LeishMANIAdb
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3'-5' exonuclease, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
3'-5' exonuclease, putative
Gene product:
3'-5' exonuclease, putative
Species:
Leishmania donovani
UniProt:
A0A3S7X5Q4_LEIDO
TriTrypDb:
LdBPK_321980.1 , LdCL_320025300 , LDHU3_32.2480
Length:
754

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 4
NetGPI no yes: 0, no: 4
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X5Q4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5Q4

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 5
GO:0003824 catalytic activity 1 5
GO:0004518 nuclease activity 4 5
GO:0004527 exonuclease activity 5 5
GO:0005488 binding 1 5
GO:0008408 3'-5' exonuclease activity 6 5
GO:0016787 hydrolase activity 2 5
GO:0016788 hydrolase activity, acting on ester bonds 3 5
GO:0097159 organic cyclic compound binding 2 5
GO:1901363 heterocyclic compound binding 2 5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 39 43 PF00656 0.637
CLV_C14_Caspase3-7 479 483 PF00656 0.645
CLV_NRD_NRD_1 138 140 PF00675 0.673
CLV_NRD_NRD_1 527 529 PF00675 0.543
CLV_PCSK_KEX2_1 137 139 PF00082 0.667
CLV_PCSK_KEX2_1 527 529 PF00082 0.539
CLV_PCSK_KEX2_1 66 68 PF00082 0.642
CLV_PCSK_PC1ET2_1 137 139 PF00082 0.653
CLV_PCSK_PC1ET2_1 66 68 PF00082 0.642
CLV_PCSK_PC7_1 523 529 PF00082 0.519
CLV_PCSK_SKI1_1 510 514 PF00082 0.462
CLV_PCSK_SKI1_1 606 610 PF00082 0.305
CLV_PCSK_SKI1_1 651 655 PF00082 0.410
CLV_PCSK_SKI1_1 672 676 PF00082 0.329
CLV_PCSK_SKI1_1 689 693 PF00082 0.407
CLV_PCSK_SKI1_1 704 708 PF00082 0.269
CLV_Separin_Metazoa 517 521 PF03568 0.414
DEG_ODPH_VHL_1 448 459 PF01847 0.678
DEG_SPOP_SBC_1 130 134 PF00917 0.547
DOC_CKS1_1 244 249 PF01111 0.647
DOC_CKS1_1 421 426 PF01111 0.692
DOC_CKS1_1 86 91 PF01111 0.640
DOC_CYCLIN_yCln2_LP_2 140 146 PF00134 0.572
DOC_MAPK_DCC_7 138 148 PF00069 0.650
DOC_MAPK_MEF2A_6 602 609 PF00069 0.530
DOC_MAPK_MEF2A_6 651 659 PF00069 0.530
DOC_MAPK_NFAT4_5 602 610 PF00069 0.530
DOC_MAPK_RevD_3 123 139 PF00069 0.579
DOC_PP1_RVXF_1 482 489 PF00149 0.579
DOC_PP1_RVXF_1 604 610 PF00149 0.530
DOC_PP2B_LxvP_1 140 143 PF13499 0.642
DOC_PP2B_LxvP_1 84 87 PF13499 0.659
DOC_PP2B_PxIxI_1 3 9 PF00149 0.653
DOC_PP4_FxxP_1 244 247 PF00568 0.648
DOC_PP4_MxPP_1 1 4 PF00568 0.657
DOC_USP7_MATH_1 167 171 PF00917 0.547
DOC_USP7_MATH_1 196 200 PF00917 0.567
DOC_USP7_MATH_1 226 230 PF00917 0.670
DOC_USP7_MATH_1 239 243 PF00917 0.565
DOC_USP7_MATH_1 267 271 PF00917 0.620
DOC_USP7_MATH_1 279 283 PF00917 0.529
DOC_USP7_MATH_1 304 308 PF00917 0.668
DOC_USP7_MATH_1 329 333 PF00917 0.509
