Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleoporin NUP109

Species:

Leishmania donovani

UniProt:

A0A3S7X5V5_LEIDO

TriTrypDb:

LdBPK_322920.1 , LdCL_320035200 , LDHU3_32.3700

Length:

1093

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005643	nuclear pore	3	1
GO:0031080	nuclear pore outer ring	3	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A0A3S7X5V5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5V5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	389	393	PF00656	0.594
CLV_NRD_NRD_1	2	4	PF00675	0.687
CLV_NRD_NRD_1	5	7	PF00675	0.654
CLV_NRD_NRD_1	619	621	PF00675	0.679
CLV_PCSK_FUR_1	3	7	PF00082	0.733
CLV_PCSK_KEX2_1	4	6	PF00082	0.674
CLV_PCSK_KEX2_1	619	621	PF00082	0.679
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.752
CLV_PCSK_SKI1_1	115	119	PF00082	0.596
CLV_PCSK_SKI1_1	5	9	PF00082	0.655
CLV_PCSK_SKI1_1	588	592	PF00082	0.462
CLV_PCSK_SKI1_1	611	615	PF00082	0.537
CLV_PCSK_SKI1_1	750	754	PF00082	0.716
CLV_PCSK_SKI1_1	931	935	PF00082	0.515
CLV_Separin_Metazoa	832	836	PF03568	0.526
DEG_Nend_UBRbox_3	1	3	PF02207	0.743
DEG_SPOP_SBC_1	1073	1077	PF00917	0.821
DEG_SPOP_SBC_1	341	345	PF00917	0.578
DOC_ANK_TNKS_1	1038	1045	PF00023	0.672
DOC_CYCLIN_RxL_1	608	617	PF00134	0.537
DOC_CYCLIN_RxL_1	928	938	PF00134	0.582
DOC_CYCLIN_yCln2_LP_2	272	278	PF00134	0.581
DOC_MAPK_gen_1	3	9	PF00069	0.727
DOC_MAPK_gen_1	515	524	PF00069	0.606
DOC_MAPK_gen_1	588	596	PF00069	0.521
DOC_MAPK_gen_1	708	718	PF00069	0.540
DOC_MAPK_MEF2A_6	161	168	PF00069	0.689
DOC_MAPK_MEF2A_6	888	895	PF00069	0.506
DOC_PP1_RVXF_1	113	120	PF00149	0.601
DOC_PP1_RVXF_1	284	290	PF00149	0.568
DOC_PP2B_LxvP_1	272	275	PF13499	0.635
DOC_PP2B_LxvP_1	49	52	PF13499	0.701
DOC_PP2B_LxvP_1	649	652	PF13499	0.503
DOC_PP2B_LxvP_1	763	766	PF13499	0.497
DOC_PP2B_LxvP_1	771	774	PF13499	0.430
DOC_PP2B_LxvP_1	972	975	PF13499	0.674
DOC_PP4_FxxP_1	718	721	PF00568	0.478
DOC_USP7_MATH_1	1021	1025	PF00917	0.698
DOC_USP7_MATH_1	1069	1073	PF00917	0.803
DOC_USP7_MATH_1	1074	1078	PF00917	0.828
DOC_USP7_MATH_1	1082	1086	PF00917	0.570
DOC_USP7_MATH_1	135	139	PF00917	0.611
DOC_USP7_MATH_1	24	28	PF00917	0.695
DOC_USP7_MATH_1	245	249	PF00917	0.725
DOC_USP7_MATH_1	278	282	PF00917	0.686
DOC_USP7_MATH_1	333	337	PF00917	0.770
DOC_USP7_MATH_1	341	345	PF00917	0.665
DOC_USP7_MATH_1	465	469	PF00917	0.751
DOC_USP7_MATH_1	50	54	PF00917	0.633
DOC_USP7_MATH_1	552	556	PF00917	0.545
DOC_USP7_MATH_1	565	569	PF00917	0.469
DOC_USP7_MATH_1	654	658	PF00917	0.623
DOC_USP7_MATH_1	663	667	PF00917	0.503
DOC_USP7_MATH_1	690	694	PF00917	0.727
DOC_USP7_MATH_1	697	701	PF00917	0.563
DOC_USP7_MATH_1	81	85	PF00917	0.578
DOC_USP7_MATH_1	821	825	PF00917	0.592
DOC_WW_Pin1_4	1076	1081	PF00397	0.778
DOC_WW_Pin1_4	136	141	PF00397	0.702
DOC_WW_Pin1_4	179	184	PF00397	0.594
DOC_WW_Pin1_4	276	281	PF00397	0.668
DOC_WW_Pin1_4	635	640	PF00397	0.508
DOC_WW_Pin1_4	668	673	PF00397	0.573
DOC_WW_Pin1_4	866	871	PF00397	0.488
DOC_WW_Pin1_4	90	95	PF00397	0.642
DOC_WW_Pin1_4	910	915	PF00397	0.664
LIG_14-3-3_CanoR_1	1055	1060	PF00244	0.605
LIG_14-3-3_CanoR_1	234	240	PF00244	0.657
LIG_14-3-3_CanoR_1	254	258	PF00244	0.746
LIG_14-3-3_CanoR_1	342	347	PF00244	0.724
LIG_14-3-3_CanoR_1	5	10	PF00244	0.655
LIG_14-3-3_CanoR_1	508	514	PF00244	0.555
LIG_14-3-3_CanoR_1	540	550	PF00244	0.598
LIG_14-3-3_CanoR_1	619	624	PF00244	0.575
LIG_14-3-3_CanoR_1	931	941	PF00244	0.642
LIG_Actin_WH2_2	157	175	PF00022	0.471
LIG_Actin_WH2_2	575	593	PF00022	0.560
LIG_Actin_WH2_2	775	792	PF00022	0.551
LIG_APCC_ABBA_1	373	378	PF00400	0.639
LIG_BIR_III_4	691	695	PF00653	0.621
LIG_Clathr_ClatBox_1	163	167	PF01394	0.613
LIG_FHA_1	112	118	PF00498	0.621
LIG_FHA_1	173	179	PF00498	0.539
LIG_FHA_1	180	186	PF00498	0.551
LIG_FHA_1	210	216	PF00498	0.550
LIG_FHA_1	269	275	PF00498	0.624
LIG_FHA_1	345	351	PF00498	0.744
LIG_FHA_1	405	411	PF00498	0.574
LIG_FHA_1	598	604	PF00498	0.562
LIG_FHA_1	669	675	PF00498	0.459
LIG_FHA_2	387	393	PF00498	0.623
LIG_FHA_2	70	76	PF00498	0.657
LIG_FHA_2	911	917	PF00498	0.616
LIG_LIR_Gen_1	238	247	PF02991	0.653
LIG_LIR_Gen_1	712	722	PF02991	0.531
LIG_LIR_Gen_1	828	838	PF02991	0.522
LIG_LIR_Gen_1	894	902	PF02991	0.394
LIG_LIR_Nem_3	238	243	PF02991	0.660
LIG_LIR_Nem_3	293	299	PF02991	0.557
LIG_LIR_Nem_3	555	561	PF02991	0.460
LIG_LIR_Nem_3	682	686	PF02991	0.494
LIG_LIR_Nem_3	712	717	PF02991	0.526
LIG_LIR_Nem_3	726	732	PF02991	0.365
LIG_LIR_Nem_3	894	899	PF02991	0.381
LIG_NRBOX	533	539	PF00104	0.540
LIG_NRBOX	784	790	PF00104	0.512
LIG_NRBOX	929	935	PF00104	0.616
LIG_PCNA_yPIPBox_3	16	29	PF02747	0.719
LIG_PCNA_yPIPBox_3	526	538	PF02747	0.532
LIG_Pex14_1	710	714	PF04695	0.522
LIG_Pex14_2	714	718	PF04695	0.462
LIG_RPA_C_Fungi	564	576	PF08784	0.433
LIG_SH2_CRK	405	409	PF00017	0.599
LIG_SH2_CRK	535	539	PF00017	0.538
LIG_SH2_CRK	558	562	PF00017	0.467
LIG_SH2_CRK	681	685	PF00017	0.544
