Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X5M8_LEIDO

TriTrypDb:

LdBPK_322250.1 , LdCL_320027900 , LDHU3_32.2810

Length:

501

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	16
GO:0110165	cellular anatomical entity	1	16

Expansion

Sequence features

A0A3S7X5M8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X5M8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	21	25	PF00656	0.536
CLV_NRD_NRD_1	286	288	PF00675	0.545
CLV_NRD_NRD_1	349	351	PF00675	0.469
CLV_PCSK_KEX2_1	204	206	PF00082	0.402
CLV_PCSK_KEX2_1	286	288	PF00082	0.545
CLV_PCSK_KEX2_1	349	351	PF00082	0.403
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.363
CLV_PCSK_PC7_1	345	351	PF00082	0.381
CLV_PCSK_SKI1_1	245	249	PF00082	0.460
CLV_PCSK_SKI1_1	317	321	PF00082	0.371
CLV_PCSK_SKI1_1	39	43	PF00082	0.390
DEG_Nend_UBRbox_3	1	3	PF02207	0.590
DOC_CDC14_PxL_1	114	122	PF14671	0.601
DOC_MAPK_DCC_7	457	465	PF00069	0.278
DOC_MAPK_MEF2A_6	219	226	PF00069	0.553
DOC_MAPK_MEF2A_6	419	428	PF00069	0.559
DOC_MAPK_MEF2A_6	457	465	PF00069	0.278
DOC_PP1_RVXF_1	315	321	PF00149	0.502
DOC_PP1_RVXF_1	92	98	PF00149	0.589
DOC_PP2B_PxIxI_1	460	466	PF00149	0.213
DOC_PP4_FxxP_1	168	171	PF00568	0.420
DOC_WW_Pin1_4	31	36	PF00397	0.649
LIG_14-3-3_CanoR_1	489	495	PF00244	0.625
LIG_14-3-3_CanoR_1	53	58	PF00244	0.500
LIG_14-3-3_CanoR_1	94	98	PF00244	0.606
LIG_Actin_WH2_2	4	19	PF00022	0.614
LIG_APCC_ABBA_1	38	43	PF00400	0.516
LIG_BRCT_BRCA1_1	162	166	PF00533	0.355
LIG_BRCT_BRCA1_1	4	8	PF00533	0.602
LIG_FHA_1	155	161	PF00498	0.402
LIG_FHA_1	307	313	PF00498	0.317
LIG_FHA_1	342	348	PF00498	0.691
LIG_FHA_1	371	377	PF00498	0.407
LIG_FHA_1	387	393	PF00498	0.258
LIG_FHA_1	476	482	PF00498	0.421
LIG_FHA_1	90	96	PF00498	0.604
LIG_FHA_2	1	7	PF00498	0.595
LIG_GBD_Chelix_1	473	481	PF00786	0.450
LIG_IRF3_LxIS_1	276	283	PF10401	0.320
LIG_LIR_Apic_2	456	461	PF02991	0.406
LIG_LIR_Gen_1	106	115	PF02991	0.524
LIG_LIR_Gen_1	128	137	PF02991	0.581
LIG_LIR_Gen_1	153	164	PF02991	0.383
LIG_LIR_Gen_1	232	240	PF02991	0.538
LIG_LIR_Gen_1	26	36	PF02991	0.559
LIG_LIR_Gen_1	278	285	PF02991	0.315
LIG_LIR_Gen_1	358	369	PF02991	0.526
LIG_LIR_Gen_1	5	16	PF02991	0.597
LIG_LIR_Gen_1	96	105	PF02991	0.546
LIG_LIR_LC3C_4	373	378	PF02991	0.290
LIG_LIR_Nem_3	106	111	PF02991	0.561
LIG_LIR_Nem_3	116	120	PF02991	0.548
LIG_LIR_Nem_3	128	132	PF02991	0.595
LIG_LIR_Nem_3	146	150	PF02991	0.244
LIG_LIR_Nem_3	215	221	PF02991	0.643
LIG_LIR_Nem_3	232	236	PF02991	0.418
LIG_LIR_Nem_3	246	250	PF02991	0.500
LIG_LIR_Nem_3	26	31	PF02991	0.629
LIG_LIR_Nem_3	278	282	PF02991	0.377
LIG_LIR_Nem_3	358	364	PF02991	0.504
LIG_LIR_Nem_3	365	370	PF02991	0.350
LIG_LIR_Nem_3	483	488	PF02991	0.598
LIG_LIR_Nem_3	5	11	PF02991	0.558
LIG_LYPXL_yS_3	117	120	PF13949	0.529
LIG_MAD2	345	353	PF02301	0.566
LIG_NRBOX	476	482	PF00104	0.448
LIG_PCNA_PIPBox_1	273	282	PF02747	0.465
LIG_PCNA_yPIPBox_3	273	287	PF02747	0.478
LIG_PCNA_yPIPBox_3	486	499	PF02747	0.655
LIG_PCNA_yPIPBox_3	53	66	PF02747	0.518
LIG_PDZ_Class_2	496	501	PF00595	0.561
LIG_Pex14_1	162	166	PF04695	0.357
LIG_Pex14_2	129	133	PF04695	0.646
LIG_Pex14_2	364	368	PF04695	0.431
LIG_Pex14_2	451	455	PF04695	0.462
LIG_PTB_Apo_2	262	269	PF02174	0.419
LIG_REV1ctd_RIR_1	245	255	PF16727	0.535
LIG_REV1ctd_RIR_1	482	490	PF16727	0.345
LIG_SH2_CRK	269	273	PF00017	0.458
LIG_SH2_CRK	315	319	PF00017	0.439
LIG_SH2_CRK	397	401	PF00017	0.345
LIG_SH2_GRB2like	206	209	PF00017	0.660
LIG_SH2_GRB2like	438	441	PF00017	0.517
LIG_SH2_NCK_1	269	273	PF00017	0.347
LIG_SH2_PTP2	110	113	PF00017	0.618
LIG_SH2_PTP2	140	143	PF00017	0.462
LIG_SH2_PTP2	233	236	PF00017	0.505
LIG_SH2_PTP2	438	441	PF00017	0.482
LIG_SH2_SRC	238	241	PF00017	0.527
LIG_SH2_SRC	291	294	PF00017	0.381
LIG_SH2_SRC	438	441	PF00017	0.580
LIG_SH2_STAP1	206	210	PF00017	0.574
LIG_SH2_STAP1	227	231	PF00017	0.601
LIG_SH2_STAP1	238	242	PF00017	0.637
LIG_SH2_STAT3	206	209	PF00017	0.660
LIG_SH2_STAT5	110	113	PF00017	0.620
LIG_SH2_STAT5	119	122	PF00017	0.580
LIG_SH2_STAT5	140	143	PF00017	0.383
LIG_SH2_STAT5	184	187	PF00017	0.315
LIG_SH2_STAT5	188	191	PF00017	0.311
LIG_SH2_STAT5	233	236	PF00017	0.483
LIG_SH2_STAT5	291	294	PF00017	0.391
LIG_SH2_STAT5	367	370	PF00017	0.334
LIG_SH2_STAT5	438	441	PF00017	0.394
LIG_SH2_STAT5	498	501	PF00017	0.595
LIG_SH2_STAT5	83	86	PF00017	0.497
LIG_SH3_1	219	225	PF00018	0.543
LIG_SH3_3	219	225	PF00018	0.541
LIG_SH3_3	410	416	PF00018	0.319
LIG_SUMO_SIM_anti_2	109	116	PF11976	0.577
LIG_SUMO_SIM_anti_2	304	309	PF11976	0.290
LIG_SUMO_SIM_anti_2	373	378	PF11976	0.411
LIG_SUMO_SIM_anti_2	404	410	PF11976	0.356
LIG_SUMO_SIM_par_1	150	155	PF11976	0.381
LIG_SUMO_SIM_par_1	478	483	PF11976	0.216
LIG_TYR_ITIM	115	120	PF00017	0.600
LIG_TYR_ITIM	138	143	PF00017	0.431
LIG_TYR_ITIM	231	236	PF00017	0.498
LIG_TYR_ITIM	436	441	PF00017	0.290
LIG_TYR_ITSM	363	370	PF00017	0.431
LIG_UBA3_1	12	17	PF00899	0.622
LIG_UBA3_1	120	126	PF00899	0.626
LIG_WRC_WIRS_1	276	281	PF05994	0.405
MOD_CK1_1	334	340	PF00069	0.678
MOD_CK1_1	86	92	PF00069	0.606
MOD_CK1_1	93	99	PF00069	0.591
MOD_GlcNHglycan	105	108	PF01048	0.369
MOD_GlcNHglycan	239	243	PF01048	0.419
MOD_GlcNHglycan	31	34	PF01048	0.379
MOD_GlcNHglycan	338	341	PF01048	0.468
MOD_GlcNHglycan	43	46	PF01048	0.319
MOD_GlcNHglycan	76	79	PF01048	0.437
MOD_GSK3_1	12	19	PF00069	0.609
MOD_GSK3_1	139	146	PF00069	0.403
MOD_GSK3_1	150	157	PF00069	0.396
MOD_GSK3_1	188	195	PF00069	0.424
MOD_GSK3_1	332	339	PF00069	0.675
MOD_GSK3_1	351	358	PF00069	0.605
MOD_GSK3_1	382	389	PF00069	0.379
MOD_GSK3_1	86	93	PF00069	0.511
MOD_N-GLC_1	255	260	PF02516	0.273
MOD_N-GLC_2	265	267	PF02516	0.322
MOD_N-GLC_2	326	328	PF02516	0.380
MOD_NEK2_1	103	108	PF00069	0.587
MOD_NEK2_1	154	159	PF00069	0.366
MOD_NEK2_1	192	197	PF00069	0.423
MOD_NEK2_1	301	306	PF00069	0.293
MOD_NEK2_1	321	326	PF00069	0.612
MOD_NEK2_1	401	406	PF00069	0.420
MOD_NEK2_1	41	46	PF00069	0.527
MOD_NEK2_1	469	474	PF00069	0.424
MOD_PIKK_1	332	338	PF00454	0.692
MOD_PIKK_1	488	494	PF00454	0.585
MOD_PK_1	53	59	PF00069	0.499
MOD_PKA_2	103	109	PF00069	0.585
MOD_PKA_2	488	494	PF00069	0.640
MOD_PKA_2	90	96	PF00069	0.614
MOD_Plk_1	341	347	PF00069	0.596
MOD_Plk_4	188	194	PF00069	0.303
MOD_Plk_4	229	235	PF00069	0.518
MOD_Plk_4	243	249	PF00069	0.583
MOD_Plk_4	255	261	PF00069	0.573
MOD_Plk_4	275	281	PF00069	0.356
MOD_Plk_4	303	309	PF00069	0.285
MOD_Plk_4	372	378	PF00069	0.347
MOD_Plk_4	396	402	PF00069	0.355
MOD_Plk_4	469	475	PF00069	0.348
MOD_Plk_4	53	59	PF00069	0.534
MOD_ProDKin_1	31	37	PF00069	0.648
MOD_SUMO_rev_2	199	203	PF00179	0.649
TRG_DiLeu_BaEn_1	26	31	PF01217	0.618
TRG_ENDOCYTIC_2	105	108	PF00928	0.566
TRG_ENDOCYTIC_2	110	113	PF00928	0.537
TRG_ENDOCYTIC_2	117	120	PF00928	0.543
TRG_ENDOCYTIC_2	140	143	PF00928	0.373
TRG_ENDOCYTIC_2	178	181	PF00928	0.350
TRG_ENDOCYTIC_2	227	230	PF00928	0.499
TRG_ENDOCYTIC_2	233	236	PF00928	0.475
TRG_ENDOCYTIC_2	297	300	PF00928	0.345
TRG_ENDOCYTIC_2	315	318	PF00928	0.439
TRG_ENDOCYTIC_2	367	370	PF00928	0.377
TRG_ENDOCYTIC_2	397	400	PF00928	0.458
TRG_ENDOCYTIC_2	438	441	PF00928	0.430
TRG_ER_diArg_1	285	287	PF00400	0.379
TRG_ER_diArg_1	349	351	PF00400	0.660

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6A4	Leptomonas seymouri	56%	71%
A0A1X0NUP0	Trypanosomatidae	32%	79%
A0A1X0P3P0	Trypanosomatidae	23%	73%
A0A3Q8IDV0	Leishmania donovani	22%	77%
A0A3R7R847	Trypanosoma rangeli	23%	75%
A0A422MY34	Trypanosoma rangeli	33%	79%
A4HKK2	Leishmania braziliensis	74%	100%
A4HLQ6	Leishmania braziliensis	23%	80%
A4I834	Leishmania infantum	100%	100%
A4I956	Leishmania infantum	22%	77%
D0AAA1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	84%
E9B2Z2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q3Z3	Leishmania major	22%	77%
Q4Q564	Leishmania major	94%	100%
V5B8R5	Trypanosoma cruzi	22%	76%
V5BBK9	Trypanosoma cruzi	30%	80%