Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X5N2_LEIDO

TriTrypDb:

LdBPK_322010.1 , LdCL_320025500 , LDHU3_32.2500

Length:

605

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X5N2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5N2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	105	109	PF00656	0.758
CLV_C14_Caspase3-7	35	39	PF00656	0.688
CLV_NRD_NRD_1	134	136	PF00675	0.633
CLV_NRD_NRD_1	26	28	PF00675	0.608
CLV_NRD_NRD_1	36	38	PF00675	0.496
CLV_NRD_NRD_1	540	542	PF00675	0.770
CLV_NRD_NRD_1	592	594	PF00675	0.633
CLV_NRD_NRD_1	602	604	PF00675	0.662
CLV_PCSK_KEX2_1	26	28	PF00082	0.608
CLV_PCSK_KEX2_1	36	38	PF00082	0.496
CLV_PCSK_KEX2_1	540	542	PF00082	0.770
CLV_PCSK_KEX2_1	546	548	PF00082	0.672
CLV_PCSK_KEX2_1	592	594	PF00082	0.634
CLV_PCSK_KEX2_1	601	603	PF00082	0.780
CLV_PCSK_PC1ET2_1	546	548	PF00082	0.693
CLV_PCSK_SKI1_1	197	201	PF00082	0.694
CLV_PCSK_SKI1_1	284	288	PF00082	0.633
CLV_PCSK_SKI1_1	29	33	PF00082	0.579
CLV_PCSK_SKI1_1	593	597	PF00082	0.654
DEG_APCC_DBOX_1	592	600	PF00400	0.664
DEG_SCF_FBW7_1	143	150	PF00400	0.753
DEG_SCF_FBW7_2	406	413	PF00400	0.779
DEG_SPOP_SBC_1	360	364	PF00917	0.762
DEG_SPOP_SBC_1	449	453	PF00917	0.730
DOC_CKS1_1	148	153	PF01111	0.705
DOC_MAPK_gen_1	135	141	PF00069	0.652
DOC_MAPK_gen_1	26	32	PF00069	0.555
DOC_MAPK_MEF2A_6	92	101	PF00069	0.582
DOC_PP1_RVXF_1	27	33	PF00149	0.427
DOC_PP1_RVXF_1	519	526	PF00149	0.812
DOC_PP2B_LxvP_1	232	235	PF13499	0.722
DOC_PP2B_LxvP_1	338	341	PF13499	0.661
DOC_PP2B_LxvP_1	493	496	PF13499	0.825
DOC_USP7_MATH_1	100	104	PF00917	0.653
DOC_USP7_MATH_1	106	110	PF00917	0.675
DOC_USP7_MATH_1	111	115	PF00917	0.577
DOC_USP7_MATH_1	214	218	PF00917	0.745
DOC_USP7_MATH_1	221	225	PF00917	0.624
DOC_USP7_MATH_1	258	262	PF00917	0.803
DOC_USP7_MATH_1	359	363	PF00917	0.731
DOC_USP7_MATH_1	386	390	PF00917	0.823
DOC_USP7_MATH_1	391	395	PF00917	0.750
DOC_USP7_MATH_1	411	415	PF00917	0.740
DOC_USP7_MATH_1	45	49	PF00917	0.565
DOC_USP7_MATH_1	545	549	PF00917	0.712
DOC_USP7_MATH_1	79	83	PF00917	0.549
DOC_WW_Pin1_4	139	144	PF00397	0.770
DOC_WW_Pin1_4	147	152	PF00397	0.708
DOC_WW_Pin1_4	153	158	PF00397	0.588
DOC_WW_Pin1_4	399	404	PF00397	0.846
DOC_WW_Pin1_4	406	411	PF00397	0.740
DOC_WW_Pin1_4	479	484	PF00397	0.789
DOC_WW_Pin1_4	499	504	PF00397	0.523
DOC_WW_Pin1_4	567	572	PF00397	0.724
LIG_14-3-3_CanoR_1	262	270	PF00244	0.834
LIG_14-3-3_CanoR_1	450	455	PF00244	0.729
LIG_Actin_WH2_2	181	199	PF00022	0.701
LIG_BRCT_BRCA1_1	117	121	PF00533	0.568
