LeishMANIAdb
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Soluble NSF attachment protein, SNAP family protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Soluble NSF attachment protein, SNAP family protein
Gene product:
SNAP protein, putative
Species:
Leishmania donovani
UniProt:
A0A3S7X611_LEIDO
TriTrypDb:
LdBPK_323040.1 , LdCL_320036400 , LDHU3_32.3820
Length:
291

Annotations

Annotations by Jardim et al.

Intracellular protein trafficking, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0031201 SNARE complex 3 1
GO:0032991 protein-containing complex 1 1
GO:0098796 membrane protein complex 2 1

Expansion

Sequence features

A0A3S7X611
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X611

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 12
GO:0006886 intracellular protein transport 4 12
GO:0008104 protein localization 4 12
GO:0009987 cellular process 1 12
GO:0015031 protein transport 4 12
GO:0033036 macromolecule localization 2 12
GO:0045184 establishment of protein localization 3 12
GO:0046907 intracellular transport 3 12
GO:0051179 localization 1 12
GO:0051234 establishment of localization 2 12
GO:0051641 cellular localization 2 12
GO:0051649 establishment of localization in cell 3 12
GO:0070727 cellular macromolecule localization 3 12
GO:0071702 organic substance transport 4 12
GO:0071705 nitrogen compound transport 4 12
GO:0016043 cellular component organization 3 1
GO:0022411 cellular component disassembly 4 1
GO:0032984 protein-containing complex disassembly 5 1
GO:0035494 SNARE complex disassembly 6 1
GO:0043933 protein-containing complex organization 4 1
GO:0071840 cellular component organization or biogenesis 2 1
Molecular functions
Term Name Level Count
GO:0000149 SNARE binding 3 1
GO:0005483 soluble NSF attachment protein activity 3 1
GO:0005488 binding 1 1
GO:0005515 protein binding 2 1
GO:0019905 syntaxin binding 4 1
GO:0030674 protein-macromolecule adaptor activity 2 1
GO:0060090 molecular adaptor activity 1 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 3 7 PF00656 0.381
CLV_NRD_NRD_1 189 191 PF00675 0.255
CLV_PCSK_KEX2_1 18 20 PF00082 0.347
CLV_PCSK_KEX2_1 57 59 PF00082 0.338
CLV_PCSK_PC1ET2_1 18 20 PF00082 0.347
CLV_PCSK_PC1ET2_1 57 59 PF00082 0.338
CLV_PCSK_SKI1_1 14 18 PF00082 0.260
CLV_PCSK_SKI1_1 177 181 PF00082 0.265
CLV_PCSK_SKI1_1 190 194 PF00082 0.210
CLV_PCSK_SKI1_1 274 278 PF00082 0.267
CLV_PCSK_SKI1_1 280 284 PF00082 0.260
DEG_Nend_UBRbox_2 1 3 PF02207 0.475
DOC_CKS1_1 203 208 PF01111 0.309
DOC_MAPK_gen_1 57 64 PF00069 0.400
DOC_PP1_RVXF_1 188 195 PF00149 0.245
DOC_USP7_UBL2_3 14 18 PF12436 0.261
DOC_USP7_UBL2_3 274 278 PF12436 0.309
DOC_USP7_UBL2_3 81 85 PF12436 0.288
DOC_WW_Pin1_4 202 207 PF00397 0.309
LIG_14-3-3_CanoR_1 19 29 PF00244 0.390
LIG_14-3-3_CanoR_1 58 64 PF00244 0.266
LIG_CaM_IQ_9 129 144 PF13499 0.390
LIG_FHA_1 193 199 PF00498 0.338
LIG_FHA_1 239 245 PF00498 0.381
LIG_FHA_2 121 127 PF00498 0.318
LIG_FHA_2 145 151 PF00498 0.299
LIG_FHA_2 25 31 PF00498 0.386
LIG_Integrin_RGD_1 4 6 PF01839 0.390
LIG_LIR_Gen_1 222 230 PF02991 0.247
LIG_LIR_Gen_1 261 268 PF02991 0.245
LIG_LIR_Nem_3 217 223 PF02991 0.248
LIG_LIR_Nem_3 261 265 PF02991 0.245
LIG_Rb_pABgroove_1 97 105 PF01858 0.338
LIG_SH2_CRK 262 266 PF00017 0.245
LIG_SH2_GRB2like 109 112 PF00017 0.390
LIG_SH2_NCK_1 103 107 PF00017 0.352
LIG_SH2_NCK_1 109 113 PF00017 0.322
LIG_SH2_STAP1 109 113 PF00017 0.302
LIG_SH2_STAP1 172 176 PF00017 0.245
LIG_SH2_STAT5 109 112 PF00017 0.356
LIG_SH2_STAT5 138 141 PF00017 0.309
LIG_SUMO_SIM_anti_2 211 218 PF11976 0.334
MOD_CK1_1 20 26 PF00069 0.336
MOD_CK1_1 60 66 PF00069 0.313
MOD_CK2_1 144 150 PF00069 0.263
MOD_CK2_1 205 211 PF00069 0.287
MOD_GlcNHglycan 161 164 PF01048 0.290
MOD_GlcNHglycan 90 93 PF01048 0.390
MOD_GSK3_1 17 24 PF00069 0.343
MOD_N-GLC_1 65 70 PF02516 0.366
MOD_NEK2_1 192 197 PF00069 0.338
MOD_PIKK_1 225 231 PF00454 0.260
MOD_PIKK_1 38 44 PF00454 0.260
MOD_PKA_1 17 23 PF00069 0.308
MOD_PKA_1 57 63 PF00069 0.390
MOD_PKA_2 285 291 PF00069 0.513
MOD_PKA_2 57 63 PF00069 0.338
MOD_Plk_1 120 126 PF00069 0.390
MOD_Plk_1 249 255 PF00069 0.327
MOD_Plk_1 60 66 PF00069 0.372
MOD_Plk_4 193 199 PF00069 0.367
MOD_Plk_4 205 211 PF00069 0.251
MOD_Plk_4 32 38 PF00069 0.443
MOD_ProDKin_1 202 208 PF00069 0.309
MOD_SUMO_rev_2 20 29 PF00179 0.301
TRG_ENDOCYTIC_2 172 175 PF00928 0.260
TRG_ENDOCYTIC_2 223 226 PF00928 0.245
TRG_ENDOCYTIC_2 262 265 PF00928 0.245
TRG_NLS_MonoExtN_4 14 21 PF00514 0.390
TRG_Pf-PMV_PEXEL_1 130 134 PF00026 0.390

