Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X5S6_LEIDO

TriTrypDb:

LdBPK_322710.1 , LdCL_320032900 , LDHU3_32.3380

Length:

725

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X5S6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5S6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	663	667	PF00656	0.537
CLV_NRD_NRD_1	151	153	PF00675	0.587
CLV_NRD_NRD_1	406	408	PF00675	0.575
CLV_NRD_NRD_1	440	442	PF00675	0.666
CLV_NRD_NRD_1	456	458	PF00675	0.466
CLV_NRD_NRD_1	48	50	PF00675	0.485
CLV_NRD_NRD_1	492	494	PF00675	0.548
CLV_NRD_NRD_1	51	53	PF00675	0.487
CLV_NRD_NRD_1	83	85	PF00675	0.739
CLV_NRD_NRD_1	88	90	PF00675	0.559
CLV_PCSK_FUR_1	438	442	PF00082	0.650
CLV_PCSK_FUR_1	454	458	PF00082	0.494
CLV_PCSK_FUR_1	489	493	PF00082	0.550
CLV_PCSK_FUR_1	49	53	PF00082	0.459
CLV_PCSK_KEX2_1	151	153	PF00082	0.561
CLV_PCSK_KEX2_1	406	408	PF00082	0.544
CLV_PCSK_KEX2_1	440	442	PF00082	0.666
CLV_PCSK_KEX2_1	456	458	PF00082	0.466
CLV_PCSK_KEX2_1	48	50	PF00082	0.485
CLV_PCSK_KEX2_1	491	493	PF00082	0.569
CLV_PCSK_KEX2_1	51	53	PF00082	0.487
CLV_PCSK_KEX2_1	529	531	PF00082	0.569
CLV_PCSK_KEX2_1	573	575	PF00082	0.713
CLV_PCSK_KEX2_1	88	90	PF00082	0.610
CLV_PCSK_PC1ET2_1	529	531	PF00082	0.620
CLV_PCSK_PC1ET2_1	573	575	PF00082	0.653
CLV_PCSK_PC7_1	84	90	PF00082	0.673
CLV_PCSK_SKI1_1	114	118	PF00082	0.595
CLV_PCSK_SKI1_1	223	227	PF00082	0.570
CLV_PCSK_SKI1_1	40	44	PF00082	0.541
CLV_PCSK_SKI1_1	467	471	PF00082	0.485
CLV_PCSK_SKI1_1	523	527	PF00082	0.666
CLV_PCSK_SKI1_1	686	690	PF00082	0.599
CLV_Separin_Metazoa	309	313	PF03568	0.541
CLV_Separin_Metazoa	612	616	PF03568	0.556
DEG_APCC_DBOX_1	529	537	PF00400	0.613
DEG_Nend_UBRbox_1	1	4	PF02207	0.581
DEG_SPOP_SBC_1	121	125	PF00917	0.638
DEG_SPOP_SBC_1	701	705	PF00917	0.472
DOC_ANK_TNKS_1	346	353	PF00023	0.643
DOC_CKS1_1	128	133	PF01111	0.702
DOC_CKS1_1	228	233	PF01111	0.654
DOC_CKS1_1	257	262	PF01111	0.720
DOC_MAPK_gen_1	406	414	PF00069	0.511
DOC_MAPK_gen_1	529	535	PF00069	0.666
DOC_MAPK_gen_1	573	583	PF00069	0.680
DOC_PP4_FxxP_1	257	260	PF00568	0.640
DOC_PP4_FxxP_1	477	480	PF00568	0.618
DOC_PP4_FxxP_1	482	485	PF00568	0.600
DOC_USP7_MATH_1	121	125	PF00917	0.638
DOC_USP7_MATH_1	131	135	PF00917	0.600
DOC_USP7_MATH_1	265	269	PF00917	0.736
DOC_USP7_MATH_1	516	520	PF00917	0.548
DOC_USP7_MATH_1	521	525	PF00917	0.529
DOC_USP7_MATH_1	548	552	PF00917	0.547
