Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X5S2_LEIDO

TriTrypDb:

LdBPK_322430.1 , LdCL_320029600 , LDHU3_32.3020

Length:

284

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X5S2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5S2

PDB structure(s): 7aih_Ao , 7ane_Ao

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	166	170	PF00656	0.479
CLV_NRD_NRD_1	209	211	PF00675	0.441
CLV_NRD_NRD_1	27	29	PF00675	0.599
CLV_NRD_NRD_1	96	98	PF00675	0.489
CLV_PCSK_KEX2_1	26	28	PF00082	0.595
CLV_PCSK_KEX2_1	96	98	PF00082	0.489
CLV_PCSK_SKI1_1	174	178	PF00082	0.525
CLV_PCSK_SKI1_1	220	224	PF00082	0.435
DEG_Nend_Nbox_1	1	3	PF02207	0.688
DEG_SCF_FBW7_2	222	229	PF00400	0.410
DOC_CDC14_PxL_1	231	239	PF14671	0.410
DOC_CKS1_1	123	128	PF01111	0.412
DOC_CKS1_1	223	228	PF01111	0.411
DOC_MAPK_MEF2A_6	238	246	PF00069	0.450
DOC_PP1_SILK_1	220	225	PF00149	0.439
DOC_USP7_MATH_1	209	213	PF00917	0.497
DOC_USP7_MATH_1	247	251	PF00917	0.551
DOC_WW_Pin1_4	122	127	PF00397	0.413
DOC_WW_Pin1_4	222	227	PF00397	0.407
DOC_WW_Pin1_4	39	44	PF00397	0.487
LIG_14-3-3_CanoR_1	210	214	PF00244	0.525
LIG_14-3-3_CanoR_1	3	9	PF00244	0.711
LIG_14-3-3_CanoR_1	81	89	PF00244	0.418
LIG_14-3-3_CanoR_1	96	105	PF00244	0.524
LIG_Actin_WH2_2	151	167	PF00022	0.399
LIG_BRCT_BRCA1_1	254	258	PF00533	0.441
LIG_FHA_1	2	8	PF00498	0.700
LIG_FHA_2	164	170	PF00498	0.504
LIG_LIR_Apic_2	132	136	PF02991	0.384
LIG_LIR_Apic_2	229	235	PF02991	0.419
LIG_LIR_Gen_1	114	123	PF02991	0.575
LIG_LIR_Gen_1	255	266	PF02991	0.464
LIG_LIR_Nem_3	112	116	PF02991	0.499
LIG_LIR_Nem_3	229	234	PF02991	0.417
LIG_PDZ_Class_2	279	284	PF00595	0.458
LIG_SH2_CRK	133	137	PF00017	0.367
LIG_SH2_CRK	232	236	PF00017	0.416
LIG_SH2_GRB2like	16	19	PF00017	0.561
LIG_SH2_NCK_1	116	120	PF00017	0.379
LIG_SH2_NCK_1	123	127	PF00017	0.346
LIG_SH2_NCK_1	133	137	PF00017	0.320
LIG_SH2_SRC	116	119	PF00017	0.376
LIG_SH2_STAT3	141	144	PF00017	0.405
LIG_SH2_STAT5	133	136	PF00017	0.377
LIG_SH2_STAT5	141	144	PF00017	0.343
LIG_SH2_STAT5	154	157	PF00017	0.367
LIG_SH2_STAT5	178	181	PF00017	0.415
LIG_SH2_STAT5	32	35	PF00017	0.593
LIG_SH3_3	237	243	PF00018	0.439
LIG_SH3_3	37	43	PF00018	0.583
LIG_SH3_5	111	115	PF00018	0.398
LIG_TRAF2_2	269	274	PF00917	0.524
MOD_CK1_1	100	106	PF00069	0.523
MOD_CK1_1	8	14	PF00069	0.555
MOD_CK2_1	150	156	PF00069	0.450
MOD_CK2_1	169	175	PF00069	0.547
MOD_CK2_1	57	63	PF00069	0.518
MOD_CMANNOS	79	82	PF00535	0.421
MOD_GlcNHglycan	161	164	PF01048	0.545
MOD_GlcNHglycan	171	174	PF01048	0.521
MOD_GlcNHglycan	249	252	PF01048	0.471
MOD_GlcNHglycan	254	257	PF01048	0.449
MOD_GlcNHglycan	59	62	PF01048	0.517
MOD_GlcNHglycan	99	102	PF01048	0.553
MOD_GSK3_1	1	8	PF00069	0.638
MOD_GSK3_1	159	166	PF00069	0.418
MOD_GSK3_1	252	259	PF00069	0.549
MOD_GSK3_1	95	102	PF00069	0.542
MOD_LATS_1	236	242	PF00433	0.441
MOD_NEK2_1	1	6	PF00069	0.690
MOD_NEK2_1	131	136	PF00069	0.469
MOD_PIKK_1	256	262	PF00454	0.474
MOD_PKA_2	2	8	PF00069	0.561
MOD_PKA_2	209	215	PF00069	0.528
MOD_PKA_2	80	86	PF00069	0.426
MOD_PKA_2	95	101	PF00069	0.498
MOD_Plk_2-3	150	156	PF00069	0.377
MOD_Plk_4	150	156	PF00069	0.493
MOD_Plk_4	176	182	PF00069	0.491
MOD_ProDKin_1	122	128	PF00069	0.418
MOD_ProDKin_1	222	228	PF00069	0.408
MOD_ProDKin_1	39	45	PF00069	0.477
TRG_ENDOCYTIC_2	116	119	PF00928	0.376
TRG_ENDOCYTIC_2	231	234	PF00928	0.404
TRG_ER_diArg_1	26	28	PF00400	0.565
TRG_ER_diArg_1	68	71	PF00400	0.417
TRG_NLS_MonoExtN_4	26	32	PF00514	0.667
TRG_Pf-PMV_PEXEL_1	165	169	PF00026	0.416

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P338	Leptomonas seymouri	77%	100%
A0A1X0NU54	Trypanosomatidae	62%	100%
A0A422MUA3	Trypanosoma rangeli	57%	100%
A4HKL9	Leishmania braziliensis	87%	100%
A4I851	Leishmania infantum	100%	100%
D0AAB7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
D0AAB9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	73%
E9B309	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4Q547	Leishmania major	99%	100%
V5BKN6	Trypanosoma cruzi	57%	100%