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IHW7 Leptomonas seymouri 25% 100%
A0A0N1PFE2 Leptomonas seymouri 87% 100%
A0A0S4J4X9 Bodo saltans 54% 100%
A0A0S4JSU5 Bodo saltans 27% 100%
A0A0S4JTB3 Bodo saltans 26% 100%
A0A1X0NRZ7 Trypanosomatidae 56% 100%
A0A1X0NWB5 Trypanosomatidae 25% 100%
A0A3R7P116 Trypanosoma rangeli 48% 100%
A0A3S5IRU0 Trypanosoma rangeli 25% 100%
A0A3S7WW84 Leishmania donovani 24% 100%
A4HKT1 Leishmania braziliensis 91% 100%
A4HYZ8 Leishmania infantum 23% 100%
A4I8B0 Leishmania infantum 100% 100%
C9ZIM9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 24% 100%
D0AAI1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 99%
E9AIL7 Leishmania braziliensis 25% 100%
E9AUV0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
E9B369 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
O90758 Fowlpox virus (strain NVSL) 23% 100%
P28663 Mus musculus 26% 98%
P32602 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 25% 100%
P54920 Homo sapiens 26% 99%
P54921 Rattus norvegicus 26% 99%
P78603 Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003) 25% 100%
P81125 Bos taurus 26% 99%
P81126 Bos taurus 25% 98%
P85969 Rattus norvegicus 26% 98%
P93798 Vitis vinifera 24% 100%
Q23983 Drosophila melanogaster 27% 100%
Q4Q4Y5 Leishmania major 98% 100%
Q4QCN3 Leishmania major 24% 100%
Q54NP6 Dictyostelium discoideum 25% 100%
Q75D68 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 22% 100%
Q9DB05 Mus musculus 26% 99%
Q9H115 Homo sapiens 26% 98%
Q9J5J0 Fowlpox virus (strain NVSL) 21% 100%
Q9LXZ5 Arabidopsis thaliana 23% 76%
Q9M5P8 Solanum tuberosum 28% 100%
Q9P4D0 Komagataella phaffii (strain GS115 / ATCC 20864) 27% 98%
Q9P4X4 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 26% 100%
Q9P6A5 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 26% 100%
Q9SPE6 Arabidopsis thaliana 29% 100%
V5BCV5 Trypanosoma cruzi 25% 100%
V5BHZ3 Trypanosoma cruzi 50% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS