TLR4 regulator and MIR-interacting MSAP family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TLR4 regulator and MIR-interacting MSAP, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X5Q1_LEIDO

TriTrypDb:

LdBPK_322130.1 , LdCL_320026700 , LDHU3_32.2640

Length:

369

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 9, no: 1
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X5Q1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5Q1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	172	176	PF00656	0.351
CLV_C14_Caspase3-7	186	190	PF00656	0.266
CLV_C14_Caspase3-7	246	250	PF00656	0.566
CLV_C14_Caspase3-7	351	355	PF00656	0.806
CLV_C14_Caspase3-7	363	367	PF00656	0.693
CLV_NRD_NRD_1	100	102	PF00675	0.529
CLV_NRD_NRD_1	2	4	PF00675	0.486
CLV_NRD_NRD_1	278	280	PF00675	0.522
CLV_NRD_NRD_1	289	291	PF00675	0.439
CLV_NRD_NRD_1	293	295	PF00675	0.403
CLV_NRD_NRD_1	301	303	PF00675	0.496
CLV_PCSK_KEX2_1	2	4	PF00082	0.486
CLV_PCSK_KEX2_1	278	280	PF00082	0.519
CLV_PCSK_KEX2_1	289	291	PF00082	0.437
CLV_PCSK_KEX2_1	293	295	PF00082	0.402
CLV_PCSK_KEX2_1	301	303	PF00082	0.500
CLV_PCSK_KEX2_1	99	101	PF00082	0.488
CLV_PCSK_PC1ET2_1	293	295	PF00082	0.544
CLV_PCSK_PC7_1	274	280	PF00082	0.584
CLV_PCSK_PC7_1	289	295	PF00082	0.510
CLV_PCSK_SKI1_1	152	156	PF00082	0.586
CLV_PCSK_SKI1_1	245	249	PF00082	0.617
CLV_PCSK_SKI1_1	290	294	PF00082	0.605
CLV_PCSK_SKI1_1	69	73	PF00082	0.562
CLV_Separin_Metazoa	271	275	PF03568	0.549
DEG_Nend_UBRbox_1	1	4	PF02207	0.708
DOC_CYCLIN_RxL_1	66	73	PF00134	0.330
DOC_MAPK_gen_1	99	110	PF00069	0.383
DOC_PP2B_LxvP_1	38	41	PF13499	0.657
DOC_PP2B_LxvP_1	8	11	PF13499	0.660
DOC_USP7_MATH_1	310	314	PF00917	0.729
DOC_USP7_MATH_1	328	332	PF00917	0.795
DOC_USP7_MATH_1	349	353	PF00917	0.785
DOC_USP7_UBL2_3	293	297	PF12436	0.594
DOC_WW_Pin1_4	199	204	PF00397	0.363
DOC_WW_Pin1_4	31	36	PF00397	0.595
DOC_WW_Pin1_4	340	345	PF00397	0.764
LIG_14-3-3_CanoR_1	104	110	PF00244	0.361
LIG_14-3-3_CanoR_1	2	8	PF00244	0.709
LIG_14-3-3_CanoR_1	74	80	PF00244	0.289
LIG_Actin_WH2_2	259	276	PF00022	0.552
LIG_eIF4E_1	103	109	PF01652	0.362
LIG_FHA_1	4	10	PF00498	0.715
LIG_FHA_1	83	89	PF00498	0.299
LIG_FHA_2	244	250	PF00498	0.681
LIG_FHA_2	319	325	PF00498	0.748
LIG_FHA_2	363	369	PF00498	0.802
LIG_FHA_2	68	74	PF00498	0.373
LIG_FHA_2	76	82	PF00498	0.349
LIG_GBD_Chelix_1	23	31	PF00786	0.422
LIG_GBD_Chelix_1	67	75	PF00786	0.586
LIG_LIR_Gen_1	70	80	PF02991	0.369
LIG_LIR_Nem_3	70	75	PF02991	0.370
LIG_NRBOX	22	28	PF00104	0.461
LIG_PCNA_yPIPBox_3	14	24	PF02747	0.400
LIG_SH2_NCK_1	350	354	PF00017	0.729
LIG_SH2_SRC	86	89	PF00017	0.330
LIG_SH2_STAT3	139	142	PF00017	0.362
