Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X5P2_LEIDO

TriTrypDb:

LdBPK_322320.1 , LdCL_320028500 , LDHU3_32.2880

Length:

611

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X5P2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5P2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	210	214	PF00656	0.478
CLV_MEL_PAP_1	338	344	PF00089	0.576
CLV_NRD_NRD_1	102	104	PF00675	0.592
CLV_NRD_NRD_1	218	220	PF00675	0.622
CLV_NRD_NRD_1	227	229	PF00675	0.413
CLV_NRD_NRD_1	326	328	PF00675	0.634
CLV_NRD_NRD_1	435	437	PF00675	0.597
CLV_PCSK_KEX2_1	218	220	PF00082	0.622
CLV_PCSK_KEX2_1	227	229	PF00082	0.413
CLV_PCSK_KEX2_1	435	437	PF00082	0.597
CLV_PCSK_SKI1_1	227	231	PF00082	0.406
CLV_PCSK_SKI1_1	436	440	PF00082	0.594
CLV_Separin_Metazoa	551	555	PF03568	0.461
DEG_APCC_DBOX_1	217	225	PF00400	0.528
DEG_APCC_DBOX_1	226	234	PF00400	0.361
DEG_COP1_1	105	113	PF00400	0.643
DEG_Nend_UBRbox_3	1	3	PF02207	0.716
DEG_SPOP_SBC_1	155	159	PF00917	0.630
DEG_SPOP_SBC_1	459	463	PF00917	0.595
DOC_CKS1_1	124	129	PF01111	0.720
DOC_CKS1_1	204	209	PF01111	0.607
DOC_CYCLIN_RxL_1	225	234	PF00134	0.440
DOC_CYCLIN_yCln2_LP_2	423	426	PF00134	0.537
DOC_MAPK_MEF2A_6	599	606	PF00069	0.464
DOC_PP1_RVXF_1	406	412	PF00149	0.418
DOC_PP2B_LxvP_1	423	426	PF13499	0.537
DOC_PP2B_LxvP_1	497	500	PF13499	0.495
DOC_USP7_MATH_1	130	134	PF00917	0.723
DOC_USP7_MATH_1	137	141	PF00917	0.812
DOC_USP7_MATH_1	156	160	PF00917	0.545
DOC_USP7_MATH_1	196	200	PF00917	0.691
DOC_USP7_MATH_1	239	243	PF00917	0.430
DOC_USP7_MATH_1	24	28	PF00917	0.454
DOC_USP7_MATH_1	298	302	PF00917	0.556
DOC_USP7_MATH_1	340	344	PF00917	0.542
DOC_USP7_MATH_1	441	445	PF00917	0.592
DOC_USP7_MATH_1	486	490	PF00917	0.563
DOC_USP7_MATH_1	544	548	PF00917	0.426
DOC_USP7_MATH_2	311	317	PF00917	0.642
DOC_USP7_UBL2_3	104	108	PF12436	0.709
DOC_WW_Pin1_4	123	128	PF00397	0.724
DOC_WW_Pin1_4	173	178	PF00397	0.658
DOC_WW_Pin1_4	203	208	PF00397	0.541
DOC_WW_Pin1_4	416	421	PF00397	0.517
LIG_14-3-3_CanoR_1	23	31	PF00244	0.507
LIG_14-3-3_CanoR_1	255	263	PF00244	0.425
LIG_14-3-3_CanoR_1	34	42	PF00244	0.403
LIG_14-3-3_CanoR_1	341	349	PF00244	0.482
LIG_14-3-3_CanoR_1	403	408	PF00244	0.427
LIG_14-3-3_CanoR_1	435	439	PF00244	0.544
LIG_14-3-3_CanoR_1	443	447	PF00244	0.515
LIG_14-3-3_CanoR_1	570	575	PF00244	0.578
LIG_Actin_WH2_2	476	494	PF00022	0.413
LIG_Clathr_ClatBox_1	578	582	PF01394	0.441
LIG_CSL_BTD_1	410	413	PF09270	0.468
LIG_deltaCOP1_diTrp_1	10	18	PF00928	0.545
LIG_eIF4E_1	476	482	PF01652	0.376
LIG_FHA_1	24	30	PF00498	0.536
LIG_FHA_1	34	40	PF00498	0.529
LIG_FHA_1	492	498	PF00498	0.542
LIG_FHA_2	100	106	PF00498	0.576
LIG_FHA_2	332	338	PF00498	0.656
