CPSF_A domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X5X2_LEIDO

TriTrypDb:

LdBPK_322870.1 , LdCL_320034600 , LDHU3_32.3630

Length:

1039

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X5X2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5X2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1021	1025	PF00656	0.488
CLV_C14_Caspase3-7	309	313	PF00656	0.594
CLV_C14_Caspase3-7	347	351	PF00656	0.570
CLV_C14_Caspase3-7	895	899	PF00656	0.565
CLV_C14_Caspase3-7	981	985	PF00656	0.499
CLV_NRD_NRD_1	458	460	PF00675	0.591
CLV_NRD_NRD_1	525	527	PF00675	0.381
CLV_PCSK_KEX2_1	110	112	PF00082	0.425
CLV_PCSK_KEX2_1	177	179	PF00082	0.595
CLV_PCSK_KEX2_1	458	460	PF00082	0.591
CLV_PCSK_KEX2_1	796	798	PF00082	0.449
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.460
CLV_PCSK_PC1ET2_1	177	179	PF00082	0.551
CLV_PCSK_PC1ET2_1	796	798	PF00082	0.449
CLV_PCSK_SKI1_1	138	142	PF00082	0.445
CLV_PCSK_SKI1_1	156	160	PF00082	0.259
CLV_PCSK_SKI1_1	453	457	PF00082	0.562
CLV_PCSK_SKI1_1	485	489	PF00082	0.501
CLV_PCSK_SKI1_1	527	531	PF00082	0.349
CLV_PCSK_SKI1_1	601	605	PF00082	0.449
CLV_PCSK_SKI1_1	651	655	PF00082	0.419
CLV_PCSK_SKI1_1	770	774	PF00082	0.483
CLV_PCSK_SKI1_1	797	801	PF00082	0.433
CLV_PCSK_SKI1_1	906	910	PF00082	0.573
CLV_PCSK_SKI1_1	942	946	PF00082	0.364
DEG_APCC_DBOX_1	769	777	PF00400	0.477
DEG_SCF_FBW7_1	732	737	PF00400	0.459
DEG_SPOP_SBC_1	83	87	PF00917	0.336
DOC_ANK_TNKS_1	177	184	PF00023	0.467
DOC_ANK_TNKS_1	403	410	PF00023	0.467
DOC_CKS1_1	669	674	PF01111	0.530
DOC_CKS1_1	910	915	PF01111	0.430
DOC_CYCLIN_RxL_1	637	648	PF00134	0.494
DOC_MAPK_DCC_7	456	465	PF00069	0.563
DOC_MAPK_gen_1	150	159	PF00069	0.364
DOC_MAPK_gen_1	456	465	PF00069	0.477
DOC_MAPK_gen_1	524	531	PF00069	0.301
DOC_MAPK_gen_1	710	719	PF00069	0.503
DOC_MAPK_gen_1	767	776	PF00069	0.482
DOC_MAPK_gen_1	909	918	PF00069	0.490
DOC_MAPK_MEF2A_6	456	465	PF00069	0.470
DOC_MAPK_MEF2A_6	767	776	PF00069	0.485
DOC_MAPK_MEF2A_6	866	873	PF00069	0.441
DOC_MAPK_MEF2A_6	987	995	PF00069	0.455
DOC_MIT_MIM_1	151	160	PF04212	0.404
DOC_PP1_RVXF_1	1013	1020	PF00149	0.468
DOC_PP1_RVXF_1	258	264	PF00149	0.391
DOC_PP1_RVXF_1	940	946	PF00149	0.413
DOC_PP4_FxxP_1	575	578	PF00568	0.370
DOC_PP4_MxPP_1	847	850	PF00568	0.461
DOC_USP7_MATH_1	129	133	PF00917	0.412
DOC_USP7_MATH_1	333	337	PF00917	0.666
DOC_USP7_MATH_1	351	355	PF00917	0.793
DOC_USP7_MATH_1	357	361	PF00917	0.676
DOC_USP7_MATH_1	379	383	PF00917	0.709
DOC_USP7_MATH_1	436	440	PF00917	0.608
DOC_USP7_MATH_1	498	502	PF00917	0.612
DOC_USP7_MATH_1	742	746	PF00917	0.584
DOC_USP7_MATH_1	753	757	PF00917	0.412
DOC_USP7_MATH_1	822	826	PF00917	0.474
DOC_USP7_MATH_1	890	894	PF00917	0.714
DOC_USP7_MATH_2	890	896	PF00917	0.602
DOC_WW_Pin1_4	276	281	PF00397	0.443
DOC_WW_Pin1_4	51	56	PF00397	0.553
DOC_WW_Pin1_4	609	614	PF00397	0.458
DOC_WW_Pin1_4	668	673	PF00397	0.522
DOC_WW_Pin1_4	730	735	PF00397	0.548
DOC_WW_Pin1_4	886	891	PF00397	0.709
DOC_WW_Pin1_4	909	914	PF00397	0.393
LIG_14-3-3_CanoR_1	215	220	PF00244	0.481
LIG_14-3-3_CanoR_1	476	480	PF00244	0.465
LIG_14-3-3_CanoR_1	710	715	PF00244	0.546
LIG_14-3-3_CanoR_1	73	83	PF00244	0.469
LIG_14-3-3_CanoR_1	797	806	PF00244	0.434
LIG_14-3-3_CanoR_1	839	847	PF00244	0.468
LIG_14-3-3_CanoR_1	880	886	PF00244	0.540
LIG_14-3-3_CanoR_1	955	964	PF00244	0.382
LIG_14-3-3_CanoR_1	987	995	PF00244	0.455
LIG_BIR_II_1	1	5	PF00653	0.598
LIG_BRCT_BRCA1_1	571	575	PF00533	0.506
LIG_CSL_BTD_1	950	953	PF09270	0.438
LIG_deltaCOP1_diTrp_1	634	638	PF00928	0.416
LIG_DLG_GKlike_1	830	838	PF00625	0.399
LIG_FHA_1	1003	1009	PF00498	0.406
LIG_FHA_1	170	176	PF00498	0.497
LIG_FHA_1	220	226	PF00498	0.491
LIG_FHA_1	267	273	PF00498	0.616
LIG_FHA_1	414	420	PF00498	0.533
LIG_FHA_1	509	515	PF00498	0.442
LIG_FHA_1	731	737	PF00498	0.462
LIG_FHA_1	75	81	PF00498	0.454
LIG_FHA_1	752	758	PF00498	0.455
LIG_FHA_1	798	804	PF00498	0.427
LIG_FHA_1	83	89	PF00498	0.422
LIG_FHA_1	927	933	PF00498	0.386
LIG_FHA_1	986	992	PF00498	0.422
LIG_FHA_2	14	20	PF00498	0.507
LIG_FHA_2	243	249	PF00498	0.611
LIG_FHA_2	486	492	PF00498	0.496
LIG_FHA_2	645	651	PF00498	0.407
LIG_FHA_2	882	888	PF00498	0.597
LIG_IRF3_LxIS_1	605	612	PF10401	0.475
LIG_LIR_Apic_2	182	187	PF02991	0.416
LIG_LIR_Apic_2	572	578	PF02991	0.398
LIG_LIR_Apic_2	579	583	PF02991	0.389
LIG_LIR_Gen_1	228	237	PF02991	0.388
LIG_LIR_Gen_1	604	613	PF02991	0.389
LIG_LIR_Gen_1	630	641	PF02991	0.417
LIG_LIR_Gen_1	718	728	PF02991	0.462
LIG_LIR_Gen_1	958	967	PF02991	0.456
LIG_LIR_Nem_3	228	233	PF02991	0.402
LIG_LIR_Nem_3	604	609	PF02991	0.350
LIG_LIR_Nem_3	630	636	PF02991	0.437
LIG_LIR_Nem_3	718	723	PF02991	0.433
LIG_LIR_Nem_3	958	964	PF02991	0.428
LIG_MYND_1	276	280	PF01753	0.541
LIG_NRBOX	830	836	PF00104	0.457
LIG_Pex14_1	1028	1032	PF04695	0.531
LIG_Rb_LxCxE_1	743	759	PF01857	0.385
LIG_RPA_C_Fungi	442	454	PF08784	0.448
LIG_SH2_CRK	1032	1036	PF00017	0.505
LIG_SH2_CRK	253	257	PF00017	0.531
LIG_SH2_CRK	34	38	PF00017	0.444
LIG_SH2_CRK	518	522	PF00017	0.329
LIG_SH2_CRK	606	610	PF00017	0.451
LIG_SH2_CRK	670	674	PF00017	0.532
LIG_SH2_NCK_1	286	290	PF00017	0.599
LIG_SH2_NCK_1	330	334	PF00017	0.671
LIG_SH2_PTP2	139	142	PF00017	0.463
LIG_SH2_PTP2	720	723	PF00017	0.434
LIG_SH2_SRC	286	289	PF00017	0.588
LIG_SH2_SRC	330	333	PF00017	0.671
LIG_SH2_SRC	34	37	PF00017	0.376
LIG_SH2_SRC	580	583	PF00017	0.436
LIG_SH2_SRC	720	723	PF00017	0.434
LIG_SH2_STAP1	286	290	PF00017	0.655
LIG_SH2_STAP1	606	610	PF00017	0.451
LIG_SH2_STAT5	139	142	PF00017	0.482
LIG_SH2_STAT5	580	583	PF00017	0.401
LIG_SH2_STAT5	606	609	PF00017	0.353
LIG_SH2_STAT5	670	673	PF00017	0.423
LIG_SH2_STAT5	720	723	PF00017	0.431
LIG_SH2_STAT5	792	795	PF00017	0.573
LIG_SH2_STAT5	81	84	PF00017	0.396
LIG_SH3_3	34	40	PF00018	0.442
LIG_SH3_3	52	58	PF00018	0.474
LIG_SH3_3	542	548	PF00018	0.507
LIG_SH3_3	582	588	PF00018	0.426
LIG_SH3_3	626	632	PF00018	0.587
LIG_SH3_3	907	913	PF00018	0.401
LIG_SH3_3	914	920	PF00018	0.374
LIG_SH3_3	947	953	PF00018	0.449
LIG_SUMO_SIM_anti_2	188	195	PF11976	0.460
LIG_SUMO_SIM_anti_2	41	49	PF11976	0.367
LIG_SUMO_SIM_anti_2	988	995	PF11976	0.364
LIG_SUMO_SIM_par_1	188	195	PF11976	0.368
LIG_SUMO_SIM_par_1	41	49	PF11976	0.393
LIG_SUMO_SIM_par_1	410	416	PF11976	0.490
LIG_SxIP_EBH_1	696	710	PF03271	0.588
LIG_TRAF2_1	336	339	PF00917	0.639
LIG_TRAF2_1	39	42	PF00917	0.403
LIG_TRAF2_1	501	504	PF00917	0.594
LIG_TRAF2_1	653	656	PF00917	0.522
LIG_TYR_ITIM	1030	1035	PF00017	0.506
LIG_UBA3_1	44	50	PF00899	0.427
LIG_UBA3_1	844	851	PF00899	0.501
LIG_WRC_WIRS_1	216	221	PF05994	0.485
MOD_CDK_SPK_2	611	616	PF00069	0.430
MOD_CDK_SPxK_1	668	674	PF00069	0.534
MOD_CDK_SPxxK_3	609	616	PF00069	0.551
MOD_CK1_1	166	172	PF00069	0.543
MOD_CK1_1	17	23	PF00069	0.602
MOD_CK1_1	266	272	PF00069	0.540
MOD_CK1_1	384	390	PF00069	0.681
MOD_CK1_1	49	55	PF00069	0.584
MOD_CK1_1	696	702	PF00069	0.618
MOD_CK1_1	833	839	PF00069	0.395
MOD_CK1_1	87	93	PF00069	0.579
MOD_CK1_1	989	995	PF00069	0.445
MOD_CK2_1	332	338	PF00069	0.744
MOD_CK2_1	485	491	PF00069	0.518
MOD_CK2_1	497	503	PF00069	0.563
MOD_CK2_1	547	553	PF00069	0.448
MOD_CK2_1	644	650	PF00069	0.438
MOD_CK2_1	752	758	PF00069	0.466
MOD_CK2_1	822	828	PF00069	0.443
MOD_CK2_1	851	857	PF00069	0.507
MOD_CK2_1	886	892	PF00069	0.670
MOD_CMANNOS	202	205	PF00535	0.380
MOD_Cter_Amidation	524	527	PF01082	0.378
MOD_GlcNHglycan	131	134	PF01048	0.376
MOD_GlcNHglycan	165	168	PF01048	0.437
MOD_GlcNHglycan	202	205	PF01048	0.499
MOD_GlcNHglycan	353	356	PF01048	0.678
MOD_GlcNHglycan	383	386	PF01048	0.720
MOD_GlcNHglycan	390	393	PF01048	0.523
MOD_GlcNHglycan	51	54	PF01048	0.541
MOD_GlcNHglycan	686	689	PF01048	0.672
MOD_GlcNHglycan	726	729	PF01048	0.385
MOD_GlcNHglycan	819	822	PF01048	0.450
MOD_GlcNHglycan	835	838	PF01048	0.443
MOD_GlcNHglycan	89	92	PF01048	0.440
MOD_GlcNHglycan	892	895	PF01048	0.705
MOD_GlcNHglycan	937	940	PF01048	0.356
MOD_GSK3_1	110	117	PF00069	0.476
MOD_GSK3_1	13	20	PF00069	0.626
MOD_GSK3_1	200	207	PF00069	0.451
MOD_GSK3_1	215	222	PF00069	0.442
MOD_GSK3_1	276	283	PF00069	0.458
MOD_GSK3_1	333	340	PF00069	0.747
MOD_GSK3_1	384	391	PF00069	0.606
MOD_GSK3_1	494	501	PF00069	0.501
MOD_GSK3_1	698	705	PF00069	0.695
MOD_GSK3_1	730	737	PF00069	0.540
MOD_GSK3_1	749	756	PF00069	0.543
MOD_GSK3_1	813	820	PF00069	0.381
MOD_GSK3_1	82	89	PF00069	0.488
MOD_GSK3_1	886	893	PF00069	0.662
MOD_GSK3_1	951	958	PF00069	0.451
MOD_GSK3_1	985	992	PF00069	0.447
MOD_LATS_1	213	219	PF00433	0.485
MOD_LATS_1	445	451	PF00433	0.603
MOD_N-GLC_1	122	127	PF02516	0.421
MOD_N-GLC_1	509	514	PF02516	0.403
MOD_N-GLC_1	74	79	PF02516	0.495
MOD_N-GLC_2	398	400	PF02516	0.481
MOD_NEK2_1	263	268	PF00069	0.511
MOD_NEK2_1	27	32	PF00069	0.421
MOD_NEK2_1	388	393	PF00069	0.519
MOD_NEK2_1	740	745	PF00069	0.496
MOD_NEK2_1	926	931	PF00069	0.384
MOD_NEK2_2	475	480	PF00069	0.513
MOD_PIKK_1	734	740	PF00454	0.540
MOD_PIKK_1	955	961	PF00454	0.475
MOD_PK_1	18	24	PF00069	0.545
MOD_PKA_1	110	116	PF00069	0.504
MOD_PKA_2	110	116	PF00069	0.505
MOD_PKA_2	17	23	PF00069	0.552
MOD_PKA_2	214	220	PF00069	0.538
MOD_PKA_2	475	481	PF00069	0.494
MOD_PKA_2	838	844	PF00069	0.457
MOD_PKA_2	954	960	PF00069	0.478
MOD_PKA_2	986	992	PF00069	0.475
MOD_Plk_1	122	128	PF00069	0.381
MOD_Plk_1	143	149	PF00069	0.541
MOD_Plk_1	18	24	PF00069	0.486
MOD_Plk_1	437	443	PF00069	0.537
MOD_Plk_1	509	515	PF00069	0.395
MOD_Plk_1	552	558	PF00069	0.395
MOD_Plk_1	83	89	PF00069	0.405
MOD_Plk_1	989	995	PF00069	0.387
MOD_Plk_2-3	337	343	PF00069	0.709
MOD_Plk_2-3	978	984	PF00069	0.541
MOD_Plk_4	122	128	PF00069	0.381
MOD_Plk_4	225	231	PF00069	0.436
MOD_Plk_4	384	390	PF00069	0.643
MOD_Plk_4	576	582	PF00069	0.481
MOD_Plk_4	601	607	PF00069	0.353
MOD_Plk_4	64	70	PF00069	0.491
MOD_Plk_4	742	748	PF00069	0.426
MOD_Plk_4	810	816	PF00069	0.387
MOD_Plk_4	830	836	PF00069	0.461
MOD_Plk_4	989	995	PF00069	0.445
MOD_ProDKin_1	276	282	PF00069	0.451
MOD_ProDKin_1	51	57	PF00069	0.539
MOD_ProDKin_1	609	615	PF00069	0.473
MOD_ProDKin_1	668	674	PF00069	0.531
MOD_ProDKin_1	730	736	PF00069	0.539
MOD_ProDKin_1	886	892	PF00069	0.715
MOD_ProDKin_1	909	915	PF00069	0.391
MOD_SUMO_rev_2	681	685	PF00179	0.468
TRG_DiLeu_BaEn_1	188	193	PF01217	0.419
TRG_DiLeu_BaEn_1	769	774	PF01217	0.478
TRG_DiLeu_BaEn_1	990	995	PF01217	0.510
TRG_DiLeu_BaEn_3	41	47	PF01217	0.423
TRG_DiLeu_BaEn_4	482	488	PF01217	0.534
TRG_DiLeu_BaLyEn_6	104	109	PF01217	0.521
TRG_DiLeu_BaLyEn_6	40	45	PF01217	0.436
TRG_DiLeu_BaLyEn_6	939	944	PF01217	0.447
TRG_DiLeu_LyEn_5	731	736	PF01217	0.455
TRG_ENDOCYTIC_2	1032	1035	PF00928	0.559
TRG_ENDOCYTIC_2	139	142	PF00928	0.427
TRG_ENDOCYTIC_2	34	37	PF00928	0.433
TRG_ENDOCYTIC_2	518	521	PF00928	0.329
TRG_ENDOCYTIC_2	606	609	PF00928	0.353
TRG_ENDOCYTIC_2	633	636	PF00928	0.389
TRG_ENDOCYTIC_2	670	673	PF00928	0.458
TRG_ENDOCYTIC_2	720	723	PF00928	0.434
TRG_ER_diArg_1	458	460	PF00400	0.591
TRG_ER_diArg_1	523	526	PF00400	0.372
TRG_ER_diArg_1	541	544	PF00400	0.414
TRG_ER_FFAT_1	324	336	PF00635	0.657
TRG_Pf-PMV_PEXEL_1	404	408	PF00026	0.491
TRG_Pf-PMV_PEXEL_1	562	566	PF00026	0.374
TRG_Pf-PMV_PEXEL_1	942	947	PF00026	0.401

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Z6	Leptomonas seymouri	61%	98%
A0A1X0NRM5	Trypanosomatidae	37%	100%
A0A422NZR3	Trypanosoma rangeli	38%	100%
A4HKR4	Leishmania braziliensis	76%	100%
A4I894	Leishmania infantum	100%	100%
E9B352	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	97%
Q4Q502	Leishmania major	93%	100%