Cyclic nucleotide-binding domain family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cyclic nucleotide-binding domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X5T2_LEIDO

TriTrypDb:

LdBPK_322670.1 , LdCL_320032500 , LDHU3_32.3340

Length:

958

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A0A3S7X5T2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5T2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	276	280	PF00656	0.749
CLV_C14_Caspase3-7	94	98	PF00656	0.637
CLV_NRD_NRD_1	202	204	PF00675	0.652
CLV_NRD_NRD_1	213	215	PF00675	0.643
CLV_NRD_NRD_1	230	232	PF00675	0.543
CLV_NRD_NRD_1	362	364	PF00675	0.488
CLV_NRD_NRD_1	432	434	PF00675	0.429
CLV_NRD_NRD_1	50	52	PF00675	0.487
CLV_NRD_NRD_1	631	633	PF00675	0.641
CLV_NRD_NRD_1	774	776	PF00675	0.416
CLV_NRD_NRD_1	795	797	PF00675	0.409
CLV_NRD_NRD_1	879	881	PF00675	0.573
CLV_NRD_NRD_1	896	898	PF00675	0.571
CLV_PCSK_KEX2_1	202	204	PF00082	0.652
CLV_PCSK_KEX2_1	230	232	PF00082	0.669
CLV_PCSK_KEX2_1	362	364	PF00082	0.437
CLV_PCSK_KEX2_1	432	434	PF00082	0.429
CLV_PCSK_KEX2_1	631	633	PF00082	0.581
CLV_PCSK_KEX2_1	774	776	PF00082	0.416
CLV_PCSK_KEX2_1	795	797	PF00082	0.450
CLV_PCSK_KEX2_1	879	881	PF00082	0.573
CLV_PCSK_KEX2_1	896	898	PF00082	0.571
CLV_PCSK_SKI1_1	100	104	PF00082	0.748
CLV_PCSK_SKI1_1	133	137	PF00082	0.465
CLV_PCSK_SKI1_1	149	153	PF00082	0.568
CLV_PCSK_SKI1_1	262	266	PF00082	0.695
CLV_PCSK_SKI1_1	362	366	PF00082	0.478
CLV_PCSK_SKI1_1	440	444	PF00082	0.572
CLV_PCSK_SKI1_1	481	485	PF00082	0.439
CLV_PCSK_SKI1_1	54	58	PF00082	0.539
CLV_PCSK_SKI1_1	60	64	PF00082	0.443
CLV_PCSK_SKI1_1	631	635	PF00082	0.585
CLV_PCSK_SKI1_1	718	722	PF00082	0.435
CLV_PCSK_SKI1_1	896	900	PF00082	0.648
CLV_PCSK_SKI1_1	917	921	PF00082	0.632
CLV_Separin_Metazoa	476	480	PF03568	0.601
DEG_APCC_DBOX_1	896	904	PF00400	0.641
DEG_SPOP_SBC_1	286	290	PF00917	0.641
DOC_ANK_TNKS_1	585	592	PF00023	0.599
DOC_CYCLIN_RxL_1	478	486	PF00134	0.562
DOC_CYCLIN_RxL_1	54	67	PF00134	0.354
DOC_CYCLIN_RxL_1	715	724	PF00134	0.427
DOC_MAPK_gen_1	49	57	PF00069	0.476
DOC_MAPK_gen_1	702	710	PF00069	0.527
DOC_MAPK_gen_1	777	785	PF00069	0.489
DOC_MAPK_gen_1	795	802	PF00069	0.401
DOC_PP1_RVXF_1	716	723	PF00149	0.446
DOC_PP2B_LxvP_1	310	313	PF13499	0.370
DOC_PP2B_LxvP_1	40	43	PF13499	0.472
DOC_PP2B_LxvP_1	407	410	PF13499	0.445
DOC_PP2B_LxvP_1	475	478	PF13499	0.643
DOC_PP4_FxxP_1	609	612	PF00568	0.635
DOC_USP7_MATH_1	2	6	PF00917	0.598
DOC_USP7_MATH_1	273	277	PF00917	0.624
DOC_USP7_MATH_1	285	289	PF00917	0.571
DOC_USP7_MATH_1	295	299	PF00917	0.638
DOC_USP7_MATH_1	602	606	PF00917	0.677
DOC_USP7_MATH_1	612	616	PF00917	0.729
DOC_USP7_MATH_1	627	631	PF00917	0.668
DOC_USP7_MATH_1	678	682	PF00917	0.473
DOC_USP7_MATH_1	745	749	PF00917	0.562
DOC_USP7_MATH_1	761	765	PF00917	0.416
DOC_USP7_MATH_1	840	844	PF00917	0.697
DOC_WW_Pin1_4	115	120	PF00397	0.579
DOC_WW_Pin1_4	332	337	PF00397	0.425
DOC_WW_Pin1_4	456	461	PF00397	0.644
DOC_WW_Pin1_4	623	628	PF00397	0.698
DOC_WW_Pin1_4	752	757	PF00397	0.501
LIG_14-3-3_CanoR_1	100	105	PF00244	0.715
LIG_14-3-3_CanoR_1	202	210	PF00244	0.633
LIG_14-3-3_CanoR_1	214	219	PF00244	0.588
LIG_14-3-3_CanoR_1	230	237	PF00244	0.564
LIG_14-3-3_CanoR_1	271	278	PF00244	0.784
LIG_14-3-3_CanoR_1	395	404	PF00244	0.422
LIG_14-3-3_CanoR_1	479	484	PF00244	0.527
LIG_14-3-3_CanoR_1	504	511	PF00244	0.482
LIG_14-3-3_CanoR_1	60	68	PF00244	0.367
LIG_14-3-3_CanoR_1	665	674	PF00244	0.599
LIG_14-3-3_CanoR_1	795	800	PF00244	0.434
LIG_14-3-3_CanoR_1	879	884	PF00244	0.605
LIG_14-3-3_CanoR_1	896	901	PF00244	0.568
LIG_14-3-3_CanoR_1	932	937	PF00244	0.666
LIG_Actin_RPEL_3	44	63	PF02755	0.425
LIG_Actin_WH2_2	14	32	PF00022	0.465
LIG_Actin_WH2_2	728	743	PF00022	0.372
LIG_APCC_ABBA_1	633	638	PF00400	0.661
LIG_APCC_ABBA_1	719	724	PF00400	0.455
LIG_APCC_ABBAyCdc20_2	632	638	PF00400	0.661
LIG_APCC_ABBAyCdc20_2	718	724	PF00400	0.455
LIG_BRCT_BRCA1_1	493	497	PF00533	0.446
LIG_Clathr_ClatBox_1	720	724	PF01394	0.431
LIG_deltaCOP1_diTrp_1	153	156	PF00928	0.514
LIG_deltaCOP1_diTrp_1	547	555	PF00928	0.594
LIG_deltaCOP1_diTrp_1	790	799	PF00928	0.342
LIG_DLG_GKlike_1	879	887	PF00625	0.524
LIG_FHA_1	254	260	PF00498	0.750
LIG_FHA_1	305	311	PF00498	0.626
LIG_FHA_1	396	402	PF00498	0.419
LIG_FHA_1	491	497	PF00498	0.437
LIG_FHA_1	549	555	PF00498	0.694
LIG_FHA_1	777	783	PF00498	0.407
LIG_FHA_1	80	86	PF00498	0.426
LIG_FHA_1	803	809	PF00498	0.523
LIG_FHA_1	814	820	PF00498	0.487
LIG_FHA_1	87	93	PF00498	0.437
LIG_FHA_1	935	941	PF00498	0.744
LIG_FHA_2	487	493	PF00498	0.371
LIG_FHA_2	507	513	PF00498	0.360
LIG_FHA_2	632	638	PF00498	0.661
LIG_FHA_2	64	70	PF00498	0.474
LIG_FHA_2	709	715	PF00498	0.506
LIG_FHA_2	918	924	PF00498	0.563
LIG_FHA_2	92	98	PF00498	0.529
LIG_HP1_1	678	682	PF01393	0.514
LIG_Integrin_RGD_1	947	949	PF01839	0.517
LIG_LIR_Apic_2	512	517	PF02991	0.309
LIG_LIR_Apic_2	607	612	PF02991	0.636
LIG_LIR_Gen_1	138	147	PF02991	0.430
LIG_LIR_Gen_1	503	513	PF02991	0.428
LIG_LIR_Gen_1	603	612	PF02991	0.542