LIG_SH2_CRK	850	854	PF00017	0.563
LIG_SH2_NCK_1	240	244	PF00017	0.657
LIG_SH2_NCK_1	799	803	PF00017	0.500
LIG_SH2_PTP2	683	686	PF00017	0.576
LIG_SH2_PTP2	896	899	PF00017	0.494
LIG_SH2_SRC	240	243	PF00017	0.738
LIG_SH2_SRC	902	905	PF00017	0.434
LIG_SH2_STAP1	1036	1040	PF00017	0.607
LIG_SH2_STAP1	240	244	PF00017	0.734
LIG_SH2_STAP1	428	432	PF00017	0.509
LIG_SH2_STAP1	574	578	PF00017	0.487
LIG_SH2_STAP1	799	803	PF00017	0.516
LIG_SH2_STAP1	902	906	PF00017	0.430
LIG_SH2_STAT3	428	431	PF00017	0.557
LIG_SH2_STAT5	456	459	PF00017	0.623
LIG_SH2_STAT5	683	686	PF00017	0.487
LIG_SH2_STAT5	799	802	PF00017	0.520
LIG_SH2_STAT5	896	899	PF00017	0.412
LIG_SH2_STAT5	929	932	PF00017	0.542
LIG_SH3_3	142	148	PF00018	0.635
LIG_SH3_3	34	40	PF00018	0.708
LIG_SH3_3	376	382	PF00018	0.598
LIG_SH3_3	864	870	PF00018	0.485
LIG_SH3_3	951	957	PF00018	0.707
LIG_SUMO_SIM_anti_2	210	215	PF11976	0.484
LIG_SUMO_SIM_par_1	162	167	PF11976	0.694
LIG_SUMO_SIM_par_1	720	726	PF11976	0.509
LIG_TRAF2_1	72	75	PF00917	0.702
LIG_TYR_ITIM	403	408	PF00017	0.596
LIG_TYR_ITIM	556	561	PF00017	0.477
LIG_TYR_ITIM	679	684	PF00017	0.519
LIG_TYR_ITIM	848	853	PF00017	0.543
LIG_UBA3_1	582	591	PF00899	0.527
LIG_WRC_WIRS_1	25	30	PF05994	0.643
LIG_WRC_WIRS_1	892	897	PF05994	0.445
MOD_CDK_SPxK_1	90	96	PF00069	0.613
MOD_CK1_1	1072	1078	PF00069	0.742
MOD_CK1_1	1085	1091	PF00069	0.702
MOD_CK1_1	156	162	PF00069	0.664
MOD_CK1_1	300	306	PF00069	0.590
MOD_CK1_1	336	342	PF00069	0.773
MOD_CK1_1	344	350	PF00069	0.707
MOD_CK1_1	491	497	PF00069	0.537
MOD_CK1_1	597	603	PF00069	0.591
MOD_CK1_1	666	672	PF00069	0.424
MOD_CK1_1	910	916	PF00069	0.594
MOD_CK1_1	932	938	PF00069	0.631
MOD_CK2_1	1058	1064	PF00069	0.744
MOD_CK2_1	314	320	PF00069	0.741
MOD_CK2_1	624	630	PF00069	0.675
MOD_CK2_1	69	75	PF00069	0.671
MOD_CK2_1	697	703	PF00069	0.640
MOD_CK2_1	798	804	PF00069	0.542
MOD_CK2_1	991	997	PF00069	0.708
MOD_GlcNHglycan	1001	1004	PF01048	0.715
MOD_GlcNHglycan	1013	1016	PF01048	0.794
MOD_GlcNHglycan	1023	1026	PF01048	0.717
MOD_GlcNHglycan	1066	1069	PF01048	0.692
MOD_GlcNHglycan	1071	1074	PF01048	0.747
MOD_GlcNHglycan	1084	1087	PF01048	0.776
MOD_GlcNHglycan	119	122	PF01048	0.557
MOD_GlcNHglycan	247	250	PF01048	0.716
MOD_GlcNHglycan	280	283	PF01048	0.683
MOD_GlcNHglycan	316	319	PF01048	0.745
MOD_GlcNHglycan	336	339	PF01048	0.473
MOD_GlcNHglycan	394	397	PF01048	0.671
MOD_GlcNHglycan	447	450	PF01048	0.686
MOD_GlcNHglycan	468	471	PF01048	0.764
