Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X601_LEIDO

TriTrypDb:

LdBPK_323030.1 , LdCL_320036300 , LDHU3_32.3810

Length:

444

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X601

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X601

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	203	207	PF00656	0.708
CLV_C14_Caspase3-7	222	226	PF00656	0.616
CLV_C14_Caspase3-7	416	420	PF00656	0.649
CLV_NRD_NRD_1	331	333	PF00675	0.603
CLV_NRD_NRD_1	351	353	PF00675	0.482
CLV_NRD_NRD_1	354	356	PF00675	0.592
CLV_PCSK_FUR_1	329	333	PF00082	0.586
CLV_PCSK_FUR_1	352	356	PF00082	0.576
CLV_PCSK_KEX2_1	331	333	PF00082	0.584
CLV_PCSK_KEX2_1	353	355	PF00082	0.636
CLV_PCSK_PC1ET2_1	353	355	PF00082	0.636
CLV_PCSK_PC7_1	327	333	PF00082	0.594
CLV_PCSK_SKI1_1	55	59	PF00082	0.408
DEG_APCC_DBOX_1	303	311	PF00400	0.483
DEG_SPOP_SBC_1	362	366	PF00917	0.650
DOC_ANK_TNKS_1	201	208	PF00023	0.551
DOC_CKS1_1	347	352	PF01111	0.474
DOC_PP1_RVXF_1	106	113	PF00149	0.562
DOC_PP2B_PxIxI_1	43	49	PF00149	0.421
DOC_PP4_FxxP_1	50	53	PF00568	0.476
DOC_USP7_MATH_1	146	150	PF00917	0.640
DOC_USP7_MATH_1	159	163	PF00917	0.673
DOC_USP7_MATH_1	165	169	PF00917	0.686
DOC_USP7_MATH_1	191	195	PF00917	0.529
DOC_USP7_MATH_1	218	222	PF00917	0.602
DOC_USP7_MATH_1	226	230	PF00917	0.494
DOC_USP7_MATH_1	292	296	PF00917	0.455
DOC_USP7_MATH_1	319	323	PF00917	0.676
DOC_USP7_MATH_1	362	366	PF00917	0.571
DOC_USP7_MATH_1	415	419	PF00917	0.613
DOC_USP7_MATH_1	439	443	PF00917	0.609
DOC_USP7_MATH_1	85	89	PF00917	0.671
DOC_WW_Pin1_4	117	122	PF00397	0.517
DOC_WW_Pin1_4	155	160	PF00397	0.697
DOC_WW_Pin1_4	163	168	PF00397	0.698
DOC_WW_Pin1_4	346	351	PF00397	0.460
DOC_WW_Pin1_4	88	93	PF00397	0.671
LIG_14-3-3_CanoR_1	304	308	PF00244	0.513
LIG_14-3-3_CanoR_1	334	343	PF00244	0.577
LIG_14-3-3_CanoR_1	74	80	PF00244	0.675
LIG_Actin_WH2_2	21	38	PF00022	0.292
LIG_APCC_ABBA_1	239	244	PF00400	0.385
LIG_BIR_III_4	84	88	PF00653	0.595
LIG_BRCT_BRCA1_1	193	197	PF00533	0.605
LIG_eIF4E_1	15	21	PF01652	0.400
LIG_FHA_1	15	21	PF00498	0.531
LIG_FHA_1	76	82	PF00498	0.663
LIG_FHA_1	84	90	PF00498	0.530
LIG_FHA_2	414	420	PF00498	0.624
LIG_GBD_Chelix_1	178	186	PF00786	0.458
LIG_LIR_Gen_1	109	118	PF02991	0.595
LIG_LIR_Gen_1	172	183	PF02991	0.450
LIG_LIR_Gen_1	3	9	PF02991	0.469
LIG_LIR_Nem_3	109	115	PF02991	0.598
LIG_LIR_Nem_3	172	178	PF02991	0.358
LIG_LIR_Nem_3	3	8	PF02991	0.472
LIG_LIR_Nem_3	78	82	PF02991	0.606
LIG_LYPXL_yS_3	79	82	PF13949	0.622
LIG_NRBOX	309	315	PF00104	0.505
LIG_PDZ_Class_1	439	444	PF00595	0.517
LIG_Pex14_2	112	116	PF04695	0.594
LIG_SH2_PTP2	5	8	PF00017	0.439
LIG_SH2_STAP1	16	20	PF00017	0.485
LIG_SH2_STAP1	61	65	PF00017	0.416
LIG_SH2_STAT5	16	19	PF00017	0.309
LIG_SH2_STAT5	188	191	PF00017	0.508
LIG_SH2_STAT5	339	342	PF00017	0.486
LIG_SH2_STAT5	393	396	PF00017	0.493
LIG_SH2_STAT5	440	443	PF00017	0.481
LIG_SH2_STAT5	5	8	PF00017	0.429
LIG_SH3_2	347	352	PF14604	0.607
LIG_SH3_3	337	343	PF00018	0.450
LIG_SH3_3	344	350	PF00018	0.508
LIG_SH3_3	433	439	PF00018	0.630
LIG_SH3_3	86	92	PF00018	0.681
LIG_SUMO_SIM_par_1	289	296	PF11976	0.462
LIG_TRAF2_1	131	134	PF00917	0.550
LIG_TRAF2_2	328	333	PF00917	0.400
LIG_WW_3	231	235	PF00397	0.656
MOD_CDK_SPxK_1	346	352	PF00069	0.465
MOD_CDK_SPxxK_3	346	353	PF00069	0.469
MOD_CK1_1	155	161	PF00069	0.672
MOD_CK1_1	166	172	PF00069	0.671
MOD_CK1_1	173	179	PF00069	0.518
MOD_CK1_1	221	227	PF00069	0.760
MOD_CK1_1	235	241	PF00069	0.520
MOD_CK1_1	83	89	PF00069	0.729
MOD_CK2_1	417	423	PF00069	0.607
MOD_CK2_1	88	94	PF00069	0.641
MOD_GlcNHglycan	129	132	PF01048	0.379
MOD_GlcNHglycan	161	164	PF01048	0.658
MOD_GlcNHglycan	194	197	PF01048	0.609
MOD_GlcNHglycan	228	231	PF01048	0.674
MOD_GlcNHglycan	234	237	PF01048	0.517
MOD_GlcNHglycan	253	256	PF01048	0.245
MOD_GlcNHglycan	317	320	PF01048	0.619
MOD_GlcNHglycan	427	430	PF01048	0.790
MOD_GlcNHglycan	62	65	PF01048	0.643
MOD_GSK3_1	102	109	PF00069	0.553
MOD_GSK3_1	134	141	PF00069	0.571
MOD_GSK3_1	155	162	PF00069	0.758
MOD_GSK3_1	165	172	PF00069	0.734
MOD_GSK3_1	315	322	PF00069	0.529
MOD_GSK3_1	413	420	PF00069	0.645
MOD_N-GLC_1	135	140	PF02516	0.574
MOD_NEK2_1	154	159	PF00069	0.592
MOD_NEK2_1	174	179	PF00069	0.446
MOD_NEK2_1	182	187	PF00069	0.336
MOD_NEK2_1	259	264	PF00069	0.423
MOD_NEK2_1	269	274	PF00069	0.410
MOD_NEK2_1	293	298	PF00069	0.366
MOD_NEK2_1	31	36	PF00069	0.378
MOD_NEK2_1	361	366	PF00069	0.487
MOD_NEK2_1	9	14	PF00069	0.383
MOD_NEK2_2	303	308	PF00069	0.452
MOD_NEK2_2	85	90	PF00069	0.575
MOD_PIKK_1	334	340	PF00454	0.563
MOD_PKA_2	303	309	PF00069	0.472
MOD_PKA_2	406	412	PF00069	0.687
MOD_PKB_1	332	340	PF00069	0.573
MOD_Plk_1	106	112	PF00069	0.689
MOD_Plk_1	135	141	PF00069	0.536
MOD_Plk_1	146	152	PF00069	0.664
MOD_Plk_1	169	175	PF00069	0.506
MOD_Plk_2-3	419	425	PF00069	0.611
MOD_Plk_4	1	7	PF00069	0.481
MOD_Plk_4	170	176	PF00069	0.375
MOD_Plk_4	235	241	PF00069	0.454
MOD_Plk_4	319	325	PF00069	0.570
MOD_Plk_4	341	347	PF00069	0.573
MOD_Plk_4	389	395	PF00069	0.547
MOD_Plk_4	85	91	PF00069	0.727
MOD_ProDKin_1	117	123	PF00069	0.515
MOD_ProDKin_1	155	161	PF00069	0.699
MOD_ProDKin_1	163	169	PF00069	0.691
MOD_ProDKin_1	346	352	PF00069	0.465
MOD_ProDKin_1	88	94	PF00069	0.674
MOD_SUMO_rev_2	238	248	PF00179	0.396
TRG_ENDOCYTIC_2	5	8	PF00928	0.455
TRG_ENDOCYTIC_2	79	82	PF00928	0.648
TRG_ER_diArg_1	116	119	PF00400	0.552
TRG_ER_diArg_1	328	331	PF00400	0.656
TRG_ER_diArg_1	351	354	PF00400	0.580
TRG_NLS_MonoCore_2	351	356	PF00514	0.576
TRG_NLS_MonoExtC_3	352	358	PF00514	0.523
TRG_NLS_MonoExtN_4	350	357	PF00514	0.574

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IME3	Leptomonas seymouri	53%	100%
A0A1X0NTD1	Trypanosomatidae	27%	100%
A0A422NZX0	Trypanosoma rangeli	29%	100%
A4HKT0	Leishmania braziliensis	79%	99%
A4I8A9	Leishmania infantum	99%	100%
D0AAI0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9B368	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%
Q4Q4Y6	Leishmania major	89%	100%
V5DE70	Trypanosoma cruzi	29%	100%