DOC_USP7_MATH_1	674	678	PF00917	0.655
DOC_USP7_MATH_1	701	705	PF00917	0.528
DOC_USP7_MATH_1	8	12	PF00917	0.610
DOC_WW_Pin1_4	127	132	PF00397	0.742
DOC_WW_Pin1_4	227	232	PF00397	0.708
DOC_WW_Pin1_4	256	261	PF00397	0.712
DOC_WW_Pin1_4	3	8	PF00397	0.706
DOC_WW_Pin1_4	372	377	PF00397	0.684
DOC_WW_Pin1_4	563	568	PF00397	0.745
DOC_WW_Pin1_4	572	577	PF00397	0.650
DOC_WW_Pin1_4	615	620	PF00397	0.672
DOC_WW_Pin1_4	640	645	PF00397	0.788
LIG_14-3-3_CanoR_1	136	145	PF00244	0.589
LIG_14-3-3_CanoR_1	165	169	PF00244	0.623
LIG_14-3-3_CanoR_1	174	180	PF00244	0.558
LIG_14-3-3_CanoR_1	209	219	PF00244	0.567
LIG_14-3-3_CanoR_1	241	249	PF00244	0.606
LIG_14-3-3_CanoR_1	343	351	PF00244	0.677
LIG_14-3-3_CanoR_1	440	448	PF00244	0.523
LIG_14-3-3_CanoR_1	515	525	PF00244	0.571
LIG_14-3-3_CanoR_1	549	553	PF00244	0.772
LIG_14-3-3_CanoR_1	9	13	PF00244	0.637
LIG_14-3-3_CanoR_1	91	100	PF00244	0.831
LIG_APCC_ABBA_1	423	428	PF00400	0.608
LIG_BIR_III_2	591	595	PF00653	0.626
LIG_BIR_III_4	666	670	PF00653	0.626
LIG_BRCT_BRCA1_1	134	138	PF00533	0.534
LIG_BRCT_BRCA1_1	198	202	PF00533	0.650
LIG_BRCT_BRCA1_1	253	257	PF00533	0.594
LIG_CSL_BTD_1	581	584	PF09270	0.618
LIG_CtBP_PxDLS_1	633	639	PF00389	0.515
LIG_EVH1_2	287	291	PF00568	0.620
LIG_FHA_1	212	218	PF00498	0.622
LIG_FHA_1	228	234	PF00498	0.780
LIG_FHA_1	358	364	PF00498	0.526
LIG_FHA_1	563	569	PF00498	0.611
LIG_FHA_1	693	699	PF00498	0.516
LIG_FHA_2	139	145	PF00498	0.510
LIG_FHA_2	158	164	PF00498	0.500
LIG_FHA_2	181	187	PF00498	0.611
LIG_FHA_2	27	33	PF00498	0.562
LIG_FHA_2	275	281	PF00498	0.641
LIG_FHA_2	334	340	PF00498	0.711
LIG_FHA_2	389	395	PF00498	0.621
LIG_FHA_2	450	456	PF00498	0.571
LIG_FHA_2	586	592	PF00498	0.639
LIG_FHA_2	714	720	PF00498	0.493
LIG_LIR_Apic_2	254	260	PF02991	0.639
LIG_LIR_Apic_2	479	485	PF02991	0.579
LIG_LIR_Apic_2	588	593	PF02991	0.546
LIG_LIR_Gen_1	391	398	PF02991	0.518
LIG_LIR_Gen_1	609	619	PF02991	0.657
LIG_LIR_Nem_3	199	205	PF02991	0.567
LIG_LIR_Nem_3	391	396	PF02991	0.524
LIG_LIR_Nem_3	420	426	PF02991	0.646
LIG_LIR_Nem_3	609	614	PF02991	0.660
LIG_Pex14_2	291	295	PF04695	0.629
LIG_SH2_STAT5	184	187	PF00017	0.695
LIG_SH2_STAT5	205	208	PF00017	0.711
LIG_SH2_STAT5	390	393	PF00017	0.507
LIG_SH2_STAT5	706	709	PF00017	0.519
LIG_SH3_3	225	231	PF00018	0.686
LIG_SH3_3	282	288	PF00018	0.669
LIG_SH3_3	320	326	PF00018	0.593
LIG_SH3_3	564	570	PF00018	0.797
LIG_SH3_3	614	620	PF00018	0.668
LIG_TRAF2_1	140	143	PF00917	0.510
LIG_TRAF2_1	160	163	PF00917	0.468
LIG_UBA3_1	497	504	PF00899	0.549
LIG_WW_3	375	379	PF00397	0.736
MOD_CDC14_SPxK_1	375	378	PF00782	0.641
MOD_CDC14_SPxK_1	6	9	PF00782	0.705
MOD_CDC14_SPxK_1	643	646	PF00782	0.541
MOD_CDK_SPK_2	227	232	PF00069	0.615
MOD_CDK_SPK_2	572	577	PF00069	0.704
MOD_CDK_SPxK_1	127	133	PF00069	0.630
MOD_CDK_SPxK_1	261	267	PF00069	0.659
MOD_CDK_SPxK_1	3	9	PF00069	0.709
MOD_CDK_SPxK_1	372	378	PF00069	0.648
MOD_CDK_SPxK_1	640	646	PF00069	0.540
MOD_CDK_SPxxK_3	566	573	PF00069	0.667
MOD_CK1_1	132	138	PF00069	0.622
MOD_CK1_1	167	173	PF00069	0.666
MOD_CK1_1	175	181	PF00069	0.579
MOD_CK1_1	21	27	PF00069	0.605
MOD_CK1_1	213	219	PF00069	0.566
MOD_CK1_1	247	253	PF00069	0.825
MOD_CK1_1	519	525	PF00069	0.562
MOD_CK1_1	618	624	PF00069	0.567
MOD_CK1_1	650	656	PF00069	0.681
MOD_CK1_1	92	98	PF00069	0.622
MOD_CK2_1	138	144	PF00069	0.503
MOD_CK2_1	157	163	PF00069	0.499
MOD_CK2_1	180	186	PF00069	0.612
MOD_CK2_1	242	248	PF00069	0.651
MOD_CK2_1	449	455	PF00069	0.584
MOD_CK2_1	521	527	PF00069	0.595
MOD_CK2_1	713	719	PF00069	0.491
MOD_CK2_1	72	78	PF00069	0.722
MOD_Cter_Amidation	527	530	PF01082	0.622
MOD_DYRK1A_RPxSP_1	615	619	PF00069	0.629
MOD_GlcNHglycan	10	13	PF01048	0.588
MOD_GlcNHglycan	124	127	PF01048	0.721
MOD_GlcNHglycan	138	141	PF01048	0.501
MOD_GlcNHglycan	234	237	PF01048	0.675
MOD_GlcNHglycan	250	253	PF01048	0.631
MOD_GlcNHglycan	330	333	PF01048	0.683
MOD_GlcNHglycan	344	347	PF01048	0.759
MOD_GlcNHglycan	505	508	PF01048	0.576
MOD_GlcNHglycan	570	573	PF01048	0.702
MOD_GlcNHglycan	676	679	PF01048	0.586
MOD_GlcNHglycan	94	97	PF01048	0.803
MOD_GSK3_1	127	134	PF00069	0.719
MOD_GSK3_1	14	21	PF00069	0.641
MOD_GSK3_1	157	164	PF00069	0.619
MOD_GSK3_1	208	215	PF00069	0.675
MOD_GSK3_1	232	239	PF00069	0.770
MOD_GSK3_1	244	251	PF00069	0.677
MOD_GSK3_1	261	268	PF00069	0.646
MOD_GSK3_1	271	278	PF00069	0.663
MOD_GSK3_1	324	331	PF00069	0.747
MOD_GSK3_1	436	443	PF00069	0.552
MOD_GSK3_1	480	487	PF00069	0.602
MOD_GSK3_1	519	526	PF00069	0.656
MOD_GSK3_1	562	569	PF00069	0.706
MOD_GSK3_1	582	589	PF00069	0.562
MOD_GSK3_1	66	73	PF00069	0.661
MOD_GSK3_1	697	704	PF00069	0.548
MOD_GSK3_1	709	716	PF00069	0.470
MOD_N-GLC_1	40	45	PF02516	0.527
MOD_N-GLC_1	554	559	PF02516	0.608
MOD_N-GLC_1	66	71	PF02516	0.711
MOD_NEK2_1	122	127	PF00069	0.664
MOD_NEK2_1	14	19	PF00069	0.656
