Kinteoplast poly(A) polymerase complex 1 subunit, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinteoplast poly(A) polymerase complex 1 subunit, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X5U8_LEIDO

TriTrypDb:

LdBPK_322810.1 , LdCL_320034000 , LDHU3_32.3540

Length:

790

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

A0A3S7X5U8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5U8

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0009894	regulation of catabolic process	4	1
GO:0009895	negative regulation of catabolic process	5	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	137	141	PF00656	0.504
CLV_C14_Caspase3-7	147	151	PF00656	0.441
CLV_C14_Caspase3-7	268	272	PF00656	0.694
CLV_C14_Caspase3-7	348	352	PF00656	0.438
CLV_C14_Caspase3-7	50	54	PF00656	0.458
CLV_C14_Caspase3-7	628	632	PF00656	0.623
CLV_C14_Caspase3-7	669	673	PF00656	0.504
CLV_C14_Caspase3-7	702	706	PF00656	0.535
CLV_NRD_NRD_1	170	172	PF00675	0.446
CLV_NRD_NRD_1	180	182	PF00675	0.407

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I355	Leptomonas seymouri	73%	93%
A0A0S4JPP8	Bodo saltans	43%	100%
A0A1X0NS88	Trypanosomatidae	49%	99%
A0A3R7LBC9	Trypanosoma rangeli	52%	100%
A4HKQ8	Leishmania braziliensis	85%	99%
A4I888	Leishmania infantum	100%	100%
E9B346	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q508	Leishmania major	96%	100%
V5AUT0	Trypanosoma cruzi	53%	96%

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