LIG_SH2_STAT3	185	188	PF00017	0.250
LIG_SH2_STAT5	86	89	PF00017	0.393
LIG_SH3_3	238	244	PF00018	0.599
LIG_SH3_3	331	337	PF00018	0.647
LIG_SH3_3	44	50	PF00018	0.502
LIG_SUMO_SIM_anti_2	269	274	PF11976	0.449
LIG_SUMO_SIM_par_1	28	34	PF11976	0.558
LIG_TRAF2_1	226	229	PF00917	0.387
LIG_TRAF2_1	315	318	PF00917	0.569
LIG_TRAF2_1	344	347	PF00917	0.750
LIG_TRFH_1	7	11	PF08558	0.589
LIG_UBA3_1	127	135	PF00899	0.480
MOD_CK1_1	223	229	PF00069	0.495
MOD_CK2_1	223	229	PF00069	0.406
MOD_CK2_1	318	324	PF00069	0.773
MOD_CK2_1	340	346	PF00069	0.787
MOD_CK2_1	67	73	PF00069	0.463
MOD_CK2_1	75	81	PF00069	0.428
MOD_Cter_Amidation	92	95	PF01082	0.363
MOD_GlcNHglycan	166	169	PF01048	0.266
MOD_GlcNHglycan	199	202	PF01048	0.471
MOD_GlcNHglycan	258	261	PF01048	0.626
MOD_GlcNHglycan	331	334	PF01048	0.801
MOD_GlcNHglycan	351	354	PF01048	0.473
MOD_GlcNHglycan	60	64	PF01048	0.335
MOD_GSK3_1	195	202	PF00069	0.406
MOD_GSK3_1	216	223	PF00069	0.465
MOD_GSK3_1	59	66	PF00069	0.430
MOD_GSK3_1	82	89	PF00069	0.338
MOD_N-GLC_1	75	80	PF02516	0.335
MOD_N-GLC_2	116	118	PF02516	0.441
MOD_N-GLC_2	265	267	PF02516	0.524
MOD_NEK2_1	144	149	PF00069	0.402
MOD_NEK2_1	220	225	PF00069	0.480
MOD_NEK2_1	304	309	PF00069	0.682
MOD_NEK2_1	329	334	PF00069	0.769
MOD_NEK2_1	59	64	PF00069	0.324
MOD_NEK2_1	75	80	PF00069	0.297
MOD_PKA_1	2	8	PF00069	0.477
MOD_PKA_2	103	109	PF00069	0.447
MOD_PKA_2	2	8	PF00069	0.668
MOD_Plk_1	230	236	PF00069	0.424
MOD_Plk_1	75	81	PF00069	0.335
MOD_Plk_2-3	249	255	PF00069	0.731
MOD_Plk_2-3	342	348	PF00069	0.615
MOD_Plk_2-3	362	368	PF00069	0.799
MOD_Plk_4	216	222	PF00069	0.376
MOD_Plk_4	3	9	PF00069	0.693
MOD_Plk_4	33	39	PF00069	0.677
MOD_Plk_4	82	88	PF00069	0.335
MOD_ProDKin_1	199	205	PF00069	0.448
MOD_ProDKin_1	31	37	PF00069	0.601
MOD_ProDKin_1	340	346	PF00069	0.767
TRG_DiLeu_BaEn_1	216	221	PF01217	0.447
TRG_DiLeu_BaLyEn_6	123	128	PF01217	0.480
TRG_DiLeu_BaLyEn_6	258	263	PF01217	0.555
TRG_ENDOCYTIC_2	56	59	PF00928	0.381
TRG_ER_diArg_1	1	3	PF00400	0.487
TRG_ER_diArg_1	98	101	PF00400	0.441
TRG_NLS_Bipartite_1	278	298	PF00514	0.447
TRG_NLS_MonoExtC_3	292	297	PF00514	0.463
TRG_NLS_MonoExtN_4	290	297	PF00514	0.568
TRG_Pf-PMV_PEXEL_1	225	229	PF00026	0.434
TRG_Pf-PMV_PEXEL_1	69	73	PF00026	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCJ7	Leptomonas seymouri	51%	100%
A0A1X0NUB5	Trypanosomatidae	28%	100%
A0A422NB75	Trypanosoma rangeli	30%	100%
A4HKJ0	Leishmania braziliensis	72%	99%
A4I822	Leishmania infantum	99%	100%
D0AA88	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9B2Y0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q576	Leishmania major	93%	100%
V5AW92	Trypanosoma cruzi	29%	100%