GPI transamidase component Tta1, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GPI transamidase component Tta1, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X5V4_LEIDO

TriTrypDb:

LdBPK_322700.1 , LdCL_320032800 , LDHU3_32.3370

Length:

418

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0008303	caspase complex	5	1
GO:0032991	protein-containing complex	1	1
GO:0042765	GPI-anchor transamidase complex	3	1
GO:0098796	membrane protein complex	2	1
GO:0140534	endoplasmic reticulum protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1905368	peptidase complex	3	1
GO:1905369	endopeptidase complex	4	1

Expansion

Sequence features

A0A3S7X5V4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5V4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0003923	GPI-anchor transamidase activity	6	1
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008234	cysteine-type peptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	233	237	PF00656	0.525
CLV_C14_Caspase3-7	410	414	PF00656	0.680
CLV_NRD_NRD_1	164	166	PF00675	0.603
CLV_NRD_NRD_1	21	23	PF00675	0.477
CLV_PCSK_KEX2_1	161	163	PF00082	0.673
CLV_PCSK_KEX2_1	21	23	PF00082	0.467
CLV_PCSK_KEX2_1	295	297	PF00082	0.568
CLV_PCSK_PC1ET2_1	161	163	PF00082	0.668
CLV_PCSK_PC1ET2_1	295	297	PF00082	0.584
CLV_PCSK_SKI1_1	161	165	PF00082	0.614
CLV_PCSK_SKI1_1	182	186	PF00082	0.676
CLV_PCSK_SKI1_1	22	26	PF00082	0.429
CLV_PCSK_SKI1_1	270	274	PF00082	0.592
DEG_APCC_DBOX_1	269	277	PF00400	0.403
DEG_SCF_FBW7_1	70	77	PF00400	0.540
DOC_CYCLIN_yCln2_LP_2	365	371	PF00134	0.463
DOC_MAPK_gen_1	347	357	PF00069	0.402
DOC_PP2B_LxvP_1	176	179	PF13499	0.449
DOC_PP2B_LxvP_1	365	368	PF13499	0.393
DOC_PP4_FxxP_1	201	204	PF00568	0.349
DOC_USP7_MATH_1	14	18	PF00917	0.741
DOC_USP7_MATH_1	235	239	PF00917	0.552
DOC_USP7_MATH_1	24	28	PF00917	0.555
DOC_USP7_MATH_1	382	386	PF00917	0.447
DOC_USP7_MATH_1	390	394	PF00917	0.552
DOC_USP7_MATH_1	65	69	PF00917	0.436
DOC_USP7_MATH_1	75	79	PF00917	0.482
DOC_WW_Pin1_4	251	256	PF00397	0.529
DOC_WW_Pin1_4	359	364	PF00397	0.501
DOC_WW_Pin1_4	70	75	PF00397	0.538
DOC_WW_Pin1_4	91	96	PF00397	0.412
LIG_14-3-3_CanoR_1	135	144	PF00244	0.374
LIG_14-3-3_CanoR_1	245	255	PF00244	0.483
LIG_14-3-3_CanoR_1	261	266	PF00244	0.491
LIG_14-3-3_CanoR_1	66	71	PF00244	0.434
LIG_14-3-3_CanoR_1	7	16	PF00244	0.713
LIG_Actin_WH2_2	300	317	PF00022	0.421
LIG_Actin_WH2_2	333	349	PF00022	0.441
LIG_BIR_III_4	211	215	PF00653	0.331
LIG_BRCT_BRCA1_1	153	157	PF00533	0.420
LIG_BRCT_BRCA1_1	341	345	PF00533	0.449
LIG_FHA_1	125	131	PF00498	0.399
LIG_FHA_1	276	282	PF00498	0.412
LIG_FHA_1	309	315	PF00498	0.440
LIG_FHA_1	360	366	PF00498	0.503
LIG_FHA_1	71	77	PF00498	0.518
LIG_GBD_Chelix_1	373	381	PF00786	0.399
LIG_LIR_Apic_2	199	204	PF02991	0.344
LIG_LIR_Gen_1	129	136	PF02991	0.427
LIG_LIR_Gen_1	25	36	PF02991	0.544
LIG_LIR_Gen_1	330	340	PF02991	0.433
