Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF778), putative

Species:

Leishmania donovani

UniProt:

A0A3S7X5W7_LEIDO

TriTrypDb:

LdBPK_323020.1 , LdCL_320036200 , LDHU3_32.3800

Length:

593

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3S7X5W7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5W7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	400	404	PF00656	0.616
CLV_C14_Caspase3-7	423	427	PF00656	0.546
CLV_NRD_NRD_1	132	134	PF00675	0.534
CLV_NRD_NRD_1	290	292	PF00675	0.346
CLV_NRD_NRD_1	327	329	PF00675	0.346
CLV_NRD_NRD_1	330	332	PF00675	0.346
CLV_NRD_NRD_1	391	393	PF00675	0.393
CLV_NRD_NRD_1	559	561	PF00675	0.510
CLV_PCSK_FUR_1	325	329	PF00082	0.346
CLV_PCSK_KEX2_1	132	134	PF00082	0.534
CLV_PCSK_KEX2_1	290	292	PF00082	0.346
CLV_PCSK_KEX2_1	327	329	PF00082	0.346
CLV_PCSK_KEX2_1	330	332	PF00082	0.346
CLV_PCSK_KEX2_1	390	392	PF00082	0.396
CLV_PCSK_KEX2_1	559	561	PF00082	0.509
CLV_PCSK_PC1ET2_1	390	392	PF00082	0.349
CLV_PCSK_SKI1_1	318	322	PF00082	0.346
CLV_PCSK_SKI1_1	543	547	PF00082	0.346
DEG_APCC_DBOX_1	222	230	PF00400	0.586
DEG_APCC_DBOX_1	239	247	PF00400	0.436
DEG_SCF_FBW7_1	381	387	PF00400	0.483
DEG_SPOP_SBC_1	230	234	PF00917	0.583
DEG_SPOP_SBC_1	384	388	PF00917	0.516
DEG_SPOP_SBC_1	46	50	PF00917	0.782
DEG_SPOP_SBC_1	504	508	PF00917	0.483
DOC_ANK_TNKS_1	444	451	PF00023	0.546
DOC_CDC14_PxL_1	114	122	PF14671	0.769
DOC_CDC14_PxL_1	214	222	PF14671	0.483
DOC_CKS1_1	381	386	PF01111	0.483
DOC_CYCLIN_RxL_1	129	140	PF00134	0.750
DOC_CYCLIN_RxL_1	538	549	PF00134	0.616
DOC_MAPK_DCC_7	313	322	PF00069	0.546
DOC_MAPK_FxFP_2	152	155	PF00069	0.671
DOC_PP1_RVXF_1	541	547	PF00149	0.546
DOC_PP2B_LxvP_1	134	137	PF13499	0.754
DOC_PP4_FxxP_1	152	155	PF00568	0.671
DOC_USP7_MATH_1	157	161	PF00917	0.612
DOC_USP7_MATH_1	174	178	PF00917	0.467
DOC_USP7_MATH_1	247	251	PF00917	0.545
DOC_USP7_MATH_1	252	256	PF00917	0.527
DOC_USP7_MATH_1	282	286	PF00917	0.542
DOC_USP7_MATH_1	385	389	PF00917	0.506
DOC_USP7_MATH_1	409	413	PF00917	0.616
DOC_USP7_MATH_1	448	452	PF00917	0.546
DOC_USP7_MATH_1	46	50	PF00917	0.770
DOC_USP7_MATH_1	483	487	PF00917	0.483
DOC_USP7_MATH_1	497	501	PF00917	0.486
DOC_USP7_MATH_1	503	507	PF00917	0.496
DOC_USP7_MATH_1	527	531	PF00917	0.562
