DNA polymerase III epsilon subunit-like exonuclease

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

exonuclease-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7X5Y8_LEIDO

TriTrypDb:

LdBPK_322930.1 , LdCL_320035300 , LDHU3_32.3710

Length:

188

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X5Y8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5Y8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	5
GO:0003824	catalytic activity	1	5
GO:0004518	nuclease activity	4	5
GO:0004527	exonuclease activity	5	5
GO:0005488	binding	1	5
GO:0016787	hydrolase activity	2	5
GO:0016788	hydrolase activity, acting on ester bonds	3	5
GO:0097159	organic cyclic compound binding	2	5
GO:1901363	heterocyclic compound binding	2	5
GO:0008408	3'-5' exonuclease activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	108	110	PF00675	0.367
CLV_NRD_NRD_1	178	180	PF00675	0.572
CLV_NRD_NRD_1	26	28	PF00675	0.349
CLV_PCSK_KEX2_1	108	110	PF00082	0.367
CLV_PCSK_KEX2_1	178	180	PF00082	0.572
CLV_PCSK_KEX2_1	26	28	PF00082	0.349
DEG_Nend_UBRbox_4	1	3	PF02207	0.557
DOC_PP4_FxxP_1	115	118	PF00568	0.567
DOC_WW_Pin1_4	44	49	PF00397	0.567
LIG_14-3-3_CanoR_1	26	35	PF00244	0.567
LIG_CSL_BTD_1	115	118	PF09270	0.567
LIG_deltaCOP1_diTrp_1	6	16	PF00928	0.456
LIG_FHA_1	167	173	PF00498	0.567
LIG_LIR_Gen_1	125	136	PF02991	0.567
LIG_LIR_Gen_1	39	48	PF02991	0.505
LIG_LIR_Nem_3	125	131	PF02991	0.532
LIG_LIR_Nem_3	39	43	PF02991	0.505
LIG_LYPXL_yS_3	133	136	PF13949	0.567
LIG_NRBOX	167	173	PF00104	0.567
LIG_Pex14_1	116	120	PF04695	0.567
LIG_Pex14_1	180	184	PF04695	0.566
LIG_Pex14_2	98	102	PF04695	0.505
LIG_SH2_CRK	59	63	PF00017	0.567
LIG_SH2_PTP2	19	22	PF00017	0.567
LIG_SH2_STAT5	19	22	PF00017	0.569
LIG_SH2_STAT6	111	115	PF00017	0.567
LIG_SH3_1	19	25	PF00018	0.567
LIG_SH3_2	22	27	PF14604	0.567
LIG_SH3_3	115	121	PF00018	0.517
LIG_SH3_3	128	134	PF00018	0.546
LIG_SH3_3	19	25	PF00018	0.505
LIG_SH3_3	83	89	PF00018	0.567
LIG_TYR_ITIM	131	136	PF00017	0.567
LIG_TYR_ITIM	57	62	PF00017	0.567
MOD_CK1_1	47	53	PF00069	0.511
MOD_GlcNHglycan	28	31	PF01048	0.340
MOD_GlcNHglycan	69	72	PF01048	0.305
MOD_GSK3_1	47	54	PF00069	0.537
MOD_N-GLC_1	94	99	PF02516	0.367
MOD_NEK2_1	122	127	PF00069	0.505
MOD_PKA_1	178	184	PF00069	0.584
MOD_PKA_1	26	32	PF00069	0.567
MOD_PKA_2	178	184	PF00069	0.460
MOD_PKA_2	20	26	PF00069	0.505
MOD_Plk_1	164	170	PF00069	0.567
MOD_Plk_1	94	100	PF00069	0.517
MOD_Plk_4	58	64	PF00069	0.488
MOD_ProDKin_1	44	50	PF00069	0.567
TRG_ENDOCYTIC_2	112	115	PF00928	0.528
TRG_ENDOCYTIC_2	133	136	PF00928	0.559
TRG_ENDOCYTIC_2	59	62	PF00928	0.567
TRG_ER_diArg_1	107	109	PF00400	0.567
TRG_ER_diArg_1	178	180	PF00400	0.543
TRG_ER_diArg_1	25	27	PF00400	0.554

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4I8A0	Leishmania infantum	99%	100%
P43745	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	30%	73%
Q4Q4Z6	Leishmania major	93%	100%
Q9CPE0	Pasteurella multocida (strain Pm70)	30%	74%
V5BHY6	Trypanosoma cruzi	32%	69%