LIG_Clathr_ClatBox_1	65	69	PF01394	0.617
LIG_CSL_BTD_1	97	100	PF09270	0.575
LIG_CtBP_PxDLS_1	495	499	PF00389	0.845
LIG_EVH1_2	173	177	PF00568	0.700
LIG_FHA_1	144	150	PF00498	0.770
LIG_FHA_1	210	216	PF00498	0.663
LIG_FHA_1	300	306	PF00498	0.734
LIG_FHA_1	361	367	PF00498	0.790
LIG_FHA_1	450	456	PF00498	0.754
LIG_FHA_1	460	466	PF00498	0.651
LIG_FHA_1	47	53	PF00498	0.712
LIG_FHA_2	20	26	PF00498	0.655
LIG_FHA_2	206	212	PF00498	0.704
LIG_FHA_2	249	255	PF00498	0.692
LIG_FHA_2	290	296	PF00498	0.737
LIG_FHA_2	33	39	PF00498	0.432
LIG_FHA_2	451	457	PF00498	0.802
LIG_IRF3_LxIS_1	278	283	PF10401	0.625
LIG_LIR_Gen_1	57	66	PF02991	0.587
LIG_LIR_Nem_3	451	457	PF02991	0.628
LIG_LIR_Nem_3	57	61	PF02991	0.617
LIG_MYND_1	147	151	PF01753	0.749
LIG_NRP_CendR_1	602	605	PF00754	0.582
LIG_PCNA_PIPBox_1	471	480	PF02747	0.770
LIG_PCNA_PIPBox_1	572	581	PF02747	0.741
LIG_Pex14_1	454	458	PF04695	0.724
LIG_SH2_CRK	478	482	PF00017	0.791
LIG_SH2_NCK_1	478	482	PF00017	0.791
LIG_SH2_SRC	579	582	PF00017	0.769
LIG_SH2_STAT5	478	481	PF00017	0.794
LIG_SH3_3	231	237	PF00018	0.636
LIG_SH3_3	243	249	PF00018	0.665
LIG_SH3_3	288	294	PF00018	0.805
LIG_SH3_3	400	406	PF00018	0.846
LIG_SH3_3	477	483	PF00018	0.789
LIG_SH3_3	94	100	PF00018	0.536
LIG_SH3_4	368	375	PF00018	0.596
LIG_SUMO_SIM_anti_2	276	283	PF11976	0.761
LIG_SUMO_SIM_anti_2	584	592	PF11976	0.667
LIG_SUMO_SIM_anti_2	62	67	PF11976	0.594
LIG_SUMO_SIM_anti_2	9	15	PF11976	0.675
LIG_SUMO_SIM_par_1	59	64	PF11976	0.600
LIG_TRAF2_1	534	537	PF00917	0.770
LIG_UBA3_1	485	490	PF00899	0.719
MOD_CDC14_SPxK_1	142	145	PF00782	0.738
MOD_CDK_SPxK_1	139	145	PF00069	0.715
MOD_CDK_SPxxK_3	567	574	PF00069	0.729
MOD_CK1_1	102	108	PF00069	0.634
MOD_CK1_1	223	229	PF00069	0.714
MOD_CK1_1	261	267	PF00069	0.836
MOD_CK1_1	276	282	PF00069	0.553
MOD_CK1_1	289	295	PF00069	0.731
MOD_CK1_1	328	334	PF00069	0.593
MOD_CK1_1	394	400	PF00069	0.815
MOD_CK1_1	402	408	PF00069	0.685
MOD_CK1_1	415	421	PF00069	0.686
MOD_CK1_1	499	505	PF00069	0.743
MOD_CK1_1	531	537	PF00069	0.769
MOD_CK1_1	564	570	PF00069	0.823
MOD_CK2_1	106	112	PF00069	0.660
MOD_CK2_1	163	169	PF00069	0.600
MOD_CK2_1	183	189	PF00069	0.498
MOD_CK2_1	19	25	PF00069	0.656
MOD_CK2_1	248	254	PF00069	0.621
MOD_CK2_1	289	295	PF00069	0.731
MOD_CK2_1	45	51	PF00069	0.727
MOD_CK2_1	531	537	PF00069	0.781
MOD_GlcNHglycan	104	107	PF01048	0.644
MOD_GlcNHglycan	108	111	PF01048	0.649
MOD_GlcNHglycan	112	116	PF01048	0.555
MOD_GlcNHglycan	165	168	PF01048	0.725
MOD_GlcNHglycan	189	192	PF01048	0.672