DOC_USP7_MATH_1	65	69	PF00917	0.692
DOC_USP7_MATH_1	7	11	PF00917	0.693
DOC_USP7_MATH_1	80	84	PF00917	0.773
DOC_USP7_UBL2_3	491	495	PF12436	0.616
DOC_WW_Pin1_4	122	127	PF00397	0.762
DOC_WW_Pin1_4	258	263	PF00397	0.546
DOC_WW_Pin1_4	274	279	PF00397	0.546
DOC_WW_Pin1_4	3	8	PF00397	0.762
DOC_WW_Pin1_4	329	334	PF00397	0.616
DOC_WW_Pin1_4	380	385	PF00397	0.524
DOC_WW_Pin1_4	451	456	PF00397	0.546
DOC_WW_Pin1_4	489	494	PF00397	0.550
DOC_WW_Pin1_4	50	55	PF00397	0.760
DOC_WW_Pin1_4	505	510	PF00397	0.473
DOC_WW_Pin1_4	95	100	PF00397	0.774
LIG_14-3-3_CanoR_1	178	183	PF00244	0.537
LIG_14-3-3_CanoR_1	272	278	PF00244	0.528
LIG_14-3-3_CanoR_1	294	302	PF00244	0.577
LIG_14-3-3_CanoR_1	515	520	PF00244	0.483
LIG_BIR_III_2	524	528	PF00653	0.616
LIG_BIR_III_4	401	405	PF00653	0.616
LIG_BRCT_BRCA1_1	159	163	PF00533	0.546
LIG_BRCT_BRCA1_1	276	280	PF00533	0.616
LIG_BRCT_BRCA1_1	463	467	PF00533	0.546
LIG_deltaCOP1_diTrp_1	536	546	PF00928	0.606
LIG_EVH1_1	381	385	PF00568	0.483
LIG_FHA_1	208	214	PF00498	0.549
LIG_FHA_1	230	236	PF00498	0.549
LIG_FHA_1	274	280	PF00498	0.616
LIG_FHA_1	307	313	PF00498	0.546
LIG_FHA_1	384	390	PF00498	0.593
LIG_FHA_1	438	444	PF00498	0.546
LIG_FHA_1	70	76	PF00498	0.774
LIG_FHA_2	138	144	PF00498	0.782
LIG_LIR_Apic_2	160	164	PF02991	0.546
LIG_LIR_Gen_1	420	430	PF02991	0.548
LIG_LIR_Gen_1	463	472	PF02991	0.546
LIG_LIR_Gen_1	574	585	PF02991	0.509
LIG_LIR_Nem_3	160	166	PF02991	0.526
LIG_LIR_Nem_3	420	425	PF02991	0.548
LIG_LIR_Nem_3	463	468	PF02991	0.546
LIG_LIR_Nem_3	574	580	PF02991	0.509
LIG_MYND_1	100	104	PF01753	0.740
LIG_NRBOX	351	357	PF00104	0.546
LIG_PDZ_Class_2	588	593	PF00595	0.533
LIG_Pex14_2	154	158	PF04695	0.616
LIG_Pex14_2	588	592	PF04695	0.467
LIG_SH2_STAP1	393	397	PF00017	0.549
LIG_SH2_STAT5	180	183	PF00017	0.563
LIG_SH2_STAT5	187	190	PF00017	0.529
LIG_SH2_STAT5	587	590	PF00017	0.441
LIG_SH3_2	490	495	PF14604	0.616
LIG_SH3_3	123	129	PF00018	0.782
LIG_SH3_3	241	247	PF00018	0.565
LIG_SH3_3	256	262	PF00018	0.611
LIG_SH3_3	275	281	PF00018	0.398
LIG_SH3_3	379	385	PF00018	0.549
LIG_SH3_3	484	490	PF00018	0.616
LIG_SUMO_SIM_par_1	190	198	PF11976	0.616
LIG_TRAF2_1	414	417	PF00917	0.616
LIG_WRC_WIRS_1	179	184	PF05994	0.411
LIG_WW_3	287	291	PF00397	0.383
