK_SPK_2	343	348	PF00069	0.578
MOD_CDK_SPK_2	39	44	PF00069	0.529
MOD_CDK_SPxK_1	798	804	PF00069	0.530
MOD_CDK_SPxxK_3	341	348	PF00069	0.537
MOD_CDK_SPxxK_3	39	46	PF00069	0.538
MOD_CK1_1	108	114	PF00069	0.524
MOD_CK1_1	121	127	PF00069	0.593
MOD_CK1_1	187	193	PF00069	0.655
MOD_CK1_1	228	234	PF00069	0.672
MOD_CK1_1	275	281	PF00069	0.468
MOD_CK1_1	310	316	PF00069	0.398
MOD_CK1_1	346	352	PF00069	0.675
MOD_CK1_1	438	444	PF00069	0.369
MOD_CK1_1	534	540	PF00069	0.329
MOD_CK1_1	570	576	PF00069	0.514
MOD_CK1_1	586	592	PF00069	0.581
MOD_CK1_1	60	66	PF00069	0.538
MOD_CK1_1	600	606	PF00069	0.518
MOD_CK1_1	686	692	PF00069	0.599
MOD_CK1_1	706	712	PF00069	0.474
MOD_CK1_1	798	804	PF00069	0.548
MOD_CK1_1	94	100	PF00069	0.714
MOD_CK2_1	205	211	PF00069	0.654
MOD_CK2_1	229	235	PF00069	0.598
MOD_CK2_1	245	251	PF00069	0.588
MOD_CK2_1	390	396	PF00069	0.448
MOD_CK2_1	514	520	PF00069	0.276
MOD_CK2_1	70	76	PF00069	0.613
MOD_CK2_1	760	766	PF00069	0.352
MOD_GlcNHglycan	187	190	PF01048	0.640
MOD_GlcNHglycan	208	211	PF01048	0.703
MOD_GlcNHglycan	230	234	PF01048	0.621
MOD_GlcNHglycan	274	277	PF01048	0.511
MOD_GlcNHglycan	588	591	PF01048	0.601
MOD_GlcNHglycan	594	597	PF01048	0.622
MOD_GlcNHglycan	599	602	PF01048	0.652
MOD_GlcNHglycan	648	651	PF01048	0.408
MOD_GlcNHglycan	688	691	PF01048	0.547
MOD_GlcNHglycan	72	75	PF01048	0.574
MOD_GlcNHglycan	723	726	PF01048	0.502
MOD_GlcNHglycan	98	101	PF01048	0.596
MOD_GSK3_1	100	107	PF00069	0.561
MOD_GSK3_1	118	125	PF00069	0.604
MOD_GSK3_1	184	191	PF00069	0.644
MOD_GSK3_1	195	202	PF00069	0.564
MOD_GSK3_1	225	232	PF00069	0.661
MOD_GSK3_1	297	304	PF00069	0.378
MOD_GSK3_1	339	346	PF00069	0.569
MOD_GSK3_1	349	356	PF00069	0.628
MOD_GSK3_1	460	467	PF00069	0.343
MOD_GSK3_1	495	502	PF00069	0.263
MOD_GSK3_1	53	60	PF00069	0.534
MOD_GSK3_1	531	538	PF00069	0.314
MOD_GSK3_1	579	586	PF00069	0.597
MOD_GSK3_1	600	607	PF00069	0.748
MOD_GSK3_1	614	621	PF00069	0.301
MOD_GSK3_1	66	73	PF00069	0.583
MOD_GSK3_1	780	787	PF00069	0.513
MOD_GSK3_1	92	99	PF00069	0.689
MOD_N-GLC_1	185	190	PF02516	0.570
MOD_N-GLC_1	720	725	PF02516	0.364
MOD_N-GLC_2	168	170	PF02516	0.552
MOD_NEK2_1	122	127	PF00069	0.525
MOD_NEK2_1	184	189	PF00069	0.616
MOD_NEK2_1	204	209	PF00069	0.700
MOD_NEK2_1	464	469	PF00069	0.302
MOD_NEK2_1	500	505	PF00069	0.355
MOD_NEK2_1	514	519	PF00069	0.279
MOD_NEK2_1	528	533	PF00069	0.302
MOD_NEK2_1	541	546	PF00069	0.251
MOD_NEK2_1	568	573	PF00069	0.468
MOD_NEK2_1	57	62	PF00069	0.549
MOD_NEK2_1	616	621	PF00069	0.349
MOD_NEK2_1	736	741	PF00069	0.515
MOD_NEK2_1	803	808	PF00069	0.642
