Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X5P1_LEIDO

TriTrypDb:

LdBPK_322020.1 , LdCL_320025600 , LDHU3_32.2510

Length:

440

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X5P1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5P1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	132	134	PF00675	0.594
CLV_NRD_NRD_1	31	33	PF00675	0.491
CLV_NRD_NRD_1	315	317	PF00675	0.639
CLV_NRD_NRD_1	36	38	PF00675	0.441
CLV_NRD_NRD_1	94	96	PF00675	0.563
CLV_PCSK_KEX2_1	132	134	PF00082	0.532
CLV_PCSK_KEX2_1	31	33	PF00082	0.485
CLV_PCSK_KEX2_1	315	317	PF00082	0.639
CLV_PCSK_KEX2_1	406	408	PF00082	0.718
CLV_PCSK_PC1ET2_1	406	408	PF00082	0.718
CLV_PCSK_SKI1_1	221	225	PF00082	0.572
CLV_PCSK_SKI1_1	253	257	PF00082	0.638
CLV_PCSK_SKI1_1	266	270	PF00082	0.455
CLV_PCSK_SKI1_1	37	41	PF00082	0.575
CLV_PCSK_SKI1_1	62	66	PF00082	0.588
CLV_PCSK_SKI1_1	67	71	PF00082	0.549
CLV_PCSK_SKI1_1	73	77	PF00082	0.428
DEG_APCC_DBOX_1	265	273	PF00400	0.604
DEG_COP1_1	394	403	PF00400	0.708
DOC_CDC14_PxL_1	285	293	PF14671	0.611
DOC_CYCLIN_RxL_1	67	77	PF00134	0.438
DOC_MAPK_DCC_7	266	274	PF00069	0.528
DOC_MAPK_gen_1	82	89	PF00069	0.499
DOC_MAPK_gen_1	95	101	PF00069	0.480
DOC_MAPK_RevD_3	25	38	PF00069	0.578
DOC_PP2B_LxvP_1	373	376	PF13499	0.696
DOC_USP7_MATH_1	155	159	PF00917	0.430
DOC_USP7_MATH_1	2	6	PF00917	0.496
DOC_USP7_MATH_1	319	323	PF00917	0.606
DOC_WW_Pin1_4	412	417	PF00397	0.675
LIG_14-3-3_CanoR_1	197	205	PF00244	0.468
LIG_14-3-3_CanoR_1	321	327	PF00244	0.653
LIG_BIR_II_1	1	5	PF00653	0.591
LIG_BRCT_BRCA1_1	4	8	PF00533	0.456
LIG_EH1_1	329	337	PF00400	0.505
LIG_FHA_1	100	106	PF00498	0.584
LIG_FHA_1	200	206	PF00498	0.563
LIG_FHA_1	21	27	PF00498	0.511
LIG_FHA_2	19	25	PF00498	0.503
LIG_FHA_2	403	409	PF00498	0.786
LIG_FHA_2	424	430	PF00498	0.728
LIG_FHA_2	432	438	PF00498	0.627
LIG_LIR_Gen_1	10	20	PF02991	0.512
LIG_LIR_Gen_1	171	182	PF02991	0.558
LIG_LIR_Gen_1	21	29	PF02991	0.506
LIG_LIR_Gen_1	234	243	PF02991	0.549
LIG_LIR_Gen_1	322	332	PF02991	0.604
LIG_LIR_Nem_3	10	15	PF02991	0.482
LIG_LIR_Nem_3	171	177	PF02991	0.559
LIG_LIR_Nem_3	188	193	PF02991	0.330
LIG_LIR_Nem_3	21	25	PF02991	0.511
LIG_LIR_Nem_3	234	239	PF02991	0.589
LIG_LIR_Nem_3	279	284	PF02991	0.529
LIG_LIR_Nem_3	322	327	PF02991	0.606
LIG_Pex14_1	232	236	PF04695	0.521
LIG_Pex14_1	326	330	PF04695	0.605
LIG_Pex14_2	281	285	PF04695	0.632
LIG_Rb_pABgroove_1	237	245	PF01858	0.466
LIG_REV1ctd_RIR_1	179	185	PF16727	0.570
LIG_SH2_CRK	190	194	PF00017	0.498