MOD_CDC14_SPxK_1	492	495	PF00782	0.416
MOD_CDK_SPxK_1	489	495	PF00069	0.448
MOD_CDK_SPxxK_3	125	132	PF00069	0.705
MOD_CK1_1	105	111	PF00069	0.683
MOD_CK1_1	16	22	PF00069	0.494
MOD_CK1_1	234	240	PF00069	0.480
MOD_CK1_1	25	31	PF00069	0.683
MOD_CK1_1	250	256	PF00069	0.309
MOD_CK1_1	263	269	PF00069	0.431
MOD_CK1_1	297	303	PF00069	0.346
MOD_CK1_1	362	368	PF00069	0.495
MOD_CK1_1	377	383	PF00069	0.250
MOD_CK1_1	451	457	PF00069	0.411
MOD_CK1_1	463	469	PF00069	0.411
MOD_CK1_1	48	54	PF00069	0.771
MOD_CK1_1	485	491	PF00069	0.415
MOD_CK1_1	530	536	PF00069	0.465
MOD_CK1_1	569	575	PF00069	0.411
MOD_CK1_1	6	12	PF00069	0.826
MOD_CK1_1	68	74	PF00069	0.623
MOD_CK1_1	94	100	PF00069	0.780
MOD_CK2_1	137	143	PF00069	0.658
MOD_CK2_1	169	175	PF00069	0.392
MOD_CK2_1	25	31	PF00069	0.717
MOD_CK2_1	410	416	PF00069	0.418
MOD_CK2_1	530	536	PF00069	0.441
MOD_CK2_1	7	13	PF00069	0.643
MOD_Cter_Amidation	325	328	PF01082	0.411
MOD_GlcNHglycan	122	125	PF01048	0.683
MOD_GlcNHglycan	225	229	PF01048	0.452
MOD_GlcNHglycan	251	255	PF01048	0.419
MOD_GlcNHglycan	264	268	PF01048	0.436
MOD_GlcNHglycan	284	287	PF01048	0.183
MOD_GlcNHglycan	296	299	PF01048	0.349
MOD_GlcNHglycan	303	306	PF01048	0.281
MOD_GlcNHglycan	35	38	PF01048	0.702
MOD_GlcNHglycan	406	409	PF01048	0.395
MOD_GlcNHglycan	413	416	PF01048	0.385
MOD_GlcNHglycan	42	45	PF01048	0.720
MOD_GlcNHglycan	446	449	PF01048	0.411
MOD_GlcNHglycan	487	490	PF01048	0.424
MOD_GlcNHglycan	499	502	PF01048	0.452
MOD_GlcNHglycan	571	574	PF01048	0.411
MOD_GlcNHglycan	67	70	PF01048	0.702
MOD_GlcNHglycan	93	96	PF01048	0.794
MOD_GSK3_1	174	181	PF00069	0.411
MOD_GSK3_1	21	28	PF00069	0.739
MOD_GSK3_1	230	237	PF00069	0.388
MOD_GSK3_1	250	257	PF00069	0.435
MOD_GSK3_1	297	304	PF00069	0.323
MOD_GSK3_1	3	10	PF00069	0.685
MOD_GSK3_1	356	363	PF00069	0.411
MOD_GSK3_1	380	387	PF00069	0.411
MOD_GSK3_1	392	399	PF00069	0.504
MOD_GSK3_1	40	47	PF00069	0.835
MOD_GSK3_1	444	451	PF00069	0.411
MOD_GSK3_1	481	488	PF00069	0.416
MOD_GSK3_1	499	506	PF00069	0.224
MOD_GSK3_1	510	517	PF00069	0.424
MOD_GSK3_1	65	72	PF00069	0.720
MOD_GSK3_1	80	87	PF00069	0.722
MOD_GSK3_1	91	98	PF00069	0.669
MOD_N-GLC_1	437	442	PF02516	0.411
MOD_N-GLC_1	7	12	PF02516	0.641
MOD_N-GLC_1	91	96	PF02516	0.842