MOD_GlcNHglycan	216	219	PF01048	0.750
MOD_GlcNHglycan	273	278	PF01048	0.617
MOD_GlcNHglycan	295	299	PF01048	0.789
MOD_GlcNHglycan	363	366	PF01048	0.633
MOD_GlcNHglycan	413	417	PF01048	0.816
MOD_GlcNHglycan	430	433	PF01048	0.578
MOD_GlcNHglycan	498	501	PF01048	0.779
MOD_GlcNHglycan	531	534	PF01048	0.788
MOD_GlcNHglycan	547	550	PF01048	0.510
MOD_GlcNHglycan	567	570	PF01048	0.798
MOD_GlcNHglycan	585	588	PF01048	0.736
MOD_GSK3_1	102	109	PF00069	0.724
MOD_GSK3_1	111	118	PF00069	0.568
MOD_GSK3_1	139	146	PF00069	0.781
MOD_GSK3_1	147	154	PF00069	0.703
MOD_GSK3_1	183	190	PF00069	0.785
MOD_GSK3_1	202	209	PF00069	0.559
MOD_GSK3_1	276	283	PF00069	0.647
MOD_GSK3_1	299	306	PF00069	0.732
MOD_GSK3_1	325	332	PF00069	0.778
MOD_GSK3_1	386	393	PF00069	0.825
MOD_GSK3_1	394	401	PF00069	0.716
MOD_GSK3_1	402	409	PF00069	0.586
MOD_GSK3_1	41	48	PF00069	0.699
MOD_GSK3_1	411	418	PF00069	0.641
MOD_GSK3_1	561	568	PF00069	0.819
MOD_N-GLC_1	523	528	PF02516	0.740
MOD_NEK2_1	163	168	PF00069	0.658
MOD_NEK2_1	177	182	PF00069	0.730
MOD_NEK2_1	263	268	PF00069	0.759
MOD_NEK2_1	280	285	PF00069	0.775
MOD_NEK2_1	287	292	PF00069	0.710
MOD_NEK2_1	32	37	PF00069	0.670
MOD_NEK2_1	398	403	PF00069	0.709
MOD_PIKK_1	177	183	PF00454	0.778
MOD_PIKK_1	313	319	PF00454	0.680
MOD_PIKK_1	459	465	PF00454	0.774
MOD_PIKK_1	523	529	PF00454	0.606
MOD_PKA_2	258	264	PF00069	0.823
MOD_PKA_2	303	309	PF00069	0.834
MOD_PKA_2	449	455	PF00069	0.729
MOD_PKA_2	528	534	PF00069	0.603
MOD_Plk_1	561	567	PF00069	0.630
MOD_Plk_4	276	282	PF00069	0.645
MOD_Plk_4	303	309	PF00069	0.777
MOD_Plk_4	450	456	PF00069	0.782
MOD_Plk_4	9	15	PF00069	0.675
MOD_ProDKin_1	139	145	PF00069	0.778
MOD_ProDKin_1	147	153	PF00069	0.705
MOD_ProDKin_1	158	164	PF00069	0.581
MOD_ProDKin_1	399	405	PF00069	0.848
MOD_ProDKin_1	406	412	PF00069	0.740
MOD_ProDKin_1	479	485	PF00069	0.789
MOD_ProDKin_1	499	505	PF00069	0.522
MOD_ProDKin_1	567	573	PF00069	0.723
MOD_SUMO_rev_2	538	548	PF00179	0.690
TRG_DiLeu_BaLyEn_6	144	149	PF01217	0.701
TRG_DiLeu_BaLyEn_6	154	159	PF01217	0.646
TRG_DiLeu_BaLyEn_6	81	86	PF01217	0.691
TRG_ENDOCYTIC_2	579	582	PF00928	0.624
TRG_ER_diArg_1	539	541	PF00400	0.693
TRG_ER_diArg_1	591	593	PF00400	0.643
TRG_ER_diArg_1	601	603	PF00400	0.653
TRG_NES_CRM1_1	59	69	PF08389	0.540
TRG_Pf-PMV_PEXEL_1	348	353	PF00026	0.635

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HKH9	Leishmania braziliensis	63%	100%
A4I811	Leishmania infantum	100%	100%
E9B2W8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q588	Leishmania major	87%	100%