Nsp1-like C-terminal region containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleoporin NUP53a

Species:

Leishmania donovani

UniProt:

A0A3S7X5T9_LEIDO

TriTrypDb:

LdBPK_322530.1 , LdCL_320030300 , LDHU3_32.3100

Length:

650

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005643	nuclear pore	3	6
GO:0032991	protein-containing complex	1	6
GO:0140513	nuclear protein-containing complex	2	6
GO:0044613	nuclear pore central transport channel	3	1

Expansion

Sequence features

A0A3S7X5T9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5T9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	6
GO:0008104	protein localization	4	6
GO:0009987	cellular process	1	6
GO:0015031	protein transport	4	6
GO:0033036	macromolecule localization	2	6
GO:0045184	establishment of protein localization	3	6
GO:0051179	localization	1	6
GO:0051234	establishment of localization	2	6
GO:0051641	cellular localization	2	6
GO:0070727	cellular macromolecule localization	3	6
GO:0071702	organic substance transport	4	6
GO:0071705	nitrogen compound transport	4	6
GO:0006405	RNA export from nucleus	5	1
GO:0006606	protein import into nucleus	5	1
GO:0006886	intracellular protein transport	4	1
GO:0006913	nucleocytoplasmic transport	5	1
GO:0015931	nucleobase-containing compound transport	5	1
GO:0033365	protein localization to organelle	5	1
GO:0034504	protein localization to nucleus	6	1
GO:0046907	intracellular transport	3	1
GO:0050657	nucleic acid transport	6	1
GO:0050658	RNA transport	4	1
GO:0051168	nuclear export	6	1
GO:0051169	nuclear transport	4	1
GO:0051170	import into nucleus	6	1
GO:0051236	establishment of RNA localization	3	1
GO:0051649	establishment of localization in cell	3	1
GO:0072594	establishment of protein localization to organelle	4	1

