Tubulin-specific chaperone A

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tubulin binding cofactor A-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7X5X5_LEIDO

TriTrypDb:

LdBPK_323130.1 , LdCL_320037200 , LDHU3_32.3910

Length:

125

Annotations

Annotations by Jardim et al.

Structural Proteins, Tubulin binding cofactor A-like

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0005874	microtubule	6	10
GO:0099080	supramolecular complex	2	10
GO:0099081	supramolecular polymer	3	10
GO:0099512	supramolecular fiber	4	10
GO:0099513	polymeric cytoskeletal fiber	5	10
GO:0110165	cellular anatomical entity	1	10
GO:0005856	cytoskeleton	5	1
GO:0015630	microtubule cytoskeleton	6	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3S7X5X5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5X5

PDB structure(s): 4cqi_A

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	10
GO:0007021	tubulin complex assembly	6	10
GO:0007023	post-chaperonin tubulin folding pathway	3	10
GO:0009987	cellular process	1	10
GO:0016043	cellular component organization	3	10
GO:0022607	cellular component assembly	4	10
GO:0043933	protein-containing complex organization	4	10
GO:0065003	protein-containing complex assembly	5	10
GO:0071840	cellular component organization or biogenesis	2	10

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0005515	protein binding	2	10
GO:0008092	cytoskeletal protein binding	3	10
GO:0015631	tubulin binding	4	10
GO:0048487	beta-tubulin binding	5	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	116	120	PF00656	0.495
CLV_PCSK_KEX2_1	34	36	PF00082	0.258
CLV_PCSK_KEX2_1	44	46	PF00082	0.258
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.258
CLV_PCSK_PC1ET2_1	44	46	PF00082	0.258
CLV_PCSK_SKI1_1	35	39	PF00082	0.267
DOC_MAPK_gen_1	34	42	PF00069	0.492
DOC_PP1_RVXF_1	36	43	PF00149	0.498
DOC_USP7_UBL2_3	34	38	PF12436	0.458
LIG_14-3-3_CanoR_1	114	118	PF00244	0.466
LIG_14-3-3_CanoR_1	27	37	PF00244	0.559
LIG_14-3-3_CanoR_1	58	62	PF00244	0.473
LIG_14-3-3_CanoR_1	85	91	PF00244	0.483
LIG_Actin_WH2_2	44	60	PF00022	0.434
LIG_BIR_II_1	1	5	PF00653	0.629
LIG_EH1_1	80	88	PF00400	0.559
LIG_FHA_1	23	29	PF00498	0.504
LIG_FHA_1	67	73	PF00498	0.553
LIG_FHA_2	114	120	PF00498	0.465
LIG_FHA_2	34	40	PF00498	0.522
LIG_SH2_STAT5	96	99	PF00017	0.529
LIG_TRAF2_1	105	108	PF00917	0.501
MOD_CK1_1	102	108	PF00069	0.559
MOD_CK1_1	2	8	PF00069	0.685
MOD_CK2_1	102	108	PF00069	0.488
MOD_GlcNHglycan	30	33	PF01048	0.329
MOD_GSK3_1	1	8	PF00069	0.716
MOD_GSK3_1	53	60	PF00069	0.489
MOD_NEK2_1	33	38	PF00069	0.514
MOD_PKA_2	113	119	PF00069	0.567
MOD_PKA_2	57	63	PF00069	0.470
MOD_Plk_1	22	28	PF00069	0.503
MOD_SUMO_for_1	43	46	PF00179	0.458
TRG_DiLeu_BaEn_4	107	113	PF01217	0.518
TRG_Pf-PMV_PEXEL_1	35	39	PF00026	0.275

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE53	Leptomonas seymouri	68%	100%
A0A1X0NSC9	Trypanosomatidae	53%	98%
A0A3R7KPE6	Trypanosoma rangeli	44%	99%
A4HKU0	Leishmania braziliensis	90%	99%
A4I8B9	Leishmania infantum	100%	100%
D0AAJ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	98%
E9B378	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
O04350	Arabidopsis thaliana	32%	100%
Q9U1D9	Leishmania major	98%	100%