Prefoldin subunit, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

prefoldin subunit, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X5Y7_LEIDO

TriTrypDb:

LdBPK_322980.1 , LdCL_320035800 , LDHU3_32.3760

Length:

570

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X5Y7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5Y7

Function

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Biological processes
Term	Name	Level	Count
GO:0000122	negative regulation of transcription by RNA polymerase II	8	1
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009890	negative regulation of biosynthetic process	5	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010558	negative regulation of macromolecule biosynthetic process	6	1
GO:0010563	negative regulation of phosphorus metabolic process	6	1

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Molecular functions
Term	Name	Level	Count
GO:0003682	chromatin binding	2	1
GO:0003712	transcription coregulator activity	2	1
GO:0003714	transcription corepressor activity	3	1
GO:0004857	enzyme inhibitor activity	3	1
GO:0005488	binding	1	1
GO:0019208	phosphatase regulator activity	3	1
GO:0019212	phosphatase inhibitor activity	4	1
GO:0030234	enzyme regulator activity	2	1
GO:0098772	molecular function regulator activity	1	1
GO:0140110	transcription regulator activity	1	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	344	348	PF00656	0.682
CLV_NRD_NRD_1	101	103	PF00675	0.279
CLV_NRD_NRD_1	107	109	PF00675	0.274
CLV_NRD_NRD_1	285	287	PF00675	0.460
CLV_NRD_NRD_1	293	295	PF00675	0.518
CLV_NRD_NRD_1	355	357	PF00675	0.575
CLV_NRD_NRD_1	445	447	PF00675	0.677
CLV_NRD_NRD_1	473	475	PF00675	0.624
CLV_NRD_NRD_1	55	57	PF00675	0.306
CLV_PCSK_FUR_1	52	56	PF00082	0.306

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8M6	Leptomonas seymouri	46%	100%
A0A3R7KPD3	Trypanosoma rangeli	36%	100%
A4HKS5	Leishmania braziliensis	70%	99%
A4I8A5	Leishmania infantum	99%	100%
E9B363	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	98%
Q4Q4Z1	Leishmania major	89%	100%

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