Dynein axonemal assembly factor 4

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CS domain/TPR repeat/Tetratricopeptide repeat, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X5V3_LEIDO

TriTrypDb:

LdBPK_322990.1 , LdCL_320035900 , LDHU3_32.3770

Length:

639

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	1
GO:0042995	cell projection	2	11
GO:0043005	neuron projection	4	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11

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Expansion

Sequence features

A0A3S7X5V3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5V3

Function

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Biological processes
Term	Name	Level	Count
GO:0003341	cilium movement	4	11
GO:0007017	microtubule-based process	2	11
GO:0007018	microtubule-based movement	3	11
GO:0007399	nervous system development	4	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0032502	developmental process	1	11
GO:0036158	outer dynein arm assembly	7	1
GO:0036159	inner dynein arm assembly	7	1

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	157	161	PF00656	0.472
CLV_C14_Caspase3-7	423	427	PF00656	0.492
CLV_C14_Caspase3-7	512	516	PF00656	0.643
CLV_C14_Caspase3-7	545	549	PF00656	0.453
CLV_C14_Caspase3-7	68	72	PF00656	0.532
CLV_NRD_NRD_1	106	108	PF00675	0.414
CLV_NRD_NRD_1	134	136	PF00675	0.514
CLV_NRD_NRD_1	373	375	PF00675	0.306
CLV_NRD_NRD_1	554	556	PF00675	0.475
CLV_PCSK_FUR_1	552	556	PF00082	0.584

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE30	Leptomonas seymouri	70%	100%
A0A0S4IMJ5	Bodo saltans	46%	100%
A0A1X0NRQ0	Trypanosomatidae	52%	100%
A0A3R7LBE5	Trypanosoma rangeli	49%	100%
A4HKS6	Leishmania braziliensis	83%	99%
A4I8A6	Leishmania infantum	99%	100%
D0AAH8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	97%
E9B364	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q4Z0	Leishmania major	93%	100%
V5BMH6	Trypanosoma cruzi	51%	100%

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