LIG_SH2_CRK	236	240	PF00017	0.517
LIG_SH2_CRK	286	290	PF00017	0.527
LIG_SH2_STAP1	12	16	PF00017	0.518
LIG_SH2_STAP1	22	26	PF00017	0.511
LIG_SH2_STAP1	243	247	PF00017	0.629
LIG_SH2_STAT3	243	246	PF00017	0.629
LIG_SH2_STAT3	81	84	PF00017	0.493
LIG_SH2_STAT5	22	25	PF00017	0.480
LIG_SH2_STAT5	238	241	PF00017	0.589
LIG_SH3_3	387	393	PF00018	0.773
LIG_SH3_3	397	403	PF00018	0.595
LIG_SH3_3	94	100	PF00018	0.592
LIG_SUMO_SIM_anti_2	417	423	PF11976	0.545
LIG_TRAF2_1	212	215	PF00917	0.546
LIG_TRAF2_1	39	42	PF00917	0.568
LIG_TRAF2_1	426	429	PF00917	0.748
LIG_WW_3	92	96	PF00397	0.524
MOD_CK1_1	231	237	PF00069	0.588
MOD_CK1_1	322	328	PF00069	0.682
MOD_CK1_1	430	436	PF00069	0.611
MOD_CK2_1	18	24	PF00069	0.484
MOD_CK2_1	4	10	PF00069	0.458
MOD_CK2_1	402	408	PF00069	0.774
MOD_CK2_1	423	429	PF00069	0.712
MOD_CK2_1	431	437	PF00069	0.666
MOD_GlcNHglycan	233	236	PF01048	0.517
MOD_GlcNHglycan	350	353	PF01048	0.791
MOD_GlcNHglycan	416	419	PF01048	0.701
MOD_GSK3_1	155	162	PF00069	0.536
MOD_GSK3_1	407	414	PF00069	0.722
MOD_GSK3_1	423	430	PF00069	0.749
MOD_N-GLC_1	295	300	PF02516	0.543
MOD_NEK2_1	295	300	PF00069	0.680
MOD_PIKK_1	2	8	PF00454	0.548
MOD_PIKK_1	295	301	PF00454	0.596
MOD_PKA_1	82	88	PF00069	0.599
MOD_PKA_2	314	320	PF00069	0.633
MOD_PKA_2	322	328	PF00069	0.589
MOD_Plk_1	172	178	PF00069	0.480
MOD_Plk_1	228	234	PF00069	0.637
MOD_Plk_1	427	433	PF00069	0.700
MOD_Plk_2-3	353	359	PF00069	0.617
MOD_Plk_4	385	391	PF00069	0.767
MOD_ProDKin_1	412	418	PF00069	0.675
MOD_SUMO_rev_2	214	220	PF00179	0.602
MOD_SUMO_rev_2	33	40	PF00179	0.517
MOD_SUMO_rev_2	60	65	PF00179	0.399
TRG_DiLeu_BaEn_3	263	269	PF01217	0.442
TRG_DiLeu_BaLyEn_6	268	273	PF01217	0.528
TRG_ENDOCYTIC_2	12	15	PF00928	0.457
TRG_ENDOCYTIC_2	190	193	PF00928	0.569
TRG_ENDOCYTIC_2	22	25	PF00928	0.451
TRG_ENDOCYTIC_2	236	239	PF00928	0.516
TRG_ER_diArg_1	132	135	PF00400	0.590
TRG_ER_diArg_1	163	166	PF00400	0.505
TRG_ER_diArg_1	314	316	PF00400	0.638
TRG_ER_diArg_1	321	324	PF00400	0.582
TRG_NES_CRM1_1	240	254	PF08389	0.435
TRG_Pf-PMV_PEXEL_1	121	125	PF00026	0.560
TRG_Pf-PMV_PEXEL_1	132	136	PF00026	0.432
TRG_Pf-PMV_PEXEL_1	38	42	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	73	77	PF00026	0.430

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NU98	Trypanosomatidae	42%	73%
A0A422NBA5	Trypanosoma rangeli	36%	100%
A4HKI0	Leishmania braziliensis	63%	100%
A4I812	Leishmania infantum	100%	100%
Q4Q587	Leishmania major	89%	100%