LIG_LIR_Gen_1	66	76	PF02991	0.426
LIG_LIR_Gen_1	798	803	PF02991	0.319
LIG_LIR_Nem_3	138	143	PF02991	0.434
LIG_LIR_Nem_3	503	508	PF02991	0.408
LIG_LIR_Nem_3	603	609	PF02991	0.573
LIG_LIR_Nem_3	66	71	PF02991	0.433
LIG_LIR_Nem_3	73	79	PF02991	0.346
LIG_LIR_Nem_3	798	802	PF02991	0.322
LIG_LIR_Nem_3	833	837	PF02991	0.534
LIG_MYND_1	836	840	PF01753	0.507
LIG_PDZ_Class_3	953	958	PF00595	0.593
LIG_Pex14_2	950	954	PF04695	0.522
LIG_PTAP_UEV_1	296	301	PF05743	0.634
LIG_PTB_Apo_2	134	141	PF02174	0.449
LIG_PTB_Phospho_1	134	140	PF10480	0.455
LIG_REV1ctd_RIR_1	427	437	PF16727	0.366
LIG_REV1ctd_RIR_1	720	730	PF16727	0.457
LIG_RPA_C_Fungi	358	370	PF08784	0.443
LIG_SH2_CRK	505	509	PF00017	0.435
LIG_SH2_CRK	770	774	PF00017	0.360
LIG_SH2_CRK	834	838	PF00017	0.596
LIG_SH2_NCK_1	505	509	PF00017	0.435
LIG_SH2_NCK_1	93	97	PF00017	0.536
LIG_SH2_PTP2	140	143	PF00017	0.440
LIG_SH2_STAT5	140	143	PF00017	0.442
LIG_SH2_STAT5	327	330	PF00017	0.389
LIG_SH2_STAT5	348	351	PF00017	0.437
LIG_SH2_STAT5	378	381	PF00017	0.456
LIG_SH2_STAT5	505	508	PF00017	0.463
LIG_SH2_STAT5	514	517	PF00017	0.306
LIG_SH2_STAT5	770	773	PF00017	0.355
LIG_SH2_STAT5	84	87	PF00017	0.452
LIG_SH2_STAT5	93	96	PF00017	0.581
LIG_SH3_3	294	300	PF00018	0.638
LIG_SH3_3	330	336	PF00018	0.425
LIG_SH3_3	338	344	PF00018	0.405
LIG_SH3_3	454	460	PF00018	0.788
LIG_SH3_3	5	11	PF00018	0.551
LIG_SH3_3	528	534	PF00018	0.415
LIG_SH3_3	816	822	PF00018	0.644
LIG_SH3_3	862	868	PF00018	0.625
LIG_SUMO_SIM_anti_2	160	167	PF11976	0.395
LIG_SUMO_SIM_par_1	781	787	PF11976	0.378
LIG_TRAF2_1	24	27	PF00917	0.485
LIG_TRAF2_1	538	541	PF00917	0.518
LIG_TRAF2_1	67	70	PF00917	0.491
LIG_TRAF2_1	712	715	PF00917	0.496
LIG_TRAF2_1	824	827	PF00917	0.527
LIG_TRAF2_1	860	863	PF00917	0.542
LIG_TYR_ITIM	768	773	PF00017	0.355
LIG_TYR_ITIM	832	837	PF00017	0.584
LIG_UBA3_1	521	526	PF00899	0.367
LIG_ULM_U2AF65_1	774	779	PF00076	0.496
LIG_WRC_WIRS_1	606	611	PF05994	0.540
MOD_CK1_1	213	219	PF00069	0.771
MOD_CK1_1	257	263	PF00069	0.627
MOD_CK1_1	288	294	PF00069	0.775
MOD_CK1_1	332	338	PF00069	0.421
MOD_CK1_1	605	611	PF00069	0.540
MOD_CK1_1	64	70	PF00069	0.614
MOD_CK1_1	902	908	PF00069	0.760
MOD_CK2_1	486	492	PF00069	0.405
MOD_CK2_1	535	541	PF00069	0.524
MOD_CK2_1	63	69	PF00069	0.492
MOD_CK2_1	631	637	PF00069	0.656
MOD_CK2_1	669	675	PF00069	0.517
MOD_CK2_1	708	714	PF00069	0.534
MOD_CK2_1	74	80	PF00069	0.445
MOD_CK2_1	879	885	PF00069	0.688
MOD_CK2_1	917	923	PF00069	0.564
MOD_Cter_Amidation	894	897	PF01082	0.680