LIG_LIR_Nem_3	129	134	PF02991	0.421
LIG_LIR_Nem_3	25	31	PF02991	0.544
LIG_LIR_Nem_3	32	37	PF02991	0.431
LIG_LIR_Nem_3	330	336	PF02991	0.423
LIG_MYND_1	359	363	PF01753	0.463
LIG_SH2_CRK	131	135	PF00017	0.372
LIG_SH2_CRK	227	231	PF00017	0.328
LIG_SH2_STAT5	131	134	PF00017	0.311
LIG_SH2_STAT5	227	230	PF00017	0.308
LIG_SH2_STAT5	366	369	PF00017	0.380
LIG_SH3_3	10	16	PF00018	0.772
LIG_SH3_3	120	126	PF00018	0.480
LIG_SH3_3	229	235	PF00018	0.393
LIG_SH3_3	376	382	PF00018	0.383
LIG_SH3_3	49	55	PF00018	0.482
LIG_SH3_3	89	95	PF00018	0.383
LIG_SUMO_SIM_anti_2	375	381	PF11976	0.434
LIG_SUMO_SIM_par_1	230	236	PF11976	0.385
LIG_SUMO_SIM_par_1	272	278	PF11976	0.383
LIG_TYR_ITSM	127	134	PF00017	0.367
LIG_WRC_WIRS_1	130	135	PF05994	0.405
LIG_WRC_WIRS_1	283	288	PF05994	0.353
MOD_CK1_1	199	205	PF00069	0.379
MOD_CK1_1	243	249	PF00069	0.475
MOD_CK1_1	275	281	PF00069	0.434
MOD_CK1_1	309	315	PF00069	0.406
MOD_CK1_1	372	378	PF00069	0.434
MOD_CK2_1	390	396	PF00069	0.557
MOD_CK2_1	65	71	PF00069	0.406
MOD_GlcNHglycan	153	156	PF01048	0.670
MOD_GlcNHglycan	158	161	PF01048	0.629
MOD_GlcNHglycan	205	208	PF01048	0.535
MOD_GlcNHglycan	242	245	PF01048	0.686
MOD_GlcNHglycan	248	251	PF01048	0.703
MOD_GlcNHglycan	31	34	PF01048	0.402
MOD_GlcNHglycan	341	344	PF01048	0.599
MOD_GlcNHglycan	77	80	PF01048	0.698
MOD_GSK3_1	199	206	PF00069	0.345
MOD_GSK3_1	235	242	PF00069	0.470
MOD_GSK3_1	306	313	PF00069	0.419
MOD_GSK3_1	66	73	PF00069	0.440
MOD_N-GLC_1	22	27	PF02516	0.487
MOD_NEK2_1	196	201	PF00069	0.408
MOD_NEK2_1	97	102	PF00069	0.301
MOD_NEK2_2	126	131	PF00069	0.407
MOD_NEK2_2	282	287	PF00069	0.387
MOD_PIKK_1	135	141	PF00454	0.425
MOD_PIKK_1	275	281	PF00454	0.423
MOD_PIKK_1	372	378	PF00454	0.434
MOD_PKA_2	244	250	PF00069	0.527
MOD_PKA_2	65	71	PF00069	0.455
MOD_PKB_1	259	267	PF00069	0.497
MOD_Plk_1	369	375	PF00069	0.324
MOD_Plk_4	126	132	PF00069	0.422
MOD_Plk_4	196	202	PF00069	0.352
MOD_Plk_4	272	278	PF00069	0.313
MOD_Plk_4	341	347	PF00069	0.389
MOD_Plk_4	369	375	PF00069	0.305
MOD_Plk_4	384	390	PF00069	0.260
MOD_ProDKin_1	251	257	PF00069	0.525
MOD_ProDKin_1	359	365	PF00069	0.492
MOD_ProDKin_1	70	76	PF00069	0.537
MOD_ProDKin_1	91	97	PF00069	0.410
TRG_ENDOCYTIC_2	131	134	PF00928	0.367
TRG_ENDOCYTIC_2	227	230	PF00928	0.308
TRG_ER_diArg_1	20	22	PF00400	0.649
TRG_ER_diArg_1	258	261	PF00400	0.521
TRG_ER_diLys_1	415	418	PF00400	0.699
TRG_Pf-PMV_PEXEL_1	392	396	PF00026	0.439
TRG_Pf-PMV_PEXEL_1	58	62	PF00026	0.566

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I345	Leptomonas seymouri	56%	97%
A0A1X0NT15	Trypanosomatidae	27%	100%
A0A3S5IR84	Trypanosoma rangeli	30%	100%
A4HKP6	Leishmania braziliensis	77%	100%
A4I877	Leishmania infantum	100%	100%
D0AAE7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9B335	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q519	Leishmania major	90%	100%
V5AUS2	Trypanosoma cruzi	29%	96%