LeishMANIAdb
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Ergosterol biosynthesis ERG4/ERG24 family protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Ergosterol biosynthesis ERG4/ERG24 family protein
Gene product:
C-14 sterol reductase, putative
Species:
Leishmania donovani
UniProt:
A0A3S7X5R0_LEIDO
TriTrypDb:
LdBPK_322470.1 , LdCL_320030000 , LDHU3_32.3060
Length:
437

Annotations

Annotations by Jardim et al.

Sterol metabolism/biosynthesis, C-14 sterol reductase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 11
GO:0110165 cellular anatomical entity 1 11

Expansion

Sequence features

A0A3S7X5R0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5R0

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 12
GO:0006694 steroid biosynthetic process 5 12
GO:0008152 metabolic process 1 12
GO:0008202 steroid metabolic process 4 12
GO:0008610 lipid biosynthetic process 4 12
GO:0009058 biosynthetic process 2 12
GO:0016125 sterol metabolic process 4 12
GO:0016126 sterol biosynthetic process 5 12
GO:0044238 primary metabolic process 2 12
GO:0071704 organic substance metabolic process 2 12
GO:1901360 organic cyclic compound metabolic process 3 12
GO:1901362 organic cyclic compound biosynthetic process 4 12
GO:1901576 organic substance biosynthetic process 3 12
GO:1901615 organic hydroxy compound metabolic process 3 12
GO:1901617 organic hydroxy compound biosynthetic process 4 12
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0016491 oxidoreductase activity 2 12
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 3 12
GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 4 12
GO:0050613 delta14-sterol reductase activity 5 6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 332 334 PF00675 0.298
CLV_PCSK_SKI1_1 175 179 PF00082 0.311
CLV_PCSK_SKI1_1 345 349 PF00082 0.216
CLV_PCSK_SKI1_1 426 430 PF00082 0.256
DEG_APCC_DBOX_1 174 182 PF00400 0.511
DOC_CYCLIN_yCln2_LP_2 148 154 PF00134 0.337
DOC_MAPK_gen_1 348 357 PF00069 0.457
DOC_MAPK_MEF2A_6 78 85 PF00069 0.303
DOC_USP7_MATH_1 44 48 PF00917 0.311
DOC_WW_Pin1_4 235 240 PF00397 0.420
LIG_14-3-3_CanoR_1 19 24 PF00244 0.537
LIG_14-3-3_CanoR_1 323 332 PF00244 0.432
LIG_14-3-3_CanoR_1 345 355 PF00244 0.456
LIG_Actin_WH2_2 62 80 PF00022 0.224
LIG_Actin_WH2_2 95 111 PF00022 0.261
LIG_BIR_II_1 1 5 PF00653 0.681
LIG_CSL_BTD_1 283 286 PF09270 0.258
LIG_deltaCOP1_diTrp_1 281 287 PF00928 0.243
LIG_deltaCOP1_diTrp_1 372 379 PF00928 0.408
LIG_deltaCOP1_diTrp_1 387 392 PF00928 0.408
LIG_deltaCOP1_diTrp_1 419 424 PF00928 0.435
LIG_deltaCOP1_diTrp_1 84 94 PF00928 0.277
LIG_EH1_1 123 131 PF00400 0.266
LIG_eIF4E_1 251 257 PF01652 0.416
LIG_eIF4E_1 369 375 PF01652 0.418
LIG_eIF4E_1 396 402 PF01652 0.408
LIG_FHA_1 135 141 PF00498 0.307
LIG_FHA_1 200 206 PF00498 0.412