LIG_FHA_2	461	467	PF00498	0.727
LIG_FHA_2	571	577	PF00498	0.476
LIG_FHA_2	72	78	PF00498	0.609
LIG_LIR_Apic_2	66	71	PF02991	0.676
LIG_LIR_Gen_1	242	251	PF02991	0.520
LIG_LIR_Gen_1	252	260	PF02991	0.493
LIG_LIR_Gen_1	272	282	PF02991	0.352
LIG_LIR_Gen_1	382	389	PF02991	0.474
LIG_LIR_Gen_1	437	447	PF02991	0.492
LIG_LIR_Gen_1	467	476	PF02991	0.465
LIG_LIR_Gen_1	93	99	PF02991	0.599
LIG_LIR_Nem_3	10	14	PF02991	0.618
LIG_LIR_Nem_3	252	256	PF02991	0.487
LIG_LIR_Nem_3	257	263	PF02991	0.427
LIG_LIR_Nem_3	272	277	PF02991	0.300
LIG_LIR_Nem_3	382	387	PF02991	0.553
LIG_LIR_Nem_3	437	442	PF02991	0.488
LIG_LIR_Nem_3	467	473	PF02991	0.478
LIG_LIR_Nem_3	475	479	PF02991	0.352
LIG_LIR_Nem_3	93	97	PF02991	0.614
LIG_NRBOX	373	379	PF00104	0.451
LIG_PDZ_Class_3	606	611	PF00595	0.546
LIG_SH2_CRK	253	257	PF00017	0.443
LIG_SH2_CRK	68	72	PF00017	0.677
LIG_SH2_NCK_1	68	72	PF00017	0.677
LIG_SH2_NCK_1	94	98	PF00017	0.595
LIG_SH2_SRC	476	479	PF00017	0.455
LIG_SH2_STAP1	476	480	PF00017	0.453
LIG_SH2_STAT5	243	246	PF00017	0.350
LIG_SH2_STAT5	350	353	PF00017	0.432
LIG_SH2_STAT5	68	71	PF00017	0.679
LIG_SH3_1	108	114	PF00018	0.669
LIG_SH3_2	336	341	PF14604	0.577
LIG_SH3_3	108	114	PF00018	0.677
LIG_SH3_3	121	127	PF00018	0.587
LIG_SH3_3	172	178	PF00018	0.633
LIG_SH3_3	183	189	PF00018	0.610
LIG_SH3_3	330	336	PF00018	0.697
LIG_SH3_3	391	397	PF00018	0.440
LIG_SH3_3	520	526	PF00018	0.627
LIG_SH3_3	538	544	PF00018	0.497
LIG_SH3_3	588	594	PF00018	0.491
LIG_SH3_3	602	608	PF00018	0.374
LIG_SH3_5	90	94	PF00018	0.665
LIG_SUMO_SIM_anti_2	157	165	PF11976	0.595
LIG_SUMO_SIM_par_1	228	234	PF11976	0.430
LIG_SUMO_SIM_par_1	576	582	PF11976	0.397
LIG_TRAF2_1	74	77	PF00917	0.612
LIG_TRFH_1	470	474	PF08558	0.510
LIG_UBA3_1	286	294	PF00899	0.347
LIG_UBA3_1	42	48	PF00899	0.525
LIG_UBA3_1	423	428	PF00899	0.527
LIG_WRPW_2	589	592	PF00400	0.408
MOD_CDK_SPxK_1	203	209	PF00069	0.609
MOD_CK1_1	123	129	PF00069	0.744
MOD_CK1_1	147	153	PF00069	0.596
MOD_CK1_1	159	165	PF00069	0.600
MOD_CK1_1	169	175	PF00069	0.658
MOD_CK1_1	242	248	PF00069	0.367
MOD_CK1_1	254	260	PF00069	0.390
MOD_CK1_1	273	279	PF00069	0.219
MOD_CK1_1	32	38	PF00069	0.544
MOD_CK1_1	331	337	PF00069	0.676
MOD_CK1_1	54	60	PF00069	0.697
MOD_CK1_1	79	85	PF00069	0.686
MOD_CK2_1	132	138	PF00069	0.681
MOD_CK2_1	246	252	PF00069	0.397
MOD_CK2_1	442	448	PF00069	0.495
MOD_CK2_1	460	466	PF00069	0.718
MOD_CK2_1	570	576	PF00069	0.486
MOD_CK2_1	71	77	PF00069	0.608
MOD_Cter_Amidation	433	436	PF01082	0.489
MOD_GlcNHglycan	115	118	PF01048	0.679
MOD_GlcNHglycan	132	135	PF01048	0.544
MOD_GlcNHglycan	138	142	PF01048	0.609
MOD_GlcNHglycan	158	161	PF01048	0.513
MOD_GlcNHglycan	168	171	PF01048	0.613
MOD_GlcNHglycan	198	201	PF01048	0.587
MOD_GlcNHglycan	213	216	PF01048	0.515
MOD_GlcNHglycan	248	251	PF01048	0.596
MOD_GlcNHglycan	329	333	PF01048	0.755
MOD_GlcNHglycan	53	56	PF01048	0.680
MOD_GlcNHglycan	546	549	PF01048	0.630
MOD_GSK3_1	109	116	PF00069	0.690
MOD_GSK3_1	126	133	PF00069	0.578
MOD_GSK3_1	155	162	PF00069	0.654
MOD_GSK3_1	165	172	PF00069	0.625
MOD_GSK3_1	184	191	PF00069	0.507
MOD_GSK3_1	192	199	PF00069	0.587
MOD_GSK3_1	242	249	PF00069	0.385
MOD_GSK3_1	269	276	PF00069	0.534
MOD_GSK3_1	29	36	PF00069	0.512
MOD_GSK3_1	309	316	PF00069	0.624
MOD_GSK3_1	327	334	PF00069	0.550
MOD_GSK3_1	50	57	PF00069	0.659
MOD_LATS_1	21	27	PF00433	0.502
MOD_LATS_1	325	331	PF00433	0.571
MOD_N-GLC_1	24	29	PF02516	0.432
MOD_N-GLC_2	536	538	PF02516	0.630
MOD_NEK2_1	192	197	PF00069	0.494
MOD_NEK2_1	246	251	PF00069	0.466
MOD_NEK2_1	29	34	PF00069	0.459
MOD_NEK2_1	42	47	PF00069	0.433
MOD_NEK2_1	491	496	PF00069	0.547
MOD_NEK2_1	51	56	PF00069	0.578
MOD_NEK2_1	99	104	PF00069	0.599
MOD_NEK2_2	434	439	PF00069	0.524
MOD_PIKK_1	132	138	PF00454	0.693
MOD_PIKK_1	254	260	PF00454	0.433
MOD_PIKK_1	486	492	PF00454	0.480
MOD_PKA_1	327	333	PF00069	0.571
MOD_PKA_2	208	214	PF00069	0.632
MOD_PKA_2	254	260	PF00069	0.415
MOD_PKA_2	33	39	PF00069	0.510
MOD_PKA_2	340	346	PF00069	0.518
MOD_PKA_2	434	440	PF00069	0.529
MOD_PKA_2	442	448	PF00069	0.491
MOD_PKA_2	491	497	PF00069	0.437
MOD_PKA_2	544	550	PF00069	0.513
MOD_PKA_2	553	559	PF00069	0.410
MOD_PKA_2	569	575	PF00069	0.442
MOD_PKA_2	79	85	PF00069	0.720
MOD_Plk_1	120	126	PF00069	0.651
MOD_Plk_1	24	30	PF00069	0.479
MOD_Plk_1	251	257	PF00069	0.469
MOD_Plk_1	92	98	PF00069	0.606
MOD_Plk_4	144	150	PF00069	0.600
MOD_Plk_4	159	165	PF00069	0.523
MOD_Plk_4	188	194	PF00069	0.487
MOD_Plk_4	239	245	PF00069	0.381
MOD_Plk_4	270	276	PF00069	0.455
MOD_Plk_4	419	425	PF00069	0.551
MOD_Plk_4	42	48	PF00069	0.452
MOD_Plk_4	560	566	PF00069	0.397
MOD_ProDKin_1	123	129	PF00069	0.722
MOD_ProDKin_1	173	179	PF00069	0.661
MOD_ProDKin_1	203	209	PF00069	0.538
MOD_ProDKin_1	416	422	PF00069	0.515
MOD_SUMO_rev_2	100	110	PF00179	0.649
TRG_DiLeu_BaLyEn_6	25	30	PF01217	0.483
TRG_DiLeu_BaLyEn_6	370	375	PF01217	0.594
TRG_ENDOCYTIC_2	243	246	PF00928	0.331
TRG_ENDOCYTIC_2	253	256	PF00928	0.460
TRG_ENDOCYTIC_2	476	479	PF00928	0.368
TRG_ENDOCYTIC_2	589	592	PF00928	0.408
TRG_ENDOCYTIC_2	94	97	PF00928	0.599
TRG_ER_diArg_1	217	219	PF00400	0.629
TRG_ER_diArg_1	227	229	PF00400	0.419

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4W3	Leptomonas seymouri	31%	100%
A4HKK7	Leishmania braziliensis	71%	100%
A4I840	Leishmania infantum	100%	100%
E9B2Z8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q558	Leishmania major	90%	100%