MOD_NEK2_2	390	395	PF00069	0.461
MOD_NEK2_2	53	58	PF00069	0.531
MOD_PIKK_1	301	307	PF00454	0.364
MOD_PIKK_1	346	352	PF00454	0.635
MOD_PIKK_1	500	506	PF00454	0.341
MOD_PIKK_1	531	537	PF00454	0.353
MOD_PK_1	774	780	PF00069	0.427
MOD_PKA_1	140	146	PF00069	0.611
MOD_PKA_1	322	328	PF00069	0.382
MOD_PKA_2	140	146	PF00069	0.594
MOD_PKA_2	270	276	PF00069	0.498
MOD_PKA_2	313	319	PF00069	0.580
MOD_PKA_2	322	328	PF00069	0.423
MOD_PKA_2	438	444	PF00069	0.369
MOD_PKA_2	464	470	PF00069	0.302
MOD_PKA_2	57	63	PF00069	0.538
MOD_PKA_2	680	686	PF00069	0.594
MOD_PKA_2	803	809	PF00069	0.737
MOD_PKB_1	295	303	PF00069	0.515
MOD_PKB_1	44	52	PF00069	0.529
MOD_Plk_1	297	303	PF00069	0.512
MOD_Plk_1	683	689	PF00069	0.612
MOD_Plk_1	706	712	PF00069	0.474
MOD_Plk_1	780	786	PF00069	0.435
MOD_Plk_4	118	124	PF00069	0.591
MOD_Plk_4	514	520	PF00069	0.302
MOD_Plk_4	551	557	PF00069	0.302
MOD_Plk_4	570	576	PF00069	0.514
MOD_Plk_4	66	72	PF00069	0.556
MOD_Plk_4	715	721	PF00069	0.402
MOD_Plk_4	755	761	PF00069	0.402
MOD_ProDKin_1	100	106	PF00069	0.632
MOD_ProDKin_1	149	155	PF00069	0.667
MOD_ProDKin_1	225	231	PF00069	0.675
MOD_ProDKin_1	334	340	PF00069	0.601
MOD_ProDKin_1	341	347	PF00069	0.570
MOD_ProDKin_1	39	45	PF00069	0.537
MOD_ProDKin_1	466	472	PF00069	0.329
MOD_ProDKin_1	798	804	PF00069	0.568
TRG_DiLeu_BaEn_1	396	401	PF01217	0.402
TRG_DiLeu_BaEn_1	428	433	PF01217	0.444
TRG_DiLeu_BaEn_1	743	748	PF01217	0.438
TRG_DiLeu_BaLyEn_6	524	529	PF01217	0.329
TRG_DiLeu_BaLyEn_6	633	638	PF01217	0.518
TRG_DiLeu_BaLyEn_6	708	713	PF01217	0.485
TRG_ENDOCYTIC_2	481	484	PF00928	0.352
TRG_ENDOCYTIC_2	515	518	PF00928	0.302
TRG_ENDOCYTIC_2	756	759	PF00928	0.432
TRG_ER_diArg_1	132	135	PF00400	0.580
TRG_ER_diArg_1	138	141	PF00400	0.562
TRG_ER_diArg_1	294	297	PF00400	0.591
TRG_ER_diArg_1	321	323	PF00400	0.408
TRG_ER_diArg_1	326	329	PF00400	0.461
TRG_ER_diArg_1	406	408	PF00400	0.542
TRG_ER_diArg_1	420	422	PF00400	0.350
TRG_ER_diArg_1	575	577	PF00400	0.540
TRG_ER_diArg_1	632	634	PF00400	0.450
TRG_ER_diArg_1	727	729	PF00400	0.464
TRG_ER_diArg_1	768	770	PF00400	0.538
TRG_Pf-PMV_PEXEL_1	326	330	PF00026	0.478
TRG_Pf-PMV_PEXEL_1	422	427	PF00026	0.439
TRG_Pf-PMV_PEXEL_1	62	66	PF00026	0.547
TRG_Pf-PMV_PEXEL_1	669	673	PF00026	0.451
TRG_Pf-PMV_PEXEL_1	762	766	PF00026	0.377

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4U7	Leptomonas seymouri	55%	98%
A4HKY1	Leishmania braziliensis	80%	100%
A4I8G1	Leishmania infantum	100%	100%
E9B3B9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q4T6	Leishmania major	93%	100%