LIG_FHA_1 236 242 PF00498 0.418
LIG_FHA_1 286 292 PF00498 0.295
LIG_FHA_1 38 44 PF00498 0.389
LIG_FHA_2 325 331 PF00498 0.456
LIG_LIR_Apic_2 22 28 PF02991 0.409
LIG_LIR_Gen_1 244 253 PF02991 0.477
LIG_LIR_Gen_1 419 428 PF02991 0.456
LIG_LIR_LC3C_4 40 43 PF02991 0.255
LIG_LIR_Nem_3 147 152 PF02991 0.240
LIG_LIR_Nem_3 244 250 PF02991 0.472
LIG_LIR_Nem_3 281 287 PF02991 0.265
LIG_LIR_Nem_3 358 363 PF02991 0.403
LIG_LIR_Nem_3 385 391 PF02991 0.428
LIG_LIR_Nem_3 419 424 PF02991 0.422
LIG_MAD2 426 434 PF02301 0.475
LIG_NRBOX 252 258 PF00104 0.511
LIG_PCNA_PIPBox_1 142 151 PF02747 0.256
LIG_Pex14_1 388 392 PF04695 0.543
LIG_Pex14_2 132 136 PF04695 0.266
LIG_Pex14_2 275 279 PF04695 0.243
LIG_Pex14_2 33 37 PF04695 0.391
LIG_PTB_Apo_2 221 228 PF02174 0.408
LIG_SH2_CRK 149 153 PF00017 0.382
LIG_SH2_STAP1 168 172 PF00017 0.365
LIG_SH2_STAP1 190 194 PF00017 0.408
LIG_SH2_STAT3 289 292 PF00017 0.357
LIG_SH2_STAT5 251 254 PF00017 0.416
LIG_SH2_STAT5 289 292 PF00017 0.259
LIG_SH2_STAT5 295 298 PF00017 0.208
LIG_SH2_STAT5 319 322 PF00017 0.296
LIG_SH2_STAT5 369 372 PF00017 0.420
LIG_SH2_STAT5 391 394 PF00017 0.426
LIG_SH2_STAT5 396 399 PF00017 0.404
LIG_SH3_1 333 339 PF00018 0.432
LIG_SH3_3 12 18 PF00018 0.532
LIG_SH3_3 294 300 PF00018 0.353
LIG_SH3_3 333 339 PF00018 0.432
LIG_SUMO_SIM_par_1 40 47 PF11976 0.285
LIG_TRFH_1 430 434 PF08558 0.243
LIG_UBA3_1 96 101 PF00899 0.328
LIG_WRC_WIRS_1 158 163 PF05994 0.415
LIG_WRC_WIRS_1 247 252 PF05994 0.302
MOD_CK1_1 171 177 PF00069 0.304
MOD_CK2_1 6 12 PF00069 0.685
MOD_GlcNHglycan 109 112 PF01048 0.393
MOD_GlcNHglycan 184 187 PF01048 0.309
MOD_GlcNHglycan 314 317 PF01048 0.243
MOD_GlcNHglycan 357 360 PF01048 0.293
MOD_GlcNHglycan 382 385 PF01048 0.278
MOD_GSK3_1 157 164 PF00069 0.260
MOD_GSK3_1 233 240 PF00069 0.246
MOD_GSK3_1 347 354 PF00069 0.246
MOD_N-GLC_1 261 266 PF02516 0.264
MOD_NEK2_1 134 139 PF00069 0.361
MOD_NEK2_1 161 166 PF00069 0.316
MOD_NEK2_1 246 251 PF00069 0.258
MOD_NEK2_1 287 292 PF00069 0.275
MOD_NEK2_1 310 315 PF00069 0.308
MOD_NEK2_1 347 352 PF00069 0.249
MOD_NEK2_1 355 360 PF00069 0.243
MOD_NEK2_1 76 81 PF00069 0.390
MOD_Plk_1 261 267 PF00069 0.263
MOD_Plk_4 135 141 PF00069 0.452
MOD_Plk_4 161 167 PF00069 0.296
MOD_Plk_4 184 190 PF00069 0.281
MOD_Plk_4 237 243 PF00069 0.250
MOD_Plk_4 246 252 PF00069 0.231
MOD_Plk_4 261 267 PF00069 0.259
MOD_Plk_4 301 307 PF00069 0.285
MOD_Plk_4 351 357 PF00069 0.258
MOD_Plk_4 37 43 PF00069 0.343
MOD_Plk_4 52 58 PF00069 0.219
MOD_ProDKin_1 235 241 PF00069 0.260
TRG_DiLeu_BaEn_1 52 57 PF01217 0.406
TRG_ENDOCYTIC_2 149 152 PF00928 0.355
TRG_ENDOCYTIC_2 319 322 PF00928 0.291
TRG_ENDOCYTIC_2 360 363 PF00928 0.243
TRG_ENDOCYTIC_2 396 399 PF00928 0.269
TRG_ENDOCYTIC_2 430 433 PF00928 0.243
TRG_ER_diArg_1 172 175 PF00400 0.387
TRG_Pf-PMV_PEXEL_1 404 408 PF00026 0.243