Molecular functions
Term	Name	Level	Count
GO:0005198	structural molecule activity	1	6
GO:0017056	structural constituent of nuclear pore	2	6
GO:0005488	binding	1	1
GO:0005543	phospholipid binding	3	1
GO:0008289	lipid binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	470	472	PF00675	0.405
CLV_PCSK_KEX2_1	439	441	PF00082	0.673
CLV_PCSK_PC1ET2_1	439	441	PF00082	0.673
CLV_PCSK_SKI1_1	513	517	PF00082	0.441
CLV_PCSK_SKI1_1	573	577	PF00082	0.544
DEG_APCC_DBOX_1	604	612	PF00400	0.578
DEG_SCF_FBW7_1	69	74	PF00400	0.554
DEG_SPOP_SBC_1	381	385	PF00917	0.586
DEG_SPOP_SBC_1	86	90	PF00917	0.611
DOC_CYCLIN_yCln2_LP_2	177	183	PF00134	0.668
DOC_MAPK_gen_1	471	479	PF00069	0.405
DOC_MAPK_MEF2A_6	471	479	PF00069	0.405
DOC_PP2B_LxvP_1	177	180	PF13499	0.662
DOC_PP2B_LxvP_1	323	326	PF13499	0.619
DOC_USP7_MATH_1	124	128	PF00917	0.784
DOC_USP7_MATH_1	132	136	PF00917	0.590
DOC_USP7_MATH_1	202	206	PF00917	0.652
DOC_USP7_MATH_1	207	211	PF00917	0.623
DOC_USP7_MATH_1	274	278	PF00917	0.611
DOC_USP7_MATH_1	337	341	PF00917	0.575
DOC_USP7_MATH_1	357	361	PF00917	0.633
DOC_USP7_MATH_1	380	384	PF00917	0.741
DOC_USP7_MATH_1	396	400	PF00917	0.578
DOC_USP7_MATH_1	434	438	PF00917	0.700
DOC_USP7_MATH_1	455	459	PF00917	0.441
DOC_USP7_MATH_1	5	9	PF00917	0.712
DOC_USP7_MATH_1	518	522	PF00917	0.405
DOC_USP7_MATH_1	633	637	PF00917	0.485
DOC_USP7_MATH_1	71	75	PF00917	0.680
DOC_USP7_MATH_1	87	91	PF00917	0.637
DOC_WW_Pin1_4	104	109	PF00397	0.671
DOC_WW_Pin1_4	133	138	PF00397	0.682
DOC_WW_Pin1_4	16	21	PF00397	0.678
DOC_WW_Pin1_4	161	166	PF00397	0.742
DOC_WW_Pin1_4	190	195	PF00397	0.646
DOC_WW_Pin1_4	226	231	PF00397	0.618
DOC_WW_Pin1_4	328	333	PF00397	0.617
DOC_WW_Pin1_4	346	351	PF00397	0.640
DOC_WW_Pin1_4	368	373	PF00397	0.631
DOC_WW_Pin1_4	414	419	PF00397	0.716
DOC_WW_Pin1_4	425	430	PF00397	0.594
DOC_WW_Pin1_4	453	458	PF00397	0.405
DOC_WW_Pin1_4	65	70	PF00397	0.657
LIG_14-3-3_CanoR_1	532	540	PF00244	0.356
LIG_14-3-3_CanoR_1	573	578	PF00244	0.543
LIG_BIR_II_1	1	5	PF00653	0.657
LIG_BRCT_BRCA1_1	134	138	PF00533	0.682
LIG_BRCT_BRCA1_1	195	199	PF00533	0.601
LIG_BRCT_BRCA1_1	276	280	PF00533	0.672
LIG_BRCT_BRCA1_1	339	343	PF00533	0.561
LIG_BRCT_BRCA1_1	384	388	PF00533	0.647
LIG_BRCT_BRCA1_1	457	461	PF00533	0.405
LIG_FHA_1	201	207	PF00498	0.601
LIG_FHA_1	268	274	PF00498	0.761
LIG_FHA_1	425	431	PF00498	0.633
LIG_FHA_2	523	529	PF00498	0.405
LIG_GBD_Chelix_1	634	642	PF00786	0.495
LIG_LIR_Gen_1	576	584	PF02991	0.453
LIG_LIR_Nem_3	164	169	PF02991	0.644
LIG_LIR_Nem_3	216	221	PF02991	0.544
LIG_LIR_Nem_3	576	580	PF02991	0.454
LIG_LIR_Nem_3	75	81	PF02991	0.645
LIG_NRBOX	641	647	PF00104	0.517
LIG_PCNA_PIPBox_1	533	542	PF02747	0.405
LIG_PCNA_yPIPBox_3	530	540	PF02747	0.405
LIG_SH2_CRK	577	581	PF00017	0.454
LIG_SH2_GRB2like	577	580	PF00017	0.515
LIG_SH2_SRC	577	580	PF00017	0.515
LIG_SH2_STAP1	577	581	PF00017	0.514
LIG_SH2_STAT3	550	553	PF00017	0.405
LIG_SH2_STAT5	539	542	PF00017	0.405
LIG_SH3_3	141	147	PF00018	0.642
LIG_SH3_3	31	37	PF00018	0.615
LIG_SH3_3	442	448	PF00018	0.572
LIG_SH3_3	98	104	PF00018	0.654
LIG_SUMO_SIM_par_1	231	236	PF11976	0.635
LIG_TRAF2_1	457	460	PF00917	0.417
LIG_TRAF2_2	457	462	PF00917	0.356
LIG_TYR_ITIM	575	580	PF00017	0.431
LIG_WW_2	445	448	PF00397	0.572
MOD_CK1_1	106	112	PF00069	0.594
MOD_CK1_1	193	199	PF00069	0.612
MOD_CK1_1	205	211	PF00069	0.615
MOD_CK1_1	254	260	PF00069	0.644
MOD_CK1_1	284	290	PF00069	0.550
MOD_CK1_1	318	324	PF00069	0.641
MOD_CK1_1	400	406	PF00069	0.614
MOD_CK1_1	412	418	PF00069	0.657
MOD_CK1_1	53	59	PF00069	0.724
MOD_CK1_1	95	101	PF00069	0.707
MOD_CK2_1	522	528	PF00069	0.405
MOD_CK2_1	601	607	PF00069	0.582
MOD_CK2_1	609	615	PF00069	0.491
MOD_CK2_1	633	639	PF00069	0.489
MOD_GlcNHglycan	111	114	PF01048	0.553
MOD_GlcNHglycan	126	129	PF01048	0.622
MOD_GlcNHglycan	148	151	PF01048	0.699
MOD_GlcNHglycan	159	162	PF01048	0.581
MOD_GlcNHglycan	166	169	PF01048	0.516
MOD_GlcNHglycan	190	193	PF01048	0.641
MOD_GlcNHglycan	195	198	PF01048	0.611
MOD_GlcNHglycan	207	210	PF01048	0.556
MOD_GlcNHglycan	237	240	PF01048	0.640
MOD_GlcNHglycan	253	256	PF01048	0.647
MOD_GlcNHglycan	259	262	PF01048	0.652
MOD_GlcNHglycan	270	273	PF01048	0.608
MOD_GlcNHglycan	276	279	PF01048	0.538
MOD_GlcNHglycan	282	286	PF01048	0.559
MOD_GlcNHglycan	290	293	PF01048	0.476
MOD_GlcNHglycan	317	320	PF01048	0.744
MOD_GlcNHglycan	339	342	PF01048	0.571
MOD_GlcNHglycan	359	362	PF01048	0.582
MOD_GlcNHglycan	368	371	PF01048	0.627
MOD_GlcNHglycan	384	387	PF01048	0.636
MOD_GlcNHglycan	411	414	PF01048	0.752
MOD_GlcNHglycan	436	439	PF01048	0.657
MOD_GlcNHglycan	48	51	PF01048	0.746
MOD_GlcNHglycan	52	55	PF01048	0.701
MOD_GlcNHglycan	520	523	PF01048	0.405
MOD_GlcNHglycan	562	565	PF01048	0.512
MOD_GlcNHglycan	58	61	PF01048	0.627
MOD_GlcNHglycan	631	634	PF01048	0.490
MOD_GlcNHglycan	635	638	PF01048	0.442
MOD_GlcNHglycan	94	97	PF01048	0.724
MOD_GSK3_1	132	139	PF00069	0.613
MOD_GSK3_1	157	164	PF00069	0.679
MOD_GSK3_1	184	191	PF00069	0.726
MOD_GSK3_1	284	291	PF00069	0.563
MOD_GSK3_1	303	310	PF00069	0.631
MOD_GSK3_1	324	331	PF00069	0.557
MOD_GSK3_1	337	344	PF00069	0.560
MOD_GSK3_1	382	389	PF00069	0.718
MOD_GSK3_1	396	403	PF00069	0.677
MOD_GSK3_1	420	427	PF00069	0.639
MOD_GSK3_1	428	435	PF00069	0.670
MOD_GSK3_1	446	453	PF00069	0.548
MOD_GSK3_1	46	53	PF00069	0.764
MOD_GSK3_1	514	521	PF00069	0.365
MOD_GSK3_1	629	636	PF00069	0.498
MOD_GSK3_1	65	72	PF00069	0.552
MOD_GSK3_1	85	92	PF00069	0.538
MOD_N-GLC_1	328	333	PF02516	0.617
MOD_N-GLC_1	601	606	PF02516	0.549
MOD_NEK2_1	111	116	PF00069	0.758
MOD_NEK2_1	154	159	PF00069	0.721
MOD_NEK2_1	365	370	PF00069	0.676
MOD_NEK2_1	390	395	PF00069	0.694
MOD_NEK2_1	6	11	PF00069	0.666
MOD_PIKK_1	455	461	PF00454	0.429
MOD_PKA_2	531	537	PF00069	0.359
MOD_Plk_1	475	481	PF00069	0.356
MOD_Plk_1	522	528	PF00069	0.405
MOD_Plk_2-3	565	571	PF00069	0.450
MOD_Plk_4	507	513	PF00069	0.441
MOD_ProDKin_1	104	110	PF00069	0.666
MOD_ProDKin_1	133	139	PF00069	0.683
MOD_ProDKin_1	16	22	PF00069	0.677
MOD_ProDKin_1	161	167	PF00069	0.743
MOD_ProDKin_1	190	196	PF00069	0.646
MOD_ProDKin_1	226	232	PF00069	0.615
MOD_ProDKin_1	328	334	PF00069	0.613
MOD_ProDKin_1	346	352	PF00069	0.637
MOD_ProDKin_1	368	374	PF00069	0.630
MOD_ProDKin_1	414	420	PF00069	0.719
MOD_ProDKin_1	425	431	PF00069	0.594
MOD_ProDKin_1	453	459	PF00069	0.405
MOD_ProDKin_1	65	71	PF00069	0.653
MOD_SUMO_rev_2	456	466	PF00179	0.356
MOD_SUMO_rev_2	538	547	PF00179	0.405
MOD_SUMO_rev_2	585	594	PF00179	0.516
TRG_DiLeu_BaEn_1	641	646	PF01217	0.514
TRG_DiLeu_BaLyEn_6	616	621	PF01217	0.514
TRG_DiLeu_LyEn_5	641	646	PF01217	0.514
TRG_ENDOCYTIC_2	577	580	PF00928	0.455
TRG_Pf-PMV_PEXEL_1	471	476	PF00026	0.405
TRG_Pf-PMV_PEXEL_1	503	507	PF00026	0.405

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HKM6	Leishmania braziliensis	63%	100%
A4I861	Leishmania infantum	100%	100%
E9B314	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	96%
Q4Q540	Leishmania major	84%	98%