MOD_GlcNHglycan	509	512	PF01048	0.504
MOD_GlcNHglycan	543	546	PF01048	0.591
MOD_GlcNHglycan	635	638	PF01048	0.632
MOD_GlcNHglycan	661	664	PF01048	0.554
MOD_GlcNHglycan	687	691	PF01048	0.583
MOD_GlcNHglycan	692	695	PF01048	0.617
MOD_GlcNHglycan	800	803	PF01048	0.628
MOD_GlcNHglycan	83	86	PF01048	0.632
MOD_GlcNHglycan	836	839	PF01048	0.454
MOD_GlcNHglycan	858	861	PF01048	0.456
MOD_GlcNHglycan	910	913	PF01048	0.603
MOD_GlcNHglycan	934	937	PF01048	0.588
MOD_GlcNHglycan	959	964	PF01048	0.761
MOD_GlcNHglycan	972	975	PF01048	0.700
MOD_GlcNHglycan	980	983	PF01048	0.643
MOD_GlcNHglycan	993	996	PF01048	0.659
MOD_GSK3_1	1017	1024	PF00069	0.691
MOD_GSK3_1	1034	1041	PF00069	0.548
MOD_GSK3_1	1054	1061	PF00069	0.577
MOD_GSK3_1	1064	1071	PF00069	0.660
MOD_GSK3_1	107	114	PF00069	0.564
MOD_GSK3_1	1072	1079	PF00069	0.588
MOD_GSK3_1	1082	1089	PF00069	0.485
MOD_GSK3_1	336	343	PF00069	0.721
MOD_GSK3_1	362	369	PF00069	0.715
MOD_GSK3_1	473	480	PF00069	0.705
MOD_GSK3_1	488	495	PF00069	0.379
MOD_GSK3_1	541	548	PF00069	0.568
MOD_GSK3_1	619	626	PF00069	0.540
MOD_GSK3_1	659	666	PF00069	0.495
MOD_GSK3_1	686	693	PF00069	0.563
MOD_GSK3_1	723	730	PF00069	0.501
MOD_GSK3_1	794	801	PF00069	0.446
MOD_GSK3_1	871	878	PF00069	0.460
MOD_GSK3_1	925	932	PF00069	0.539
MOD_GSK3_1	95	102	PF00069	0.605
MOD_N-GLC_1	366	371	PF02516	0.594
MOD_NEK2_1	172	177	PF00069	0.586
MOD_NEK2_1	193	198	PF00069	0.698
MOD_NEK2_1	386	391	PF00069	0.488
MOD_NEK2_1	445	450	PF00069	0.672
MOD_NEK2_1	481	486	PF00069	0.580
MOD_NEK2_1	507	512	PF00069	0.505
MOD_NEK2_1	614	619	PF00069	0.561
MOD_NEK2_1	633	638	PF00069	0.290
MOD_NEK2_1	679	684	PF00069	0.384
MOD_NEK2_1	934	939	PF00069	0.672
MOD_NEK2_1	95	100	PF00069	0.664
MOD_NEK2_1	977	982	PF00069	0.672
MOD_NEK2_2	727	732	PF00069	0.473
MOD_PIKK_1	326	332	PF00454	0.761
MOD_PIKK_1	336	342	PF00454	0.798
MOD_PIKK_1	350	356	PF00454	0.468
MOD_PIKK_1	443	449	PF00454	0.589
MOD_PIKK_1	69	75	PF00454	0.637
MOD_PIKK_1	915	921	PF00454	0.600
MOD_PK_1	619	625	PF00069	0.615
MOD_PKA_1	5	11	PF00069	0.653
MOD_PKA_1	619	625	PF00069	0.669
MOD_PKA_2	1038	1044	PF00069	0.730
MOD_PKA_2	1054	1060	PF00069	0.552
MOD_PKA_2	1064	1070	PF00069	0.680
MOD_PKA_2	233	239	PF00069	0.727
MOD_PKA_2	253	259	PF00069	0.743
MOD_PKA_2	341	347	PF00069	0.665
MOD_PKA_2	5	11	PF00069	0.653
MOD_PKA_2	507	513	PF00069	0.506
MOD_PKA_2	619	625	PF00069	0.627
MOD_PKA_2	710	716	PF00069	0.529
MOD_PKA_2	834	840	PF00069	0.495
MOD_PKA_2	95	101	PF00069	0.725
MOD_PKB_1	3	11	PF00069	0.724
MOD_Plk_1	156	162	PF00069	0.643
MOD_Plk_1	193	199	PF00069	0.689
MOD_Plk_1	209	215	PF00069	0.492
MOD_Plk_1	366	372	PF00069	0.487
MOD_Plk_1	654	660	PF00069	0.543
MOD_Plk_1	875	881	PF00069	0.497
MOD_Plk_1	959	965	PF00069	0.748
MOD_Plk_4	1055	1061	PF00069	0.649
MOD_Plk_4	209	215	PF00069	0.552
MOD_Plk_4	24	30	PF00069	0.658
MOD_Plk_4	253	259	PF00069	0.743
MOD_Plk_4	290	296	PF00069	0.481
MOD_Plk_4	300	306	PF00069	0.480
MOD_Plk_4	366	372	PF00069	0.641
MOD_Plk_4	456	462	PF00069	0.580
MOD_Plk_4	481	487	PF00069	0.637
MOD_Plk_4	609	615	PF00069	0.560
MOD_Plk_4	619	625	PF00069	0.539
MOD_Plk_4	679	685	PF00069	0.454
MOD_Plk_4	710	716	PF00069	0.529
MOD_Plk_4	748	754	PF00069	0.711
MOD_Plk_4	925	931	PF00069	0.501
MOD_ProDKin_1	1076	1082	PF00069	0.777
MOD_ProDKin_1	136	142	PF00069	0.701
MOD_ProDKin_1	179	185	PF00069	0.606
MOD_ProDKin_1	276	282	PF00069	0.658
MOD_ProDKin_1	635	641	PF00069	0.495
MOD_ProDKin_1	668	674	PF00069	0.567
MOD_ProDKin_1	866	872	PF00069	0.479
MOD_ProDKin_1	90	96	PF00069	0.652
MOD_ProDKin_1	910	916	PF00069	0.666
MOD_SUMO_for_1	514	517	PF00179	0.349
MOD_SUMO_rev_2	742	751	PF00179	0.632
MOD_SUMO_rev_2	937	947	PF00179	0.639
TRG_DiLeu_BaEn_1	397	402	PF01217	0.401
TRG_DiLeu_BaEn_1	712	717	PF01217	0.545
TRG_DiLeu_BaEn_2	672	678	PF01217	0.458
TRG_DiLeu_BaLyEn_6	556	561	PF01217	0.547
TRG_DiLeu_BaLyEn_6	767	772	PF01217	0.458
TRG_DiLeu_BaLyEn_6	787	792	PF01217	0.257
TRG_DiLeu_BaLyEn_6	810	815	PF01217	0.535
TRG_DiLeu_BaLyEn_6	972	977	PF01217	0.709
TRG_ENDOCYTIC_2	240	243	PF00928	0.660
TRG_ENDOCYTIC_2	405	408	PF00928	0.596
TRG_ENDOCYTIC_2	535	538	PF00928	0.538
TRG_ENDOCYTIC_2	558	561	PF00928	0.461
TRG_ENDOCYTIC_2	574	577	PF00928	0.360
TRG_ENDOCYTIC_2	681	684	PF00928	0.440
TRG_ENDOCYTIC_2	831	834	PF00928	0.509
TRG_ENDOCYTIC_2	850	853	PF00928	0.494
TRG_ENDOCYTIC_2	896	899	PF00928	0.414
TRG_ER_diArg_1	3	6	PF00400	0.676
TRG_ER_diArg_1	618	620	PF00400	0.651
TRG_NLS_MonoCore_2	2	7	PF00514	0.736
TRG_NLS_MonoExtN_4	3	8	PF00514	0.731
TRG_Pf-PMV_PEXEL_1	5	10	PF00026	0.791

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IML2	Leptomonas seymouri	52%	100%
A0A1X0NRY7	Trypanosomatidae	24%	100%
A0A3S5ISF7	Trypanosoma rangeli	24%	100%
A4HKR9	Leishmania braziliensis	79%	100%
A4I899	Leishmania infantum	99%	99%
E9B357	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q4Z7	Leishmania major	93%	100%