DOC_USP7_MATH_1 388 392 PF00917 0.687
DOC_USP7_MATH_1 394 398 PF00917 0.618
DOC_USP7_MATH_1 415 419 PF00917 0.716
DOC_USP7_MATH_1 433 437 PF00917 0.635
DOC_USP7_MATH_1 439 443 PF00917 0.638
DOC_USP7_MATH_1 588 592 PF00917 0.459
DOC_WW_Pin1_4 123 128 PF00397 0.645
DOC_WW_Pin1_4 243 248 PF00397 0.651
DOC_WW_Pin1_4 250 255 PF00397 0.597
DOC_WW_Pin1_4 290 295 PF00397 0.683
DOC_WW_Pin1_4 343 348 PF00397 0.546
DOC_WW_Pin1_4 417 422 PF00397 0.708
DOC_WW_Pin1_4 59 64 PF00397 0.647
DOC_WW_Pin1_4 590 595 PF00397 0.530
DOC_WW_Pin1_4 641 646 PF00397 0.530
DOC_WW_Pin1_4 85 90 PF00397 0.646
LIG_14-3-3_CanoR_1 179 184 PF00244 0.612
LIG_14-3-3_CanoR_1 339 347 PF00244 0.559
LIG_14-3-3_CanoR_1 410 415 PF00244 0.699
LIG_14-3-3_CanoR_1 530 535 PF00244 0.609
LIG_14-3-3_CanoR_1 689 698 PF00244 0.530
LIG_14-3-3_CanoR_1 727 732 PF00244 0.399
LIG_Actin_WH2_2 574 592 PF00022 0.480
LIG_APCC_ABBA_1 657 662 PF00400 0.530
LIG_BIR_III_4 42 46 PF00653 0.644
LIG_BRCT_BRCA1_1 240 244 PF00533 0.659
LIG_BRCT_BRCA1_1 430 434 PF00533 0.576
LIG_BRCT_BRCA1_1 634 638 PF00533 0.530
LIG_BRCT_BRCA1_1 741 745 PF00533 0.482
LIG_CtBP_PxDLS_1 294 298 PF00389 0.590
LIG_FHA_1 102 108 PF00498 0.632
LIG_FHA_1 150 156 PF00498 0.650
LIG_FHA_1 543 549 PF00498 0.499
LIG_FHA_1 573 579 PF00498 0.530
LIG_FHA_1 690 696 PF00498 0.530
LIG_FHA_2 368 374 PF00498 0.667
LIG_FHA_2 474 480 PF00498 0.654
LIG_FHA_2 659 665 PF00498 0.575
LIG_FHA_2 89 95 PF00498 0.653
LIG_FXI_DFP_1 745 749 PF00024 0.470
LIG_IRF3_LxIS_1 629 635 PF10401 0.530
LIG_LIR_Apic_2 241 247 PF02991 0.652
LIG_LIR_Apic_2 250 254 PF02991 0.578
LIG_LIR_Gen_1 431 441 PF02991 0.566
LIG_LIR_Gen_1 572 581 PF02991 0.530
LIG_LIR_Gen_1 635 645 PF02991 0.530
LIG_LIR_Gen_1 652 660 PF02991 0.419
LIG_LIR_Nem_3 256 260 PF02991 0.606
LIG_LIR_Nem_3 431 437 PF02991 0.570
LIG_LIR_Nem_3 572 576 PF02991 0.530
LIG_LIR_Nem_3 616 622 PF02991 0.530
LIG_LIR_Nem_3 635 641 PF02991 0.406
LIG_LIR_Nem_3 652 657 PF02991 0.419
LIG_LIR_Nem_3 742 748 PF02991 0.481
LIG_MLH1_MIPbox_1 240 244 PF16413 0.561
LIG_MYND_1 213 217 PF01753 0.659
LIG_PCNA_yPIPBox_3 231 244 PF02747 0.661
LIG_PTAP_UEV_1 429 434 PF05743 0.606
LIG_PTB_Apo_2 730 737 PF02174 0.459
LIG_Rb_pABgroove_1 603 611 PF01858 0.530
LIG_SH2_CRK 251 255 PF00017 0.661
LIG_SH2_CRK 573 577 PF00017 0.530
LIG_SH2_NCK_1 257 261 PF00017 0.574
LIG_SH2_NCK_1 573 577 PF00017 0.530
LIG_SH2_SRC 257 260 PF00017 0.675
LIG_SH2_SRC 464 467 PF00017 0.643
LIG_SH2_STAP1 544 548 PF00017 0.470
LIG_SH2_STAP1 573 577 PF00017 0.530
LIG_SH2_STAT5 273 276 PF00017 0.564
LIG_SH2_STAT5 544 547 PF00017 0.416