MOD_GlcNHglycan	100	103	PF01048	0.692
MOD_GlcNHglycan	11	14	PF01048	0.473
MOD_GlcNHglycan	111	114	PF01048	0.635
MOD_GlcNHglycan	204	207	PF01048	0.741
MOD_GlcNHglycan	232	235	PF01048	0.718
MOD_GlcNHglycan	248	251	PF01048	0.773
MOD_GlcNHglycan	273	276	PF01048	0.647
MOD_GlcNHglycan	297	300	PF01048	0.711
MOD_GlcNHglycan	537	540	PF01048	0.519
MOD_GlcNHglycan	612	615	PF01048	0.802
MOD_GlcNHglycan	654	657	PF01048	0.674
MOD_GlcNHglycan	667	670	PF01048	0.538
MOD_GlcNHglycan	671	674	PF01048	0.600
MOD_GlcNHglycan	711	714	PF01048	0.547
MOD_GlcNHglycan	747	750	PF01048	0.591
MOD_GlcNHglycan	752	755	PF01048	0.582
MOD_GlcNHglycan	76	79	PF01048	0.425
MOD_GlcNHglycan	763	766	PF01048	0.444
MOD_GlcNHglycan	891	894	PF01048	0.701
MOD_GlcNHglycan	917	920	PF01048	0.631
MOD_GlcNHglycan	923	927	PF01048	0.635
MOD_GSK3_1	105	112	PF00069	0.720
MOD_GSK3_1	194	201	PF00069	0.773
MOD_GSK3_1	210	217	PF00069	0.627
MOD_GSK3_1	239	246	PF00069	0.699
MOD_GSK3_1	253	260	PF00069	0.660
MOD_GSK3_1	304	311	PF00069	0.560
MOD_GSK3_1	350	357	PF00069	0.448
MOD_GSK3_1	391	398	PF00069	0.428
MOD_GSK3_1	448	455	PF00069	0.620
MOD_GSK3_1	486	493	PF00069	0.437
MOD_GSK3_1	623	630	PF00069	0.690
MOD_GSK3_1	665	672	PF00069	0.508
MOD_GSK3_1	898	905	PF00069	0.793
MOD_GSK3_1	927	934	PF00069	0.715
MOD_GSK3_1	939	946	PF00069	0.776
MOD_N-GLC_1	136	141	PF02516	0.449
MOD_N-GLC_1	238	243	PF02516	0.569
MOD_N-GLC_1	471	476	PF02516	0.621
MOD_N-GLC_1	479	484	PF02516	0.461
MOD_NEK2_1	136	141	PF00069	0.484
MOD_NEK2_1	198	203	PF00069	0.620
MOD_NEK2_1	237	242	PF00069	0.634
MOD_NEK2_1	287	292	PF00069	0.639
MOD_NEK2_1	331	336	PF00069	0.334
MOD_NEK2_1	497	502	PF00069	0.542
MOD_NEK2_1	61	66	PF00069	0.524
MOD_NEK2_1	79	84	PF00069	0.285
MOD_NEK2_1	802	807	PF00069	0.499
MOD_NEK2_1	884	889	PF00069	0.682
MOD_NEK2_1	915	920	PF00069	0.630
MOD_NEK2_1	922	927	PF00069	0.485
MOD_PK_1	214	220	PF00069	0.612
MOD_PK_1	932	938	PF00069	0.604
MOD_PKA_1	202	208	PF00069	0.646
MOD_PKA_1	214	220	PF00069	0.636
MOD_PKA_1	230	236	PF00069	0.557
MOD_PKA_1	631	637	PF00069	0.597
MOD_PKA_1	795	801	PF00069	0.387
MOD_PKA_1	879	885	PF00069	0.625
MOD_PKA_1	896	902	PF00069	0.586
MOD_PKA_2	202	208	PF00069	0.646
MOD_PKA_2	213	219	PF00069	0.607
MOD_PKA_2	230	236	PF00069	0.528
MOD_PKA_2	237	243	PF00069	0.631
MOD_PKA_2	503	509	PF00069	0.438
MOD_PKA_2	631	637	PF00069	0.573
MOD_PKA_2	664	670	PF00069	0.584
MOD_PKA_2	776	782	PF00069	0.505
MOD_PKA_2	795	801	PF00069	0.386
MOD_PKA_2	879	885	PF00069	0.561