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3C6 Leptomonas seymouri 25% 87%
A0A0N1PBH8 Leptomonas seymouri 76% 100%
A0A0S4IS37 Bodo saltans 59% 100%
A0A0S4KLN5 Bodo saltans 25% 93%
A0A1D8PIC7 Candida albicans (strain SC5314 / ATCC MYA-2876) 36% 98%
A0A1D8PJ25 Candida albicans (strain SC5314 / ATCC MYA-2876) 26% 93%
A0A1X0NRH6 Trypanosomatidae 60% 95%
A0A1X0P0Q6 Trypanosomatidae 28% 88%
A0A3Q8IM20 Leishmania donovani 27% 100%
A0A3R7KUI7 Trypanosoma rangeli 28% 90%
A0A3R7N804 Trypanosoma rangeli 59% 96%
A4HKM3 Leishmania braziliensis 86% 100%
A4HLA8 Leishmania braziliensis 26% 100%
A4I855 Leishmania infantum 100% 100%
A4I8T4 Leishmania infantum 27% 100%
D0AAC2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 58% 95%
E9B312 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
E9B3Q0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
G4SW86 Methylotuvimicrobium alcaliphilum (strain DSM 19304 / NCIMB 14124 / VKM B-2133 / 20Z) 38% 100%
I1RF79 Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) 34% 91%
I1RR90 Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) 34% 90%
I1RZZ3 Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) 29% 73%
O08984 Rattus norvegicus 42% 70%
O13597 Septoria lycopersici 34% 85%
O76062 Homo sapiens 47% 100%
O88455 Mus musculus 30% 93%
P23913 Gallus gallus 40% 69%
P25340 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 29% 92%
P32462 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 36% 100%
P36209 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 30% 96%
P38670 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 37% 89%
P78575 Ascobolus immersus 40% 100%
Q01447 Fusarium vanettenii 35% 90%
Q09195 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 40% 100%
Q14739 Homo sapiens 41% 71%
Q3U9G9 Mus musculus 42% 70%
Q4Q4D7 Leishmania major 26% 100%
Q4Q543 Leishmania major 95% 100%
Q4WJ59 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 28% 77%
Q4WJJ9 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 39% 84%
Q4WKA5 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 36% 88%
Q4WW43 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 29% 93%
Q54PP1 Dictyostelium discoideum 33% 95%
Q5E9J5 Bos taurus 30% 92%
Q5R7H4 Pongo abelii 41% 71%
Q5UQI4 Acanthamoeba polyphaga mimivirus 31% 98%
Q6P4M0 Xenopus tropicalis 31% 92%
Q71KT5 Mus musculus 43% 100%
Q7SXF1 Danio rerio 30% 91%
Q7ZXH1 Xenopus laevis 33% 92%
Q8WMV1 Bos taurus 46% 100%
Q9LDR4 Arabidopsis thaliana 35% 100%
Q9LDU6 Arabidopsis thaliana 31% 100%
Q9UBM7 Homo sapiens 31% 92%
Q9Z2Z8 Rattus norvegicus 31% 93%
V5BKN3 Trypanosoma cruzi 57% 96%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS