SAM_MT_RSMB_NOP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X5W5_LEIDO

TriTrypDb:

LdBPK_323090.1 , LdCL_320036900 , LDHU3_32.3870

Length:

604

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X5W5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5W5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	484	488	PF00656	0.355
CLV_NRD_NRD_1	109	111	PF00675	0.353
CLV_NRD_NRD_1	129	131	PF00675	0.624
CLV_NRD_NRD_1	397	399	PF00675	0.550
CLV_NRD_NRD_1	464	466	PF00675	0.428
CLV_NRD_NRD_1	567	569	PF00675	0.686
CLV_NRD_NRD_1	75	77	PF00675	0.579
CLV_PCSK_KEX2_1	210	212	PF00082	0.319
CLV_PCSK_KEX2_1	396	398	PF00082	0.524
CLV_PCSK_KEX2_1	536	538	PF00082	0.504
CLV_PCSK_KEX2_1	569	571	PF00082	0.731
CLV_PCSK_KEX2_1	75	77	PF00082	0.602
CLV_PCSK_PC1ET2_1	210	212	PF00082	0.319
CLV_PCSK_PC1ET2_1	536	538	PF00082	0.514
CLV_PCSK_PC1ET2_1	569	571	PF00082	0.731
CLV_PCSK_SKI1_1	110	114	PF00082	0.580
CLV_PCSK_SKI1_1	134	138	PF00082	0.446
CLV_PCSK_SKI1_1	152	156	PF00082	0.483
CLV_PCSK_SKI1_1	16	20	PF00082	0.632
CLV_PCSK_SKI1_1	4	8	PF00082	0.580
CLV_PCSK_SKI1_1	521	525	PF00082	0.563
DEG_Nend_UBRbox_1	1	4	PF02207	0.605
DOC_CYCLIN_RxL_1	1	11	PF00134	0.697
DOC_CYCLIN_RxL_1	238	246	PF00134	0.344
DOC_CYCLIN_yCln2_LP_2	14	20	PF00134	0.711
DOC_CYCLIN_yCln2_LP_2	443	449	PF00134	0.344
DOC_MAPK_DCC_7	10	20	PF00069	0.735
DOC_MAPK_gen_1	167	176	PF00069	0.480
DOC_MAPK_gen_1	2	9	PF00069	0.579
DOC_MAPK_gen_1	440	449	PF00069	0.335
DOC_MAPK_gen_1	465	472	PF00069	0.476
DOC_MAPK_gen_1	536	543	PF00069	0.476
DOC_MAPK_gen_1	75	83	PF00069	0.596
DOC_MAPK_JIP1_4	598	604	PF00069	0.694
DOC_MAPK_MEF2A_6	152	160	PF00069	0.419
DOC_MAPK_MEF2A_6	536	545	PF00069	0.475
DOC_MAPK_MEF2A_6	87	95	PF00069	0.621
DOC_MAPK_RevD_3	93	107	PF00069	0.504
DOC_PP1_RVXF_1	508	515	PF00149	0.551
DOC_PP1_SILK_1	223	228	PF00149	0.408
DOC_PP1_SILK_1	431	436	PF00149	0.402
DOC_PP2B_LxvP_1	410	413	PF13499	0.499
DOC_PP4_FxxP_1	495	498	PF00568	0.494
DOC_SPAK_OSR1_1	66	70	PF12202	0.672
DOC_USP7_MATH_1	306	310	PF00917	0.616
DOC_USP7_MATH_1	367	371	PF00917	0.728
DOC_USP7_MATH_1	506	510	PF00917	0.543
DOC_USP7_MATH_2	498	504	PF00917	0.538
DOC_USP7_UBL2_3	102	106	PF12436	0.462
DOC_USP7_UBL2_3	107	111	PF12436	0.437
DOC_USP7_UBL2_3	507	511	PF12436	0.655
DOC_WW_Pin1_4	228	233	PF00397	0.335
DOC_WW_Pin1_4	350	355	PF00397	0.702
DOC_WW_Pin1_4	442	447	PF00397	0.335
LIG_14-3-3_CanoR_1	177	183	PF00244	0.476
LIG_14-3-3_CanoR_1	227	232	PF00244	0.348
LIG_14-3-3_CanoR_1	556	562	PF00244	0.609
LIG_14-3-3_CanoR_1	576	586	PF00244	0.679
LIG_14-3-3_CanoR_1	66	72	PF00244	0.534
LIG_14-3-3_CanoR_1	75	83	PF00244	0.563
LIG_BIR_III_2	478	482	PF00653	0.460
LIG_BIR_III_4	289	293	PF00653	0.503
LIG_BRCT_BRCA1_1	63	67	PF00533	0.648
LIG_FHA_1	22	28	PF00498	0.691
LIG_FHA_1	260	266	PF00498	0.335
LIG_FHA_1	360	366	PF00498	0.659
LIG_FHA_1	434	440	PF00498	0.490
LIG_FHA_1	582	588	PF00498	0.616
LIG_FHA_1	9	15	PF00498	0.640
LIG_LIR_Apic_2	493	498	PF02991	0.482
LIG_LIR_Apic_2	593	599	PF02991	0.555
LIG_LIR_Gen_1	323	334	PF02991	0.497
LIG_LIR_Gen_1	406	417	PF02991	0.662
LIG_LIR_Nem_3	294	299	PF02991	0.449
LIG_LIR_Nem_3	323	329	PF02991	0.501
LIG_LIR_Nem_3	385	389	PF02991	0.530
LIG_LIR_Nem_3	487	492	PF02991	0.336
LIG_LIR_Nem_3	517	523	PF02991	0.533
LIG_NRBOX	140	146	PF00104	0.469
LIG_Pex14_2	386	390	PF04695	0.624
LIG_PTB_Apo_2	40	47	PF02174	0.569
LIG_SH2_CRK	229	233	PF00017	0.346
LIG_SH2_CRK	341	345	PF00017	0.557
LIG_SH2_CRK	596	600	PF00017	0.529
LIG_SH2_GRB2like	242	245	PF00017	0.447
LIG_SH2_GRB2like	399	402	PF00017	0.530
LIG_SH2_NCK_1	596	600	PF00017	0.548
LIG_SH2_PTP2	469	472	PF00017	0.447
LIG_SH2_STAP1	341	345	PF00017	0.518
LIG_SH2_STAP1	63	67	PF00017	0.608
LIG_SH2_STAT3	578	581	PF00017	0.656
LIG_SH2_STAT5	229	232	PF00017	0.334
LIG_SH2_STAT5	242	245	PF00017	0.335
LIG_SH2_STAT5	409	412	PF00017	0.636
LIG_SH2_STAT5	469	472	PF00017	0.447
LIG_SH2_STAT5	531	534	PF00017	0.568
LIG_SH2_STAT5	596	599	PF00017	0.521
LIG_SH3_3	253	259	PF00018	0.335
LIG_SH3_3	267	273	PF00018	0.418
LIG_SH3_3	66	72	PF00018	0.539
LIG_SH3_3	78	84	PF00018	0.531
LIG_SUMO_SIM_anti_2	267	272	PF11976	0.479
LIG_SUMO_SIM_par_1	172	178	PF11976	0.569
LIG_SUMO_SIM_par_1	264	269	PF11976	0.312
LIG_SUMO_SIM_par_1	5	11	PF11976	0.643
LIG_TRAF2_1	147	150	PF00917	0.586
LIG_TRAF2_1	481	484	PF00917	0.402
LIG_UBA3_1	279	285	PF00899	0.564
LIG_UBA3_1	501	507	PF00899	0.558
LIG_WRC_WIRS_1	434	439	PF05994	0.408
MOD_CK1_1	178	184	PF00069	0.506
MOD_CK1_1	343	349	PF00069	0.612
MOD_CK1_1	39	45	PF00069	0.644
MOD_CK1_1	563	569	PF00069	0.615
MOD_CK1_1	580	586	PF00069	0.641
MOD_CK1_1	594	600	PF00069	0.528
MOD_CK1_1	74	80	PF00069	0.543
MOD_CK2_1	355	361	PF00069	0.678
MOD_CK2_1	449	455	PF00069	0.305
MOD_CK2_1	541	547	PF00069	0.475
MOD_CK2_1	548	554	PF00069	0.547
MOD_Cter_Amidation	208	211	PF01082	0.335
MOD_GlcNHglycan	121	124	PF01048	0.480
MOD_GlcNHglycan	177	180	PF01048	0.569
MOD_GlcNHglycan	256	259	PF01048	0.344
MOD_GlcNHglycan	357	360	PF01048	0.691
MOD_GlcNHglycan	451	454	PF01048	0.305
MOD_GlcNHglycan	550	553	PF01048	0.542
MOD_GSK3_1	33	40	PF00069	0.612
MOD_GSK3_1	339	346	PF00069	0.606
MOD_GSK3_1	355	362	PF00069	0.425
MOD_GSK3_1	429	436	PF00069	0.402
MOD_GSK3_1	556	563	PF00069	0.579
MOD_GSK3_1	577	584	PF00069	0.643
MOD_GSK3_1	590	597	PF00069	0.531
MOD_GSK3_1	67	74	PF00069	0.491
MOD_N-GLC_1	259	264	PF02516	0.355
MOD_N-GLC_2	546	548	PF02516	0.537
MOD_NEK2_1	119	124	PF00069	0.495
MOD_NEK2_1	264	269	PF00069	0.312
MOD_NEK2_1	355	360	PF00069	0.636
MOD_NEK2_1	365	370	PF00069	0.618
MOD_NEK2_1	37	42	PF00069	0.633
MOD_NEK2_1	515	520	PF00069	0.519
MOD_NEK2_1	541	546	PF00069	0.504
MOD_NEK2_1	577	582	PF00069	0.671
MOD_NEK2_1	62	67	PF00069	0.644
MOD_NEK2_1	8	13	PF00069	0.596
MOD_NEK2_2	531	536	PF00069	0.573
MOD_NEK2_2	591	596	PF00069	0.558
MOD_PIKK_1	577	583	PF00454	0.654
MOD_PIKK_1	67	73	PF00454	0.627
MOD_PK_1	429	435	PF00069	0.402
MOD_PKA_2	346	352	PF00069	0.569
MOD_PKA_2	74	80	PF00069	0.562
MOD_PKB_1	568	576	PF00069	0.746
MOD_Plk_1	33	39	PF00069	0.605
MOD_Plk_1	429	435	PF00069	0.434
MOD_Plk_4	266	272	PF00069	0.488
MOD_Plk_4	27	33	PF00069	0.628
MOD_Plk_4	340	346	PF00069	0.606
MOD_Plk_4	429	435	PF00069	0.419
MOD_Plk_4	500	506	PF00069	0.525
MOD_Plk_4	557	563	PF00069	0.615
MOD_Plk_4	591	597	PF00069	0.552
MOD_ProDKin_1	228	234	PF00069	0.335
MOD_ProDKin_1	350	356	PF00069	0.702
MOD_ProDKin_1	442	448	PF00069	0.335
MOD_SUMO_for_1	496	499	PF00179	0.625
TRG_DiLeu_BaEn_3	150	156	PF01217	0.529
TRG_DiLeu_BaLyEn_6	10	15	PF01217	0.653
TRG_DiLeu_BaLyEn_6	137	142	PF01217	0.497
TRG_DiLeu_BaLyEn_6	421	426	PF01217	0.480
TRG_ENDOCYTIC_2	242	245	PF00928	0.447
TRG_ENDOCYTIC_2	341	344	PF00928	0.564
TRG_ENDOCYTIC_2	409	412	PF00928	0.627
TRG_ENDOCYTIC_2	469	472	PF00928	0.447
TRG_ER_diArg_1	308	311	PF00400	0.520
TRG_ER_diArg_1	396	398	PF00400	0.539
TRG_NLS_MonoExtC_3	283	288	PF00514	0.602
TRG_NLS_MonoExtN_4	130	135	PF00514	0.611
TRG_Pf-PMV_PEXEL_1	111	115	PF00026	0.484
TRG_Pf-PMV_PEXEL_1	152	157	PF00026	0.433

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IBK1	Leptomonas seymouri	71%	100%
A0A1X0NRN7	Trypanosomatidae	58%	99%
A0A3R7NSK8	Trypanosoma rangeli	60%	100%
A4HKT6	Leishmania braziliensis	88%	100%
A4I8B5	Leishmania infantum	100%	100%
D0AAI7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	99%
E9B374	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q9U1E2	Leishmania major	95%	100%
V5DE73	Trypanosoma cruzi	56%	100%