MOD_PKA_2	896	902	PF00069	0.581
MOD_PKA_2	931	937	PF00069	0.770
MOD_Plk_1	136	142	PF00069	0.450
MOD_Plk_1	440	446	PF00069	0.619
MOD_Plk_1	471	477	PF00069	0.619
MOD_Plk_1	479	485	PF00069	0.453
MOD_Plk_1	491	497	PF00069	0.255
MOD_Plk_1	540	546	PF00069	0.528
MOD_Plk_1	602	608	PF00069	0.641
MOD_Plk_1	79	85	PF00069	0.470
MOD_Plk_1	861	867	PF00069	0.662
MOD_Plk_2-3	486	492	PF00069	0.379
MOD_Plk_2-3	91	97	PF00069	0.521
MOD_Plk_4	136	142	PF00069	0.450
MOD_Plk_4	194	200	PF00069	0.551
MOD_Plk_4	2	8	PF00069	0.563
MOD_Plk_4	214	220	PF00069	0.678
MOD_Plk_4	254	260	PF00069	0.680
MOD_Plk_4	288	294	PF00069	0.659
MOD_Plk_4	540	546	PF00069	0.560
MOD_Plk_4	631	637	PF00069	0.694
MOD_Plk_4	678	684	PF00069	0.480
MOD_Plk_4	795	801	PF00069	0.387
MOD_Plk_4	80	86	PF00069	0.447
MOD_Plk_4	841	847	PF00069	0.554
MOD_Plk_4	861	867	PF00069	0.664
MOD_Plk_4	879	885	PF00069	0.552
MOD_ProDKin_1	115	121	PF00069	0.574
MOD_ProDKin_1	332	338	PF00069	0.421
MOD_ProDKin_1	456	462	PF00069	0.645
MOD_ProDKin_1	623	629	PF00069	0.697
MOD_ProDKin_1	752	758	PF00069	0.491
MOD_SUMO_for_1	525	528	PF00179	0.468
MOD_SUMO_rev_2	418	426	PF00179	0.342
TRG_DiLeu_BaEn_1	161	166	PF01217	0.430
TRG_DiLeu_BaEn_1	715	720	PF01217	0.417
TRG_DiLeu_BaLyEn_6	360	365	PF01217	0.466
TRG_DiLeu_BaLyEn_6	371	376	PF01217	0.411
TRG_DiLeu_BaLyEn_6	388	393	PF01217	0.314
TRG_DiLeu_BaLyEn_6	57	62	PF01217	0.498
TRG_DiLeu_BaLyEn_6	833	838	PF01217	0.510
TRG_DiLeu_LyEn_5	715	720	PF01217	0.417
TRG_ENDOCYTIC_2	140	143	PF00928	0.529
TRG_ENDOCYTIC_2	348	351	PF00928	0.342
TRG_ENDOCYTIC_2	505	508	PF00928	0.428
TRG_ENDOCYTIC_2	770	773	PF00928	0.355
TRG_ENDOCYTIC_2	834	837	PF00928	0.593
TRG_ER_diArg_1	362	364	PF00400	0.488
TRG_ER_diArg_1	384	387	PF00400	0.425
TRG_ER_diArg_1	431	433	PF00400	0.414
TRG_ER_diArg_1	478	481	PF00400	0.621
TRG_ER_diArg_1	48	51	PF00400	0.438
TRG_ER_diArg_1	631	633	PF00400	0.626
TRG_ER_diArg_1	773	775	PF00400	0.404
TRG_ER_diArg_1	794	796	PF00400	0.439
TRG_NLS_MonoExtN_4	49	55	PF00514	0.476
TRG_Pf-PMV_PEXEL_1	262	266	PF00026	0.533
TRG_Pf-PMV_PEXEL_1	362	367	PF00026	0.527
TRG_Pf-PMV_PEXEL_1	481	486	PF00026	0.472
TRG_Pf-PMV_PEXEL_1	519	523	PF00026	0.331

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I352	Leptomonas seymouri	51%	100%
A0A1X0NRJ2	Trypanosomatidae	32%	100%
A4I874	Leishmania infantum	99%	100%
D0AAE4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9B332	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q522	Leishmania major	92%	100%