MOD_NEK2_1	226	231	PF00069	0.672
MOD_NEK2_1	600	605	PF00069	0.602
MOD_NEK2_2	449	454	PF00069	0.600
MOD_NEK2_2	66	71	PF00069	0.627
MOD_PIKK_1	138	144	PF00454	0.510
MOD_PIKK_1	480	486	PF00454	0.603
MOD_PIKK_1	516	522	PF00454	0.657
MOD_PIKK_1	647	653	PF00454	0.634
MOD_PIKK_1	72	78	PF00454	0.682
MOD_PKA_1	440	446	PF00069	0.592
MOD_PKA_1	84	90	PF00069	0.726
MOD_PKA_2	132	138	PF00069	0.552
MOD_PKA_2	164	170	PF00069	0.638
MOD_PKA_2	208	214	PF00069	0.568
MOD_PKA_2	295	301	PF00069	0.597
MOD_PKA_2	342	348	PF00069	0.726
MOD_PKA_2	440	446	PF00069	0.616
MOD_PKA_2	455	461	PF00069	0.455
MOD_PKA_2	548	554	PF00069	0.610
MOD_PKA_2	8	14	PF00069	0.636
MOD_PKB_1	269	277	PF00069	0.604
MOD_PKB_1	438	446	PF00069	0.545
MOD_PKB_1	82	90	PF00069	0.650
MOD_Plk_1	14	20	PF00069	0.646
MOD_Plk_1	554	560	PF00069	0.570
MOD_Plk_1	66	72	PF00069	0.590
MOD_Plk_2-3	234	240	PF00069	0.599
MOD_Plk_4	180	186	PF00069	0.549
MOD_Plk_4	388	394	PF00069	0.591
MOD_Plk_4	702	708	PF00069	0.513
MOD_ProDKin_1	127	133	PF00069	0.739
MOD_ProDKin_1	227	233	PF00069	0.707
MOD_ProDKin_1	256	262	PF00069	0.712
MOD_ProDKin_1	3	9	PF00069	0.709
MOD_ProDKin_1	372	378	PF00069	0.686
MOD_ProDKin_1	563	569	PF00069	0.746
MOD_ProDKin_1	572	578	PF00069	0.649
MOD_ProDKin_1	615	621	PF00069	0.668
MOD_ProDKin_1	640	646	PF00069	0.790
MOD_SUMO_rev_2	524	531	PF00179	0.558
MOD_SUMO_rev_2	537	542	PF00179	0.444
MOD_SUMO_rev_2	78	87	PF00179	0.604
TRG_ENDOCYTIC_2	390	393	PF00928	0.494
TRG_ENDOCYTIC_2	611	614	PF00928	0.665
TRG_ER_diArg_1	150	152	PF00400	0.599
TRG_ER_diArg_1	267	270	PF00400	0.610
TRG_ER_diArg_1	347	350	PF00400	0.665
TRG_ER_diArg_1	405	407	PF00400	0.527
TRG_ER_diArg_1	430	433	PF00400	0.596
TRG_ER_diArg_1	438	441	PF00400	0.629
TRG_ER_diArg_1	456	459	PF00400	0.456
TRG_ER_diArg_1	489	492	PF00400	0.565
TRG_ER_diArg_1	51	53	PF00400	0.483
TRG_ER_diArg_1	576	579	PF00400	0.689
TRG_ER_diArg_1	88	91	PF00400	0.676
TRG_Pf-PMV_PEXEL_1	151	155	PF00026	0.579
TRG_Pf-PMV_PEXEL_1	410	415	PF00026	0.509
TRG_Pf-PMV_PEXEL_1	432	436	PF00026	0.557
TRG_Pf-PMV_PEXEL_1	440	444	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	708	713	PF00026	0.496

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PGB2	Leptomonas seymouri	34%	77%
A4HKP7	Leishmania braziliensis	55%	100%
A4I878	Leishmania infantum	99%	100%
E9B336	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q518	Leishmania major	83%	99%