LIG_SH2_STAT5 577 580 PF00017 0.530
LIG_SH2_STAT5 622 625 PF00017 0.480
LIG_SH2_STAT5 698 701 PF00017 0.530
LIG_SH2_STAT5 705 708 PF00017 0.477
LIG_SH3_1 139 145 PF00018 0.643
LIG_SH3_1 419 425 PF00018 0.628
LIG_SH3_2 421 426 PF14604 0.692
LIG_SH3_3 124 130 PF00018 0.615
LIG_SH3_3 139 145 PF00018 0.527
LIG_SH3_3 210 216 PF00018 0.639
LIG_SH3_3 418 424 PF00018 0.700
LIG_SH3_3 427 433 PF00018 0.598
LIG_SH3_3 639 645 PF00018 0.625
LIG_SH3_3 84 90 PF00018 0.649
LIG_SUMO_SIM_par_1 293 299 PF11976 0.591
LIG_SUMO_SIM_par_1 545 553 PF11976 0.379
LIG_SUMO_SIM_par_1 566 572 PF11976 0.530
LIG_TRAF2_1 14 17 PF00917 0.600
LIG_TRFH_1 638 642 PF08558 0.530
LIG_TYR_ITIM 696 701 PF00017 0.530
LIG_WRC_WIRS_1 180 185 PF05994 0.533
LIG_WRC_WIRS_1 203 208 PF05994 0.588
LIG_WRC_WIRS_1 240 245 PF05994 0.559
LIG_WW_2 213 216 PF00397 0.632
LIG_WW_3 423 427 PF00397 0.688
MOD_CDK_SPxK_1 420 426 PF00069 0.692
MOD_CDK_SPxxK_3 59 66 PF00069 0.650
MOD_CDK_SPxxK_3 590 597 PF00069 0.510
MOD_CK1_1 100 106 PF00069 0.631
MOD_CK1_1 11 17 PF00069 0.669
MOD_CK1_1 129 135 PF00069 0.574
MOD_CK1_1 189 195 PF00069 0.648
MOD_CK1_1 199 205 PF00069 0.556
MOD_CK1_1 242 248 PF00069 0.646
MOD_CK1_1 293 299 PF00069 0.689
MOD_CK1_1 33 39 PF00069 0.666
MOD_CK1_1 341 347 PF00069 0.654
MOD_CK1_1 367 373 PF00069 0.667
MOD_CK1_1 397 403 PF00069 0.682
MOD_CK1_1 420 426 PF00069 0.692
MOD_CK1_1 71 77 PF00069 0.643
MOD_CK1_1 739 745 PF00069 0.482
MOD_CK2_1 11 17 PF00069 0.665
MOD_CK2_1 367 373 PF00069 0.667
MOD_CK2_1 389 395 PF00069 0.682
MOD_CK2_1 473 479 PF00069 0.657
MOD_CK2_1 88 94 PF00069 0.647
MOD_DYRK1A_RPxSP_1 59 63 PF00069 0.645
MOD_DYRK1A_RPxSP_1 590 594 PF00069 0.480
MOD_GlcNHglycan 10 13 PF01048 0.670
MOD_GlcNHglycan 119 122 PF01048 0.630
MOD_GlcNHglycan 152 155 PF01048 0.584
MOD_GlcNHglycan 169 172 PF01048 0.479
MOD_GlcNHglycan 187 191 PF01048 0.567
MOD_GlcNHglycan 198 201 PF01048 0.531
MOD_GlcNHglycan 206 209 PF01048 0.492
MOD_GlcNHglycan 277 280 PF01048 0.616
MOD_GlcNHglycan 281 284 PF01048 0.599
MOD_GlcNHglycan 298 301 PF01048 0.543
MOD_GlcNHglycan 318 321 PF01048 0.503
MOD_GlcNHglycan 358 361 PF01048 0.643
MOD_GlcNHglycan 386 389 PF01048 0.693
MOD_GlcNHglycan 391 394 PF01048 0.635
MOD_GlcNHglycan 395 399 PF01048 0.593
MOD_GlcNHglycan 430 433 PF01048 0.652
MOD_GlcNHglycan 441 444 PF01048 0.581
MOD_GlcNHglycan 590 593 PF01048 0.260
MOD_GlcNHglycan 73 76 PF01048 0.622
MOD_GSK3_1 126 133 PF00069 0.638
MOD_GSK3_1 169 176 PF00069 0.612
MOD_GSK3_1 204 211 PF00069 0.648
MOD_GSK3_1 215 222 PF00069 0.579
MOD_GSK3_1 238 245 PF00069 0.656
MOD_GSK3_1 262 269 PF00069 0.642
MOD_GSK3_1 275 282 PF00069 0.525
MOD_GSK3_1 30 37 PF00069 0.650
MOD_GSK3_1 339 346 PF00069 0.658
MOD_GSK3_1 384 391 PF00069 0.692
MOD_GSK3_1 406 413 PF00069 0.656
MOD_GSK3_1 44 51 PF00069 0.547
MOD_GSK3_1 464 471 PF00069 0.790
MOD_GSK3_1 542 549 PF00069 0.482
MOD_GSK3_1 658 665 PF00069 0.481
MOD_GSK3_1 66 73 PF00069 0.658
MOD_GSK3_1 737 744 PF00069 0.481
MOD_GSK3_1 97 104 PF00069 0.644
MOD_LATS_1 337 343 PF00433 0.563
MOD_N-GLC_1 208 213 PF02516 0.663
MOD_N-GLC_1 373 378 PF02516 0.616
MOD_N-GLC_1 383 388 PF02516 0.651
MOD_N-GLC_2 628 630 PF02516 0.329
MOD_N-GLC_2 77 79 PF02516 0.656
MOD_NEK2_1 101 106 PF00069 0.603
MOD_NEK2_1 131 136 PF00069 0.633
MOD_NEK2_1 174 179 PF00069 0.620
MOD_NEK2_1 266 271 PF00069 0.649
MOD_NEK2_1 316 321 PF00069 0.566
MOD_NEK2_1 34 39 PF00069 0.666
MOD_NEK2_1 632 637 PF00069 0.530
MOD_NEK2_1 736 741 PF00069 0.480
MOD_NEK2_2 239 244 PF00069 0.630
MOD_NEK2_2 267 272 PF00069 0.635
MOD_NEK2_2 52 57 PF00069 0.574
MOD_NEK2_2 649 654 PF00069 0.530
MOD_OFUCOSY 630 637 PF10250 0.329
MOD_PIKK_1 169 175 PF00454 0.539
MOD_PIKK_1 219 225 PF00454 0.638
MOD_PK_1 410 416 PF00069 0.668
MOD_PK_1 530 536 PF00069 0.611
MOD_PK_1 561 567 PF00069 0.530
MOD_PK_1 727 733 PF00069 0.408
MOD_PKA_1 66 72 PF00069 0.633
MOD_PKA_2 178 184 PF00069 0.612
MOD_PKA_2 262 268 PF00069 0.642
MOD_PKA_2 338 344 PF00069 0.562
MOD_PKA_2 415 421 PF00069 0.683
MOD_PKA_2 66 72 PF00069 0.633
MOD_PKA_2 736 742 PF00069 0.482
MOD_PKB_1 528 536 PF00069 0.568
MOD_Plk_1 186 192 PF00069 0.571
MOD_Plk_1 373 379 PF00069 0.665
MOD_Plk_1 97 103 PF00069 0.645
MOD_Plk_2-3 373 379 PF00069 0.665
MOD_Plk_4 179 185 PF00069 0.479
MOD_Plk_4 239 245 PF00069 0.624
MOD_Plk_4 572 578 PF00069 0.601
MOD_Plk_4 649 655 PF00069 0.530
MOD_ProDKin_1 123 129 PF00069 0.644
MOD_ProDKin_1 243 249 PF00069 0.650
MOD_ProDKin_1 250 256 PF00069 0.600
MOD_ProDKin_1 290 296 PF00069 0.684
MOD_ProDKin_1 343 349 PF00069 0.548
MOD_ProDKin_1 417 423 PF00069 0.707
MOD_ProDKin_1 59 65 PF00069 0.648
MOD_ProDKin_1 590 596 PF00069 0.530
MOD_ProDKin_1 641 647 PF00069 0.530
MOD_ProDKin_1 85 91 PF00069 0.645
TRG_ENDOCYTIC_2 257 260 PF00928 0.606
TRG_ENDOCYTIC_2 573 576 PF00928 0.530
TRG_ENDOCYTIC_2 698 701 PF00928 0.530
TRG_ER_diArg_1 138 140 PF00400 0.672
TRG_ER_KDEL_1 751 754 PF00810 0.431
TRG_NES_CRM1_1 616 627 PF08389 0.382
TRG_Pf-PMV_PEXEL_1 689 693 PF00026 0.382

Homologs

Protein Taxonomy Sequence identity Coverage
A4I804 Leishmania infantum 99% 100%
E9B2W6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%
Q4Q590 Leishmania major 86% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS