Dynein axonemal assembly factor 4

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CS domain/TPR repeat/Tetratricopeptide repeat, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X5V3_LEIDO

TriTrypDb:

LdBPK_322990.1 , LdCL_320035900 , LDHU3_32.3770

Length:

639

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0042995	cell projection	2	11
GO:0043005	neuron projection	4	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	11
GO:0120293	dynein axonemal particle	5	11
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3S7X5V3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5V3

Function

Biological processes
Term	Name	Level	Count
GO:0003341	cilium movement	4	11
GO:0007017	microtubule-based process	2	11
GO:0007018	microtubule-based movement	3	11
GO:0007399	nervous system development	4	11
GO:0009987	cellular process	1	11
GO:0032502	developmental process	1	11
GO:0048731	system development	3	11
GO:0048856	anatomical structure development	2	11
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0036158	outer dynein arm assembly	7	1
GO:0036159	inner dynein arm assembly	7	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0070286	axonemal dynein complex assembly	6	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	157	161	PF00656	0.472
CLV_C14_Caspase3-7	423	427	PF00656	0.492
CLV_C14_Caspase3-7	512	516	PF00656	0.643
CLV_C14_Caspase3-7	545	549	PF00656	0.453
CLV_C14_Caspase3-7	68	72	PF00656	0.532
CLV_NRD_NRD_1	106	108	PF00675	0.414
CLV_NRD_NRD_1	134	136	PF00675	0.514
CLV_NRD_NRD_1	373	375	PF00675	0.306
CLV_NRD_NRD_1	554	556	PF00675	0.475
CLV_PCSK_FUR_1	552	556	PF00082	0.584
CLV_PCSK_KEX2_1	106	108	PF00082	0.414
CLV_PCSK_KEX2_1	133	135	PF00082	0.495
CLV_PCSK_KEX2_1	314	316	PF00082	0.383
CLV_PCSK_KEX2_1	337	339	PF00082	0.360
CLV_PCSK_KEX2_1	373	375	PF00082	0.306
CLV_PCSK_KEX2_1	554	556	PF00082	0.552
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.459
CLV_PCSK_PC1ET2_1	314	316	PF00082	0.372
CLV_PCSK_PC1ET2_1	337	339	PF00082	0.360
CLV_PCSK_PC7_1	129	135	PF00082	0.455
CLV_PCSK_SKI1_1	100	104	PF00082	0.493
CLV_PCSK_SKI1_1	134	138	PF00082	0.462
CLV_PCSK_SKI1_1	420	424	PF00082	0.480
CLV_PCSK_SKI1_1	547	551	PF00082	0.593
DEG_SCF_FBW7_1	226	233	PF00400	0.563
DEG_SCF_FBW7_2	350	357	PF00400	0.455
DEG_SPOP_SBC_1	231	235	PF00917	0.561
DOC_CKS1_1	236	241	PF01111	0.475
DOC_MAPK_gen_1	23	32	PF00069	0.442
DOC_MAPK_gen_1	273	282	PF00069	0.575
DOC_MAPK_gen_1	478	488	PF00069	0.401
DOC_MAPK_MEF2A_6	243	252	PF00069	0.487
DOC_MAPK_MEF2A_6	26	34	PF00069	0.450
DOC_PP4_FxxP_1	259	262	PF00568	0.683
DOC_USP7_MATH_1	231	235	PF00917	0.507
DOC_USP7_MATH_1	262	266	PF00917	0.545
