Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X5N4_LEIDO

TriTrypDb:

LdBPK_321970.1 , LdCL_320025200 , LDHU3_32.2470

Length:

158

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X5N4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5N4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0005515	protein binding	2	7
GO:0046982	protein heterodimerization activity	4	7
GO:0046983	protein dimerization activity	3	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	117	119	PF00675	0.546
CLV_NRD_NRD_1	31	33	PF00675	0.656
CLV_PCSK_KEX2_1	154	156	PF00082	0.601
CLV_PCSK_PC1ET2_1	154	156	PF00082	0.566
CLV_PCSK_SKI1_1	101	105	PF00082	0.580
CLV_PCSK_SKI1_1	118	122	PF00082	0.477
CLV_PCSK_SKI1_1	96	100	PF00082	0.518
DEG_Nend_UBRbox_3	1	3	PF02207	0.631
DOC_USP7_MATH_1	120	124	PF00917	0.614
DOC_USP7_MATH_1	147	151	PF00917	0.479
LIG_14-3-3_CanoR_1	125	129	PF00244	0.456
LIG_BRCT_BRCA1_1	8	12	PF00533	0.533
LIG_FHA_1	102	108	PF00498	0.451
LIG_FHA_1	125	131	PF00498	0.528
LIG_FHA_2	22	28	PF00498	0.548
LIG_SH2_STAT5	109	112	PF00017	0.471
LIG_SUMO_SIM_anti_2	104	109	PF11976	0.437
LIG_UBA3_1	145	154	PF00899	0.489
MOD_CK1_1	123	129	PF00069	0.555
MOD_CK1_1	13	19	PF00069	0.662
MOD_CK1_1	35	41	PF00069	0.636
MOD_CK1_1	60	66	PF00069	0.657
MOD_GlcNHglycan	101	104	PF01048	0.380
MOD_GlcNHglycan	14	18	PF01048	0.721
MOD_GlcNHglycan	35	38	PF01048	0.709
MOD_GlcNHglycan	59	62	PF01048	0.573
MOD_GSK3_1	114	121	PF00069	0.419
MOD_GSK3_1	17	24	PF00069	0.619
MOD_GSK3_1	6	13	PF00069	0.671
MOD_GSK3_1	99	106	PF00069	0.456
MOD_NEK2_1	148	153	PF00069	0.580
MOD_NEK2_1	99	104	PF00069	0.401
MOD_PIKK_1	19	25	PF00454	0.572
MOD_PIKK_1	6	12	PF00454	0.633
MOD_PKA_1	118	124	PF00069	0.481
MOD_PKA_1	32	38	PF00069	0.650
MOD_PKA_2	10	16	PF00069	0.660
MOD_PKA_2	124	130	PF00069	0.461
MOD_Plk_1	17	23	PF00069	0.698
MOD_Plk_1	26	32	PF00069	0.608
TRG_ER_diArg_1	51	54	PF00400	0.559

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4KIL7	Bodo saltans	33%	100%
A4HKH6	Leishmania braziliensis	72%	100%
A4I803	Leishmania infantum	100%	100%
E9B2W5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q591	Leishmania major	92%	100%