MOD_NEK2_1	120	125	PF00069	0.735
MOD_NEK2_1	182	187	PF00069	0.411
MOD_NEK2_1	231	236	PF00069	0.414
MOD_NEK2_1	321	326	PF00069	0.411
MOD_NEK2_1	33	38	PF00069	0.640
MOD_NEK2_1	437	442	PF00069	0.411
MOD_NEK2_1	546	551	PF00069	0.509
MOD_NEK2_2	385	390	PF00069	0.369
MOD_PIKK_1	238	244	PF00454	0.439
MOD_PIKK_1	306	312	PF00454	0.509
MOD_PIKK_1	335	341	PF00454	0.509
MOD_PIKK_1	476	482	PF00454	0.411
MOD_PK_1	192	198	PF00069	0.509
MOD_PKA_2	273	279	PF00069	0.444
MOD_PKA_2	289	295	PF00069	0.353
MOD_PKA_2	326	332	PF00069	0.509
MOD_PKA_2	367	373	PF00069	0.417
MOD_PKA_2	444	450	PF00069	0.411
MOD_PKA_2	514	520	PF00069	0.323
MOD_PKB_1	133	141	PF00069	0.637
MOD_PKB_1	270	278	PF00069	0.323
MOD_Plk_1	182	188	PF00069	0.411
MOD_Plk_1	224	230	PF00069	0.398
MOD_Plk_1	437	443	PF00069	0.411
MOD_Plk_1	7	13	PF00069	0.643
MOD_Plk_2-3	396	402	PF00069	0.416
MOD_Plk_4	157	163	PF00069	0.509
MOD_Plk_4	182	188	PF00069	0.411
MOD_Plk_4	209	215	PF00069	0.383
MOD_Plk_4	546	552	PF00069	0.509
MOD_Plk_4	571	577	PF00069	0.509
MOD_Plk_4	71	77	PF00069	0.773
MOD_ProDKin_1	122	128	PF00069	0.711
MOD_ProDKin_1	258	264	PF00069	0.411
MOD_ProDKin_1	274	280	PF00069	0.411
MOD_ProDKin_1	3	9	PF00069	0.716
MOD_ProDKin_1	329	335	PF00069	0.509
MOD_ProDKin_1	380	386	PF00069	0.381
MOD_ProDKin_1	451	457	PF00069	0.411
MOD_ProDKin_1	489	495	PF00069	0.417
MOD_ProDKin_1	50	56	PF00069	0.711
MOD_ProDKin_1	505	511	PF00069	0.309
MOD_ProDKin_1	95	101	PF00069	0.731
MOD_SUMO_rev_2	184	194	PF00179	0.411
TRG_DiLeu_BaEn_1	420	425	PF01217	0.416
TRG_DiLeu_BaEn_4	420	426	PF01217	0.416
TRG_DiLeu_BaLyEn_6	316	321	PF01217	0.411
TRG_ENDOCYTIC_2	422	425	PF00928	0.411
TRG_ENDOCYTIC_2	585	588	PF00928	0.549
TRG_ER_diArg_1	132	135	PF00400	0.676
TRG_ER_diArg_1	271	274	PF00400	0.509
TRG_ER_diArg_1	289	291	PF00400	0.323
TRG_ER_diArg_1	325	328	PF00400	0.411
TRG_ER_diArg_1	391	393	PF00400	0.472
TRG_ER_diArg_1	559	561	PF00400	0.632
TRG_Pf-PMV_PEXEL_1	199	203	PF00026	0.315

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1M3	Leptomonas seymouri	51%	77%
A4HKS9	Leishmania braziliensis	73%	100%
A4I8A8	Leishmania infantum	100%	100%
E9B367	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%
Q4Q4Y7	Leishmania major	93%	100%