DOC_USP7_MATH_1	56	60	PF00917	0.473
DOC_USP7_UBL2_3	23	27	PF12436	0.456
DOC_USP7_UBL2_3	586	590	PF12436	0.399
DOC_WW_Pin1_4	172	177	PF00397	0.686
DOC_WW_Pin1_4	181	186	PF00397	0.668
DOC_WW_Pin1_4	192	197	PF00397	0.450
DOC_WW_Pin1_4	213	218	PF00397	0.610
DOC_WW_Pin1_4	226	231	PF00397	0.643
DOC_WW_Pin1_4	235	240	PF00397	0.638
DOC_WW_Pin1_4	252	257	PF00397	0.421
DOC_WW_Pin1_4	282	287	PF00397	0.427
DOC_WW_Pin1_4	350	355	PF00397	0.427
DOC_WW_Pin1_4	599	604	PF00397	0.397
LIG_14-3-3_CanoR_1	125	131	PF00244	0.430
LIG_14-3-3_CanoR_1	94	99	PF00244	0.600
LIG_BRCT_BRCA1_1	62	66	PF00533	0.485
LIG_Clathr_ClatBox_1	48	52	PF01394	0.442
LIG_FHA_1	219	225	PF00498	0.633
LIG_FHA_1	227	233	PF00498	0.634
LIG_FHA_1	245	251	PF00498	0.467
LIG_FHA_1	481	487	PF00498	0.431
LIG_FHA_2	10	16	PF00498	0.442
LIG_FHA_2	125	131	PF00498	0.584
LIG_FHA_2	399	405	PF00498	0.463
LIG_FHA_2	421	427	PF00498	0.627
LIG_FHA_2	600	606	PF00498	0.406
LIG_LIR_Apic_2	258	262	PF02991	0.683
LIG_LIR_Gen_1	327	336	PF02991	0.384
LIG_LIR_Gen_1	36	45	PF02991	0.456
LIG_LIR_Gen_1	452	463	PF02991	0.430
LIG_LIR_Nem_3	275	280	PF02991	0.570
LIG_LIR_Nem_3	36	41	PF02991	0.464
LIG_LIR_Nem_3	361	366	PF02991	0.412
LIG_LIR_Nem_3	452	458	PF02991	0.409
LIG_MLH1_MIPbox_1	62	66	PF16413	0.446
LIG_PCNA_yPIPBox_3	467	476	PF02747	0.274
LIG_RPA_C_Fungi	102	114	PF08784	0.412
LIG_SH2_CRK	277	281	PF00017	0.558
LIG_SH2_CRK	363	367	PF00017	0.384
LIG_SH2_CRK	455	459	PF00017	0.406
LIG_SH2_CRK	569	573	PF00017	0.359
LIG_SH2_GRB2like	604	607	PF00017	0.512
LIG_SH2_NCK_1	448	452	PF00017	0.382
LIG_SH2_STAP1	309	313	PF00017	0.337
LIG_SH2_STAP1	604	608	PF00017	0.409
LIG_SH2_STAT3	118	121	PF00017	0.574
LIG_SH2_STAT3	271	274	PF00017	0.650
LIG_SH2_STAT3	297	300	PF00017	0.468
LIG_SH2_STAT5	330	333	PF00017	0.389
LIG_SH2_STAT5	378	381	PF00017	0.450
LIG_SH2_STAT5	47	50	PF00017	0.281
LIG_SH2_STAT5	575	578	PF00017	0.413
LIG_SH2_STAT5	65	68	PF00017	0.281
LIG_SH3_3	233	239	PF00018	0.590
LIG_SH3_3	38	44	PF00018	0.360
LIG_SUMO_SIM_anti_2	28	34	PF11976	0.399
LIG_SUMO_SIM_par_1	278	285	PF11976	0.545
LIG_SUMO_SIM_par_1	47	52	PF11976	0.285
LIG_TRAF2_1	537	540	PF00917	0.632
LIG_UBA3_1	17	23	PF00899	0.360
LIG_UBA3_1	53	61	PF00899	0.325
LIG_WW_1	44	47	PF00397	0.360
MOD_CDK_SPK_2	252	257	PF00069	0.527
MOD_CK1_1	172	178	PF00069	0.682
MOD_CK1_1	235	241	PF00069	0.631
MOD_CK1_1	356	362	PF00069	0.452
MOD_CK1_1	59	65	PF00069	0.396
MOD_CK1_1	628	634	PF00069	0.514
MOD_CK2_1	124	130	PF00069	0.502
MOD_CK2_1	513	519	PF00069	0.635
MOD_CK2_1	533	539	PF00069	0.594
MOD_GlcNHglycan	181	184	PF01048	0.794
MOD_GlcNHglycan	199	202	PF01048	0.682
MOD_GlcNHglycan	326	329	PF01048	0.362
MOD_GlcNHglycan	385	388	PF01048	0.412
MOD_GlcNHglycan	535	538	PF01048	0.618
MOD_GlcNHglycan	563	567	PF01048	0.419
MOD_GlcNHglycan	577	580	PF01048	0.281
MOD_GlcNHglycan	627	630	PF01048	0.451
MOD_GSK3_1	177	184	PF00069	0.744
MOD_GSK3_1	188	195	PF00069	0.642
MOD_GSK3_1	205	212	PF00069	0.741
MOD_GSK3_1	226	233	PF00069	0.771
MOD_GSK3_1	244	251	PF00069	0.480
MOD_GSK3_1	278	285	PF00069	0.597
MOD_GSK3_1	341	348	PF00069	0.360
MOD_GSK3_1	5	12	PF00069	0.331
MOD_GSK3_1	529	536	PF00069	0.715
MOD_GSK3_1	56	63	PF00069	0.402
MOD_GSK3_1	89	96	PF00069	0.566
MOD_N-GLC_1	248	253	PF02516	0.598
MOD_N-GLC_1	324	329	PF02516	0.364
MOD_NEK2_1	18	23	PF00069	0.300
MOD_NEK2_1	188	193	PF00069	0.581
MOD_NEK2_1	232	237	PF00069	0.493
MOD_NEK2_1	324	329	PF00069	0.364
MOD_NEK2_1	345	350	PF00069	0.358
MOD_NEK2_2	309	314	PF00069	0.346
MOD_PIKK_1	124	130	PF00454	0.582
MOD_PIKK_1	296	302	PF00454	0.388
MOD_PIKK_1	356	362	PF00454	0.452
MOD_PIKK_1	480	486	PF00454	0.483
MOD_PIKK_1	60	66	PF00454	0.331
MOD_PK_1	278	284	PF00069	0.553
MOD_PK_1	94	100	PF00069	0.546
MOD_PKA_2	124	130	PF00069	0.525
MOD_PKA_2	272	278	PF00069	0.488
MOD_PKA_2	93	99	PF00069	0.556
MOD_Plk_1	248	254	PF00069	0.622
MOD_Plk_1	341	347	PF00069	0.353
MOD_Plk_1	451	457	PF00069	0.435
MOD_Plk_2-3	399	405	PF00069	0.587
MOD_Plk_4	345	351	PF00069	0.368
MOD_Plk_4	620	626	PF00069	0.397
MOD_ProDKin_1	172	178	PF00069	0.692
MOD_ProDKin_1	181	187	PF00069	0.666
MOD_ProDKin_1	192	198	PF00069	0.447
MOD_ProDKin_1	213	219	PF00069	0.608
MOD_ProDKin_1	226	232	PF00069	0.646
MOD_ProDKin_1	235	241	PF00069	0.635
MOD_ProDKin_1	252	258	PF00069	0.424
MOD_ProDKin_1	282	288	PF00069	0.422
MOD_ProDKin_1	350	356	PF00069	0.437
MOD_ProDKin_1	599	605	PF00069	0.398
MOD_SUMO_for_1	155	158	PF00179	0.454
MOD_SUMO_rev_2	152	161	PF00179	0.394
MOD_SUMO_rev_2	382	386	PF00179	0.412
TRG_ENDOCYTIC_2	277	280	PF00928	0.566
TRG_ENDOCYTIC_2	330	333	PF00928	0.389
TRG_ENDOCYTIC_2	363	366	PF00928	0.394
TRG_ENDOCYTIC_2	455	458	PF00928	0.347
TRG_ENDOCYTIC_2	569	572	PF00928	0.342
TRG_ER_diArg_1	134	136	PF00400	0.525
TRG_ER_diArg_1	551	554	PF00400	0.451
TRG_Pf-PMV_PEXEL_1	135	140	PF00026	0.517
TRG_Pf-PMV_PEXEL_1	338	342	PF00026	0.344
TRG_Pf-PMV_PEXEL_1	420	424	PF00026	0.470
TRG_Pf-PMV_PEXEL_1	559	563	PF00026	0.570

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE30	Leptomonas seymouri	70%	100%
A0A0S4IMJ5	Bodo saltans	46%	100%
A0A1X0NRQ0	Trypanosomatidae	52%	100%
A0A3R7LBE5	Trypanosoma rangeli	49%	100%
A4HKS6	Leishmania braziliensis	83%	99%
A4I8A6	Leishmania infantum	99%	100%
D0AAH8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	97%
E9B364	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q4Z0	Leishmania major	93%	100%
V5BMH6	Trypanosoma cruzi	51%	100%